{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:11:01Z","timestamp":1778865061448,"version":"3.51.4"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T00:00:00Z","timestamp":1384214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081014","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T23:03:48Z","timestamp":1384383828000},"page":"e81014","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["The Osteogenic Potential of Mesoporous Bioglasses\/Silk and Non-Mesoporous Bioglasses\/Silk Scaffolds in Ovariectomized Rats: In vitro and In vivo Evaluation"],"prefix":"10.1371","volume":"8","author":[{"given":"Ning","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,12]]},"reference":[{"key":"ref1","first-page":"569","article-title":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conference","volume":"94","year":"2001","journal-title":"South Med J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bone.2011.03.720","article-title":"Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model","volume":"48","author":"YX He","year":"2011","journal-title":"Bone"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00223-009-9314-y","article-title":"Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration","volume":"86","author":"L Monfoulet","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1007\/s00198-005-1859-7","article-title":"Animal models for fracture treatment in osteoporosis","volume":"16","author":"M Egermann","year":"2005","journal-title":"Osteoporos Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.22203\/eCM.v001a08","article-title":"Animal models of osteoporosis--necessity and limitations","volume":"1","author":"AS Turner","year":"2001","journal-title":"Eur Cell Mater"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1067404","article-title":"Third-generation biomedical materials","volume":"295","author":"LL Hench","year":"2002","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0142-9612(98)00133-1","article-title":"Biomaterials: a forecast for the future","volume":"19","author":"LL Hench","year":"1998","journal-title":"Biomaterials"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jconrel.2005.11.002","article-title":"Well-ordered mesoporous bioactive glasses (MBG): a promising bioactive drug delivery system","volume":"110","author":"W Xia","year":"2006","journal-title":"J Control Release"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S379","DOI":"10.1098\/rsif.2010.0151.focus","article-title":"Twenty-first century challenges for biomaterials","volume":"7","author":"LL Hench","year":"2010","journal-title":"J R Soc Interface"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1002\/anie.200460598","article-title":"Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities","volume":"43","author":"X Yan","year":"2004","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/j.biomaterials.2010.01.061","article-title":"Structure-property relationships of silk-modified mesoporous bioglass scaffolds","volume":"31","author":"C Wu","year":"2010","journal-title":"Biomaterials"},{"key":"ref12","first-page":"273","article-title":"Calcium phosphate-based composites as injectable bone substitute materials","volume":"94","author":"KL Low","year":"2010","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1016\/j.biomaterials.2010.04.028","article-title":"Relationships between degradability of silk scaffolds and osteogenesis","volume":"31","author":"SH Park","year":"2010","journal-title":"Biomaterials"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jbm.b.31875","article-title":"Effect of processing on silk-based biomaterials: reproducibility and biocompatibility","volume":"99","author":"LS Wray","year":"2011","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1021\/bm900416b","article-title":"Fabrication and properties of the electrospun polylactide\/silk fibroin-gelatin composite tubular scaffold","volume":"10","author":"S Wang","year":"2009","journal-title":"Biomacromolecules"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.biomaterials.2011.10.063","article-title":"Impact of processing parameters on the haemocompatibility of Bombyx mori silk films","volume":"33","author":"FP Seib","year":"2012","journal-title":"Biomaterials"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2012.01.004","article-title":"Silk fibroin\/poly(vinyl alcohol) photocrosslinked hydrogels for delivery of macromolecular drugs","author":"J Kundu","year":"2012"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1016\/j.biomaterials.2011.12.028","article-title":"Chondrogenic differentiation of rat MSCs on porous scaffolds of silk fibroin\/chitosan blends","volume":"33","author":"N Bhardwaj","year":"2012","journal-title":"Biomaterials"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/nprot.2011.379","article-title":"Materials fabrication from Bombyx mori silk fibroin","volume":"6","author":"DN Rockwood","year":"2011","journal-title":"Nat Protoc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.actbio.2010.12.019","article-title":"A comparative study of mesoporous glass\/silk and non-mesoporous glass\/silk scaffolds: physiochemistry and in vivo osteogenesis","volume":"7","author":"C Wu","year":"2011","journal-title":"Acta Biomater"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1016\/j.biomaterials.2012.06.021","article-title":"Delivery of PDGF-B and BMP-7 by mesoporous bioglass\/silk fibrin scaffolds for the repair of osteoporotic defects","volume":"33","author":"Y Zhang","year":"2012","journal-title":"Biomaterials"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00225804","article-title":"Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats","volume":"254","author":"C Maniatopoulos","year":"1988","journal-title":"Cell Tissue Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1016\/j.biomaterials.2011.06.009","article-title":"Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds","volume":"32","author":"C Wu","year":"2011","journal-title":"Biomaterials"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/j.biomaterials.2008.06.030","article-title":"Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering","volume":"29","author":"T Osathanon","year":"2008","journal-title":"Biomaterials"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.biomaterials.2008.12.055","article-title":"The stimulation of healing within a rat calvarial defect by mPCL-TCP\/collagen scaffolds loaded with rhBMP-2","volume":"30","author":"DW Hutmacher","year":"2009","journal-title":"Biomaterials"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1167\/iovs.10-5284","article-title":"Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury","volume":"51","author":"A Ebneter","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/mt.2008.99","article-title":"Bone-protective effects of nonviral gene therapy with folate-chitosan DNA nanoparticle containing interleukin-1 receptor antagonist gene in rats with adjuvant-induced arthritis","volume":"16","author":"JC Fernandes","year":"2008","journal-title":"Mol Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jbm.820050611","article-title":"Bonding mechanism at the interface of ceramic prosthetic materials","volume":"5","author":"LLS Hench","year":"1971","journal-title":"J Biomed Mater Res A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.biomaterials.2011.01.004","article-title":"A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics","volume":"32","author":"A Hoppe","year":"2011","journal-title":"Biomaterials"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1016\/j.biomaterials.2008.03.013","article-title":"Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics","volume":"29","author":"S Xu","year":"2008","journal-title":"Biomaterials"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.167.3916.279","article-title":"Silicon: a possible factor in bone calcification","volume":"167","author":"EM Carlisle","year":"1970","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1016\/j.biomaterials.2004.01.043","article-title":"Assessment of polyglycolic acid mesh and bioactive glass for soft-tissue engineering scaffolds","volume":"25","author":"RM Day","year":"2004","journal-title":"Biomaterials"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1359\/JBMR.0301225","article-title":"Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort","volume":"19","author":"R Jugdaohsingh","year":"2004","journal-title":"J Bone Miner Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bone.2009.07.082","article-title":"The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis","volume":"46","author":"PJ Marie","year":"2010","journal-title":"Bone"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bbrc.2009.02.034","article-title":"Inorganic phosphate regulates Glvr-1 and -2 expression: role of calcium and ERK1\/2","volume":"381","author":"Y Wittrant","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jeurceramsoc.2008.08.002","article-title":"Genetic design of bioactive glass","volume":"29","author":"LH Larry","year":"2009","journal-title":"J Eur Ceram Soc"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"V Karageorgiou","year":"2005","journal-title":"Biomaterials"},{"key":"ref38","first-page":"2003","article-title":"Glasses with Medical Applications","author":"M Vallet-Reg\u00ed","year":"2003","journal-title":"Eur J Inorg Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1016\/j.biomaterials.2006.01.043","article-title":"The in-vitro bioactivity of mesoporous bioactive glasses","volume":"27","author":"X Yan","year":"2006","journal-title":"Biomaterials"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1002\/chem.201000137","article-title":"Functionalizing mesoporous bioglasses for long-term anti-osteoporotic drug delivery","volume":"16","author":"A L\u00f3pez-Noriega","year":"2010","journal-title":"Chemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1016\/j.biomaterials.2009.12.049","article-title":"The osteogenic properties of CaP\/silk composite scaffolds","volume":"31","author":"Y Zhang","year":"2010","journal-title":"Biomaterials"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.progpolymsci.2007.05.013","article-title":"Silk as a biomaterial","volume":"32","author":"C Vepari","year":"2007","journal-title":"Prog Polym Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.actbio.2007.08.010","article-title":"Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification","volume":"4","author":"C Wu","year":"2008","journal-title":"Acta Biomater"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/jcb.21885","article-title":"TNAP, TrAP, ecto-purinergic signaling, and bone remodeling","volume":"105","author":"JD Kaunitz","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"E112","DOI":"10.1152\/ajpendo.2001.280.1.E112","article-title":"pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis","volume":"280","author":"S Meghji","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.actbio.2009.09.008","article-title":"Interaction of an ordered mesoporous bioactive glass with osteoblasts, fibroblasts and lymphocytes, demonstrating its biocompatibility as a potential bone graft material","volume":"6","author":"M Alcaide","year":"2010","journal-title":"Acta Biomater"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1002\/anie.200351027","article-title":"Cubic mesoporous silica with large controllable entrance sizes and advanced adsorption properties","volume":"42","author":"J Fan","year":"2003","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S8756-3282(02)00950-X","article-title":"Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro","volume":"32","author":"DM Reffitt","year":"2003","journal-title":"Bone"},{"key":"ref49","article-title":"Bioactive glasses for in situ tissue regeneration","author":"LL Hench","year":"2004","journal-title":"J Biomater Sci Polym"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T19:24:54Z","timestamp":1564687494000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081014"}},"subtitle":[],"editor":[{"given":"Songtao","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,12]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081014","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,12]]}}}