{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:30:03Z","timestamp":1790998203083,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081669","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T22:28:30Z","timestamp":1384813710000},"page":"e81669","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Targeting Eukaryotic Translation in Mesothelioma Cells with an eIF4E-Specific Antisense Oligonucleotide"],"prefix":"10.1371","volume":"8","author":[{"given":"Blake A.","family":"Jacobson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saritha C.","family":"Thumma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jay-Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dubear Kroening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian G.","family":"Kratzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Etchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Konicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R.","family":"Graff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kratzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/sonc.2002.30237","article-title":"The epidemiology of mesothelioma","volume":"29","author":"M Britton","year":"2002","journal-title":"Semin Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1038\/sj.onc.1210515","article-title":"Eighth international mesothelioma interest group","volume":"26","author":"M Carbone","year":"2007","journal-title":"Oncogene"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"7843","DOI":"10.1016\/S0021-9258(17)39529-7","article-title":"Immunological detection of the messenger RNA cap-binding protein","volume":"260","author":"LS Hiremath","year":"1985","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0021-9258(19)75938-9","article-title":"Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F","volume":"262","author":"R Duncan","year":"1987","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nrc2824","article-title":"Translational control in cancer","volume":"10","author":"D Silvera","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2007.08.022","article-title":"Translational control: a target for cancer therapy","volume":"258","author":"SC Thumma","year":"2007","journal-title":"Cancer Lett"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets","volume":"136","author":"N Sonenberg","year":"2009","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1158\/1078-0432.CCR-10-0433","article-title":"Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer","volume":"16","author":"AC Hsieh","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4161\/rna.3.1.2718","article-title":"The cap-dependent translation apparatus integrates and amplifies cancer pathways","volume":"3","author":"VA Polunovsky","year":"2006","journal-title":"RNA Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/345544a0","article-title":"Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5&apos; cap","volume":"345","author":"A Lazaris-Karatzas","year":"1990","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ccr.2004.05.024","article-title":"Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells","volume":"5","author":"S Avdulov","year":"2004","journal-title":"Cancer Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1158\/0008-5472.CAN-08-3472","article-title":"eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival","volume":"69","author":"JR Graff","year":"2009","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1158\/0008-5472.CAN-05-2879","article-title":"Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo","volume":"66","author":"BA Jacobson","year":"2006","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/sj.bjc.6605044","article-title":"Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity","volume":"100","author":"LJ Coleman","year":"2009","journal-title":"Br J Cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jso.20037","article-title":"Expression of eukaryotic initiation factor 4E in gastric adenocarcinoma and its association with clinical outcome","volume":"86","author":"CN Chen","year":"2004","journal-title":"J Surg Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1038\/sj.onc.1202563","article-title":"Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis","volume":"18","author":"IB Rosenwald","year":"1999","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.cellbi.2007.06.006","article-title":"Significance of eIF4E expression in skin squamous cell carcinoma","volume":"31","author":"Z Salehi","year":"2007","journal-title":"Cell Biol Int"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0002-9440(10)65118-8","article-title":"Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin&apos;s lymphomas","volume":"155","author":"S Wang","year":"1999","journal-title":"Am J Pathol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/JTO.0b013e31811f3aab","article-title":"Ras pathway activation in malignant mesothelioma","volume":"2","author":"MR Patel","year":"2007","journal-title":"J Thorac Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.bjc.6605184","article-title":"Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma","volume":"101","author":"BA Jacobson","year":"2009","journal-title":"Br J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1097\/00005537-200006000-00007","article-title":"Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line","volume":"110","author":"RJ DeFatta","year":"2000","journal-title":"Laryngoscope"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1158\/1535-7163.MCT-07-2357","article-title":"eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling","volume":"7","author":"A Soni","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0960-9822(00)00567-4","article-title":"Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E","volume":"10","author":"TP Herbert","year":"2000","journal-title":"Curr Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1158\/1078-0432.CCR-08-2924","article-title":"Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E","volume":"15","author":"SY Ko","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2006.11.046","article-title":"Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G","volume":"128","author":"NJ Moerke","year":"2007","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1073\/pnas.1011477108","article-title":"Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F","volume":"108","author":"R Cencic","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.ejmech.2009.11.054","article-title":"Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP","volume":"45","author":"Y Jia","year":"2010","journal-title":"Eur J Med Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1172\/JCI32044","article-title":"Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity","volume":"117","author":"JR Graff","year":"2007","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1158\/1078-0432.CCR-11-0430","article-title":"A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer","volume":"17","author":"DS Hong","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"TC Chou","year":"2010","journal-title":"Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/1523-1747.ep12396876","article-title":"Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes","volume":"103","author":"FO Nestle","year":"1994","journal-title":"J Invest Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/oli.1.1998.8.427","article-title":"Optimal lipofection reagent varies with the molecular modifications of the DNA","volume":"8","author":"AH Conrad","year":"1998","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0003-4975(95)00045-M","article-title":"Characteristics of nine newly derived mesothelioma cell lines","volume":"59","author":"HI Pass","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1038\/sj.onc.1207545","article-title":"eIF-4E expression and its role in malignancies and metastases","volume":"23","author":"A De Benedetti","year":"2004","journal-title":"Oncogene"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1093\/nar\/gkl558","article-title":"Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure","volume":"34","author":"O Larsson","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21312","DOI":"10.1074\/jbc.M312467200","article-title":"Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis","volume":"279","author":"S Li","year":"2004","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1074\/jbc.M208821200","article-title":"Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release","volume":"278","author":"S Li","year":"2003","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1128\/MCB.16.11.6573","article-title":"Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc","volume":"16","author":"VA Polunovsky","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.leukres.2009.07.043","article-title":"Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells","volume":"34","author":"R Cencic","year":"2009","journal-title":"Leuk Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10549-008-9956-x","article-title":"Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells","volume":"113","author":"K Dong","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1022943419011","article-title":"Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs","volume":"20","author":"JR Graff","year":"2003","journal-title":"Clin Exp Metastasis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1038\/sj.onc.1207549","article-title":"eIF4E--from translation to transformation","volume":"23","author":"Y Mamane","year":"2004","journal-title":"Oncogene"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1158\/0008-5472.CAN-05-4623","article-title":"Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin\/eIF4E pathway","volume":"67","author":"S Pervin","year":"2007","journal-title":"Cancer Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nm1042","article-title":"The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis","volume":"10","author":"D Ruggero","year":"2004","journal-title":"Nat Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature02369","article-title":"Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy","volume":"428","author":"HG Wendel","year":"2004","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1158\/0008-5472.CAN-12-0329","article-title":"Translation Initiation Factor eIF4E Is a Target for Tumor Cell Radiosensitization","volume":"72","author":"TJ Hayman","year":"2012","journal-title":"Cancer Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T17:56:06Z","timestamp":1647107766000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081669"}},"subtitle":[],"editor":[{"given":"Yoon Ki","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081669","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718183327.793522107","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}