{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:55:58Z","timestamp":1762271758495},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081405","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T03:28:42Z","timestamp":1384831722000},"page":"e81405","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antagonist Properties of Conus parius Peptides on N-Methyl-D-Aspartate Receptors and Their Effects on CREB Signaling"],"prefix":"10.1371","volume":"8","author":[{"given":"Shailaja","family":"Kunda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Cheriyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashna D.","family":"Balsara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis J.","family":"Castellino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1152\/physrev.00020.2003","article-title":"Conus venoms: a rich source of novel ion channel-targeted peptides","volume":"84","author":"H Terlau","year":"2004","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14343","DOI":"10.1016\/S0021-9258(17)42601-9","article-title":"\u03b3-Carboxyglutamate in a neuroactive toxin","volume":"259","author":"JM McIntosh","year":"1984","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1016\/S0021-9258(19)39285-3","article-title":"Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity","volume":"265","author":"JA Haack","year":"1990","journal-title":"J Biol Chem"},{"key":"ref4","first-page":"425","article-title":"In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus","volume":"292","author":"HS White","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12641","DOI":"10.1074\/jbc.M609087200","article-title":"Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives","volume":"282","author":"Q Dai","year":"2007","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1021\/bi9621122","article-title":"Calcium binding properties of synthetic gamma-carboxyglutamic acid-containing marine cone snail &quot;sleeper&quot; peptides, conantokin-G and conantokin-T","volume":"35","author":"M Prorok","year":"1996","journal-title":"Biochemistry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1074\/jbc.272.4.2291","article-title":"Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy","volume":"272","author":"N Skjaerbaek","year":"1997","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1399-3011.1996.tb00842.x","article-title":"The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor","volume":"48","author":"M Prorok","year":"1996","journal-title":"Int J Pept Protein Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0959-4388(00)00215-4","article-title":"NMDA receptor subunits: diversity, development and disease","volume":"11","author":"S Cull-Candy","year":"2001","journal-title":"Curr Opin Neurobiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature715","article-title":"Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits","volume":"415","author":"JE Chatterton","year":"2002","journal-title":"Nature"},{"key":"ref11","article-title":"Role of distinct NMDA receptor subtypes at central synapses. Science STKE 2004: re16","author":"SG Cull-Candy","year":"2004"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000112101","article-title":"Neuronal injury associated with HIV-1 and potential treatment with calcium-channel and NMDA antagonists","volume":"16","author":"SA Lipton","year":"1994","journal-title":"Dev Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1523\/JNEUROSCI.1362-04.2004","article-title":"Vulnerability of central neurons to secondary insults after in vitro mechanical stretch","volume":"24","author":"M Arundine","year":"2004","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00005072-199704000-00013","article-title":"Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington&apos;s disease--an in situ hybridization study","volume":"56","author":"T Arzberger","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.03.042","article-title":"The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia","volume":"1046","author":"G M\u00f6ddel","year":"2005","journal-title":"Brain Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2006.06.040","article-title":"Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice","volume":"405","author":"J Wei","year":"2006","journal-title":"Neurosci Lett"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nn936","article-title":"NMDA receptor pathways as drug targets","volume":"5","author":"JA Kemp","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3959(02)00303-2","article-title":"Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T","volume":"101","author":"AB Malmberg","year":"2003","journal-title":"Pain"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.npep.2008.09.003","article-title":"NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins","volume":"42","author":"C Xiao","year":"2008","journal-title":"Neuropeptides"},{"key":"ref20","first-page":"378","article-title":"Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: In vitro (Primary cerebellar neurons) and In vivo (Rat model of transient focal brain ischemia)","volume":"294","author":"AJ Williams","year":"2000","journal-title":"Studies - J Pharmacol Exp Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00221-003-1566-6","article-title":"Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats","volume":"153","author":"AJ Williams","year":"2003","journal-title":"Exp Brain Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"36905","DOI":"10.1074\/jbc.M706611200","article-title":"Novel conantokins from conus parius venom are specific antagonists of NMDA receptors","volume":"282","author":"RW Teichert","year":"2007","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.mcn.2010.06.007","article-title":"Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation","volume":"45","author":"L Huang","year":"2010","journal-title":"Mol Cell Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/373151a0","article-title":"Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit","volume":"373","author":"K Sakimura","year":"1995","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0896-6273(00)80051-3","article-title":"Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice","volume":"16","author":"T Kutsuwada","year":"1996","journal-title":"Neuron"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1021\/bi00178a006","article-title":"Calcium and phospholipid binding properties of synthetic gamma-carboxyglutamic acid-containing peptides with sequence counterparts in human protein C","volume":"33","author":"TL Colpitts","year":"1994","journal-title":"Biochemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0006-8993(77)90594-7","article-title":"Rat hippocampal neurons in dispersed cell culture","volume":"126","author":"GA Banker","year":"1977","journal-title":"Brain Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1042\/bj3280777","article-title":"Metal ion binding properties of synthetic conantokin-G","volume":"328","author":"T Blandl","year":"1997","journal-title":"Biochem J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/1389450013348542","article-title":"Structure-function relationships of the NMDA receptor antagonist conantokin peptides","volume":"2","author":"M Prorok","year":"2001","journal-title":"Curr Drug Targets"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-5793(97)00573-5","article-title":"The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions","volume":"411","author":"SE Warder","year":"1997","journal-title":"FEBS Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1074\/jbc.273.13.7512","article-title":"The roles of individual gamma-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T","volume":"273","author":"SE Warder","year":"1998","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"16248","DOI":"10.1074\/jbc.273.26.16248","article-title":"Conformational changes in conantokin-G induced upon binding of calcium and magnesium as revealed by NMR structural analysis","volume":"273","author":"ZG Chen","year":"1998","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1021\/ja065722q","article-title":"The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif","volume":"129","author":"SE Cnudde","year":"2007","journal-title":"J Am Chem Soc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","article-title":"Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path","volume":"232","author":"TV Bliss","year":"1973","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1152\/jn.01325.2005","article-title":"Effect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons","volume":"96","author":"AB Alex","year":"2006","journal-title":"J Neurophysiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroscience.2008.01.080","article-title":"In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death","volume":"158","author":"MA Martel","year":"2009","journal-title":"Neuroscience"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature04089","article-title":"Subunit arrangement and function in NMDA receptors","volume":"438","author":"H Furukawa","year":"2005","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.1382314","article-title":"Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor","volume":"257","author":"N Burnashev","year":"1992","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"10767","DOI":"10.1523\/JNEUROSCI.5622-11.2012","article-title":"Interaction between alphaCaMKII and GluN2B controls ERK-dependent plasticity","volume":"32","author":"F El Gaamouch","year":"2012","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e42318","DOI":"10.1371\/journal.pone.0042318","article-title":"Involvement of calpain\/p35-p25\/Cdk5\/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons","volume":"7","author":"Y Miao","year":"2012","journal-title":"PLOS ONE"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0960-894X(02)00074-4","article-title":"5-phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A\/2A, rather than 1A\/2B receptor composition","volume":"12","author":"YP Auberson","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.1715095","article-title":"Stimulation of protein tyrosine phosphorylation by NMDA receptor activation","volume":"253","author":"H Bading","year":"1991","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(03)00496-3","article-title":"Calcium channel and NMDA receptor activities differentially regulate nuclear C\/EBPbeta levels to control neuronal survival","volume":"39","author":"J Marshall","year":"2003","journal-title":"Neuron"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.neuropharm.2012.01.018","article-title":"Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors","volume":"62","author":"R Balsara","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1046\/j.1471-4159.2001.00170.x","article-title":"Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons","volume":"76","author":"RC Klein","year":"2001","journal-title":"J Neurochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0028-3908(01)00119-8","article-title":"Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides","volume":"41","author":"RC Klein","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuropharm.2007.04.016","article-title":"Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides","volume":"53","author":"Z Sheng","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00221-004-2193-6","article-title":"Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices","volume":"162","author":"AP Mallon","year":"2005","journal-title":"Exp Brain Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1570-9639(02)00455-7","article-title":"Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated","volume":"1600","author":"GE Hardingham","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuron.2012.03.021","article-title":"The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults","volume":"73","author":"MA Martel","year":"2012","journal-title":"Neuron"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1021\/bi300055n","article-title":"Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits","volume":"51","author":"KH Gowd","year":"2012","journal-title":"Biochemistry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"20727","DOI":"10.1074\/jbc.M112.350462","article-title":"Stapling mimics noncovalent interactions of \u03b3-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors","volume":"287","author":"RJ Platt","year":"2012","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T22:56:07Z","timestamp":1647125767000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081405"}},"subtitle":[],"editor":[{"given":"Michael\u00a0A","family":"Cousin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081405","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}