{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:26:24Z","timestamp":1791509184203,"version":"4.3.4"},"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081736","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T23:47:23Z","timestamp":1385596043000},"page":"e81736","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Tumor Necrosis Factor B (TNFB) Genetic Variants and Its Increased Expression Are Associated with Vitiligo Susceptibility"],"prefix":"10.1371","volume":"8","author":[{"given":"Naresh C.","family":"Laddha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitesh","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina R.","family":"Gani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohmmad Shoab","family":"Mansuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasheedunnisa","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0749.1993.tb00584.x","article-title":"Vitiligo: Where do we stand?","volume":"8","author":"JP Ortonne","year":"1993","journal-title":"Pigment Cell Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1001\/archderm.1993.01680290066010","article-title":"Pattern of familial aggregation of vitiligo","volume":"129","author":"PP Majumder","year":"1993","journal-title":"Arch Dermatol"},{"key":"ref3","first-page":"981","article-title":"Genetic epidemiology of vitiligo: multilocus recessivity cross-validated","volume":"55","author":"SK Nath","year":"1994","journal-title":"Am J Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1365-4632.2006.02907.x","article-title":"Genetic epidemiology of vitiligo: a study of 815 probands and their families from south China","volume":"45","author":"X Sun","year":"2006","journal-title":"Int J Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0749.2006.00355.x","article-title":"The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force","volume":"20","author":"A Taieb","year":"2007","journal-title":"Pigment Cell Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","article-title":"Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families","volume":"16","author":"A Alkhateeb","year":"2003","journal-title":"Pigment Cell Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0749.2005.00242.x","article-title":"Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo","volume":"18","author":"G Laberge","year":"2005","journal-title":"Pigment Cell Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0749.2007.00384.x","article-title":"The genetics of generalized vitiligo and associated autoimmune diseases","volume":"20","author":"RA Spritz","year":"2007","journal-title":"Pigment Cell Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000131501","article-title":"The genetics of generalized vitiligo","volume":"10","author":"RA Spritz","year":"2008","journal-title":"Curr Dir Autoimmunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/08830189809084493","article-title":"Cytokines in autoimmune disorders","volume":"17","author":"M Feldmann","year":"1998","journal-title":"Int Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1034\/j.1600-0749.2002.1o049.x","article-title":"New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions","volume":"15","author":"S Moretti","year":"2002","journal-title":"Pigment Cell Res"},{"key":"ref12","first-page":"273","article-title":"Vitiligo and epidermal microenvironment: possible involvement of keratinocyte-derived cytokines. Arch","volume":"138","author":"S Moretti","year":"2002","journal-title":"Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(94)90372-7","article-title":"The TNF receptor super family of cellular and viral proteins-activation, co stimulation and death","volume":"76","author":"CA Smith","year":"1994","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.iy.10.040192.002211","article-title":"The pathophysiology of tumor necrosis factors","volume":"10","author":"P Vassalli","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00002371-199102000-00005","article-title":"Usefulness of glycosylated and recombinant human lymphotoxin for growth inhibition of human and murine solid tumors and experimental metastasis in mice","volume":"10","author":"I Funahashi","year":"1991","journal-title":"J Immunother"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jlb.61.5.551","article-title":"TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria","volume":"61","author":"R Lucas","year":"1997","journal-title":"J Leukocyte Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/bcmd.1998.0187","article-title":"TNF, apoptosis and autoimmunity: a common thread?","volume":"24","author":"B Beutler","year":"1998","journal-title":"Blood Cells Mol Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e52298","DOI":"10.1371\/journal.pone.0052298","article-title":"Increased Tumor Necrosis Factor (TNF)-\u03b1 and its promoter polymorphisms correlate with disease progression and higher susceptibility towards vitiligo","volume":"7","author":"NC Laddha","year":"2012","journal-title":"PLoS ONE"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1084\/jem.173.1.209","article-title":"Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-b gene correlates with a variant amino acid in position 26 and a reduced level of TNF-b production","volume":"173","author":"G Messer","year":"1991","journal-title":"J Exp Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1744-313X.1996.tb00133.x","article-title":"The effect of TNF*B gene polymorphism on TNF-alpha and \u2013beta secretion level in patients with insulin dependent diabetes mellitus and healthy controls","volume":"23","author":"CE Whichelow","year":"1996","journal-title":"Eur J Immunogenet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng1047","article-title":"Functional SNPs in the lymphotoxin alpha gene that are associated with susceptibility to myocardial infarction","volume":"32","author":"K Ozaki","year":"2002","journal-title":"Nat Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2165\/00128071-200203050-00001","article-title":"Vitiligo: A manifestation of apoptosis","volume":"3","author":"CL Huang","year":"2002","journal-title":"Am J Clin Dermatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/1523-1747.ep12478093","article-title":"Modulation of melanocyte intercellular adhesion molecule-1 by immune cytokines","volume":"90","author":"JJ Yohn","year":"1990","journal-title":"J Invest Dermatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/path.1711690205","article-title":"Abnormal expression of MHC class ll and ICAM-l by melanocytes in vitiligo","volume":"169","author":"AM Al Badri","year":"1993","journal-title":"J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/art.20060","article-title":"Association of transforming growth factor-\u03b21 and tumor necrosis factor alpha polymorphisms with anti-SSB\/La antibody secretion in patients with primary Sjogren&apos;s syndrome","volume":"50","author":"JE Gottenberg","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jdermsci.2005.06.004","article-title":"The genetic concept of vitiligo","volume":"39","author":"XJ Zhang","year":"2005","journal-title":"J Dermatol Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0019-5154.26928","article-title":"Vitiligo: Clinical profiles in Vadodara, Gujarat","volume":"51","author":"EM Shajil","year":"2006","journal-title":"Ind J Dermatol"},{"key":"ref29","first-page":"526","article-title":"Vitiligo: Pathomechanisms and genetic polymorphism of susceptible genes","volume":"44","author":"EM Shajil","year":"2006","journal-title":"Ind J Exp Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399401003362","article-title":"Immunological pathomechanisms in vitiligo","volume":"23","author":"EH Kemp","year":"2001","journal-title":"Expert Rev Mol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1001\/archderm.1995.01690150078015","article-title":"Melanoma and vitiligo are associated with antibody responses to similar antigens on pigment cells","volume":"131","author":"J Cui","year":"1995","journal-title":"Arch Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/1523-1747.ep12492607","article-title":"Relation between the incidence and level of pigment cell antibodies and disease activity in vitiligo","volume":"97","author":"R Harning","year":"1991","journal-title":"J Invest Dermatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/1523-1747.ep12276556","article-title":"Detection of tyrosinase autoantibodies in patients with vitiligo using 35Slabeled recombinant human tyrosinase in a radioimmunoassay","volume":"109","author":"EH Kemp","year":"1997","journal-title":"J Invest Dermatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1046\/j.0022-202x.2001.01605.x","article-title":"Direct evidence to support the role of antigen-specific CD8 (+) T-cells in melanoma-associated vitiligo","volume":"117","author":"FA Le Gal","year":"2001","journal-title":"J Invest Dermatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1046\/j.1523-1747.2003.12413.x","article-title":"Cytotoxic T lymphocyte reactivity to gp100, MelanA\/MART-1, and tyrosinase, in HLA-A2- positive vitiligo patients","volume":"121","author":"RL Mandelcorn-Monson","year":"2003","journal-title":"J Invest Dermatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000131485","article-title":"Autoimmune etiology of generalized vitiligo","volume":"10","author":"I Le Poole","year":"2008","journal-title":"Curr Dir Autoimmun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0167-5699(97)84664-6","article-title":"Cancer vaccines based on the identification of genes encoding cancer regression antigens","volume":"18","author":"SA Rosenberg","year":"1997","journal-title":"Immunol Today"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0190-9622(97)70181-6","article-title":"The immune response in halo nevi","volume":"37","author":"RA Zeff","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jaad.2003.12.031","article-title":"Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines","volume":"51","author":"PE Grimes","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/exd.12103","article-title":"Vitiligo: interplay between oxidative stress and immune system","volume":"22","author":"NC Laddha","year":"2013","journal-title":"Exp Dermatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1046\/j.1523-1747.2000.00001.x","article-title":"Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNFalpha 238A promoter polymorphism","volume":"114","author":"W Kaluza","year":"2000","journal-title":"J Invest Dermatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor-a promoter on transcriptional activation","volume":"94","author":"A Wilson","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref43","first-page":"1101","article-title":"TNF-a -308A promoter polymorphism is associated with enhanced TNF-a production and inflammatory activity in Crohn&apos;s patients with fistulizing disease","volume":"98","author":"S Gonza' lez","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-065X.1983.tb00707.x","article-title":"Disease associations with complotypes, supratypes and haplotypes","volume":"70","author":"RL Dawkins","year":"1983","journal-title":"Immunol Rev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1568-9972(01)00004-0","article-title":"Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions","volume":"1","author":"G Candore","year":"2002","journal-title":"Autoimmun Rev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0753-3322(03)00079-9","article-title":"Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameters of healthy carriers of the haplotype","volume":"57","author":"G Candore","year":"2003","journal-title":"Biomed Pharmacother"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0198-8859(89)90094-3","article-title":"Some disease-associated ancestral haplotype carry a polymorphism of TNF","volume":"26","author":"RL Dawkins","year":"1989","journal-title":"Hum Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0606349103","article-title":"Extreme genetic risk for type 1A diabetes","volume":"103","author":"TA Aly","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/rheumatology\/kei015","article-title":"Systemic lupus erythematosus and the extended major histocompatibility complex- evidence for several predisposing loci","volume":"44","author":"A Smerdel-Ramoya","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard.2005.039842","article-title":"MHC Class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus","volume":"65","author":"NJ McHugh","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pgen.0020107","article-title":"Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study","volume":"2","author":"R Clarke","year":"2006","journal-title":"PLoS Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/oxfordjournals.jbchem.a121765","article-title":"Cloning and expression of human lymphotoxin mRNA derived from a human T cell hydrydoma","volume":"100","author":"Y Kobayashi","year":"1986","journal-title":"J Biochem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/jlb.66.4.562","article-title":"Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease","volume":"66","author":"LJ Abraham","year":"1999","journal-title":"J Leukoc Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0092-8674(95)90443-3","article-title":"Escape from \u2018horror autotoxicus\u2019: pathogenesis and treatment of autoimmune disease","volume":"80","author":"L Steinman","year":"1995","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00109-004-0556-x","article-title":"Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese","volume":"82","author":"A Yamada","year":"2004","journal-title":"J Mol Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00125-004-1659-1","article-title":"The common T60N polymorphism of the lymphotoxin-alpha gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome","volume":"48","author":"YH Hamid","year":"2005","journal-title":"Diabetologia"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/eji.1830230135","article-title":"Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-a and TNF-b by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus","volume":"23","author":"F Pociot","year":"1993","journal-title":"Eur J Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/01.LAB.0000069521.42488.1B","article-title":"Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo","volume":"83","author":"A Wajkowicz-Kalijska","year":"2003","journal-title":"Lab Invest"},{"key":"ref59","first-page":"663","article-title":"Elevated serum tumor necrosis factor-a levels in patients with systemic sclerosis: association with pulmonary fibrosis","volume":"24","author":"M Hasegawa","year":"1983","journal-title":"J Rheumatol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00222469","article-title":"Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB MHC haplotypes","volume":"37","author":"MP Bettinotti","year":"1993","journal-title":"Immunogenetics"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0198-8859(95)00170-0","article-title":"Systemic lupus erythematosus with nephritis is strongly associated with the TNFB*2 homozygote in the Korean population","volume":"46","author":"TG Kim","year":"1996","journal-title":"Hum Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/096120339700600708","article-title":"Decreased tumour necrosis factor-beta production in TNFB*2 homozygote: an important predisposing factor of lupus nephritis in Koreans","volume":"6","author":"SH Lee","year":"1997","journal-title":"Lupus"},{"key":"ref63","first-page":"107","article-title":"The polymorphisms of HLA-DR and TNF B loci in northern Chinese Han nationality and susceptibility to systemic lupus erythematosus","volume":"12","author":"J Zhang","year":"1997","journal-title":"Chin Med Sci J"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni0901-777","article-title":"Sex differences in autoimmune disease","volume":"2","author":"CC Whitacre","year":"2001","journal-title":"Nat Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molimm.2012.06.013","article-title":"Murine BAFF expression is up-regulated by estrogen and interferons: Implications for sex bias in the development of autoimmunity","volume":"53","author":"R Panchanathan","year":"2012","journal-title":"Mol Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1432-1327.1998.2550139.x","article-title":"Mechanisms of melanogenesis inhibition by tumor necrosis factor-\u03b1 in B16\u2013F10 mouse melanoma cells","volume":"255","author":"M Martinez-Esparza","year":"1998","journal-title":"Eur J Biochem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/01.LAB.0000069521.42488.1B","article-title":"Immunopolarization of CD4<sup>+<\/sup> and CD8<sup>+<\/sup> T cells to Type-1-like is associated with melanocyte loss in human vitiligo","volume":"83","author":"A Wajkowicz-Kalijska","year":"2003","journal-title":"Lab Invest"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/pcmr.12105","article-title":"Decreased regulatory T-Cells and CD4<sup>+<\/sup>\/CD8<sup>+<\/sup> ratio correlate with disease onset and progression in patients with generalized vitiligo","volume":"26","author":"M Dwivedi","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.1365-2133.1998.02550.x","article-title":"Vitiligo melanocytes in long-term culture show normal constitutive and cytokine-induced expression of intercellular adhesion molecule-1 and major histocompatibility complex class I and class II molecules","volume":"139","author":"SJ Hedley","year":"1998","journal-title":"Br J Dermatol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3349\/ymj.1994.35.4.404","article-title":"Immunohistochemical studies from vitiligo- comparison between active and inactive lesions","volume":"35","author":"SK Ahn","year":"1994","journal-title":"Yonsei Med J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/jid.1993.75","article-title":"Influence of inflammatory mediators and cytokines on human melanocyte function","volume":"100","author":"JG Morelli","year":"1993","journal-title":"J Invest Dermatol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.humimm.2012.01.011","article-title":"The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells","volume":"73","author":"E Reimann","year":"2012","journal-title":"Hum Immunol"},{"key":"ref73","first-page":"19","article-title":"Vitiligo with raised inflammatory borders: involvement of T cell immunity and keratinocytes expressing MHC class II and ICAM-1 molecules","volume":"7","author":"H Yagi","year":"1997","journal-title":"Eur J Dermatol Clin"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/jid.2011.240","article-title":"HLA alleles and amino acid signatures of the peptide binding pockets of HLA molecules in Vitiligo","volume":"132","author":"A Singh","year":"2012","journal-title":"J Invest Dermatol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/jid.2012.501","article-title":"Association of Generalized Vitiligo with HLA Class II Loci in Patients from the Indian Subcontinent","volume":"133","author":"SA Birlea","year":"2013","journal-title":"J Invest Dermatol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1755-148X.2011.00892.x","article-title":"Cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) in isolated vitiligo: a genotype-phenotype correlation","volume":"24","author":"M Dwivedi","year":"2011","journal-title":"Pigment cell Melanoma Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2133.2012.11000.x","article-title":"Interleukin-4 genetic variants correlate with its transcript and protein levels in vitiligo patients","volume":"167","author":"M Imran","year":"2012","journal-title":"Brit J Dermatol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jdermsci.2013.04.026","article-title":"Correlation of increased <italic>MYG1<\/italic> expression and its promoter polymorphism with disease progression and higher susceptibility in vitiligo patients","volume":"71","author":"M Dwivedi","year":"2013","journal-title":"J Dermatol Sci"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Dwivedi M, Laddha NC, Shah K, Shah BJ, Begum R (2013) Involvement of interferon-gamma genetic variants and intercellular adhesion molecule-1 in disease onset and progression of generalized vitiligo. J Interferon Cytokine Res. doi:10.1089\/jir.2012.0171.","DOI":"10.1089\/jir.2012.0171"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Dwivedi M, Laddha NC, Mansuri MS, Marfatia YS, Begum R (2013) Association of <italic>NLRP1<\/italic> genetic variants and mRNA overexpression with generalized vitiligo and disease activity in a Gujarat population. Brit J Dermatol. doi: 10.1111\/bjd.12467.","DOI":"10.1111\/bjd.12467"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1600-0749.2007.00406.x","article-title":"Association of catalase T\/C exon 9 and glutathione peroxidase codon 200 polymorphisms in relation to their activities and oxidative stress with vitiligo susceptibility in Gujarat population","volume":"20","author":"EM Shajil","year":"2007","journal-title":"Pigment Cell Res"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2133.2009.09140.x","article-title":"Lack of genetic association of promoter and structural variants of Mannan-binding lectin (MBL2) gene with susceptibility to generalized vitiligo","volume":"161","author":"M Dwivedi","year":"2009","journal-title":"Brit J Dermatol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1755-148X.2008.00462.x","article-title":"The ACE gene I\/D polymorphism is not associated with generalized Vitiligo Susceptibility in Gujarat population","volume":"21","author":"M Dwivedi","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jdermsci.2007.10.002","article-title":"Association of PTPN22 1858C\/T polymorphism with vitiligo susceptibility in Gujarat population","volume":"49","author":"NC Laddha","year":"2008","journal-title":"J Dermatol Sci"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.freeradbiomed.2013.08.189","article-title":"Involvement of superoxide dismutase isoenzymes and their genetic variants in progression of and higher susceptibility to vitiligo","volume":"65","author":"NC Laddha","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.3263703","article-title":"Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism","volume":"242","author":"GH Wong","year":"1988","journal-title":"Science"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1016\/S0021-9258(19)50482-3","article-title":"Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isoenzymes in fibroblasts","volume":"267","author":"SL Marklund","year":"1992","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T21:59:39Z","timestamp":1647554379000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081736"}},"subtitle":[],"editor":[{"given":"Srinivas","family":"Mummidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":87,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081736","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}