{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:35:38Z","timestamp":1791171338122,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079180","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T23:23:26Z","timestamp":1384212206000},"page":"e79180","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Guanylate Cyclase C Deficiency Causes Severe Inflammation in a Murine Model of Spontaneous Colitis"],"prefix":"10.1371","volume":"8","author":[{"given":"Eleana","family":"Harmel-Laws","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris A.","family":"Steinbrecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MOG.0b013e328341ead5","article-title":"Transmembrane guanylate cyclase in intestinal pathophysiology","volume":"27","author":"KA Steinbrecher","year":"2011","journal-title":"Curr Opin Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.coph.2012.10.005","article-title":"Guanylate cyclase-C receptor activation: unexpected biology","volume":"12","author":"SM Brierley","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1073\/pnas.89.3.947","article-title":"Guanylin: an endogenous activator of intestinal guanylate cyclase","volume":"89","author":"MG Currie","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/0016-5085(95)90753-X","article-title":"Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine","volume":"109","author":"Z Li","year":"1995","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1006\/bbrc.1995.1571","article-title":"Immunohistochemical localization of guanylin in the rat small intestine and colon","volume":"209","author":"MB Cohen","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0016-5085(00)70419-7","article-title":"Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon","volume":"118","author":"AB Vaandrager","year":"2000","journal-title":"Gastroenterology"},{"key":"ref7","unstructured":"Cohen MB, Gianella R.A. (2002) Enterotoxigenic E. coli. In: Blaser MJ SP, Ravdin JI, Greenberg HB, editor. Infections of the Gastrointestinal Tract. 2 ed. New York: Raven Press. 579\u2013597."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ajhg.2012.03.022","article-title":"Meconium Ileus Caused by Mutations in GUCY2C, Encoding the CFTR-Activating Guanylate Cyclase 2C","volume":"90","author":"H Romi","year":"2012","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/000992288502400809","article-title":"Familial meconium ileus with normal sweat electrolytes","volume":"24","author":"A Tal","year":"1985","journal-title":"Clin Pediatr (Phila)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1056\/NEJMoa1110132","article-title":"Familial diarrhea syndrome caused by an activating GUCY2C mutation","volume":"366","author":"T Fiskerstrand","year":"2012","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"G740","DOI":"10.1152\/ajpgi.90268.2008","article-title":"Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis","volume":"296","author":"MP Garin-Laflam","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e16139","DOI":"10.1371\/journal.pone.0016139","article-title":"Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier","volume":"6","author":"X Han","year":"2011","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e31686","DOI":"10.1371\/journal.pone.0031686","article-title":"GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity","volume":"7","author":"JE Lin","year":"2012","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaci.2006.04.039","article-title":"Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility","volume":"118","author":"SP Hogan","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1172\/JCI6211","article-title":"A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells","volume":"104","author":"H Itoh","year":"1999","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.4049\/jimmunol.1002469","article-title":"Murine guanylate cyclase C regulates colonic injury and inflammation","volume":"186","author":"KA Steinbrecher","year":"2011","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-230X-13-135","article-title":"Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen","volume":"13","author":"EA Mann","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1006\/bbrc.1997.7487","article-title":"Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion","volume":"239","author":"EA Mann","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.4049\/jimmunol.180.4.2588","article-title":"Loss of epithelial RelA results in deregulated intestinal proliferative\/apoptotic homeostasis and susceptibility to inflammation","volume":"180","author":"KA Steinbrecher","year":"2008","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8444","DOI":"10.1128\/MCB.25.19.8444-8455.2005","article-title":"Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription","volume":"25","author":"KA Steinbrecher","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-09-3465","article-title":"Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen","volume":"70","author":"KA Steinbrecher","year":"2010","journal-title":"Cancer Res"},{"key":"ref22","first-page":"G1461","article-title":"IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation","volume":"276","author":"M Schultz","year":"1999","journal-title":"Am J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses","volume":"98","author":"DJ Berg","year":"1996","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"C1729","DOI":"10.1152\/ajpcell.00010.2002","article-title":"Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells","volume":"283","author":"KA Steinbrecher","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature05698","article-title":"Epithelial NEMO links innate immunity to chronic intestinal inflammation","volume":"446","author":"A Nenci","year":"2007","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"M Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1172\/JCI28121","article-title":"Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis","volume":"116","author":"LD McVay","year":"2006","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.2008.150888","article-title":"Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse","volume":"58","author":"MC Arrieta","year":"2009","journal-title":"Gut"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00054725-199911000-00004","article-title":"Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora","volume":"5","author":"KL Madsen","year":"1999","journal-title":"Inflamm Bowel Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1126\/science.1069094","article-title":"Colorectal cancer in mice genetically deficient in the mucin Muc2","volume":"295","author":"A Velcich","year":"2002","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/bj3410461","article-title":"Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements","volume":"2)","author":"H Itoh","year":"1999","journal-title":"Biochem J 341 (Pt"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0016-5085(88)90423-4","article-title":"Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children","volume":"94","author":"MB Cohen","year":"1988","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1203\/00006450-198706000-00009","article-title":"Small and large intestinal guanylate cyclase activity in children: effect of age and stimulation by Escherichia coli heat-stable enterotoxin","volume":"21","author":"A Guarino","year":"1987","journal-title":"Pediatr Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1172\/JCI57925","article-title":"A uroguanylin-GUCY2C endocrine axis regulates feeding in mice","volume":"121","author":"MA Valentino","year":"2011","journal-title":"J Clin Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1207675","article-title":"Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior","volume":"333","author":"R Gong","year":"2011","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1172\/JCI119683","article-title":"Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice","volume":"100","author":"S Schulz","year":"1997","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/geno.1998.5636","article-title":"Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice","volume":"55","author":"M Mahler","year":"1999","journal-title":"Genomics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cellimm.2009.05.009","article-title":"Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis","volume":"259","author":"M Berglund","year":"2009","journal-title":"Cell Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.gastro.2006.12.028","article-title":"Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat","volume":"132","author":"E Houdeau","year":"2007","journal-title":"Gastroenterology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"G209","DOI":"10.1152\/ajpgi.00500.2011","article-title":"Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa","volume":"303","author":"R Wang","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1128\/MCB.00001-09","article-title":"Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis","volume":"29","author":"N Basu","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1053\/j.gastro.2009.08.064","article-title":"The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling","volume":"138","author":"JE Lin","year":"2010","journal-title":"Gastroenterology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e4664","DOI":"10.1371\/journal.pone.0004664","article-title":"CFTR is a negative regulator of NFkappaB mediated innate immune response","volume":"4","author":"N Vij","year":"2009","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.bcp.2007.03.019","article-title":"Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways","volume":"73","author":"C Verhaeghe","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.bbrc.2007.02.166","article-title":"Intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells","volume":"356","author":"C Verhaeghe","year":"2007","journal-title":"Biochem Biophys Res Commun"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:13:13Z","timestamp":1540307593000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079180"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Karhausen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079180","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,11]]}}}