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Available: http:\/\/edition.cnn.com\/2007\/HEALTH\/10\/18\/hearing.loss\/<\/ext-link>. Accessed 3 May 2013."},{"key":"ref3","unstructured":"Pfizer (2012) 2012 Financial report. Availabe: http:\/\/www.pfizer.com\/files\/annualreport\/2012\/financial\/financial2012.pdf<\/ext-link>. Accessed 12 May 2013."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0735-1097(98)00656-1","article-title":"Use of sildenafil (Viagra) in patients with cardiovascular disease","volume":"(21)","author":"MD Cheitlin","year":"1999","journal-title":"J. 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Accessed 3 May 3 2013."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S0022215106005512","article-title":"A case of sensorineural deafness following ingestion of sildenafil","volume":"121","author":"B Mukherjee","year":"2007","journal-title":"J Laryngol Otol"},{"key":"ref9","unstructured":"FDA (2011) Information for Healthcare Professionals: Sildenafil (marketed as Viagra and Revatio), Vardenafil (marketed as Levitra), Tadalfil (marketed as Cialis). Available: http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm124841.htm<\/ext-link>. Accessed 3 May 3 2013."},{"key":"ref10","unstructured":"FDA (2007) FDA Announces Revisions to Labels for Cialis, Levitra and Viagra; Potential risk for sudden hearing loss with ED drugs to be displayed more prominently. Available: http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/2007\/ucm109012.htm<\/ext-link>. Accessed 3 May 2013."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/lary.20511","article-title":"Sudden hearing loss from PDE- 5 inhibitors: A possible cellular stress etiology","volume":"119","author":"PT Maddox","year":"2009","journal-title":"Laryngoscope"},{"key":"ref12","first-page":"488","article-title":"Phosphodiesterase type 5 inhibitor use and hearing impairment. Arch. Otolaryngol. 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Bull","volume":"31","author":"BN Hong","year":"2008"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Bakir S, Firat U, Gun R, Bozkurt Y, Yorgancilar E, et al<\/etal>.. (2012) Histpathologic results of long-term sildenafil administration on rat inner ear. American Journal of Otolaryngology \u2013 Head and Neck Medicine and Surgery.","DOI":"10.1016\/j.amjoto.2012.04.005"},{"key":"ref18","unstructured":"Pfizer (2010) Viagra. Available at: http:\/\/www.pfizer.com\/files\/products\/uspi_viagra.pdf<\/ext-link>. Accessed 3 May 2013."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9485","DOI":"10.1523\/JNEUROSCI.0311-12.2012","article-title":"The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene","volume":"32(28)","author":"R Geng","year":"2012","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/hmg\/ddq025","article-title":"Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in usher syndrome type 1F","volume":"19(8)","author":"MR Chance","year":"2010","journal-title":"Human Molecular Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-5955(03)00107-2","article-title":"A new spontaneous mutation in the mouse Ames waltzer gene, Pcdh15","volume":"180","author":"LL Hampton","year":"2003","journal-title":"Hear Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1093\/hmg\/ddp210","article-title":"Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation","volume":"18","author":"R Geng","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/hmg\/dds084","article-title":"Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes","volume":"21","author":"QY Zheng","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.heares.2010.05.002","article-title":"Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL\/6J mice","volume":"268","author":"KR Johnson","year":"2010","journal-title":"Hear Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1288\/00005537-199304000-00001","article-title":"Cisplatin-induced ototoxicity: the effect of pigmentation and inhibitory agents","volume":"103","author":"VG Schweitzer","year":"1993","journal-title":"Laryngoscope"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Yoo J, Hamilton SJ, Angel D, Fung K, Franklin J, et al<\/etal>.. (2013) Cisplatin otoprotection using transtympanic L-N-acetylcysteine: A pilot randomized study in head and neck cancer patients. Laryngoscope.","DOI":"10.1002\/lary.24360"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJM199805143382001","article-title":"Oral Sildenafil in the Treatment of Erectile Dysfunction","volume":"338","author":"I Goldstein","year":"1998","journal-title":"NEJM"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1152\/jappl.2001.91.3.1421","article-title":"Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression","volume":"91(3)","author":"TM Lincoln","year":"2001","journal-title":"J of Applied Physiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","article-title":"A major gene affecting age-related hearing loss in C57BL\/6J mice","volume":"114(1\u20132)","author":"KM Johnson","year":"1997","journal-title":"Hearing Research"},{"key":"ref30","unstructured":"Uptodate (2013) Sildenafil: Drug Information. Availabe: http:\/\/www.uptodate.com\/contents\/sildenafil-drug-information?source=search_result&search=sildenafil&selectedTitle=1~131#F221000<\/ext-link>. Accessed 3 May 2013."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:08:34Z","timestamp":1589011714000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079226"}},"subtitle":[],"editor":[{"given":"Olivia","family":"Bermingham-McDonogh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079226","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}