{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:24Z","timestamp":1787237124122,"version":"build-2736575974"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081229","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T17:26:08Z","timestamp":1390411568000},"page":"e81229","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Network Analysis Reveals Distinct Clinical Syndromes Underlying Acute Mountain Sickness"],"prefix":"10.1371","volume":"9","author":[{"given":"David P.","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J. C.","family":"MacCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex T.","family":"Phythian-Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina M.","family":"Rzechorzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hope-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorrel","family":"Cosens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G. D.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A. Roger","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Kenneth","family":"Baillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/bmj.301.6756.853","article-title":"Prevalence of acute mountain sickness in the Swiss Alps","volume":"301","author":"M Maggiorini","year":"1990","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/jeb.204.18.3161","article-title":"Frontiers of hypoxia research: acute mountain sickness","volume":"204","author":"RC Roach","year":"2001","journal-title":"J Exp Biol"},{"key":"ref3","unstructured":"Roach RC, Bartsch P, Hackett PH, Oelz O (1993) The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, editors. Hypoxia and Molecular Medicine. Burlington, VT: Queens City Printers. pp. 272\u2013274."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/ham.2010.1068","article-title":"Con: Headache should not be a required symptom for the diagnosis of acute mountain sickness","volume":"12","author":"JB West","year":"2011","journal-title":"High Alt Med Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/sj.jcbfm.9600404","article-title":"Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness","volume":"27","author":"K Kallenberg","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1152\/japplphysiol.01188.2007","article-title":"Optic nerve sheath diameter correlates with the presence and severity of acute mountain sickness: evidence for increased intracranial pressure","volume":"106","author":"PJ Fagenholz","year":"2009","journal-title":"J Appl Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/bjsm.2007.045286","article-title":"Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: a longitudinal cohort study","volume":"42","author":"AI Sutherland","year":"2008","journal-title":"Br J Sports Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/exnr.2000.7596","article-title":"Volumetric quantification of brain swelling after hypobaric hypoxia exposure","volume":"168","author":"IA Morocz","year":"2001","journal-title":"Exp Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1007\/s00018-009-0145-9","article-title":"Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological","volume":"66","author":"DM Bailey","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ana.23796","article-title":"Cerebral venous system and anatomical predisposition to high-altitude headache","volume":"73","author":"MH Wilson","year":"2013","journal-title":"Ann Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1474-4422(09)70014-6","article-title":"The cerebral effects of ascent to high altitudes","volume":"8","author":"MH Wilson","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1440-1843.2004.00625.x","article-title":"Acute mountain sickness is associated with sleep desaturation at high altitude","volume":"9","author":"KR Burgess","year":"2004","journal-title":"Respirology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(83)90126-4","article-title":"The validation of visual analogue scales as ratio scale measures for chronic and experimental pain","volume":"17","author":"DD Price","year":"1983","journal-title":"Pain"},{"key":"ref14","first-page":"102","article-title":"The visual analog scale in the immediate postoperative period: intrasubject variability and correlation with a numeric scale","volume":"86","author":"LJ DeLoach","year":"1998","journal-title":"Anesth Analg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1067\/mem.2001.118863","article-title":"Prospective validation of clinically important changes in pain severity measured on a visual analog scale","volume":"38","author":"EJ Gallagher","year":"2001","journal-title":"Ann Emerg Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0196-0644(96)70238-X","article-title":"Clinical significance of reported changes in pain severity","volume":"27","author":"KH Todd","year":"1996","journal-title":"Ann Emerg Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/ham.2007.8301","article-title":"Measuring mountain maladies","volume":"8","author":"R Roach","year":"2007","journal-title":"High Alt Med Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0736-4679(03)00034-9","article-title":"High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial","volume":"24","author":"NS Harris","year":"2003","journal-title":"J Emerg Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/ham.2006.0814","article-title":"Reliability and utility of a visual analog scale for the assessment of acute mountain sickness","volume":"8","author":"DR Wagner","year":"2007","journal-title":"High Alt Med Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/ham.2009.1046","article-title":"Comparison of a visual analogue scale and Lake Louise symptom scores for acute mountain sickness","volume":"11","author":"B Kayser","year":"2010","journal-title":"High Alt Med Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.wem.2010.10.002","article-title":"Visual analog scale (VAS) for assessment of acute mountain sickness (AMS) on Aconcagua","volume":"22","author":"JD Van Roo","year":"2011","journal-title":"Wilderness Environ Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/ham.2010.1055","article-title":"Visual analogue scores in assessment of acute mountain sickness","volume":"12","author":"F Hext","year":"2011","journal-title":"High Alt Med Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ygeno.2010.03.002","article-title":"Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations","volume":"95","author":"DA Hume","year":"2010","journal-title":"Genomics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/hrt.2005.065375","article-title":"Pericardial effusions in healthy lowlanders after acute ascent to high altitude","volume":"92","author":"AA Thompson","year":"2006","journal-title":"Heart"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/qjmed\/hcp026","article-title":"Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial","volume":"102","author":"JK Baillie","year":"2009","journal-title":"QJM"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/ham.2011.0007","article-title":"Sildenafil citrate for the prevention of high altitude hypoxic pulmonary hypertension: double blind, randomized, placebo-controlled trial","volume":"12","author":"MG Bates","year":"2011","journal-title":"High Alt Med Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/ham.2010.1003","article-title":"Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro","volume":"11","author":"SJ Jackson","year":"2010","journal-title":"High Alt Med Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/nprot.2009.177","article-title":"Network visualization and analysis of gene expression data using BioLayout Express(3D)","volume":"4","author":"A Theocharidis","year":"2009","journal-title":"Nat Protoc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1371\/journal.pcbi.0030206","article-title":"Construction, visualisation, and clustering of transcription networks from microarray expression data","volume":"3","author":"TC Freeman","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"ref30","unstructured":"van Dongen S (2000) Graph clustering by flow simulation."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/nar\/30.7.1575","article-title":"An efficient algorithm for large-scale detection of protein families","volume":"30","author":"AJ Enright","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/prot.10505","article-title":"Detection of functional modules from protein interaction networks","volume":"54","author":"JB Pereira-Leal","year":"2004","journal-title":"Proteins"},{"key":"ref33","unstructured":"(2011) R: A Language and Environment for Statistical Computing."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.imbio.2010.05.012","article-title":"Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations","volume":"215","author":"NA Mabbott","year":"2010","journal-title":"Immunobiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/ejhg.2010.91","article-title":"Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome","volume":"18","author":"KM Summers","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1378\/chest.116.5.1208","article-title":"A comparison of the reproducibility and the sensitivity to change of visual analogue scales, Borg scales, and Likert scales in normal subjects during submaximal exercise","volume":"116","author":"S Grant","year":"1999","journal-title":"Chest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/1527029041352108","article-title":"Acute mountain sickness: controversies and advances","volume":"5","author":"P Bartsch","year":"2004","journal-title":"High Alt Med Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T04:50:39Z","timestamp":1648097439000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081229"}},"subtitle":[],"editor":[{"given":"Christian","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081229","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]}}}