{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:09:36Z","timestamp":1790456976940,"version":"4.1.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0080321","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T18:02:25Z","timestamp":1385143345000},"page":"e80321","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":86,"title":["Functional Digestive Symptoms and Quality of Life in Patients with Ehlers-Danlos Syndromes: Results of a National Cohort Study on 134 Patients"],"prefix":"10.1371","volume":"8","author":[{"given":"Jean-David","family":"Zeitoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie H.","family":"Lef\u00e8vre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"de Parades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"S\u00e9journ\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iradj","family":"Sobhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Coffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Hamonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O","article-title":"Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK)","volume":"77","author":"P Beighton","year":"1998","journal-title":"Am J Med Genet"},{"key":"ref2","first-page":"70","article-title":"Un cas de cutis laxa avec tumeurs par contusion chronique des coudes et des genoux (xanthome juv\u00e9nile pseudo-diab\u00e9tique de MM Hallopeau et Marc de L\u00e9pinay)","volume":"19","author":"M Danlos","year":"1908","journal-title":"Bull Soc Franc Derm Syph"},{"key":"ref3","first-page":"173","article-title":"Cutis laxa, neigung zu haemorrhagien in der haut, lockerung mehrerer artikulationen","volume":"18","author":"E Ehlers","year":"1901","journal-title":"Derm Zschr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0004.2012.01858.x","article-title":"The Ehlers-Danlos syndrome, a disorder with many faces","volume":"82","author":"A De Paepe","year":"2012","journal-title":"Clin Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJM200003093421001","article-title":"Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type","volume":"342","author":"M Pepin","year":"2000","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ajmg.a.33231","article-title":"Natural history and manifestations of the hypermobility type Ehlers-Danlos syndrome: a pilot study on 21 patients","volume":"152A","author":"M Castori","year":"2010","journal-title":"Am J Med Genet A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/gut.10.12.1004","article-title":"Gastrointestinal complications of the Ehlers-Danlos syndrome","volume":"10","author":"PH Beighton","year":"1969","journal-title":"Gut"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/ard.32.5.413","article-title":"Articular mobility in an African population","volume":"32","author":"P Beighton","year":"1973","journal-title":"Ann Rheum Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1056\/NEJMcp0804684","article-title":"Clinical practice. Gastroesophageal reflux disease","volume":"359","author":"PJ Kahrilas","year":"2008","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/bjs.1800820229","article-title":"Gastrointestinal Quality of Life Index: development, validation and application of a new instrument","volume":"82","author":"E Eypasch","year":"1995","journal-title":"Br J Surg"},{"key":"ref11","first-page":"25","article-title":"First validation of the French version of the Gastrointestinal Quality of Life Index (GIQLI)","volume":"23","author":"K Slim","year":"1999","journal-title":"Gastroenterol Clin Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.berh.2007.12.005","article-title":"Ehlers-Danlos syndromes and Marfan syndrome","volume":"22","author":"B Callewaert","year":"2008","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/ajmg.a.35483","article-title":"Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach","volume":"158A","author":"M Castori","year":"2012","journal-title":"Am J Med Genet A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/00042737-200410000-00008","article-title":"Irritable bowel syndrome in France: a common, debilitating and costly disorder","volume":"16","author":"M Dapoigny","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref15","first-page":"23","article-title":"Gastroesophageal reflux in the French general population: national survey of 8000 adults","volume":"35","author":"JF Bretagne","year":"2006","journal-title":"Presse Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1001\/jama.2012.3532","article-title":"Response rates and nonresponse errors in surveys","volume":"307","author":"TP Johnson","year":"2012","journal-title":"JAMA"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0080321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T19:52:33Z","timestamp":1540324353000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0080321"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Karhausen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0080321","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}