{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:45:42Z","timestamp":1770684342479,"version":"3.49.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079327","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T03:34:06Z","timestamp":1384832046000},"page":"e79327","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Potentiation of the Effect of Thiazide Derivatives by Carbonic Anhydrase Inhibitors: Molecular Mechanisms and Potential Clinical Implications"],"prefix":"10.1371","volume":"8","author":[{"given":"Kamyar","family":"Zahedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Barone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoocher","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Aronson PS (2002) Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochem Biophys. 36(2\u20133): 147\u201353. Review.","DOI":"10.1385\/CBB:36:2-3:147"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Sindi\u0107 A, Chang MH, Mount DB, Romero MF (2007) Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 16(5): 484\u201390. Review.","DOI":"10.1097\/MNH.0b013e3282e7d7d0"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Baum M (2008) Developmental changes in proximal tubule NaCl transport. Pediatr Nephrol. 23(2): 185\u201394. Review.","DOI":"10.1007\/s00467-007-0569-0"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Bernstein PL, Ellison DH (2011) Diuretics and salt transport along the nephron. Semin Nephrol. 31(6): 475\u201382. Review.","DOI":"10.1016\/j.semnephrol.2011.09.002"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Lifton RP, Gharavi AG, Geller DS (2001) Molecular mechanisms of human hypertension. Cell. 104(4): 545\u201356. Review.","DOI":"10.1016\/S0092-8674(01)00241-0"},{"key":"ref6","first-page":"F619","article-title":"Localization and regulation of the rat renal Na(+)-K(+)-2Cl- cotransporter, BSC-1","volume":"2)","author":"CA Ecelbarger","year":"1996","journal-title":"Am J Physiol. 271(3 Pt"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Hebert SC, Mount DB, Gamba G (2004) Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflugers Arch. 447(5): 580\u201393. Review.","DOI":"10.1007\/s00424-003-1066-3"},{"key":"ref8","first-page":"538","article-title":"The thiazide-sensitive Na-Cl cotransporter and human disease: reemergence of an old player. J Am Soc Nephrol","volume":"14","author":"DH Ellison","year":"2003"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Wall SM, Pech V (2008) The interaction of pendrin and the epithelial sodium channel in blood pressure regulation. Curr Opin Nephrol Hypertens. 17(1): 18\u201324. Review.","DOI":"10.1097\/MNH.0b013e3282f29086"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, <etal>et al<\/etal>. (2001) Pendrin: an apical Cl-\/OH-\/HCO3- exchanger in the kidney cortex. Am J Physiol Renal Physiol 280, F356\u2013F364.","DOI":"10.1152\/ajprenal.2001.280.2.F356"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Eladari D, H\u00fcbner CA (2011) Novel mechanisms for NaCl reabsorption in the collecting duct. Curr Opin Nephrol Hypertens. 20(5): 506\u201311. Review.","DOI":"10.1097\/MNH.0b013e3283486c4a"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Purkerson JM, Schwartz GJ (2007) The role of carbonic anhydrases in renal physiology. Kidney Int. 71(2): 103\u201315. Review.","DOI":"10.1038\/sj.ki.5002020"},{"key":"ref13","unstructured":"Alper SL (2010) Familial renal tubular acidosis. J Nephrol. Suppl 16: S57\u201376. Review."},{"key":"ref14","unstructured":"Schwartz GJ (2002) Physiology and molecular biology of renal carbonic anhydrase. J Nephrol. 15 Suppl 5: S61\u201374. Review."},{"key":"ref15","first-page":"F437","article-title":"Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition. Am J Physiol Renal Physiol","volume":"280(3)","author":"C Bagnis","year":"2001"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Friedman DI, Jacobson DM (2004) Idiopathic intracranial hypertension. J Neuroophthalmol. 24(2): 138\u201345. Review.","DOI":"10.1097\/00041327-200406000-00009"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Toris CB (2010) Pharmacotherapies for glaucoma. Curr Mol Med. 10(9): 824\u201340. Review.","DOI":"10.2174\/156652410793937778"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Messerli FH, Bangalore S (2011) Half a century of hydrochlorothiazide: facts, fads, fiction, and follies. Am J Med. 124(10): 896\u20139. Review.","DOI":"10.1016\/j.amjmed.2011.05.009"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Ko B, Hoover RS (2009) Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter. Curr Opin Nephrol Hypertens. 18(5): 421\u20137. Review.","DOI":"10.1097\/MNH.0b013e32832f2fcb"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Uchida S (2010) Pathophysiological roles of WNK kinases in the kidney. Pflugers Arch. 460(4): 695\u2013702. Review.","DOI":"10.1007\/s00424-010-0848-7"},{"key":"ref21","first-page":"29150","article-title":"Phenotype resembling Gitelman&apos;s syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. J Biol Chem","volume":"273(44)","author":"PJ Schultheis","year":"1998"},{"key":"ref22","first-page":"13368","article-title":"Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure. Proc Natl Acad Sci U S A","volume":"109(33)","author":"M Soleimani","year":"2012"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Reyes AJ, Taylor SH (1999) Diuretics in cardiovascular therapy: the new clinicopharmacological bases that matter. Cardiovasc Drugs Ther. 13(5): 371\u201398. Review.","DOI":"10.1023\/A:1007835821228"},{"key":"ref24","first-page":"95","article-title":"Decreased expression of Slc26a4 (Pendrin) and Slc26a7 in the kidneys of carbonic anhydrase II-deficient mice. Cell Physiol Biochem","volume":"21(1\u20133)","author":"X Sun","year":"2008"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Leaf DE, Goldfarb DS (2007) Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness. J Appl Physiol. 102(4): 1313\u201322. Epub 2006 Oct 5. Review.","DOI":"10.1152\/japplphysiol.01572.2005"},{"key":"ref26","first-page":"2153","article-title":"Pendrin regulation in mouse kidney primarily is chloride-dependent. J Am Soc Nephrol","volume":"17(8)","author":"M Vallet","year":"2006"},{"key":"ref27","unstructured":"Zahedi K, Xu J, Barone S, Soleimani M. The Double Deletion of Pendrin and the Sodium Chloride Co-transporter Causes Aberrant Trafficking of the AQP2 Water Channel in Medullary Collecting Duct. Cell Physiology Biochem (under review)."},{"key":"ref28","first-page":"1557","article-title":"Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kid. International","volume":"74(12)","author":"EA Zalyapin","year":"2008"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Horisberger JD, Rossier BC (1992) Aldosterone regulation of gene transcription leading to control of ion transport. Hypertension. 19(3): 221\u20137. Review.","DOI":"10.1161\/01.HYP.19.3.221"},{"key":"ref30","first-page":"1627","article-title":"The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest","volume":"120(5)","author":"F Leviel","year":"2010"},{"key":"ref31","first-page":"982","article-title":"NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: role in Cl- conservation. Hypertension","volume":"44","author":"SM Wall","year":"2004"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Grieff M, Bushinsky DA. Diuretics and disorders of calcium homeostasis. Semin Nephrol. 2011, 31(6): 535\u201341. Review.","DOI":"10.1016\/j.semnephrol.2011.09.008"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Greenberg A (2000) Diuretic complications. Am J Med Sci. 319(1): 10\u201324. Review.","DOI":"10.1016\/S0002-9629(15)40676-7"},{"key":"ref34","first-page":"1651","article-title":"Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest","volume":"115(6)","author":"T Nijenhuis","year":"2005"},{"key":"ref35","article-title":"Effects of thiazide on the expression of TRPV5, calbindin-D28K, and sodium transporters in hypercalciuric rats. J Korean Med Sci","volume":"24","author":"HR Jang","year":"2009"},{"key":"ref36","first-page":"F137","article-title":"Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion","volume":"2)","author":"P Morsing","year":"1991","journal-title":"Am J Physiol. 261(1 Pt"},{"key":"ref37","first-page":"1388","article-title":"Inhibition of renal uptake of indium-111-DTPA-octreotide in vivo. J Nucl Med","volume":"37(8)","author":"M de Jong","year":"1996"},{"key":"ref38","first-page":"C33","article-title":"Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl-\/HCO3- exchanger activity and impairs bicarbonate secretion in kidney collecting duct. Am J Physiol Cell Physiol","volume":"299(1)","author":"H Amlal","year":"2010"},{"key":"ref39","first-page":"29470","article-title":"Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem","volume":"284(43)","author":"J Xu","year":"2009"},{"key":"ref40","first-page":"F290","article-title":"The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol","volume":"295(1)","author":"HJ Lu","year":"2008"},{"key":"ref41","first-page":"e32843","article-title":"Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells. PLoS One","volume":"7(2)","author":"WL Rice","year":"2012"},{"key":"ref42","first-page":"1991","article-title":"Genomic sequencing. Proc Natl Acad Sci U S A","volume":"81(7)","author":"GM Church","year":"1984"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:11:23Z","timestamp":1588993883000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079327"}},"subtitle":[],"editor":[{"given":"Robert A.","family":"Fenton","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079327","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}