{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:12:07Z","timestamp":1790986327819,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0080015","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T22:34:34Z","timestamp":1385073274000},"page":"e80015","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Correlation of Chromosomal Instability, Telomere Length and Telomere Maintenance in Microsatellite Stable Rectal Cancer: A Molecular Subclass of Rectal Cancer"],"prefix":"10.1371","volume":"8","author":[{"given":"Lisa A.","family":"Boardman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly B.","family":"Viker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari A.","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Riegert-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Smyrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Litzelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwon","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Gangnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne D.","family":"Engelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell J.","family":"Vanderboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen N.","family":"Thibodeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria M.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halcyon G.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.1038\/sj.onc.1203368","article-title":"Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence of chromosomal or microsatellite instability","volume":"18","author":"IB Georgiades","year":"1999","journal-title":"Oncogene"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/carcin\/bgh074","article-title":"Colorectal cancer without high microsatellite instability and chromosomal instability- an alternative genetic pathway to human colorectal cancer","volume":"25","author":"R Tang","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1053\/j.gastro.2006.06.005","article-title":"Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients","volume":"131","author":"FA Sinicrope","year":"2006","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1054\/bjoc.2000.1554","article-title":"Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer","volume":"84","author":"NJ Hawkins","year":"2001","journal-title":"Br J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0531-5565(01)00160-7","article-title":"Cellular senescence, cancer and aging: the telomere connection","volume":"36","author":"J Campisi","year":"2001","journal-title":"Exp Gerontol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/gcc.20749","article-title":"Whole chromosome loss is promoted by telomere dysfunction in primary cells","volume":"49","author":"J Pampalona","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","article-title":"Identification of a specific telomere terminal transferase activity in Tetrahymena extracts","volume":"43","author":"CW Greider","year":"1985","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1002\/j.1460-2075.1995.tb00098.x","article-title":"Telomere elongation in immortal human cells without detectable telomerase activity","volume":"14","author":"TM Bryan","year":"1995","journal-title":"EMBO J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1158\/1078-0432.CCR-06-2739","article-title":"Higher frequency of diploidy in <underline>young-onset<\/underline> <underline>microsatellite-stable<\/underline> <underline>colorectal<\/underline> <underline>cancer<\/underline>","volume":"13","author":"LA Boardman","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1086\/323658","article-title":"The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas","volume":"69","author":"JM Cunningham","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.8484122","article-title":"Microsatellite instability in cancer of the proximal colon","volume":"260","author":"SN Thibodeau","year":"1993","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1200\/JCO.20.4.1043","article-title":"Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors","volume":"20","author":"NM Lindor","year":"2002","journal-title":"J Clin Oncol"},{"key":"ref13","first-page":"5248","article-title":"National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"CR Boland","year":"1998","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"RM Cawthon","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/386623a0","article-title":"Genetic instability in colorectal cancers","volume":"386","author":"C Lengauer","year":"1997","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nbt.1587","article-title":"DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity","volume":"27","author":"JD Henson","year":"2009","journal-title":"Nat Biotechnol"},{"key":"ref17","article-title":"aCGH: Classes and functions for Array Comparative Genomic Hybridization data. R package version 1.34.0","author":"J Fridlyand","year":"2010"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm.3175","article-title":"A colorectal cancer classification system that associates cellular phenotype and responses to therapy","volume":"19","author":"A Sadanandam","year":"2013","journal-title":"Nat Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm.3174","article-title":"Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions","volume":"19","author":"E De Sousa","year":"2013","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1073\/pnas.211357798","article-title":"Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors","volume":"98","author":"D Gisselsson","year":"2001","journal-title":"Proc of the Natl Acad of Sciences of the USA"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0140-6736(03)12681-5","article-title":"Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme","volume":"361","author":"V Hakin-Smith","year":"2003","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/hmg\/ddi266","article-title":"The first molecular details of ALT in human tumor cells","volume":"14","author":"A Muntoni","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1593\/neo.121398","article-title":"The roles of telomerase in the generation of polyploidy during neoplastic cell growth","volume":"5","author":"A Christodoulidou","year":"2013","journal-title":"Neoplasia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/cbt.3.3.695","article-title":"Telomerase is frequently activated in tumors with microsatellite instability","volume":"3","author":"I Ibanez de Caceres","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/346866a0","article-title":"Telomere reduction in human colorectal carcinoma and with ageing","volume":"346","author":"ND Hastie","year":"1990","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/gut.52.9.1304","article-title":"Telomere shortening of epithelial cells characterizes the adenoma-carcinoma transition of human colorectal cancer","volume":"52","author":"RR Plentz","year":"2003","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/carcin\/bgp268","article-title":"Telomeres and telomerase in cancer","volume":"31","author":"SE Artandi","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/ijc.21563","article-title":"Relationship between genetic alterations and prognosis in sporadic colorectal cancer","volume":"118","author":"S-C Chang","year":"2006","journal-title":"Int J Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.cellbio.22.010305.104518","article-title":"Telomeres: Cancer to human aging","volume":"22","author":"SA Stewart","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/gcc.10203","article-title":"Near-diploid and near-triploid human sporadic colorectal adenocarcinomas differ for KRAS2 and TP53 mutational status","volume":"37","author":"W Giaretti","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1158\/0008-5472.CAN-10-3604","article-title":"Chromosomal instability confers intrinsic multidrug resistance","volume":"71","author":"AJ Lee","year":"2011","journal-title":"Cancer Res"},{"key":"ref32","first-page":"785","article-title":"Comparison of clinicopathological features and hRad21 expression between telomerase-dependent and telomerase-independent colorectal cancer","volume":"58","author":"B-Q Yi","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1101\/gad.1029903","article-title":"Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression","volume":"17","author":"S Chang","year":"2003","journal-title":"Genes Dev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9494","DOI":"10.1158\/0008-5472.CAN-10-0233","article-title":"The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines","volume":"70","author":"I Joseph","year":"2010","journal-title":"Cancer Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.1158\/0008-5472.CAN-10-2227","article-title":"Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner","volume":"70","author":"RA Tamakawa","year":"2010","journal-title":"Cancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0102207","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0080015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T05:59:46Z","timestamp":1716184786000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0080015"}},"subtitle":[],"editor":[{"given":"Michel\u00a0M","family":"Ouellette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0080015","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]}}}