{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:58:24Z","timestamp":1787021904915,"version":"build-2736575974"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079240","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T18:13:49Z","timestamp":1383329629000},"page":"e79240","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Identification of New Sphingomyelinases D in Pathogenic Fungi and Other Pathogenic Organisms"],"prefix":"10.1371","volume":"8","author":[{"given":"Camila","family":"Dias-Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella A. P.","family":"Neshich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Neshich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Granier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ch\u00e1vez-Olortegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Felicori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1471-2180-10-270","article-title":"Phospholipase D promotes <italic>Arcanobacterium<\/italic> <italic>haemolyticum<\/italic> adhesion via lipid raft remodeling and host cell death following bacterial invasion","volume":"10","author":"EA Lucas","year":"2010","journal-title":"BMC Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"13658","DOI":"10.1074\/jbc.M412437200","article-title":"Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D","volume":"280","author":"MT Murakami","year":"2005","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/BJ20050043","article-title":"Brown recluse spider (<italic>Loxosceles<\/italic> <italic>reclusa<\/italic>) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA)","volume":"391","author":"S Lee","year":"2005","journal-title":"Biochem J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.1998.9474","article-title":"Sphingomyelinases in the venom of the spider <italic>Loxosceles<\/italic> <italic>intermedia<\/italic> are responsible for both dermonecrosis and complement-dependent hemolysis","volume":"251","author":"DV Tambourgi","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V95.2.683","article-title":"<italic>Loxosceles<\/italic> <italic>intermedia<\/italic> spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis","volume":"95","author":"DV Tambourgi","year":"2000","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molimm.2004.03.027","article-title":"Molecular cloning, expression, function and immunoreactivities of members of a gene family of sphingomyelinases from <italic>Loxosceles<\/italic> venom glands","volume":"41","author":"DV Tambourgi","year":"2004","journal-title":"Mol Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.taap.2005.05.015","article-title":"Brown spider dermonecrotic toxin directly induces nephrotoxicity","volume":"211","author":"OM Chaim","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.biochi.2008.07.011","article-title":"Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity","volume":"90","author":"J Kusma","year":"2008","journal-title":"Biochimie"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-3024.2009.01095.x","article-title":"A novel sphingomyelinase-like enzyme in Ixodes scapularis tick saliva drives host CD4 T cells to express IL-4","volume":"31","author":"FJ Alarcon-Chaidez","year":"2009","journal-title":"Parasite Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-1119(95)00002-N","article-title":"Toxic phospholipases D of <italic>Corynebacterium<\/italic> <italic>pseudotuberculosis<\/italic>, <italic>C.<\/italic> <italic>ulcerans<\/italic> and <italic>Arcanobacterium<\/italic> <italic>haemolyticum<\/italic>: cloning and sequence homology","volume":"156","author":"PJ McNamara","year":"1995","journal-title":"Gene"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.genom.9.081307.164356","article-title":"The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms","volume":"10","author":"BG Fry","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/bioinformatics\/bti811","article-title":"Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria","volume":"22","author":"MHJ Cordes","year":"2006","journal-title":"Bioinformatics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"D511","DOI":"10.1093\/nar\/gkl972","article-title":"BRENDA, AMENDA and FRENDA: the enzyme information system in 2007","volume":"35","author":"J Barthelmes","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1101\/gr.9.9.868","article-title":"CAP3: A DNA Sequence Assembly Program","volume":"9","author":"X Huang","year":"1999","journal-title":"Genome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/bioinformatics\/btm076","article-title":"COBALT: constraint-based alignment tool for multiple protein sequences","volume":"23","author":"JS Papadopoulos","year":"2007","journal-title":"Bioinformatics"},{"key":"ref17","article-title":"Jalview","author":"AM Waterhouse","year":"2009"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref19","first-page":"275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"DT Jones","year":"1992","journal-title":"Comput Appl Biosci CABIOS"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"W197","DOI":"10.1093\/nar\/gkn238","article-title":"The Jpred 3 secondary structure prediction server","volume":"36","author":"C Cole","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref21","first-page":"315","article-title":"Elmar Krieger and Gert Vriend","volume":"18","author":"E Krieger","year":"2002","journal-title":"Bioinformatics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"M Wiederstein","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"W595","DOI":"10.1093\/nar\/gkh480","article-title":"JavaProtein Dossier: a novel web-based data visualization tool for comprehensive analysis of protein structure","volume":"32","author":"G Neshich","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref24","first-page":"717","article-title":"The Star STING server: a multiplatform environment for protein structure analysis","volume":"5","author":"G Neshich","year":"2006","journal-title":"Genet Molecular Res GMR"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/prot.20921","article-title":"MUSTANG: a multiple structural alignment algorithm","volume":"64","author":"AS Konagurthu","year":"2006","journal-title":"Proteins"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling","volume":"18","author":"N Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"D269","DOI":"10.1093\/nar\/gki111","article-title":"STING Report: convenient web-based application for graphic and tabular presentations of protein sequence, structure and function descriptors from the STING database","volume":"33","author":"G Neshich","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/bioinformatics\/bth203","article-title":"STING Contacts: a web-based application for identification and analysis of amino acid contacts within protein structure and across protein interfaces","volume":"20","author":"AL Mancini","year":"2004","journal-title":"Bioinformatics"},{"key":"ref29","first-page":"533","article-title":"Structural basis of the lisinopril-binding specificity in N- and C-domains of human somatic ACE","volume":"308","author":"JH Fernandes","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0014-5793(96)00375-4","article-title":"Modified 2S albumins with improved tryptophan content are correctly expressed in transgenic tobacco plants","volume":"385","author":"LH Marcellino","year":"1996","journal-title":"FEBS Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1472-6807-10-36","article-title":"Analysis of binding properties and specificity through identification of the interface forming residues (IFR) for serine proteases in silico docked to different inhibitors","volume":"10","author":"C Ribeiro","year":"2010","journal-title":"BMC Struct Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1073\/pnas.0607669103","article-title":"Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2","volume":"103","author":"I Sitkiewicz","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1365-2958.2001.02236.x","article-title":"Extracellular phospholipase activity is a virulence factor for <italic>Cryptococcus<\/italic> <italic>neoformans<\/italic>","volume":"39","author":"GM Cox","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1099\/mic.0.2006\/003004-0","article-title":"Characterization of two distinct phospholipase C enzymes from <italic>Burkholderia<\/italic> <italic>pseudomallei<\/italic>","volume":"153","author":"S Korbsrisate","year":"2007","journal-title":"Microbiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1128\/IAI.05830-11","article-title":"Disruption of the phospholipase D gene attenuates the virulence of <italic>Aspergillus<\/italic> <italic>fumigatus<\/italic>","volume":"80","author":"X Li","year":"2012","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molimm.2006.02.002","article-title":"Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis","volume":"44","author":"DV Tambourgi","year":"2007","journal-title":"Mol Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/molbev\/msn274","article-title":"Molecular Evolution, Functional Variation and Proposed Nomenclature of the Gene Family That Includes Sphingomyelinase D in Sicariid Spider Venoms","volume":"26","author":"GJ Binford","year":"2009","journal-title":"Mol Biol Evol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/mic.0.2007\/007641-0","article-title":"<italic>Aspergillus<\/italic> <italic>flavus<\/italic>: human pathogen, allergen and mycotoxin producer","volume":"153","author":"MT Hedayati","year":"2007","journal-title":"Microbiology (Reading, England)"},{"key":"ref39","first-page":"1","article-title":"Health TC for FS and P, Biologics I for IC in A","year":"2005","journal-title":"Dermatophytosis"},{"key":"ref40","first-page":"88","article-title":"arling \u2019 s Dis Rev","volume":"1","author":"NS Dighe","year":"2009"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-2230.2009.03647.x","article-title":"Advances in paracoccidioidomycosis","volume":"35","author":"M Ameen","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1513\/pats.200907-080AL","article-title":"New perspectives on coccidioidomycosis","volume":"7","author":"NM Ampel","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.meegid.2005.12.002","article-title":"Phylogenetic and evolutionary aspects of <italic>Paracoccidioides<\/italic> <italic>brasiliensis<\/italic> reveal a long coexistence with animal hosts that explain several biological features of the pathogen","volume":"6","author":"E Bagagli","year":"2006","journal-title":"Infect Genet Evol J Mol Epidemiol Evol Genet Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.vetpar.2012.02.010","article-title":"Tick prevention at a crossroad: new and renewed solutions","volume":"187","author":"T Kiss","year":"2012","journal-title":"Vet Parasitol"},{"key":"ref45","first-page":"1","article-title":"Health TC for FS and P, Biologics I for IC in A","year":"2009","journal-title":"Rhipicephalus appendiculatus"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2011.09.038","article-title":"Gotch ear: a poorly described, local, pathologic condition of livestock associated primarily with the Gulf Coast tick, <italic>Amblyomma<\/italic> <italic>maculatum<\/italic>","volume":"183","author":"KT Edwards","year":"2011","journal-title":"Vet Parasitol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1472-765X.1998.00439.x","article-title":"Phenotypic, genotypic and pathogenic variation among streptomycetes implicated in common scab disease","volume":"27","author":"PA Bramwell","year":"1998","journal-title":"Lett Appl Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00253-011-3616-5","article-title":"Molecular approaches to pathogenesis study of <italic>Burkholderia<\/italic> <italic>cenocepacia<\/italic>, an important cystic fibrosis opportunistic bacterium","volume":"92","author":"S Bazzini","year":"2011","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1128\/AEM.68.4.1972-1979.2002","article-title":"Expanded Genetic Map of <italic>Gibberella<\/italic> <italic>moniliformis<\/italic> (<italic>Fusarium<\/italic> <italic>verticillioides<\/italic>)","volume":"68","author":"JE Jurgenson","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1007\/s00253-012-4377-5","article-title":"Strategies for strain improvement in <italic>Fusarium<\/italic> <italic>fujikuroi<\/italic>: overexpression and localization of key enzymes of the isoprenoid pathway and their impact on gibberellin biosynthesis","volume":"97","author":"S Albermann","year":"2013","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1364-3703.2005.00292.x","article-title":"Pathogen profile <italic>Cladosporium<\/italic> <italic>fulvum<\/italic> ( syn . <italic>Passalora<\/italic> <italic>fulva<\/italic> ), a highly specialized plant pathogen as a model for functional studies on plant pathogenic Mycosphaerellaceae","volume":"6","author":"BPHJ Thomma","year":"2005","journal-title":"Mol Plant Pathol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1021\/cr200296t","article-title":"Phospholiapse D - enzymology, functionality and chemical modulation","volume":"12","author":"PE Selvy","year":"2011","journal-title":"Chem Rev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1074\/jbc.C300563200","article-title":"Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine","volume":"279","author":"LA Van Meeteren","year":"2004","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/jid.2013.40","article-title":"Lysophosphatidic acid mediates the release of cytokines and chemokines by human fibroblasts treated with loxosceles spider venom","volume":"6","author":"CCR Horta","year":"2013","journal-title":"J Invest Dermatol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T04:08:08Z","timestamp":1596773288000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079240"}},"subtitle":[],"editor":[{"given":"Eugene\u00a0A.","family":"Permyakov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079240","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}