{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:23:58Z","timestamp":1759962238943},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081360","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T21:24:10Z","timestamp":1386624250000},"page":"e81360","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of the LILRA3 Deletion with B-NHL and Functional Characterization of the Immunostimulatory Molecule"],"prefix":"10.1371","volume":"8","author":[{"given":"Hui Zhi","family":"Low","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Topperwien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Dankenbrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Peest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Kabalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Stripecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold E.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Matthias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0960-9822(06)00263-6","article-title":"A new human gene complex encoding the killer cell inhibitory receptors and related monocyte\/macrophage receptors","volume":"7","author":"N Wagtmann","year":"1997","journal-title":"Curr Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s003359900961","article-title":"Organization of the leukocyte receptor cluster (LRC) on human chromosome 19q13.4","volume":"10","author":"H Wende","year":"1999","journal-title":"Mamm Genome"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s002510000187","article-title":"Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster","volume":"51","author":"H Wende","year":"2000","journal-title":"Immunogenetics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/eji.1830270313","article-title":"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways","volume":"27","author":"J Samaridis","year":"1997","journal-title":"Eur J Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1084\/jem.186.11.1809","article-title":"A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells","volume":"186","author":"M Colonna","year":"1997","journal-title":"J Exp Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2","article-title":"Isotypic variation of novel immunoglobulin-like transcript\/killer cell inhibitory receptor loci in the leukocyte receptor complex","volume":"28","author":"M Torkar","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/intimm\/dxm127","article-title":"SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production","volume":"20","author":"M Cho","year":"2008","journal-title":"Int Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4049\/jimmunol.162.1.5","article-title":"Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain","volume":"162","author":"H Nakajima","year":"1999","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4049\/jimmunol.159.5.2342","article-title":"Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor","volume":"159","author":"JP Arm","year":"1997","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.4049\/jimmunol.159.11.5192","article-title":"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules","volume":"159","author":"L Borges","year":"1997","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1073\/pnas.080588597","article-title":"Plasticity in the organization and sequences of human KIR\/ILT gene families","volume":"97","author":"MJ Wilson","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/1521-4141(200012)30:12<3655::AID-IMMU3655>3.0.CO;2-Y","article-title":"Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion","volume":"30","author":"M Torkar","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1286-4579(00)00294-X","article-title":"Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells","volume":"2","author":"J Dietrich","year":"2000","journal-title":"Microbes Infect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1182\/blood-2008-10-183814","article-title":"Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients","volume":"114","author":"K Pfistershammer","year":"2009","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/sj.gene.6364187","article-title":"Association of multiple sclerosis with ILT6 deficiency","volume":"6","author":"S Koch","year":"2005","journal-title":"Genes Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/art.24804","article-title":"Association of immunoglobulin-like transcript 6 deficiency with Sjogren\u2019s syndrome","volume":"60","author":"G Kabalak","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0140-6736(07)61050-2","article-title":"Incidence of cancers in people with HIV\/AIDS compared with immunosuppressed transplant recipients: a meta-analysis","volume":"370","author":"AE Grulich","year":"2007","journal-title":"Lancet"},{"key":"ref18","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","journal-title":"MMWR Recomm Rep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(05)70434-4","article-title":"Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium","volume":"7","author":"N Rothman","year":"2006","journal-title":"Lancet Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1158\/0008-5472.CAN-06-0324","article-title":"Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma","volume":"66","author":"SS Wang","year":"2006","journal-title":"Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/intimm\/11.1.29","article-title":"The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1+ NK cell clones","volume":"11","author":"M Vitale","year":"1999","journal-title":"Int Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1074-7613(00)80529-4","article-title":"A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules","volume":"7","author":"D Cosman","year":"1997","journal-title":"Immunity"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.4049\/jimmunol.166.4.2514","article-title":"Ig-like transcript 2 (ILT2)\/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization","volume":"166","author":"J Dietrich","year":"2001","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.4049\/jimmunol.165.7.3742","article-title":"The CD85\/LIR-1\/ILT2 inhibitory receptor is expressed by all human T lymphocytes and down-regulates their functions","volume":"165","author":"D Saverino","year":"2000","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4049\/jimmunol.168.1.207","article-title":"Dual effect of CD85\/leukocyte Ig-like receptor-1\/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells","volume":"168","author":"D Saverino","year":"2002","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/CDLI.12.6.705-712.2005","article-title":"Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes","volume":"12","author":"A Merlo","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2","article-title":"The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes","volume":"28","author":"NA Fanger","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1084\/jem.20090547","article-title":"Regulation of TLR7\/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction","volume":"206","author":"W Cao","year":"2009","journal-title":"J Exp Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/art.23267","article-title":"Autoimmune disease in individuals and close family members and susceptibility to non-Hodgkin\u2019s lymphoma","volume":"58","author":"L Mellemkjaer","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1002\/eji.200839080","article-title":"Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes","volume":"39","author":"DC Jones","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e19245","DOI":"10.1371\/journal.pone.0019245","article-title":"LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1\/LILRB2: structural evidence","volume":"6","author":"M Ryu","year":"2011","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.4049\/jimmunol.1003078","article-title":"HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding","volume":"186","author":"DC Jones","year":"2011","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/rheumatology\/kel305","article-title":"Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles","volume":"45","author":"T Raine","year":"2006","journal-title":"Rheumatology (Oxford)"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T21:44:30Z","timestamp":1688852670000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081360"}},"subtitle":[],"editor":[{"given":"Cristina","family":"Bonorino","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,9]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081360","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,9]]}}}