{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:44:38Z","timestamp":1782996278426,"version":"3.54.5"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0080846","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T22:15:21Z","timestamp":1384899321000},"page":"e80846","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of the DNMT3B -579G>T Polymorphism with Risk of Thymomas in Patients with Myasthenia Gravis"],"prefix":"10.1371","volume":"8","author":[{"given":"Fabio","family":"Copped\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Denaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Bartoccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Baggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Mussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Migliore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaut.2012.09.002","article-title":"Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review","volume":"39","author":"O Ngalamika","year":"2012","journal-title":"J Autoimmun"},{"key":"ref2","first-page":"155","article-title":"Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer","volume":"1835","author":"Y Jiang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref3","first-page":"2012","article-title":"Epigenetics and Autoimmune Diseases","author":"P Quintero-Ronderos","year":"2012","journal-title":"Autoimm Dis"},{"key":"ref4","first-page":"506","article-title":"How epigenomics brings phenotype into being","volume":"9","author":"JI Mart\u00edn-Subero","year":"2011","journal-title":"Pediatr Endocrinol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"M Esteller","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"PA Jones","year":"2012","journal-title":"Nat Rev Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/cmi.2010.78","article-title":"The epigenetics of autoimmunity","volume":"8","author":"F Meda","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1468-3083.2011.04261.x","article-title":"Epigenetics and psoriasis","volume":"26","author":"P Zhang","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1056\/NEJM197510092931508","article-title":"Acetylcholine receptor antibodies in myasthenia gravis","volume":"293","author":"SH Appel","year":"1975","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2302\/kjm.60.10","article-title":"Epigenetics and autoimmunity, with special emphasis on methylation","volume":"60","author":"Y Renaudineau","year":"2011","journal-title":"Keio J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2353\/ajpath.2007.070240","article-title":"Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status","volume":"171","author":"MI Leite","year":"2007","journal-title":"Am J Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.lungcan.2008.07.015","article-title":"Aberrant methylation of tumour-related genes in thymic epithelial tumours","volume":"64","author":"Y Hirose","year":"2009","journal-title":"Lung Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/07357900802620869","article-title":"Aberrant DNA methylation in thymic epithelial tumors","volume":"27","author":"C Chen","year":"2009","journal-title":"Cancer Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10528-006-9047-9","article-title":"DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans","volume":"45","author":"YS Hong","year":"2007","journal-title":"Biochem Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11033-009-9626-z","article-title":"Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma","volume":"37","author":"X Guo","year":"2010","journal-title":"Mol Biol Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10620-009-0831-3","article-title":"DNMT3B promoter polymorphism and risk of gastric cancer","volume":"55","author":"J Hu","year":"2010","journal-title":"Dig Dis Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3892\/etm.2011.420","article-title":"The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer","volume":"3","author":"H Liu","year":"2012","journal-title":"Exp Ther Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.3748\/wjg.14.2230","article-title":"DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese","volume":"14","author":"H Fan","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1002\/cncr.26736","article-title":"The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma","volume":"118","author":"MF Chen","year":"2012","journal-title":"Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.canlet.2008.03.034","article-title":"Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study","volume":"268","author":"Z Liu","year":"2008","journal-title":"Cancer Lett"},{"key":"ref21","first-page":"217","article-title":"Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case\u2013control study","volume":"19","author":"KP Chang","year":"2008","journal-title":"Oncol Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1007\/s11033-011-1231-2","article-title":"DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies","volume":"39","author":"S Zhu","year":"2012","journal-title":"Mol Biol Rep"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1601-183X.2012.00865.x","article-title":"Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients","volume":"12","author":"TM Murphy","year":"2013","journal-title":"Genes Brain Behav"},{"key":"ref24","first-page":"697","article-title":"Association of DNA methyltransferase 3B gene polymorphism with early-onset schizophrenia","volume":"27","author":"C Zhang","year":"2010","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/humrep\/des376","article-title":"DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome","volume":"28","author":"F Copped\u00e8","year":"2013","journal-title":"Hum Reprod"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000330171","article-title":"DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus","volume":"79","author":"T Fonseca-Silva","year":"2012","journal-title":"Pathobiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00296-009-1141-y","article-title":"The -283C\/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis","volume":"30","author":"EJ Nam","year":"2010","journal-title":"Rheumatol Int"},{"key":"ref28","first-page":"403","article-title":"DNMT3B polymorphisms and risk of primary lung cancer","volume":"26","author":"SJ Lee","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2174\/156720512800618062","article-title":"DNMT3B promoter polymorphisms and risk of late onset","volume":"9","author":"F Copped\u00e8","year":"2012","journal-title":"Journal of Alzheimer'S Disease - Curr Alzheimer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.canlet.2010.10.017","article-title":"DNA methylation in thoracic neoplasms","volume":"301","author":"C Chen","year":"2011","journal-title":"Cancer Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s00018-013-1296-2","article-title":"The role of genetics in the establishment and maintenance of the epigenome","volume":"70","author":"C Huidobro","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00384-011-1199-3","article-title":"Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer","volume":"26","author":"Q Bao","year":"2011","journal-title":"Int J Colorectal Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-2249.2012.04646.x","article-title":"Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease","volume":"170","author":"Y Arakawa","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.autrev.2013.03.007","article-title":"The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes","volume":"12","author":"A Marx","year":"2013","journal-title":"Autoimmun Rev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0080846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T18:13:40Z","timestamp":1564769620000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0080846"}},"subtitle":[],"editor":[{"given":"Lorenzo","family":"Chiariotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,19]]},"references-count":34,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0080846","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,19]]}}}