{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:01:27Z","timestamp":1772780487874,"version":"3.50.1"},"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0079671","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T03:37:55Z","timestamp":1384832275000},"page":"e79671","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Effect of Tetrandrine against Candida albicans Biofilms"],"prefix":"10.1371","volume":"8","author":[{"given":"Lan-Xue","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Dan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan-Hai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.diagmicrobio.2012.06.012","article-title":"The PATH (Prospective Antifungal Therapy) Alliance\u00ae registry and invasive fungal infections: update 2012","volume":"73","author":"A Nkechi","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11046-013-9638-z","article-title":"<italic>Candida albicans<\/italic> and Non-<italic>C. albicans Candida<\/italic> Species: Comparison of Biofilm Production and Metabolic Activity in Biofilms, and Putative Virulence Properties of Isolates from Hospital Environments and Infections","volume":"175","author":"AV Ferreira","year":"2013","journal-title":"Mycopathologia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2165\/00003495-199754050-00002","article-title":"Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches","volume":"54","author":"BD Alexander","year":"1997","journal-title":"Drugs"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1128\/EC.05126-11","article-title":"Interface of <italic>Candida albicans<\/italic> biofilm matrix-associated drug resistance and cell wall integrity regulation","volume":"10","author":"JE Nett","year":"2011","journal-title":"Eukaryot Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1128\/JB.183.18.5385-5394.2001","article-title":"Biofilm formation by the fungal pathogen <italic>Candida albicans<\/italic>: development, architecture, and drug resistance","volume":"183","author":"J Chandra","year":"2001","journal-title":"J Bacteriol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/EC.4.4.633-638.2005","article-title":"<italic>Candida<\/italic> biofilms: an update","volume":"4","author":"G Ramage","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e7967","DOI":"10.1371\/journal.pone.0007967","article-title":"Characterization of mucosal <italic>Candida albicans<\/italic> biofilms","volume":"4","author":"A Dongari-Bagtzoglou","year":"2009","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.micinf.2009.04.018","article-title":"Biofilm formation in clinical <italic>Candida<\/italic> isolates and its association with virulence","volume":"11","author":"F Hasan","year":"2009","journal-title":"Microbes Infect"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/infdis\/167.5.1247","article-title":"Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980\u20131990","volume":"167","author":"CMB Sagu\u00e9","year":"1993","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3201\/eid0702.010240","article-title":"Engineering out the risk for infection with urinary catheters","volume":"7","author":"DG Maki","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1001\/archinte.1995.00430220087009","article-title":"Therapeutic approaches in patients with candidemia: evaluation in a multicenter, prospective, observational study","volume":"155","author":"MH Nguyen","year":"1995","journal-title":"Arch Intern Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1086\/380796","article-title":"Guidelines for treatment of candidiasis","volume":"38","author":"PG Pappas","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1086\/339863","article-title":"The promise of novel technology for the prevention of intravascular device-related bloodstream infection. I. Pathogenesis and short-term devices","volume":"34","author":"CJ Crnich","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/archinte.1988.00380120094019","article-title":"Hospital-acquired candidemia: the attributable mortality and excess length of stay","volume":"148","author":"SB Wey","year":"1988","journal-title":"Arch Intern Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"J Costerton","year":"1999","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1128\/MMBR.64.4.847-867.2000","article-title":"Microbial biofilms: from ecology to molecular genetics","volume":"64","author":"ME Davey","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"RM Donlan","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1086\/322972","article-title":"Biofilm formation: a clinically relevant microbiological process","volume":"33","author":"RM Donlan","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/00220345010800031101","article-title":"Antifungal resistance of candidal biofilms formed on denture acrylic in vitro","volume":"80","author":"J Chandra","year":"2001","journal-title":"J Dent Res"},{"key":"ref20","first-page":"163","article-title":"Characteristics of biofilm formation by <italic>Candida albicans<\/italic>","volume":"18","author":"G Ramage","year":"2001","journal-title":"Rev Iberoam Micol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1439-0507.2009.01690.x","article-title":"Antifungal activity of amphotericin B, caspofungin and posaconazole on <italic>Candida albicans<\/italic> biofilms in intermediate and mature development phases","volume":"53","author":"S Tobudic","year":"2010","journal-title":"Mycoses"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1128\/AAC.39.9.2128","article-title":"Resistance of <italic>Candida albicans<\/italic> biofilms to antifungal agents in vitro","volume":"39","author":"SP Hawser","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1179\/1743132813Y.0000000175","article-title":"Tetrandrine ameliorates cognitive impairment via inhibiting astrocyte-derived S100B activation in a rat model of chronic cerebral hypoperfusion","volume":"36","author":"L Chen","year":"2013","journal-title":"Neurol Res"},{"key":"ref24","first-page":"79","article-title":"Toxicology studies with d-tetrandrine (NSC-77037), a plant alkaloid with vascular and lymphotoxic effects in dogs and monkeys","volume":"5","author":"EJ Gralla","year":"1974","journal-title":"Cancer Chemother Rep 3"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0147-6513(82)90034-3","article-title":"Studies of the chronic toxicity of tetrandrine in dogs: an inhibitor of silicosis","volume":"6","author":"L Tainlin","year":"1982","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref26","first-page":"504","article-title":"The clinical observation of tetrandrine in the treatment of 270 cases of hypertensive patients and hypertensive crisis","volume":"13","author":"Y Gao","year":"1965","journal-title":"Chin J Int Med"},{"key":"ref27","first-page":"1069","article-title":"Effects of tetrandrine on cardiovascular electrophysiologic properties","volume":"23","author":"W-X Yao","year":"2002","journal-title":"Acta Pharmacologica Sinica"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-8741(97)00092-5","article-title":"Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat","volume":"58","author":"HS Kim","year":"1997","journal-title":"J Ethnopharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0147-6513(83)90075-1","article-title":"Observation of the effect of tetrandrine on experimental silicosis of rats","volume":"7","author":"X Yu","year":"1983","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref30","first-page":"321","article-title":"The therapeutic effect of tetrandrine on silicosis (author&apos;s transl)","volume":"4","author":"Q Li","year":"1981","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"ref31","first-page":"3163","article-title":"Effects of tetrandrine plus radiation on neuroblastoma cells","volume":"29","author":"Y Chen","year":"2009","journal-title":"Anticancer Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1248\/bpb.22.703","article-title":"The effect of tetrandrine and extracts of <italic>Centella asiatica<\/italic> on acute radiation dermatitis in rats","volume":"22","author":"YJ Chen","year":"1999","journal-title":"Biol Pharm Bull"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/bbrc.1997.6057","article-title":"Tetrandrine inhibits signal-induced NF-\u03baB activation in rat alveolar macrophages","volume":"231","author":"F Chen","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1124\/mol.60.5.1083","article-title":"Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions","volume":"60","author":"YC Shen","year":"2001","journal-title":"Mol pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0959-8049(01)00356-2","article-title":"The multidrug resistance of tumour cells was reversed by tetrandrine <italic>in vitro<\/italic> and in xenografts derived from human breast adenocarcinoma MCF-7\/adr cells","volume":"38","author":"L Fu","year":"2002","journal-title":"Eur J cancer"},{"key":"ref36","first-page":"1239","article-title":"Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells","volume":"21","author":"JH Lee","year":"2002","journal-title":"Int J Oncol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"PL135","DOI":"10.1016\/S0024-3205(96)00695-9","article-title":"<italic>In vitro<\/italic> inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs","volume":"60","author":"Y Dong","year":"1997","journal-title":"Life Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tips.2004.01.009","article-title":"Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation","volume":"25","author":"G Wang","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-0029-1185973","article-title":"Synergistic anti-candidal activity of tetrandrine on ketoconazole: an experimental study","volume":"76","author":"H Zhang","year":"2010","journal-title":"Planta Med"},{"key":"ref40","first-page":"010","article-title":"An <italic>in vivo<\/italic> study on tetrandrine as a synergist to econazole against <italic>Trichophyton mentagrophytes<\/italic>","volume":"3","author":"D Zhang","year":"2010","journal-title":"Chinese Journal of Zoonoses"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1034\/j.1600-0463.2002.1100902.x","article-title":"<italic>Candida glabrata<\/italic>, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with <italic>Candida albicans<\/italic>","volume":"110","author":"G Luo","year":"2002","journal-title":"APMIS"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1574-6968.2008.01292.x","article-title":"Factors associated with adherence to and biofilm formation on polystyrene by <italic>Stenotrophomonas maltophilia<\/italic>: the role of cell surface hydrophobicity and motility","volume":"287","author":"A Pompilio","year":"2008","journal-title":"FEMS Microbiol Lett"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1699-0463.1995.tb01427.x","article-title":"Relationship between the cell surface hydrophobicity and adherence of <italic>Candida krusei<\/italic> and <italic>Candida albicans<\/italic> to epithelial and denture acrylic surfaces","volume":"103","author":"YH Samaranayake","year":"1995","journal-title":"APMIS"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1128\/EC.3.4.919-931.2004","article-title":"Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus <italic>Candida albicans<\/italic>","volume":"3","author":"T Miwa","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/genetics\/155.1.57","article-title":"TUP1, CPH1 and EFG1 make independent contributions to filamentation in <italic>Candida albicans<\/italic>","volume":"155","author":"BR Braun","year":"2000","journal-title":"Genetics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.2217\/fmb.09.106","article-title":"The Ras\/cAMP\/PKA signaling pathway and virulence in <italic>Candida albicans<\/italic>","volume":"4","author":"DA Hogan","year":"2009","journal-title":"Future Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1128\/AEM.68.11.5459-5463.2002","article-title":"Inhibition of <italic>Candida albicans<\/italic> biofilm formation by farnesol, a quorum-sensing molecule","volume":"68","author":"G Ramage","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jac\/dks353","article-title":"Effect of alkylphospholipids on <italic>Candida albicans<\/italic> biofilm formation and maturation","volume":"68","author":"TV Vila","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/j.1462-5822.2006.00761.x","article-title":"Genetics and genomics of <italic>Candida albicans<\/italic> biofilm formation","volume":"8","author":"CJ Nobile","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/EC.4.4.633-638.2005","article-title":"<italic>Candida<\/italic> biofilms: an update","volume":"4","author":"G Ramage","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1601-0825.2007.01424.x","article-title":"Biofilm lifestyle of <italic>Candida<\/italic>: a mini review","volume":"14","author":"CJ Seneviratne","year":"2008","journal-title":"Oral Dis"},{"key":"ref52","first-page":"50","article-title":"ECM17-Dependent Methionine\/Cysteine Biosynthesis Contributes to Biofilm Formation in <italic>Candida albicans<\/italic>","volume":"51","author":"DD Li","year":"2012","journal-title":"Fungal Genet Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/10408410903241436","article-title":"Our current understanding of fungal biofilms","volume":"35","author":"G Ramage","year":"2009","journal-title":"Crit Rev Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1128\/IAI.61.9.3648-3655.1993","article-title":"Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen <italic>Candida albicans<\/italic>","volume":"61","author":"CE Birse","year":"1993","journal-title":"Infect Immun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/sj.emboj.7600195","article-title":"Hgc1, a novel hypha-specific G1 cyclin-related protein regulates <italic>Candida albicans<\/italic> hyphal morphogenesis","volume":"23","author":"X Zheng","year":"2004","journal-title":"EMBO J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1128\/JB.181.20.6339-6346.1999","article-title":"Ras signaling is required for serum-induced hyphal differentiation in <italic>Candida albicans<\/italic>","volume":"181","author":"Q Feng","year":"1999","journal-title":"J Bacteriol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-2958.2001.02672.x","article-title":"Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus <italic>Candida albicans<\/italic>","volume":"42","author":"E Leberer","year":"2001","journal-title":"Mol microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1091\/mbc.12.11.3631","article-title":"Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus <italic>Candida albicans<\/italic>","volume":"12","author":"CR Rocha","year":"2001","journal-title":"Mol Biol Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/emboj\/16.8.1982","article-title":"Efg1p, an essential regulator of morphogenesis of the human pathogen <italic>Candida albicans<\/italic>, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi","volume":"16","author":"VR Stoldt","year":"1997","journal-title":"EMBO J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1128\/MCB.21.19.6418-6428.2001","article-title":"The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in <italic>Candida albicans<\/italic> partly via TEC1","volume":"21","author":"S Lane","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"48988","DOI":"10.1074\/jbc.M104484200","article-title":"DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in <italic>Candida albicans<\/italic>","volume":"276","author":"S Lane","year":"2001","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.2217\/fmb.09.106","article-title":"The Ras\/cAMP\/PKA signaling pathway and virulence in <italic>Candida albicans<\/italic>","volume":"4","author":"DA Hogan","year":"2009","journal-title":"Future Microbiol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/MMBR.00032-07","article-title":"<italic>Candida albicans<\/italic> cell wall proteins","volume":"72","author":"WL Chaffin","year":"2008","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1371\/journal.ppat.0020063","article-title":"Critical role of Bcr1-dependent adhesins in <italic>C. albicans<\/italic> biofilm formation <italic>in vitro<\/italic> and <italic>in vivo<\/italic>","volume":"2","author":"CJ Nobile","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1462-5822.2002.00206.x","article-title":"Adhesion in <italic>Candida<\/italic> spp","volume":"4","author":"P Sundstrom","year":"2002","journal-title":"Cell Microbiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/13693780802206435","article-title":"Adherence mechanisms in human pathogenic fungi","volume":"46","author":"G Tronchin","year":"2008","journal-title":"Med Mycol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nrmicro2636","article-title":"Growth of <italic>Candida albicans<\/italic> hyphae","volume":"9","author":"PE Sudbery","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.leukres.2005.08.005","article-title":"Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia","volume":"30","author":"WL Xu","year":"2006","journal-title":"Leuk Res"},{"key":"ref69","first-page":"454","article-title":"Tetrandine: pharmacology and clinical usefulness","volume":"31","author":"J Fang","year":"1996","journal-title":"Chin Pharm J"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/nprot.2008.141","article-title":"A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing","volume":"3","author":"CG Pierce","year":"2008","journal-title":"Nat Protoc"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijantimicag.2008.04.022","article-title":"Automating a 96-well microtitre plate model for Staphylococcus aureus biofilms: an approach to screening of natural antimicrobial compounds","volume":"32","author":"M Sandberg","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/IAI.50.1.97-101.1985","article-title":"Factors governing adherence of <italic>Candida<\/italic> species to plastic surfaces","volume":"50","author":"SA Klotz","year":"1985","journal-title":"Infect Immun"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.3390\/ijms140612054","article-title":"(+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits <italic>Staphylococcus aureus<\/italic> Biofilms <italic>in Vitro<\/italic>","volume":"14","author":"A Fallarero","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijantimicag.2008.01.026","article-title":"<italic>In vitro<\/italic> activity of baicalein against <italic>Candida albicans<\/italic> biofilms","volume":"32","author":"Y Cao","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ijantimicag.2007.12.013","article-title":"Thymol inhibits <italic>Candida albicans<\/italic> biofilm formation and mature biofilm","volume":"31","author":"PC Braga","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1128\/IAI.50.1.97-101.1985","article-title":"Factors governing adherence of <italic>Candida<\/italic> species to plastic surfaces","volume":"50","author":"S Klotz","year":"1985","journal-title":"Infect Immun"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1128\/AAC.50.3.1096-1099.2006","article-title":"Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of <italic>Candida albicans<\/italic> resistant to fluconazole","volume":"50","author":"H Quan","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1439-0507.1997.tb00234.x","article-title":"Comparison of Etest, microdilution and colorimetric dilution with reference broth macrodilution method for antifungal susceptibility testing of clinically significant <italic>Candida<\/italic> species isolated from immunocompromised patients","volume":"40","author":"S Arikan","year":"1997","journal-title":"Mycoses"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jac\/38.6.1107","article-title":"<italic>In-vitro<\/italic> activity of antimicrobial agent combinations against multiresistant <italic>Acinetobacter baumannii<\/italic>","volume":"38","author":"L Martinez-Martinez","year":"1996","journal-title":"J Antimicrob Chemother"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/aps.2009.157","article-title":"2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway","volume":"30","author":"R Liang","year":"2009","journal-title":"Acta Pharmacol Sin"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1128\/EC.3.4.919-931.2004","article-title":"Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus <italic>Candida albicans<\/italic>","volume":"3","author":"T Miwa","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/EC.00163-09","article-title":"<italic>Candida albicans<\/italic> hyphal formation and virulence assessed using a <italic>Caenorhabditis elegans<\/italic> infection model","volume":"8","author":"R Pukkila-Worley","year":"2009","journal-title":"Eukaryot Cell"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"e7025","DOI":"10.1371\/journal.pone.0007025","article-title":"Identification of antifungal compounds active against <italic>Candida albicans<\/italic> using an improved high-throughput <italic>Caenorhabditis elegans<\/italic> assay","volume":"4","author":"I Okoli","year":"2009","journal-title":"PLoS One"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.ppat.0030018","article-title":"Antifungal chemical compounds identified using a <italic>C. elegans<\/italic> pathogenicity assay","volume":"3","author":"J Breger","year":"2007","journal-title":"PLoS Pathog"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0079671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T22:58:44Z","timestamp":1647125924000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0079671"}},"subtitle":[],"editor":[{"given":"Tom","family":"Coenye","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":84,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0079671","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}