{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:37:22Z","timestamp":1775075842860,"version":"3.50.1"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079031","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T22:33:02Z","timestamp":1383345182000},"page":"e79031","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Risk of Schizophrenia and Child Psychiatric Disorders in Offspring of Mothers with Lung Cancer and Other Types of Cancer: A Danish Nationwide Register Study"],"prefix":"10.1371","volume":"8","author":[{"given":"Michael Eriksen","family":"Benros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Munk","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne Oksbjerg","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"Nordentoft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preben Bo","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pediatrneurol.2007.10.009","article-title":"Fetal mechanisms in neurodevelopmental disorders","volume":"38","author":"SL Connors","year":"2008","journal-title":"Pediatr Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"167","author":"AS Brown","year":"2010","journal-title":"Am J Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1017\/S095457940800062X","article-title":"Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia","volume":"20","author":"KH Karlsgodt","year":"2008","journal-title":"Dev Psychopathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/mp.2008.5","article-title":"Are some cases of psychosis caused by microbial agents? A review of the evidence","volume":"13","author":"RH Yolken","year":"2008","journal-title":"Mol Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archpsyc.58.11.1032","article-title":"Maternal infections and subsequent psychosis among offspring","volume":"58","author":"SL Buka","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/17402520600801745","article-title":"The possible role of transplacentally-acquired antibodies to infectious agents, with molecular mimicry to nervous system sialic acid epitopes, as causes of neuromental disorders: prevention and vaccine implications","volume":"13","author":"AJ Nahmias","year":"2006","journal-title":"Clin Dev Immunol"},{"key":"ref7","first-page":"226","article-title":"Autism: maternally derived antibodies specific for fetal brain proteins","volume":"29","author":"D Braunschweig","year":"2008","journal-title":"Neurotoxicology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","article-title":"Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia","volume":"59","author":"K Ozawa","year":"2006","journal-title":"Biol Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.155.2.264","article-title":"Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases","volume":"155","author":"SE Swedo","year":"1998","journal-title":"Am J Psychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1749-6632.2003.tb03137.x","article-title":"Antibodies to neuronal targets in neurological and psychiatric diseases","volume":"992","author":"A Vincent","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/aje\/kwm342","article-title":"Maternal thyroid autoantibodies during the third trimester and hearing deficits in children: an epidemiologic assessment","volume":"167","author":"EE Wasserman","year":"2008","journal-title":"Am J Epidemiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbi.2006.08.005","article-title":"Maternal antibrain antibodies in autism","volume":"21","author":"AW Zimmerman","year":"2007","journal-title":"Brain Behav Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbi.2007.12.007","article-title":"Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism","volume":"22","author":"LA Martin","year":"2008","journal-title":"Brain Behav Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneuroim.2009.03.011","article-title":"Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model","volume":"211","author":"HS Singer","year":"2009","journal-title":"J Neuroimmunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nri2529","article-title":"Losing your nerves? Maybe it&apos;s the antibodies","volume":"9","author":"B Diamond","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/156720206776875894","article-title":"Autoantibodies associated with psychiatric disorders","volume":"3","author":"P Margutti","year":"2006","journal-title":"Curr Neurovasc Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s00415-010-5788-9","article-title":"Disease-relevant autoantibodies in first episode schizophrenia","volume":"258","author":"MS Zandi","year":"2011","journal-title":"J Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1056\/NEJMra023009","article-title":"Paraneoplastic syndromes involving the nervous system","volume":"349","author":"RB Darnell","year":"2003","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1176\/appi.ajp.2010.09101547","article-title":"Psychiatric manifestations of paraneoplastic disorders","volume":"167","author":"MS Kayser","year":"2010","journal-title":"Am J Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/ijc.24274","article-title":"Psychiatric disorder as a first manifestation of cancer: a 10-year population-based study","volume":"124","author":"ME Benros","year":"2009","journal-title":"Int J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00415-009-5431-9","article-title":"Antibodies and neuronal autoimmune disorders of the CNS","volume":"257","author":"F Graus","year":"2010","journal-title":"J Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1212\/WNL.50.6.1919","article-title":"Absence of HuD gene mutations in paraneoplastic small cell lung cancer tissue","volume":"50","author":"AF Carpentier","year":"1998","journal-title":"Neurology"},{"key":"ref23","first-page":"388","article-title":"Limbic encephalitis. A rare presentation of the small-cell lung carcinoma","volume":"11","author":"AM den Hollander","year":"1989","journal-title":"Gen Hosp Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/1097-0142(19950101)75:1<99::AID-CNCR2820750117>3.0.CO;2-I","article-title":"Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer","volume":"75","author":"J Dalmau","year":"1995","journal-title":"Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/ana.410380117","article-title":"Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites","volume":"38","author":"GT Manley","year":"1995","journal-title":"Ann Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jnnp.67.3.353","article-title":"Anti-Hu antibody titre and brain metastases before and after treatment for small cell lung cancer","volume":"67","author":"JJ Verschuuren","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1200\/JCO.2004.01.028","article-title":"Hu and voltage-gated calcium channel (VGCC) antibodies related to the prognosis of small-cell lung cancer","volume":"22","author":"SE Monstad","year":"2004","journal-title":"J Clin Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1176\/appi.ajp.161.5.903","article-title":"Risk for cancer in parents of patients with schizophrenia","volume":"161","author":"SO Dalton","year":"2004","journal-title":"Am J Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/archpsyc.58.6.573","article-title":"Incidence of cancer among persons with schizophrenia and their relatives","volume":"58","author":"D Lichtermann","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1192\/bjp.bp.106.024943","article-title":"Cancer risk among parents and siblings of patients with schizophrenia","volume":"190","author":"I Levav","year":"2007","journal-title":"Br J Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/schbul\/sbs065","article-title":"Incidence of Cancer in Patients With Schizophrenia and Their First-Degree Relatives: A Population-Based Study in Sweden","volume":"39","author":"J Ji","year":"2013","journal-title":"Schizophr Bull"},{"key":"ref32","article-title":"2005)","author":"SO Dalton"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/bjc.1997.24","article-title":"Psychological stress, cancer incidence and mortality from non-malignant diseases","volume":"75","author":"C Johansen","year":"1997","journal-title":"Br J Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM199512143332403","article-title":"Cancer in the parents of children with cancer","volume":"333","author":"JH Olsen","year":"1995","journal-title":"N Engl J Med"},{"key":"ref35","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"CB Pedersen","year":"2006","journal-title":"Dan Med Bull"},{"key":"ref36","first-page":"82","article-title":"The Danish Psychiatric Central Register","volume":"44","author":"P Munk-J\u00f8rgensen","year":"1997","journal-title":"Dan Med Bull"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1403494810395825","article-title":"The Danish Psychiatric Central Research Register","volume":"39","author":"O Mors","year":"2011","journal-title":"Scand J Public Health"},{"key":"ref38","first-page":"535","article-title":"The Danish Cancer Registry--history, content, quality and use","volume":"44","author":"HH Storm","year":"1997","journal-title":"Dan Med Bull"},{"key":"ref39","first-page":"1965","article-title":"Klassifikation af sygdomme; Udvidet dansk-latinsk udgave af verdenssundhedsorganisationens internationale klassifikation af sygdomme","volume":"8","year":"1971","journal-title":"ReVision"},{"key":"ref40","article-title":"WHO ICD-10: Psykiske lidelser og adf\u00e6rdsm\u00e6ssige forstyrelser. Klassifikation og diagnosekriterier [WHO ICD-10: Mental and behavioural Disorders","year":"1994"},{"key":"ref41","article-title":"Statistical Models in Epidemiology","author":"D Clayton","year":"1993"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0197-2456(00)00104-5","article-title":"Sample-size calculations for the Cox proportional hazards regression model with nonbinary covariates","volume":"21","author":"FY Hsieh","year":"2000","journal-title":"Control Clin Trials"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.schres.2005.06.005","article-title":"Maternal-fetal blood incompatibility and the risk of schizophrenia in offspring","volume":"80","author":"BJ Insel","year":"2005","journal-title":"Schizophr Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nm.1892","article-title":"Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus","volume":"15","author":"JY Lee","year":"2009","journal-title":"Nat Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/schbul\/sbr149","article-title":"Association Between Parental Hospital-Treated Infection and the Risk of Schizophrenia in Adolescence and Early Adulthood","volume":"39","author":"PR Nielsen","year":"2013","journal-title":"Schizophr Bull"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1399-5618.2010.00853.x","article-title":"Autoimmune diseases, bipolar disorder, and non-affective psychosis","volume":"12","author":"WW Eaton","year":"2010","journal-title":"Bipolar Disord"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.162.4.767","article-title":"Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring","volume":"162","author":"AS Brown","year":"2005","journal-title":"Am J Psychiatry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archpsyc.1988.01800260109013","article-title":"Adult schizophrenia following prenatal exposure to an influenza epidemic","volume":"45","author":"SA Mednick","year":"1988","journal-title":"Arch Gen Psychiatry"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.biopsych.2006.05.024","article-title":"Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth","volume":"61","author":"PB Mortensen","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/pbc.22303","article-title":"Autism in children and adolescents with cancer","volume":"54","author":"J Blatt","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/14622200701825908","article-title":"Cigarette smoking during pregnancy","volume":"10","author":"AK Shea","year":"2008","journal-title":"Nicotine Tob Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1176\/appi.ajp.160.6.1028","article-title":"Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence","volume":"160","author":"KM Linnet","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/CLEP.S28984","article-title":"Children and young adults with parents with cancer: a population-based study","volume":"4","author":"A Syse","year":"2012","journal-title":"J Clin Epidemiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/ijc.27466","article-title":"The prevalence of children affected by parental cancer and their use of specialized psychiatric services: the 1987 Finnish Birth Cohort study","volume":"131","author":"M Niemel\u00e4","year":"2012","journal-title":"Int J Cancer"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/archpsyc.58.11.1039","article-title":"Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk","volume":"58","author":"CB Pedersen","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1192\/bjp.179.1.46","article-title":"Family history, place and season of birth as risk factors for schizophrenia in Denmark: a replication and reanalysis","volume":"179","author":"CB Pedersen","year":"2001","journal-title":"Br J Psychiatry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T23:50:30Z","timestamp":1688601030000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079031"}},"subtitle":[],"editor":[{"given":"Xiang\u00a0Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":56,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079031","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}