{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:00:35Z","timestamp":1791986435803,"version":"4.4.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079167","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T23:06:45Z","timestamp":1384384005000},"page":"e79167","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":231,"title":["Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance"],"prefix":"10.1371","volume":"8","author":[{"given":"Sanjib","family":"Bhattacharyya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sounik","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Giri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Sreekumar","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas B.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Rodriguez-Aguayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Lopez-Berestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eati","family":"Basal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Visscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Cliby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resham","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyabrata","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6(11)","author":"C Szabo","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H(2)S signalling through protein sulfhydration and beyond","volume":"13(8)","author":"BD Paul","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.2174\/092986712801215928","article-title":"Hydrogen sulphide: biopharmacological roles in the cardiovascular system and pharmaceutical perspectives","volume":"19(20)","author":"A Martelli","year":"2012","journal-title":"Curr Med Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00109-012-0873-4","article-title":"Hydrogen sulfide: a gasotransmitter of clinical relevance","volume":"90(3)","author":"M Vandiver","year":"2012","journal-title":"J Mol Med (Berl)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3892\/ijmm.2012.1090","article-title":"Hydrogen sulfide protects PC12 cells against reactive oxygen species and extracellular signal-regulated kinase 1\/2-mediated downregulation of glutamate transporter-1 expression induced by chemical hypoxia","volume":"30(5)","author":"L Xiao","year":"2012","journal-title":"Int J Mol Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed","volume":"92(2)","author":"R Wang","year":"2012","journal-title":"Physiol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice","volume":"308(5721)","author":"E Blackstone","year":"2005","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.1209855","article-title":"H2S: a universal defense against antibiotics in bacteria","volume":"334(6058)","author":"K Shatalin","year":"2011","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.gastro.2006.02.033","article-title":"The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver","volume":"131(1)","author":"S Fiorucci","year":"2006","journal-title":"Gastroenterology"},{"key":"ref10","first-page":"1585","article-title":"Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U.S.A","volume":"92(5)","author":"M Watanabe","year":"1995"},{"key":"ref11","first-page":"H13","article-title":"Vascular complications of cystathionine beta-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research","volume":"300(1)","author":"RS Beard Jr","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1182\/blood-2011-09-380568","article-title":"Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia","volume":"119(13)","author":"S Dayal","year":"2012","journal-title":"Blood"},{"key":"ref13","first-page":"12474","article-title":"B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci USA","volume":"105(34)","author":"AM Troen","year":"2008","journal-title":"2008"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354(15)","author":"KH Bonaa","year":"2006","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.300.7.795","article-title":"Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial","volume":"300(7)","author":"M Ebbing","year":"2008","journal-title":"Jama"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc1123","article-title":"Ovarian cancer: strategies for overcoming resistance to chemotherapy","volume":"3(7)","author":"R Agarwal","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/or.2013.2446","article-title":"Tumor suppressor genes associated with drug resistance in ovarian cancer","volume":"30(1)","author":"F Yin","year":"2013","journal-title":"Oncol Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1158\/1078-0432.CCR-08-2306","article-title":"Therapeutic Targeting of ATP7B in Ovarian Carcinoma","volume":"15(11)","author":"LS Mangala","year":"2009","journal-title":"Clin Cancer Res 2009"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1158\/1078-0432.CCR-08-1414","article-title":"Role of hedgehog signaling in ovarian cancer","volume":"14(23)","author":"R Bhattacharya","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3(6)","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1158\/1078-0432.CCR-04-2482","article-title":"Antiangiogenic properties of gold nanoparticles","volume":"11(9)","author":"P Mukherjee","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cmet.2011.08.012","article-title":"Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor","volume":"(4)","author":"YP Hung","year":"2011","journal-title":"Cell Metab"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/smll.201000463","article-title":"The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles","volume":"6(20)","author":"A Chompoosor","year":"2010","journal-title":"Small"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj20040095","article-title":"Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts","volume":"3)","author":"E Hutter","year":"2004","journal-title":"Biochem J 380(Pt"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/nprot.2007.327","article-title":"Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy","volume":"2(9)","author":"P Mukhopadhyay","year":"2007","journal-title":"Nat Protoc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"15364","DOI":"10.1073\/pnas.93.26.15364","article-title":"Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle","volume":"93(26)","author":"OE Rooyackers","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/jnci\/djn024","article-title":"Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth","volume":"100(5)","author":"WM Merritt","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.1171362","article-title":"Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer","volume":"324(5933)","author":"KP Olive","year":"2009","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/abbi.1997.0486","article-title":"Identification and tissue distribution of human cystathionine beta-synthase mRNA isoforms","volume":"350(1)","author":"L Bao","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1093\/hmg\/ddl393","article-title":"Cystathionine beta-synthase is essential for female reproductive function","volume":"15(21)","author":"MA Guzman","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.biochem.66.1.269","article-title":"Structure-based perspectives on B12-dependent enzymes","volume":"6","author":"ML Ludwig","year":"1997","journal-title":"Annu Rev Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/jm901638j","article-title":"Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals","volume":"53(17)","author":"G Caliendo","year":"2010","journal-title":"J Med Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12265-010-9201-y","article-title":"Development of hydrogen sulfide-based therapeutics for cardiovascular disease","volume":"3(5)","author":"BL Predmore","year":"2010","journal-title":"J Cardiovasc Transl Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrc2715","article-title":"p53 and metabolism","volume":"9(10)","author":"KH Vousden","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.93.17.9166","article-title":"Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines","volume":"93(17)","author":"J Lotem","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/sj.cdd.4401694","article-title":"NF-kappaB meets ROS: an &apos;iron-ic&apos; encounter","volume":"12(10)","author":"S Papa","year":"2005","journal-title":"Cell Death Differ"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1038\/onc.2011.156","article-title":"NF-kappaB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death","volume":"30(45)","author":"SJ Stein","year":"2011","journal-title":"Oncogene"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-kappaB signaling","volume":"21(1)","author":"MJ Morgan","year":"2011","journal-title":"Cell Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e17918","DOI":"10.1371\/journal.pone.0017918","article-title":"Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer","volume":"6(3)","author":"E Wang","year":"2011","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0076-6879(09)05020-4","article-title":"Functional assessment of isolated mitochondria in vitro","volume":"457","author":"IR Lanza","year":"2009","journal-title":"Methods Enzymol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109(8)","author":"M Fu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","article-title":"The role of glutathione-S-transferase in anti-cancer drug resistance","volume":"22(47)","author":"DM Townsend","year":"2003","journal-title":"Oncogene"},{"key":"ref43","first-page":"303","article-title":"Role of glutathione in cancer pathophysiology and therapeutic interventions","volume":"9(4)","author":"S Singh","year":"2012","journal-title":"J Exp Ther Oncol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/cdd.2010.80","article-title":"Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death","volume":"17(9)","author":"E Laborde","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bcp.2011.11.016","article-title":"The role of glutathione in brain tumor drug resistance","volume":"83(8)","author":"DS Backos","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-\u03b2-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110(30)","author":"C Szabo","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuro.2004.06.002","article-title":"Role of ERK activation in cisplatin-induced apoptosis in A172 human glioma cells","volume":"25(6)","author":"BK Choi","year":"2004","journal-title":"Neurotoxicology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"29470","DOI":"10.1074\/jbc.M706145200","article-title":"Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms","volume":"282(40)","author":"H Lou","year":"2007","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"23477","DOI":"10.1074\/jbc.M313709200","article-title":"Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models","volume":"279(22)","author":"S Mabuchi","year":"2004","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"31157","DOI":"10.1074\/jbc.M401888200","article-title":"Mammalian antioxidant defenses are not inducible by H2O2","volume":"279(30)","author":"S Desaint","year":"2004","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T19:28:10Z","timestamp":1564687690000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079167"}},"subtitle":[],"editor":[{"given":"Soumitro","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,13]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079167","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,13]]}}}