{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:15:35Z","timestamp":1784783735443,"version":"3.55.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0080302","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T21:08:43Z","timestamp":1385759323000},"page":"e80302","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":87,"title":["High Morbidity during Treatment and Residual Pulmonary Disability in Pulmonary Tuberculosis: Under-Recognised Phenomena"],"prefix":"10.1371","volume":"8","author":[{"given":"Anna P.","family":"Ralph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enny","family":"Kenangalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert","family":"Waramori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gysje J.","family":"Pontororing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sandjaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliana","family":"Tjitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme P.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Anstey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/heapol\/czl018","article-title":"Calculating QALYs, comparing QALY and DALY calculations","volume":"21","author":"F Sassi","year":"2006","journal-title":"Health Policy Plan"},{"key":"ref2","year":"2011"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2458-10-259","article-title":"Pulmonary impairment after tuberculosis and its contribution to TB burden","volume":"10","author":"JG Pasipanodya","year":"2010","journal-title":"BMC Public Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1164\/rccm.200206-626OC","article-title":"Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis","volume":"167","author":"D Yee","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1183\/09031936.96.09102026","article-title":"Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis","volume":"9","author":"T Schaberg","year":"1996","journal-title":"Eur Respir J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.rmed.2006.01.014","article-title":"Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patients for tuberculosis","volume":"100","author":"BE G\u00fclbay","year":"2006","journal-title":"Respir Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/thorax.55.1.32","article-title":"Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment","volume":"55","author":"E Hnizdo","year":"2000","journal-title":"Thorax"},{"key":"ref8","first-page":"1500","article-title":"Pulmonary tuberculosis, impaired lung function, disability and quality of life in a high-burden setting","volume":"13","author":"GP Maguire","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1183\/09031936.00083507","article-title":"Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America","volume":"30","author":"AM Menezes","year":"2007","journal-title":"Eur Respir J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1378\/chest.06-2949","article-title":"Pulmonary impairment after tuberculosis","volume":"131","author":"JG Pasipanodya","year":"2007","journal-title":"Chest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(09)61303-9","article-title":"Chronic obstructive pulmonary disease in non-smokers","volume":"374","author":"SS Salvi","year":"2009","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1183\/09031936.98.12020351","article-title":"Influence of antimicrobial chemotherapy on spirometric parameters and pro-inflammatory indices in severe pulmonary tuberculosis","volume":"12","author":"ML Plit","year":"1998","journal-title":"Eur Respir J"},{"key":"ref13","first-page":"571","article-title":"Normal spirometry, gas transfer and lung volume values in Papua","volume":"37","author":"T Handojo","year":"2006","journal-title":"Indonesia - Southeast Asian J Trop Med Public Health"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1378\/chest.07-0755","article-title":"Using the St. George respiratory questionnaire to ascertain health quality in persons with treated pulmonary tuberculosis","volume":"132","author":"JG Pasipanodya","year":"2007","journal-title":"Chest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1164\/ajrccm\/145.6.1321","article-title":"A self-complete measure of health status for chronic airflow limitation. The St. George&apos;s Respiratory Questionnaire","volume":"145","author":"PW Jones","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"ref16","article-title":"St George&apos;s Respiratory Questionnaire (SGRQ)","year":"2013"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e70032","DOI":"10.1371\/journal.pone.0070032","article-title":"L-arginine and Vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial","volume":"8","author":"AP Ralph","year":"2013","journal-title":"PLOS ONE"},{"key":"ref18","article-title":"Operational guide for the for national tuberculosis programs on the introduction and use of fixed-dose combination drugs. WHO\/CDS\/TB\/2002.308","year":"2002"},{"key":"ref19","first-page":"1101","article-title":"A public-private partnership for TB control in Timika, Papua Province","volume":"11","author":"M Ardian","year":"2007","journal-title":"Indonesia - Int J Tuberc Lung Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/1471-2334-10-362","article-title":"The burden and treatment of HIV in tuberculosis patients in Papua Province, Indonesia: a prospective observational study","volume":"10","author":"GJ Pontororing","year":"2010","journal-title":"BMC Infect Dis"},{"key":"ref21","article-title":"Risk Behaviour and HIV Prevalence in Tanah Papua 2006: Results of the IBBS 2006 in Tanah Papua","year":"2006"},{"key":"ref22","year":"2010"},{"key":"ref23","article-title":"Note for guidance on Good Clinical Practice (CPMP\/ICH\/135\/95) annotated with TGA comments. Commonwealth Department of Health and Aged Care","year":"2000"},{"key":"ref24","article-title":"Republik Indonesia","author":"Kesehatan","year":"2007"},{"key":"ref25","first-page":"213","article-title":"2001) Revised international definitions in tuberculosis control","volume":"5","year":"2001","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/thx.2010.136242","article-title":"A simple, valid, numerical score for grading chest x-ray severity in adult smear-positive pulmonary tuberculosis","volume":"65","author":"AP Ralph","year":"2010","journal-title":"Thorax"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1183\/09031936.02.00063702","article-title":"Interpreting thresholds for a clinically significant change in health status in asthma and COPD","volume":"19","author":"PW Jones","year":"2002","journal-title":"Eur Respir J"},{"key":"ref28","first-page":"111","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","year":"2002"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.rmed.2005.08.003","article-title":"Six minute walk distance in healthy subjects aged 55-75 years","volume":"100","author":"B Camarri","year":"2006","journal-title":"Respir Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1164\/ajrccm.160.5.9808139","article-title":"Comparison of hallway and treadmill six-minute walk tests","volume":"160","author":"D Stevens","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","author":"R Pellegrino","year":"2005","journal-title":"Eur Respir J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1001\/jama.281.11.1014","article-title":"Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic","volume":"281","author":"CM Nolan","year":"1999","journal-title":"JAMA"},{"key":"ref33","first-page":"1374","article-title":"Age-related risk of hepatotoxicity in the treatment of latent tuberculosis infection: a systematic review","volume":"14","author":"H Kunst","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/infdis\/jit248","article-title":"Impaired pulmonary nitric oxide bioavailability in pulmonary tuberculosis: association with disease severity and delayed mycobacterial clearance with treatment","volume":"208","author":"AP Ralph","year":"2013","journal-title":"J Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e76077","DOI":"10.1371\/journal.pone.0076077","article-title":"Tuberculosis outcomes in Papua, Indonesia: the relationship with different body mass index characteristics between Papuan and non-Papuan ethnic groups","volume":"8","author":"E Kenangalem","year":"2013","journal-title":"PLOS ONE"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e70032","DOI":"10.1371\/journal.pone.0070032","article-title":"L-arginine and Vitamin D Adjunctive Therapies in Pulmonary Tuberculosis: A Randomised, Double-Blind, Placebo-Controlled Trial","volume":"8","author":"AP Ralph","year":"2013","journal-title":"PLOS ONE"},{"key":"ref37","article-title":"Pocket Guide to COPD Diagnosis, Management and Prevention: A guide for health care professionals","year":"2013"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1475-2875-7-148","article-title":"Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum","volume":"7","author":"M Karyana","year":"2008","journal-title":"Malar J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0962-8479(96)90073-8","article-title":"Frequency and type of reactions to antituberculosis drugs: observations in routine treatment","volume":"77","author":"LP Ormerod","year":"1996","journal-title":"Tuber Lung Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/AAC.01550-06","article-title":"Pharmacokinetics and tolerability of a higher rifampin dose versus the standard dose in pulmonary tuberculosis patients","volume":"51","author":"R Ruslami","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1183\/09031936.00194909","article-title":"The 6-min walk distance in healthy subjects: reference standards from seven countries","volume":"37","author":"C Casanova","year":"2011","journal-title":"Eur Respir J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1164\/ajrccm.161.2.9906015","article-title":"Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing","volume":"161","author":"S Miyamoto","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref43","article-title":"ST GEORGE\u2019S RESPIRATORY QUESTIONNAIRE MANUAL","author":"PW Jones","year":"2009"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.02.00213202","article-title":"Interpretation of quality of life scores from the St George&apos;s Respiratory Questionnaire","volume":"19","author":"M Ferrer","year":"2002","journal-title":"Eur Respir J"},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.1378\/chest.134.4_MeetingAbstracts.p132003","article-title":"Evaluation of functional capacity among patients with pulmonary tuberculosis using six minute walk test","author":"GE Erhabor","year":"2008"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"CJ Murray","year":"2012","journal-title":"Lancet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1164\/rccm.200603-360OC","article-title":"Moxifloxacin versus ethambutol in the first 2 months of treatment for pulmonary tuberculosis","volume":"174","author":"WJ Burman","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1056\/NEJMoa0808427","article-title":"The diarylquinoline TMC207 for multidrug-resistant tuberculosis","volume":"360","author":"AH Diacon","year":"2009","journal-title":"N Engl J Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0080302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T07:52:50Z","timestamp":1564905170000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0080302"}},"subtitle":[],"editor":[{"given":"Robert\u00a0J","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0080302","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,29]]}}}