{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:17:26Z","timestamp":1762928246158},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0080326","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T19:35:19Z","timestamp":1384976119000},"page":"e80326","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Performance of Polygenic Scores for Predicting Phobic Anxiety"],"prefix":"10.1371","volume":"8","author":[{"given":"Stefan","family":"Walter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Maria","family":"Glymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karestan","family":"Koenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Tchetgen Tchetgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Cornelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Chiao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Rimm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kawachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D.","family":"Kubzansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"RC Kessler","year":"2005","journal-title":"Archives of General Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1001\/archpsyc.64.10.1180","article-title":"The impact of comorbidity of mental and physical conditions on role disability in the US adult household population","volume":"64","author":"KR Merikangas","year":"2007","journal-title":"Archives of General Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"JM Hettema","year":"2001","journal-title":"American Journal of Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/archpsyc.62.2.182","article-title":"The structure of genetic and environmental risk factors for anxiety disorders in men and women","volume":"62","author":"JM Hettema","year":"2005","journal-title":"Archives of General Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/da.20492","article-title":"Genetics of anxiety: would the genome recognize the DSM","volume":"25","author":"JW Smoller","year":"2008","journal-title":"Depression and Anxiety"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ajmg.c.30174","article-title":"The genetic basis of panic and phobic anxiety disorders","volume":"148C","author":"JW Smoller","year":"2008","journal-title":"American Journal of Medical Genetics Part C: Seminars in Medical Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-0327(99)00031-2","article-title":"Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic","volume":"57","author":"JF Scherrer","year":"2000","journal-title":"Journal of Affective Disorders"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S0033291701003622","article-title":"Monozygotic twins discordant for major depression: A preliminary exploration of the role of environmental experiences in the aetiology and course of illness","volume":"31","author":"KS Kendler","year":"2001","journal-title":"Psychological Medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00005053-200107000-00001","article-title":"A population-based twin study of generalized anxiety disorder in men and women","volume":"189","author":"JM Hettema","year":"2001","journal-title":"The Journal of Nervous and Mental Disease"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/jhg.2009.127","article-title":"Replication of a genome-wide association study of panic disorder in a Japanese population","volume":"55","author":"T Otowa","year":"2009","journal-title":"J Hum Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e11504","DOI":"10.1371\/journal.pone.0011504","article-title":"A genome-wide association study of neuroticism in a population-based sample","volume":"5","author":"FCF Calboli","year":"2010","journal-title":"PloS one"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/archpsyc.65.9.1062","article-title":"Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism","volume":"65","author":"EJCG van den Oord","year":"2008","journal-title":"Archives of General Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj.mp.4002048","article-title":"A whole genome association study of neuroticism using DNA pooling","volume":"13","author":"S Shifman","year":"2007","journal-title":"Mol Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1176\/appi.ajp.2011.11020191","article-title":"A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry","volume":"168","author":"LE Duncan","year":"2011","journal-title":"American Journal of Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/mp.2008.126","article-title":"A framework for interpreting genome-wide association studies of psychiatric disorders","volume":"14","author":"G Psychiatric","year":"2009","journal-title":"Molecular Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/YPG.0b013e32832cec22","article-title":"Follow-up association study of novel neuroticism gene MAMDC1","volume":"19","author":"JM Hettema","year":"2009","journal-title":"Psychiatric Genetics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1176\/appi.ajp.2008.08091354","article-title":"Genomewide association studies: history, rationale, and prospects for psychiatric disorders","volume":"166","author":"S Cichon","year":"2009","journal-title":"Am J Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/mp.2010.65","article-title":"Genetic risk profiles for depression and anxiety in adult and elderly cohorts","volume":"16","author":"A Demirkan","year":"2010","journal-title":"Molecular psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"SM Purcell","year":"2009","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrc1608","article-title":"The Nurses&apos; Health Study: lifestyle and health among women","volume":"5","author":"GA Colditz","year":"2005","journal-title":"Nature Reviews Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.ijo.0801468","article-title":"Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men","volume":"25","author":"NF Chu","year":"2001","journal-title":"International Journal of Obesity"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nature Genetics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1192\/bjp.112.490.917","article-title":"A short clinical diagnostic self-rating scale for psychoneurotic patients: The Middlesex Hospital Questionnaire (MHQ)","volume":"112","author":"S Crown","year":"1966","journal-title":"British Journal of Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.119.551.393","article-title":"The inheritance of neurotic traits: A twin study of the Middlesex Hospital Questionnaire","volume":"119","author":"JPR Young","year":"1971","journal-title":"The British Journal of Psychiatry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/01.CIR.0000153813.64165.5D","article-title":"Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women","volume":"111","author":"CM Albert","year":"2005","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/bmj.295.6593.297","article-title":"Phobic anxiety and ischaemic heart disease","volume":"295","author":"AP Haines","year":"1987","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1161\/01.CIR.89.5.1992","article-title":"Prospective study of phobic anxiety and risk of coronary heart disease in men","volume":"89","author":"I Kawachi","year":"1994","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/gepi.20540","article-title":"Meta-analysis of sex-specific genome-wide association studies","volume":"34","author":"R M\u00e4gi","year":"2010","journal-title":"Genetic Epidemiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2105-11-288","article-title":"GWAMA: software for genome-wide association meta-analysis","volume":"11","author":"R M\u00e4gi","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"ref30","unstructured":"Organization WH (1992) Composite International Diagnostic Interview (CIDI), Version 2.1. Geneva."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11920-004-0073-1","article-title":"Genetics of anxiety disorders","volume":"6","author":"PD Arnold","year":"2004","journal-title":"Current Psychiatry Reports"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Hamilton SP (2009) The Genetics of Anxiety Disorders In: Wildenauer DB, editor. Molecular Biology of Neuropsychiatric Disorders: Springer Berlin Heidelberg. pp. 165\u2013185.","DOI":"10.1007\/978-3-540-85383-1_5"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"J Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1093\/hmg\/ddp295","article-title":"Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk","volume":"18","author":"DM Evans","year":"2009","journal-title":"Human Molecular Genetics"},{"key":"ref35","first-page":"506","article-title":"Evaluation of polygenic risk scores for predicting breast and prostate cancer risk","volume":"35","author":"MJ Machiela","year":"2011","journal-title":"Genetic Epidemiology"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/b91ba224-10be-409d-93f4-7423d502cba0","article-title":"Correction: Power and Predictive Accuracy of Polygenic Risk Scores","volume":"9","author":"F Dudbridge","year":"2013","journal-title":"PLoS Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.biopsych.2010.10.010","article-title":"Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways","volume":"69","author":"M Mui\u00f1os-Gimeno","year":"2010","journal-title":"Biological Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.biopsych.2010.10.008","article-title":"A deletion in tropomyosin-related kinase B and the development of human anxiety","volume":"69","author":"C Ernst","year":"2011","journal-title":"Biological Psychiatry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra0905980","article-title":"Genomewide association studies and assessment of the risk of disease","volume":"363","author":"TA Manolio","year":"2010","journal-title":"New England Journal of Medicine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.biopsych.2011.01.020","article-title":"Who&apos;s afraid of anxiety genetics","volume":"69","author":"JW Smoller","year":"2011","journal-title":"Biological Psychiatry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/gepi.20424","article-title":"Genome-wide association scans for secondary traits using case-control samples","volume":"33","author":"GM Monsees","year":"2009","journal-title":"Genet Epidemiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0080326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T16:59:02Z","timestamp":1564851542000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0080326"}},"subtitle":[],"editor":[{"given":"Monica","family":"Uddin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0080326","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]}}}