{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:08:27Z","timestamp":1791482907895,"version":"4.3.4"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078586","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T22:11:24Z","timestamp":1383775884000},"page":"e78586","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Rapid Kill\u2014Novel Endodontic Sealer and Enterococcus faecalis"],"prefix":"10.1371","volume":"8","author":[{"given":"Nurit","family":"Beyth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Kesler Shvero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Zaltsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Houri-Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Abramovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Perez","family":"Davidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervin I.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrmicro821","article-title":"Bacterial biofilms: from the natural environment to infectious diseases","volume":"2","author":"L Hall-Stoodley","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.joen.2009.04.030","article-title":"Evaluation of the effect of two chlorhexidine preparations on biofilm bacteria in vitro: a three-dimensional quantitative analysis","volume":"35","author":"Y Shen","year":"2009","journal-title":"J Endod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/01.don.0000164856.27920.85","article-title":"Clinical efficacy of treatment procedures in endodontic infection control and one year follow-up of periapical healing","volume":"31","author":"T Waltimo","year":"2005","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.joen.2008.07.028","article-title":"Clinical implications and microbiology of bacterial persistence after treatment procedures","volume":"34","author":"JF Siqueira Jr","year":"2008","journal-title":"J Endod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2009.09.038","article-title":"Fate of the tissue in lateral canals and apical ramifications in response to pathologic conditions and treatment procedures","volume":"36","author":"D Ricucci","year":"2010","journal-title":"J Endod"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.joen.2010.03.035","article-title":"Comparative evaluation of the antimicrobial efficacy of a 5% sodium hypochlorite subsonic-activated solution","volume":"36","author":"D Pasqualini","year":"2010","journal-title":"J Endod"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1365-2591.2001.00373.x","article-title":"Effects of four Ni-Ti preparation techniques on root canal geometry assessed by micro computed tomography","volume":"34","author":"OA Peters","year":"2001","journal-title":"Int Endod J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-9657.1990.tb00409.x","article-title":"Disinfection by endodontic irrigants and dressings of experimentally infected dentinal tubules","volume":"6","author":"D Orstavik","year":"1990","journal-title":"Endod Dent Traumatol"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Hancock Hh III, Sigurdsson A, Trope M, Moiseiwitsch J (2001) Bacteria isolated after unsuccessfulendodontic treatment in a North American population. Oral Surgery, Oral Medicine, Oral Pathology Oral Radiology and Endodontics 91, 579\u2013586.","DOI":"10.1067\/moe.2001.113587"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2334\/josnusd.51.207","article-title":"Evaluation of microleakage following application of a dentin bonding agent as root canal sealer in the presence or absence of smear layer","volume":"51","author":"S Moradi","year":"2009","journal-title":"J Oral Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.don.0000140569.33867.bf","article-title":"Periapical inflammation after coronal microbial inoculation of dog roots filled with gutta-percha or resilon","volume":"31","author":"G Shipper","year":"2005","journal-title":"J Endod"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0099-2399(85)80141-2","article-title":"A comparison of the area of the canal space occupied by gutta-percha following four gutta-percha obturation techniques using Procosol sealer","volume":"11","author":"DS Eguchi","year":"1985","journal-title":"J Endod"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1365-2591.2011.01931.x","article-title":"Antibacterial activity of two MTA-based root canal sealers","volume":"44","author":"RD Morgental","year":"2011","journal-title":"Int Endod J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.17796\/jcpd.33.2.d526512310970142","article-title":"An analysis of the antimicrobial activity of ten root canal sealers-a duration based in vitro evaluation","volume":"33","author":"P Neelakantan","year":"2008","journal-title":"J Clin Pediatr Dent"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.joen.2008.03.012","article-title":"Antibacterial properties of four endodontic sealers","volume":"34","author":"I Slutzky-Goldberg","year":"2008","journal-title":"J Endod"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.joen.2009.04.022","article-title":"Antibacterial activity of endodontic sealers by modified direct contact test against Enterococcus faecalis","volume":"35","author":"H Zhang","year":"2009","journal-title":"J Endod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.joen.2011.05.034","article-title":"A Bacterial and Candida albicans adhesion on different root canal filling materials and sealers","volume":"37","author":"C Senges","year":"2011","journal-title":"J Endod"},{"key":"ref18","volume":"77","unstructured":"Nonaka T, Noda E, Kurihara S (2000) Graft copolymerization of vinyl monomers bearing positive charges or episulfide groups onto loofah fibers and their antibacterial activity. Journal of Applied Polymer Science <volume>77<\/volume>: : 1077 \u2013 1086."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/AEM.24.6.859-863.1972","article-title":"Surface-bonded antimicrobial activity of an organosilicon quaternary ammonium chloride","volume":"24","author":"AJ Isquith","year":"1972","journal-title":"Appl Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/1097-4628(20001017)78:3<676::AID-APP240>3.0.CO;2-E","article-title":"A study of pyridinium-type functional polymers. IV. Behavioral features of the antibacterial activity of insoluble pyridinium-type polymers","volume":"78","author":"G Li","year":"2000","journal-title":"Jouornal of Applied Polymer Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/1097-4628(20001017)78:3<668::AID-APP230>3.0.CO;2-A","article-title":"A study of pyridinium-type functional polymers. III. Preparation and characterization of insoluble pyridinium-type polymers","volume":"78","author":"G Li","year":"2000","journal-title":"J Appl Polym Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0005-2736(90)90339-P","article-title":"Phase separation in phospholipid bilayers induced by biologically active polycations","volume":"1026","author":"T Ikeda","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/bit.10299","article-title":"Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria","volume":"79","author":"JC Tiller","year":"2002","journal-title":"Biotechnol Bioeng"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1073\/pnas.111143098","article-title":"Designing surfaces that kill bacteria on contact","volume":"98","author":"JC Tiller","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tibtech.2005.05.004","article-title":"Surpassing nature: rational design of sterile-surface materials","volume":"23","author":"K Lewis","year":"2005","journal-title":"Trends Biotechnol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1021\/bp025597w","article-title":"Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines","volume":"18","author":"J Lin","year":"2002","journal-title":"Biotechnol Prog"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/bit.10651","article-title":"Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine","volume":"83","author":"J Lin","year":"2003","journal-title":"Biotechnol Bioeng"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1128\/AEM.54.10.2532-2535.1988","article-title":"Antibacterial activity of soluble pyridinium-type polymers","volume":"54","author":"N Kawabata","year":"1998","journal-title":"Appl Environ Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1163\/156856207780852523","article-title":"Studies on the preparation and antibacterial properties of quaternized polyethyleneimine","volume":"18","author":"B Gao","year":"2007","journal-title":"J Biomater Sci Polym Ed"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1016\/j.biomaterials.2006.03.003","article-title":"Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans","volume":"27","author":"N Beyth","year":"2006","journal-title":"Biomaterials"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1016\/j.biomaterials.2008.07.003","article-title":"Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles","volume":"29","author":"N Beyth","year":"2008","journal-title":"Biomaterials"},{"key":"ref32","first-page":"827","article-title":"Long-term antibacterial surface properties of composite resin incorporating polyethyleneimine nanoparticles","volume":"41","author":"N Beyth","year":"2010","journal-title":"Quintessence Int"},{"key":"ref33","first-page":"22038","article-title":"Polyethyleneimine nanoparticles incorporated into resin composite cause cell death and trigger biofilm stress in vivo (2010) Proc Natl Acad Sci U S A","volume":"107","author":"N Beyth","year":"2010"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Beyth N, Domb AJ, Weiss EI (2007). An in vitro quantitative antibacterial analysis of amalgam and composite resins. J Dent 35 : 201\u2013206.","DOI":"10.1016\/j.jdent.2006.07.009"},{"key":"ref35","first-page":"147","article-title":"Antimicrobial activity of endodontic sealers based on calcium hydroxide and MTA","volume":"21","author":"JM Tanomaru","year":"2008","journal-title":"Acta Odontol Latinoam"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cden.2007.04.005","article-title":"Endodontic materials","volume":"51","author":"RS Gatewood","year":"2007","journal-title":"Dent Clin North Am"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1747-4477.2010.00241.x","article-title":"An agar diffusion study comparing the antimicrobial activity of Nanoseal with some other endodontic sealers","volume":"38","author":"AB Aal-Saraj","year":"2012","journal-title":"Aust Endod J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4103\/0970-4388.76151","article-title":"Antimicrobial activity of different endodontic sealers: an in vitro evaluation","volume":"28","author":"S Saha","year":"2010","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jdent.2005.03.001","article-title":"In vitro antibacterial activity of endodontic sealers","volume":"34","author":"G Pizzo","year":"2006","journal-title":"J Dent"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00004770-200405000-00004","article-title":"Association of Enterococcus faecalis with different forms of periradicular diseases","volume":"30","author":"IN R\u00f4\u00e7as","year":"2004","journal-title":"J Endod"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1399-302X.2005.00227.x","article-title":"Detection of bacteria in endodontic samples by polymerase chain reaction assays and association with defined clinical signs in Italian patients","volume":"20","author":"F Foschi","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2591.1988.tb00969.x","article-title":"Antibacterial properties of dental restorative materials: a review","volume":"21","author":"RS Tobias","year":"1988","journal-title":"Int Endod J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.joen.2006.05.006","article-title":"Initial in vitro biological response to contemporary endodontic sealers","volume":"32","author":"S Bouillaguet","year":"2006","journal-title":"J Endod"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00004770-200005000-00005","article-title":"Antimicrobial activity and flow rate of newer and established root canal sealers","volume":"26","author":"JF Siqueira Jr","year":"2000","journal-title":"J Endod"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T12:32:51Z","timestamp":1596803571000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078586"}},"subtitle":[],"editor":[{"given":"Daniela Flavia","family":"Hozbor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":44,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078586","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]}}}