{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:35Z","timestamp":1790740055087,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0080131","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T23:08:59Z","timestamp":1385507339000},"page":"e80131","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Occurrence of Nodular Lymphocyte-Predominant Hodgkin Lymphoma in Hermansky-Pudlak Type 2 Syndrome Is Associated to Natural Killer and Natural Killer T Cell Defects"],"prefix":"10.1371","volume":"8","author":[{"given":"Luisa","family":"Lorenzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Tabellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vermi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Moratto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia D.","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Patrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Sozzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"de Saint Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Latour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Badolato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Parolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","article-title":"Cancer immunoediting: integrating immunity&apos;s roles in cancer suppression and promotion","volume":"331","author":"RD Schreiber","year":"2011","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-immunol-031210-101324","article-title":"Natural innate and adaptive immunity to cancer","volume":"29","author":"MD Vesely","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI31405","article-title":"Immune surveillance of tumors","volume":"117","author":"JB Swann","year":"2007","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.blre.2008.03.009","article-title":"Immunodeficiency-associated lymphomas","volume":"22","author":"H Tran","year":"2008","journal-title":"Blood Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/PAP.0b013e31805048fc","article-title":"Immunodeficiency-related Hodgkin lymphoma and its mimics","volume":"14","author":"JW Said","year":"2007","journal-title":"Adv Anat Pathol"},{"key":"ref6","first-page":"35","article-title":"Lymphoproliferative disorders associated with congenital immunodeficiencies","volume":"14","author":"KS Elenitoba-Johnson","year":"1997","journal-title":"Semin Diagn Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1182\/blood.V99.4.1492","article-title":"Germline FAS gene mutation in a case of ALPS and NLP Hodgkin lymphoma","volume":"99","author":"A Van den Berg","year":"2002","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10428190310001593166","article-title":"Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations","volume":"45","author":"S Poppema","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3324\/haematol.2009.012286","article-title":"Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1","volume":"95","author":"M Wenham","year":"2010","journal-title":"Haematologica"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0002-9343(99)00436-2","article-title":"A new variant of Hermansky-Pudlak syndrome due to mutations in a gene responsible for vesicle formation","volume":"108","author":"V Shotelersuk","year":"2000","journal-title":"Am J Med"},{"key":"ref11","first-page":"90","article-title":"Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase","volume":"35","author":"KF Benson","year":"2003","journal-title":"NatGenet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1182\/blood-2005-11-4398","article-title":"Innate immunity defects in Hermansky-Pudlak type 2 syndrome","volume":"107","author":"S Fontana","year":"2006","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.cdd.4402170","article-title":"NK cells at the interface between innate and adaptive immunity","volume":"15","author":"A Moretta","year":"2008","journal-title":"Cell Death Differ"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0167-5699(00)01735-7","article-title":"NKT cells: facts, functions and fallacies","volume":"21","author":"DI Godfrey","year":"2000","journal-title":"Immunol Today"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2904","article-title":"Presumed guilty: natural killer T cell defects and human disease","volume":"11","author":"SP Berzins","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.imbio.2009.06.013","article-title":"Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage","volume":"214","author":"W Vermi","year":"2009","journal-title":"Immunobiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/eji.200324668","article-title":"Analysis of the activating receptors and cytolytic function of human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation","volume":"34","author":"C Vitale","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1084\/jem.174.1.21","article-title":"In vitro proliferation and cloning of CD3\u2212 CD16+ cells from human thymocyte precursors","volume":"174","author":"MC Mingari","year":"1991","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1084\/jem.171.3.695","article-title":"A novel surface antigen expressed by a subset of human CD3\u2212 CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function","volume":"171","author":"A Moretta","year":"1990","journal-title":"J Exp Med"},{"key":"ref20","first-page":"8400","article-title":"Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug","volume":"63","author":"TK Li","year":"2003","journal-title":"Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"509089","DOI":"10.1155\/2013\/509089","article-title":"Dual effect of serum amyloid A on the invasiveness of glioma cells","volume":"2013","author":"FH Knebel","year":"2013","journal-title":"Mediators Inflamm"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tox.2005.10.005","article-title":"Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: a comparative study","volume":"218","author":"DA Boaru","year":"2006","journal-title":"Toxicology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/1521-4141(200104)31:4<1076::AID-IMMU1076>3.0.CO;2-Y","article-title":"Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin","volume":"31","author":"D Pende","year":"2001","journal-title":"Eur J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0167-5699(00)01596-6","article-title":"Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis","volume":"21","author":"A Moretta","year":"2000","journal-title":"Immunol Today"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.192.3.337","article-title":"X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells","volume":"192","author":"S Parolini","year":"2000","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood-2010-04-281675","article-title":"Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education","volume":"116","author":"NK Bjorkstrom","year":"2010","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1182\/blood-2010-09-303057","article-title":"Dissecting CD56dim human NK cells","volume":"116","author":"L Moretta","year":"2010","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1182\/blood-2010-04-282301","article-title":"CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset","volume":"116","author":"S Lopez-Verges","year":"2010","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.4049\/jimmunol.178.8.4947","article-title":"CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation","volume":"178","author":"C Romagnani","year":"2007","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1182\/blood-2005-11-4413","article-title":"Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II","volume":"108","author":"A Enders","year":"2006","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/ni1000","article-title":"Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse","volume":"4","author":"RH Clark","year":"2003","journal-title":"Nat Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaci.2005.12.1347","article-title":"Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005","volume":"117","author":"L Notarangelo","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref33","first-page":"S122","article-title":"Lymphoproliferative disease associated with immune deficiency in children","volume":"122","author":"JH Van Krieken","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1365-2141.2005.05672.x","article-title":"Clustering and anticipation for nodular lymphocyte predominance Hodgkin lymphoma within a French Basque kindred","volume":"130","author":"F Bauduer","year":"2005","journal-title":"Br J Haematol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10428190310001602354","article-title":"Nodular lymphocyte predominant Hodgkin lymphoma in siblings","volume":"45","author":"GN Campbell","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1080\/10428190500236502","article-title":"Familial nodular lymphocyte predominant Hodgkin lymphoma: Successful treatment with CHOP plus rituximab","volume":"46","author":"A Unal","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2141.2010.08528.x","article-title":"Analysis of KLHDC8B in familial nodular lymphocyte predominant Hodgkin lymphoma","volume":"154","author":"S Saarinen","year":"2011","journal-title":"Br J Haematol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2217\/imt.11.99","article-title":"NK cells and their receptors during viral infections","volume":"3","author":"E Marcenaro","year":"2011","journal-title":"Immunotherapy"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.1012356108","article-title":"Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation","volume":"108","author":"A De Maria","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/emmm.200900009","article-title":"Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice","volume":"1","author":"J Pachlopnik Schmid","year":"2009","journal-title":"EMBO Mol Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2217\/imt.11.106","article-title":"Variation of tumor-infiltrating lymphocytes in human cancers: controversy on clinical significance","volume":"3","author":"T Sasada","year":"2011","journal-title":"Immunotherapy"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1084\/jem.20030143","article-title":"The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells","volume":"198","author":"D Elewaut","year":"2003","journal-title":"J Exp Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1182\/blood-2009-02-203042","article-title":"Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders","volume":"114","author":"K Azakami","year":"2009","journal-title":"Blood"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1182\/blood-2010-07-298372","article-title":"Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1\/SAP deficiency) versus type 2 (XLP-2\/XIAP deficiency)","volume":"117","author":"J Pachlopnik Schmid","year":"2011","journal-title":"Blood"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0002-9343(82)90923-8","article-title":"Epstein-Barr virus-induced diseases in boys with the X-linked lymphoproliferative syndrome (XLP): update on studies of the registry","volume":"73","author":"DT Purtilo","year":"1982","journal-title":"Am J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ajh.21743","article-title":"Expression of CD1d and presence of invariant NKT cells in classical Hodgkin lymphoma","volume":"85","author":"C Xu","year":"2010","journal-title":"Am J Hematol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1038\/sj.leu.2402711","article-title":"Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells","volume":"16","author":"Z Zheng","year":"2002","journal-title":"Leukemia"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ijc.11723","article-title":"CD1d is expressed on B-chronic lymphocytic leukemia cells and mediates alpha-galactosylceramide presentation to natural killer T lymphocytes","volume":"109","author":"F Fais","year":"2004","journal-title":"Int J Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0080131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:45:24Z","timestamp":1540255524000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0080131"}},"subtitle":[],"editor":[{"given":"Evren","family":"Alici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0080131","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}