{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:03:13Z","timestamp":1773320593936,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079566","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T22:11:57Z","timestamp":1383603117000},"page":"e79566","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Epithelial Cells Are Less Tolerant to Infection by Staphylococcus aureus"],"prefix":"10.1371","volume":"8","author":[{"given":"Yi-Ting","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Yao","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei-Chin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jwu-Ching","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(08)60073-2","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"371","author":"MD Cappellini","year":"2008","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00203619","article-title":"Increased induction of apoptosis in mononuclear cells of a glucose-6-phosphate dehydrogenase deficient patient","volume":"73","author":"T Efferth","year":"1995","journal-title":"J Mol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/sj.cdd.4401420","article-title":"Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis","volume":"11","author":"A Fico","year":"2004","journal-title":"Cell Death Differ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcmd.2008.12.005","article-title":"The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis","volume":"42","author":"ET Nkhoma","year":"2009","journal-title":"Blood Cells Mol Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/376246a0","article-title":"Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria","volume":"376","author":"C Ruwende","year":"1995","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1000402","DOI":"10.1371\/journal.pmed.1000402","article-title":"A research agenda for malaria eradication: drugs","volume":"8","year":"2011","journal-title":"PLoS Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2165\/11536520-000000000-00000","article-title":"Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review","volume":"33","author":"I Youngster","year":"2010","journal-title":"Drug Saf"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/milmed\/163.6.434","article-title":"Hepatitis A and cytomegalovirus infection precipitating acute hemolysis in glucose-6-phosphate dehydrogenase deficiency","volume":"163","author":"T Siddiqui","year":"1998","journal-title":"Mil Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00277-011-1167-6","article-title":"Hemolysis and methemoglobinemia due to hepatitis E virus infection in patient with G6PD deficiency","volume":"90","author":"WY Au","year":"2011","journal-title":"Ann Hematol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1557","DOI":"10.1371\/journal.pone.0001557","article-title":"Higher infection of dengue virus serotype 2 in human monocytes of patients with G6PD deficiency","volume":"3","author":"YC Chao","year":"2008","journal-title":"PLOS ONE"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1086\/528377","article-title":"Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection","volume":"197","author":"YH Wu","year":"2008","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1099\/vir.0.2008\/001404-0","article-title":"Glucose-6-phosphate dehydrogenase deficiency enhances enterovirus 71 infection","volume":"89","author":"HY Ho","year":"2008","journal-title":"J Gen Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0163-4453(97)93574-X","article-title":"Community-acquired <italic>Acinetobacter<\/italic> <italic>pneumonia<\/italic>: a case report","volume":"35","author":"CH Yang","year":"1997","journal-title":"J Infect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.jp.7211853","article-title":"<italic>Clostridium<\/italic> <italic>difficile<\/italic> infection precipitating hemolysis in glucose-6-phosphate dehydrogenase-deficient preterm twins causing severe neonatal jaundice","volume":"28","author":"A Lodha","year":"2008","journal-title":"J Perinatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/01.CCM.0000254337.50361.2E","article-title":"Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis","volume":"35","author":"J Wilmanski","year":"2007","journal-title":"Crit Care Med"},{"key":"ref16","first-page":"169","article-title":"Glucose-6-phosphate dehydrogenase deficiency and infection: a study of hospitalized patients in Iran","volume":"52","author":"M Clark","year":"1979","journal-title":"Yale J Biol Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1203\/01.PDR.0000120680.47846.47","article-title":"Diurnal fluctuation of leukocyte G6PD activity. A possible explanation for the normal neutrophil bactericidal activity and the low incidence of pyogenic infections in patients with severe G6PD deficiency in Israel","volume":"55","author":"B Wolach","year":"2004","journal-title":"Pediatr Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jemermed.2007.10.049","article-title":"Treatment of MRSA infections in an African-American male with G6PD deficiency","volume":"37","author":"DS Paek","year":"2009","journal-title":"J Emerg Med"},{"key":"ref19","article-title":"Internalization of <italic>Staphylococcus<\/italic> <italic>aureus<\/italic> in lymphocytes induces oxidative stress and DNA fragmentation: possible ameliorative role of nanoconjugated vancomycin. Oxid Med Cell Longev 2011: 942123","author":"SP Chakraborty","year":"2011"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1099\/jmm.0.030833-0","article-title":"<italic>Aeromonas<\/italic> spp. induce apoptosis of epithelial cells through an oxidant-dependent activation of the mitochondrial pathway","volume":"60","author":"S Krzyminska","year":"2011","journal-title":"J Med Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/infdis\/jir764","article-title":"The effects of sepsis on mitochondria","volume":"205","author":"G Garrabou","year":"2012","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e24472","DOI":"10.1371\/journal.pone.0024472","article-title":"Vancomycin activates \u03c3<sup>B<\/sup> in vancomycin-resistant <italic>Staphylococcus<\/italic> <italic>aureus<\/italic> resulting in the enhancement of cytotoxicity","volume":"6","author":"HY Chen","year":"2011","journal-title":"PLOS ONE"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1574-695X.2011.00846.x","article-title":"Vancomycin promotes the bacterial autolysis, release of extracellular DNA, and biofilm formation in vancomycin-non-susceptible <italic>Staphylococcus<\/italic> <italic>aureus<\/italic>","volume":"63","author":"CY Hsu","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1002869","DOI":"10.1371\/journal.pcbi.1002869","article-title":"Oroxylin A inhibits hemolysis via hindering the self-assembly of \u03b1-hemolysin heptameric transmembrane pore","volume":"9","author":"J Dong","year":"2013","journal-title":"PLOS Comput Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"T Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.freeradbiomed.2003.11.031","article-title":"Glucose-6-phosphate dehydrogenase-deficient cells show an increased propensity for oxidant-induced senescence","volume":"36","author":"ML Cheng","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: enemies within","volume":"281","author":"NA Thornberry","year":"1998","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2443.2011.01579.x","article-title":"Beyond apoptosis: caspase regulatory mechanisms and functions in vivo","volume":"17","author":"E Kuranaga","year":"2012","journal-title":"Genes Cells"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0268-960X(95)90024-1","article-title":"Disorders of neutrophil function","volume":"9","author":"V Bogomolski-Yahalom","year":"1995","journal-title":"Blood Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1128\/IAI.00575-08","article-title":"<italic>Mycoplasma<\/italic> <italic>pneumoniae<\/italic> infection induces reactive oxygen species and DNA damage in A549 human lung carcinoma cells","volume":"76","author":"G Sun","year":"2008","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.resmic.2008.07.006","article-title":"Bacterial and H<sub>2<\/sub>O<sub>2<\/sub> stress-induced apoptosis-like events in Cryptococcus neoformans","volume":"159","author":"R Ikeda","year":"2008","journal-title":"Res Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1152\/physiolgenomics.00155.2011","article-title":"Genetic susceptibility to <italic>S.<\/italic> <italic>aureus<\/italic> mastitis in sheep: differential expression of mammary epithelial cells in response to live bacteria or supernatant","volume":"44","author":"CM Bonnefont","year":"2012","journal-title":"Physiol Genomics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"PD Ray","year":"2012","journal-title":"Cell Signal"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrm2312","article-title":"Apoptosis: controlled demolition at the cellular level","volume":"9","author":"RC Taylor","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1128\/JCM.36.9.2548-2553.1998","article-title":"Rapid and specific detection of toxigenic <italic>Staphylococcus<\/italic> <italic>aureus<\/italic>: use of two multiplex PCR enzyme immunoassays for amplification and hybridization of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 gene","volume":"36","author":"K Becker","year":"1998","journal-title":"J Clin Microbiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1111\/j.1462-5822.2007.00917.x","article-title":"Involvement of \u03b15\u03b21-integrin and TNF-\u03b1 in <italic>Staphylococcus<\/italic> <italic>aureus<\/italic> \u03b1-toxin-induced death of epithelial cells","volume":"9","author":"X Liang","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/CS20110643","article-title":"Systems biology of antioxidants","volume":"123","author":"R Andriantsitohaina","year":"2012","journal-title":"Clin Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T09:51:49Z","timestamp":1596793909000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079566"}},"subtitle":[],"editor":[{"given":"Patrick\u00a0M","family":"Schlievert","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,4]]},"references-count":37,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079566","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,4]]}}}