{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:48:20Z","timestamp":1789015700833,"version":"build-2803163510"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0078812","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T18:52:13Z","timestamp":1384195933000},"page":"e78812","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":110,"title":["Nodular Lymphocyte Predominant Hodgkin Lymphoma and T Cell\/Histiocyte Rich Large B Cell Lymphoma - Endpoints of a Spectrum of One Disease?"],"prefix":"10.1371","volume":"8","author":[{"given":"Sylvia","family":"Hartmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"D\u00f6ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Jakobus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Rengstl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Newrzela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tousseyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Sagaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"de Wolf-Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Steidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"K\u00fcppers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin-Leo","family":"Hansmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1073\/pnas.91.23.10962","article-title":"Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development","volume":"91","author":"R K\u00fcppers","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1073\/pnas.94.17.9337","article-title":"Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells","volume":"94","author":"A Braeuninger","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1200\/JCO.1999.17.3.776","article-title":"Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin\u2019s disease and lymphocyte-rich classical Hodgkin\u2019s disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin\u2019s Disease","volume":"17","author":"V Diehl","year":"1999","journal-title":"J Clin Oncol"},{"key":"ref4","unstructured":"Swerdlow SH, International Agency for Research on Cancer, World Health Organization (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer. 439 p. p."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/00000478-200310000-00007","article-title":"Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation","volume":"27","author":"Z Fan","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1182\/blood-2003-02-0626","article-title":"Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell\/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell\/histiocyte-rich B-cell lymphoma","volume":"102","author":"L Boudova","year":"2003","journal-title":"Blood"},{"key":"ref7","first-page":"1269","article-title":"T-cell\/histiocyte-rich large B-cell lymphoma: a distinct clinicopathologic entity","volume":"20","author":"R Achten","year":"2002","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1080\/10428190701559124","article-title":"T-cell\/histiocyte-rich B-cell lymphoma: Clinical presentation, management and prognostic factors: report on 61 patients and review of literature","volume":"48","author":"A El Weshi","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1200\/JCO.2003.06.046","article-title":"T-cell\/histiocyte-rich large B-cell lymphomas and classical diffuse large B-cell lymphomas have similar outcome after chemotherapy: a matched-control analysis","volume":"21","author":"R Bouabdallah","year":"2003","journal-title":"J Clin Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/annonc\/13.S1.44","article-title":"Workshop on the relationship between nodular lymphocyte predominant Hodgkin\u2019s lymphoma and T cell\/histiocyte-rich B cell lymphoma","volume":"13","author":"T Rudiger","year":"2002","journal-title":"Ann Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2559.2002.01291.x","article-title":"Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features","volume":"40","author":"R Achten","year":"2002","journal-title":"Histopathology"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Hartmann S, Tousseyn T, D\u00f6ring C, Fl\u00fcchter P, Hackstein C, et al. (in press) Macrophages in T cell\/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype Int J Cancer.","DOI":"10.1002\/ijc.28273"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1084\/jem.20080809","article-title":"Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis","volume":"205","author":"V Brune","year":"2008","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1182\/blood-2004-10-4008","article-title":"Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma","volume":"105","author":"C Renn\u00e9","year":"2005","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hartmann S, Jakobus C, Rengstl B, Doring C, Newrzela S, <etal>et al<\/etal>.. (2013) Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma. Mod Pathol.","DOI":"10.1038\/modpathol.2012.217"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1365-2559.2011.04069.x","article-title":"Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert\u2019s lymphoma nowadays?","volume":"59","author":"S Hartmann","year":"2011","journal-title":"Histopathology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4161\/cc.5.2.2353","article-title":"Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription","volume":"5","author":"LH Kasper","year":"2006","journal-title":"Cell Cycle"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00335-007-9065-x","article-title":"Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin","volume":"18","author":"EA Peterson","year":"2007","journal-title":"Mamm Genome"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1101\/gad.1534107","article-title":"HLA-B-associated transcript 3 (Bat3)\/Scythe is essential for p300-mediated acetylation of p53","volume":"21","author":"T Sasaki","year":"2007","journal-title":"Genes Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature10181","article-title":"Protein targeting and degradation are coupled for elimination of mislocalized proteins","volume":"475","author":"T Hessa","year":"2011","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e40836","DOI":"10.1371\/journal.pone.0040836","article-title":"BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages","volume":"7","author":"A Grover","year":"2012","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.abb.2011.02.017","article-title":"FAT10 modifies p53 and upregulates its transcriptional activity","volume":"509","author":"T Li","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1681\/ASN.2009050479","article-title":"The ubiquitin-like protein FAT10 mediates NF-kappaB activation","volume":"21","author":"P Gong","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1073\/pnas.96.8.4313","article-title":"A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2","volume":"96","author":"YC Liu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/modpathol.3800625","article-title":"Expression of CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified","volume":"19","author":"KL Grogg","year":"2006","journal-title":"Mod Pathol"},{"key":"ref26","first-page":"1893","article-title":"TIA-1 expression in lymphoid neoplasms. Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation","volume":"150","author":"RE Felgar","year":"1997","journal-title":"Am J Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00428-011-1165-z","article-title":"T cell\/histiocyte-rich large B-cell lymphoma: an update on its biology and classification","volume":"459","author":"T Tousseyn","year":"2011","journal-title":"Virchows Arch"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/PAS.0b013e318165b0d6","article-title":"PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma","volume":"32","author":"SH Nam-Cha","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.humpath.2010.05.010","article-title":"Programmed death 1 expression in variant immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma: comparison with CD57 and lymphomas in the differential diagnosis","volume":"41","author":"HR Churchill","year":"2010","journal-title":"Hum Pathol"},{"key":"ref30","first-page":"957","article-title":"Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin\u2019s disease","volume":"89","author":"T Marafioti","year":"2004","journal-title":"Haematologica"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000478-198801000-00002","article-title":"Monoclonal antibodies in the diagnosis of Hodgkin\u2019s disease. The search for a rational panel","volume":"12","author":"SM Chittal","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00000478-198806000-00003","article-title":"T-cell-rich B-cell lymphoma","volume":"12","author":"AD Ramsay","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1365-2559.2002.01466.x","article-title":"T-cell\/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin\u2019s lymphoma","volume":"41","author":"M Fraga","year":"2002","journal-title":"Histopathology"},{"key":"ref34","first-page":"1281","article-title":"L and H cells of nodular lymphocyte predominant Hodgkin\u2019s disease show immunoglobulin light-chain restriction","volume":"139","author":"C Schmid","year":"1991","journal-title":"Am J Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00000478-200307000-00005","article-title":"Micronodular T-cell\/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis","volume":"27","author":"A Dogan","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1658-3876(08)50056-2","article-title":"Morphologic, immunphenotypic and clinical discriminators between T-cell\/histiocyte-rich large B-cell lymphoma and lymphocyte-predominant Hodgkin lymphoma","volume":"1","author":"WA Mourad","year":"2008","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/00000478-200008000-00004","article-title":"Lymphocyte predominance Hodgkin\u2019s disease: the use of bcl-6 and CD57 in diagnosis and differential diagnosis","volume":"24","author":"MD Kraus","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1182\/blood.V97.6.1845","article-title":"Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances","volume":"97","author":"S Franke","year":"2001","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0002-9440(10)64462-8","article-title":"Comparative genomic hybridization pattern distinguishes T-cell\/histiocyte-rich B-cell lymphoma from nodular lymphocyte predominance Hodgkin\u2019s lymphoma","volume":"161","author":"S Franke","year":"2002","journal-title":"Am J Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature03147","article-title":"The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells","volume":"432","author":"RT Phan","year":"2004","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1182\/blood-2002-05-1592","article-title":"Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma","volume":"101","author":"I Wlodarska","year":"2003","journal-title":"Blood"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.immuni.2007.10.010","article-title":"Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells","volume":"27","author":"E Pogge von Strandmann","year":"2007","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1038\/onc.2008.201","article-title":"Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon","volume":"27","author":"S Lukasiak","year":"2008","journal-title":"Oncogene"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1096\/fj.11-196063","article-title":"HIG1, a novel regulator of mitochondrial gamma-secretase, maintains normal mitochondrial function","volume":"26","author":"H Hayashi","year":"2012","journal-title":"FASEB J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1023\/A:1020913123054","article-title":"cDNA microarray analysis of changes in gene expression induced by neuronal hypoxia in vitro","volume":"27","author":"K Jin","year":"2002","journal-title":"Neurochem Res"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Nathwani B, Vornanen M, Winkelmann R, Kansal R, D\u00f6ring C, <etal>et al<\/etal>.. (2013) Intranodular Clusters of Activated Cells with T Follicular Helper (TFH) phenotype in Nodular Lymphocyte Predominant Hodgkin Lymphoma: A Pilot Study of 32 cases from Finland. Hum Pathol.","DOI":"10.1016\/j.humpath.2013.02.010"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3324\/haematol.2009.010991","article-title":"The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation","volume":"95","author":"T Marafioti","year":"2010","journal-title":"Haematologica"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3324\/haematol.2009.009647","article-title":"T cell\/histiocyte rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response","volume":"95","author":"P Van Loo","year":"2009","journal-title":"Haematologica"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa0905680","article-title":"Tumor-associated macrophages and survival in classic Hodgkin\u2019s lymphoma","volume":"362","author":"C Steidl","year":"2010","journal-title":"N Engl J Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3324\/haematol.2010.031542","article-title":"Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin\u2019s lymphoma","volume":"96","author":"P Kamper","year":"2011","journal-title":"Haematologica"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000321567","article-title":"Refined prognostic role of CD68-positive tumor macrophages in the context of the cellular micromilieu of classical Hodgkin lymphoma","volume":"77","author":"A Tzankov","year":"2010","journal-title":"Pathobiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/blood-2012-04-421057","article-title":"Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial","volume":"120","author":"KL Tan","year":"2012","journal-title":"Blood"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-2141.2012.09067.x","article-title":"Peripheral blood lymphocyte\/monocyte ratio at diagnosis and survival in nodular lymphocyte-predominant Hodgkin lymphoma","volume":"157","author":"LF Porrata","year":"2012","journal-title":"Br J Haematol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3324\/haematol.2011.050138","article-title":"Peripheral blood lymphocyte\/monocyte ratio at diagnosis and survival in classical Hodgkin\u2019s lymphoma","volume":"97","author":"LF Porrata","year":"2012","journal-title":"Haematologica"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1634\/theoncologist.2012-0034","article-title":"The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin\u2019s lymphoma: correlation with tumor-associated macrophages","volume":"17","author":"YW Koh","year":"2012","journal-title":"Oncologist"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1182\/blood-2007-09-112128","article-title":"Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes","volume":"111","author":"Y Ma","year":"2008","journal-title":"Blood"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ijc.10399","article-title":"Common and differential chemokine expression patterns in rs cells of NLP, EBV positive and negative classical Hodgkin lymphomas","volume":"99","author":"EM Maggio","year":"2002","journal-title":"Int J Cancer"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1200\/JCO.2012.41.8137","article-title":"Stage-adapted treatment of HIV-associated Hodgkin lymphoma: results of a prospective multicenter study","volume":"30","author":"M Hentrich","year":"2012","journal-title":"J Clin Oncol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0078812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T09:27:04Z","timestamp":1564651624000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0078812"}},"subtitle":[],"editor":[{"given":"Jose Angel Martinez","family":"Climent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0078812","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,11]]}}}