{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:33:43Z","timestamp":1790616823686,"version":"4.1.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0081948","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T21:51:03Z","timestamp":1386021063000},"page":"e81948","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury"],"prefix":"10.1371","volume":"8","author":[{"given":"Daniel","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Zai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Schaffling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ahlborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry I.","family":"Benowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","article-title":"Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS","volume":"4","author":"MT Filbin","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.expneurol.2007.05.014","article-title":"CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure","volume":"209","author":"MT Fitch","year":"2008","journal-title":"Exp Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11782","DOI":"10.1523\/JNEUROSCI.3444-07.2007","article-title":"Spinal cord injury: time to move?","volume":"27","author":"S Rossignol","year":"2007","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-neuro-061010-113723","article-title":"Neuronal intrinsic mechanisms of axon regeneration","volume":"34","author":"K Liu","year":"2011","journal-title":"Annu Rev Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1067840","article-title":"Repairing the injured spinal cord","volume":"295","author":"ME Schwab","year":"2002","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.1217416","article-title":"Restoring voluntary control of locomotion after paralyzing spinal cord injury","volume":"336","author":"R van den Brand","year":"2012","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nn.2603","article-title":"PTEN deletion enhances the regenerative ability of adult corticospinal neurons","volume":"13","author":"K Liu","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cell.2012.08.020","article-title":"Long-distance growth and connectivity of neural stem cells after severe spinal cord injury","volume":"150","author":"P Lu","year":"2012","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nn1195","article-title":"The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats","volume":"7","author":"FM Bareyre","year":"2004","journal-title":"Nat Neurosci"},{"key":"ref10","first-page":"30411","article-title":"Single Collateral Reconstructions Reveal Distinct Phases of Corticospinal Remodeling after Spinal Cord","volume":"7","author":"C Lang","year":"2012","journal-title":"Injury - PLOS ONE"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/brain\/awl087","article-title":"BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats","volume":"129","author":"R Vavrek","year":"2006","journal-title":"Brain"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1073\/pnas.051626798","article-title":"Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury","volume":"98","author":"N Weidner","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"18320","DOI":"10.1073\/pnas.0605135103","article-title":"Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth","volume":"103","author":"N Irwin","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nn.2414","article-title":"Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways","volume":"12","author":"B Lorber","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8301","DOI":"10.1073\/pnas.85.21.8301","article-title":"Purine metabolite inosine is an adrenergic neurotrophic substance for cultured chicken sympathetic neurons","volume":"85","author":"AD Zurn","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29626","DOI":"10.1074\/jbc.273.45.29626","article-title":"Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells","volume":"273","author":"LI Benowitz","year":"1998","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1523\/JNEUROSCI.20-21-08031.2000","article-title":"A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells","volume":"20","author":"B Petrausch","year":"2000","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1073\/pnas.132076299","article-title":"Inosine induces axonal rewiring and improves behavioral outcome after stroke","volume":"99","author":"P Chen","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/brain\/awl393","article-title":"Inosine promotes recovery of skilled motor function in a model of focal brain injury","volume":"130","author":"JM Smith","year":"2007","journal-title":"Brain"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1523\/JNEUROSCI.4498-10.2011","article-title":"Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke","volume":"31","author":"L Zai","year":"2011","journal-title":"J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8187","DOI":"10.1523\/JNEUROSCI.0414-09.2009","article-title":"Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb","volume":"29","author":"L Zai","year":"2009","journal-title":"J Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"DM Basso","year":"1995","journal-title":"J Neurotrauma"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0270(02)00012-2","article-title":"Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination","volume":"115","author":"GA Metz","year":"2002","journal-title":"J Neurosci Methods"},{"key":"ref24","article-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1986"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbr.2009.03.018","article-title":"Functional mapping of the motor cortex of the rat using transdural electrical stimulation","volume":"202","author":"ET Fonoff","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/325711a0","article-title":"Regeneration by supernumerary axons with synaptic terminals in spinal motoneurons of cats","volume":"325","author":"L Havton","year":"1987","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/brain\/awl393","article-title":"Inosine promotes recovery of skilled motor function in a model of focal brain injury","volume":"130","author":"JM Smith","year":"2007","journal-title":"Brain"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1089\/neu.2006.23.1632","article-title":"Quantification of locomotor recovery following spinal cord contusion in adult rats","volume":"23","author":"ML McEwen","year":"2006","journal-title":"J Neurotrauma"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/exnr.2002.7909","article-title":"Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord","volume":"176","author":"P Schucht","year":"2002","journal-title":"Exp Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10593","article-title":"False resurrections: distinguishing regenerated from spared axons in the injured central nervous system","volume":"459","author":"O Steward","year":"2003","journal-title":"J Comp Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.neuroscience.2006.07.017","article-title":"Inter-enlargement pathways in the ventrolateral funiculus of the adult rat spinal cord","volume":"142","author":"WR Reed","year":"2006","journal-title":"Neuroscience"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tins.2008.02.004","article-title":"Axonal growth therapeutics: regeneration or sprouting or plasticity?","volume":"31","author":"WB Cafferty","year":"2008","journal-title":"Trends Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s13311-011-0034-4","article-title":"Plasticity after spinal cord injury: relevance to recovery and approaches to facilitate it","volume":"8","author":"SM Onifer","year":"2011","journal-title":"Neurotherapeutics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/nn.2691","article-title":"Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury","volume":"13","author":"ES Rosenzweig","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.expneurol.2012.04.004","article-title":"Extensive respiratory plasticity after cervical spinal cord injury in rats : Axonal sprouting and rerouting of ventrolateral bulbospinal pathways","volume":"236","author":"F Darlot","year":"2012","journal-title":"Exp Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-neuro-061010-113746","article-title":"Recovery of locomotion after spinal cord injury: some facts and mechanisms","volume":"34","author":"S Rossignol","year":"2011","journal-title":"Annu Rev Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.neuro.31.060407.125547","article-title":"Descending pathways in motor control","volume":"31","author":"RN Lemon","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-4886(02)00055-9","article-title":"NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection","volume":"181","author":"MH Tuszynski","year":"2003","journal-title":"Exp Neurol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1523\/JNEUROSCI.23-13-05393.2003","article-title":"Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions","volume":"23","author":"T Oertle","year":"2003","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.STR.0000119754.85848.0D","article-title":"Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia","volume":"35","author":"WR Sch\u00e4bitz","year":"2004","journal-title":"Stroke"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"12242","DOI":"10.1523\/JNEUROSCI.3827-06.2006","article-title":"The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth","volume":"26","author":"WB Cafferty","year":"2006","journal-title":"J Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1523\/JNEUROSCI.1697-08.2008","article-title":"Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury","volume":"28","author":"IC Maier","year":"2008","journal-title":"J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/neu.2007.0464","article-title":"Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth","volume":"26","author":"X Wang","year":"2009","journal-title":"J Neurotrauma"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nn.2401","article-title":"Transformation of nonfunctional spinal circuits into functional states after the loss of brain input","volume":"12","author":"G Courtine","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/STROKEAHA.109.572073","article-title":"Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats","volume":"41","author":"PC Fang","year":"2010","journal-title":"Stroke"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1111\/j.1460-9568.2006.04726.x","article-title":"Spontaneous locomotor recovery in spinal cord injured rats is accompanied by anatomical plasticity of reticulospinal fibers","volume":"23","author":"M Ballermann","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"12145","DOI":"10.1523\/JNEUROSCI.0897-09.2009","article-title":"Spinal interneuron axons spontaneously regenerate after spinal cord injury in the adult feline","volume":"29","author":"KK Fenrich","year":"2009","journal-title":"J Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.sc.3101878","article-title":"Secondary degeneration reduced by inosine after spinal cord injury in rats","volume":"44","author":"F Liu","year":"2006","journal-title":"Spinal Cord"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0306-4522(85)90225-8","article-title":"Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat","volume":"15","author":"G Skagerberg","year":"1985","journal-title":"Neuroscience"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00019052-199412000-00008","article-title":"Enhancement of locomotor recovery following spinal cord injury","volume":"7","author":"H Barbeau","year":"1994","journal-title":"Curr Opin Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1523\/JNEUROSCI.20-13-05144.2000","article-title":"Activation of locomotion in adult chronic spinal rats is achieved by transplantation of embryonic raphe cells reinnervating a precise lumbar level","volume":"20","author":"MG Ribotta","year":"2000","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1523\/JNEUROSCI.19-14-06213.1999","article-title":"Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection","volume":"19","author":"D Kim","year":"1999","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/exnr.1996.0094","article-title":"The recovery of 5-HT immunoreactivity in lumbosacral spinal cord and locomotor function after thoracic hemisection","volume":"139","author":"Y Saruhashi","year":"1996","journal-title":"Exp Neurol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1152\/jn.00499.2010","article-title":"Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors","volume":"104","author":"K Fouad","year":"2010","journal-title":"J Neurophysiol"},{"key":"ref55","first-page":"CD","article-title":"Recovery from spinal cord injury in mice lacking the Nogo-66 receptor. Program No 41511 Abstract Viewer and Itinerary Planner Washington, DC","author":"JE Kim","year":"2003"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"13486","DOI":"10.1073\/pnas.96.23.13486","article-title":"Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury","volume":"96","author":"LI Benowitz","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.expneurol.2011.09.019","article-title":"A re-assessment of the effects of intracortical delivery of inosine on transmidline growth of corticospinal tract axons after unilateral lesions of the medullary pyramid","volume":"233","author":"O Steward","year":"2012","journal-title":"Exp Neurol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.expneurol.2011.09.034","article-title":"Author's response to Steward et al., "A re-assessment of the effects of intra-cortical delivery of inosine...."","volume":"233","author":"L Benowitz","year":"2012","journal-title":"Exp Neurol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/01.STR.0000155747.15679.04","article-title":"Inosine reduces ischemic brain injury in rats","volume":"36","author":"H Shen","year":"2005","journal-title":"Stroke"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00432183","article-title":"Anticonvulsant doses of inosine result in brain levels sufficient to inhibit [3H] diazepam binding","volume":"75","author":"PJ Marangos","year":"1981","journal-title":"Psychopharmacology (Berl)"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tips.2004.01.006","article-title":"Immunomodulatory and neuroprotective effects of inosine","volume":"25","author":"G Hask\u00f3","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.164.2.1013","article-title":"Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock","volume":"164","author":"G Hask\u00f3","year":"2000","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1046\/j.1471-4159.1996.67052051.x","article-title":"Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose-oxygen deprivation","volume":"67","author":"SE Haun","year":"1996","journal-title":"J Neurochem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1471-4159.1998.71020535.x","article-title":"Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation","volume":"71","author":"MS Jurkowitz","year":"1998","journal-title":"J Neurochem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"16303","DOI":"10.1073\/pnas.212645999","article-title":"Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors","volume":"99","author":"GS Scott","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1073\/pnas.0500307102","article-title":"Uric acid protects against secondary damage after spinal cord injury","volume":"102","author":"GS Scott","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/1043-6618(89)90200-4","article-title":"Haemodynamic effects of inosine. A new drug for failing human heart?","volume":"21","author":"W Czarnecki","year":"1989","journal-title":"Pharmacolpharmacol Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1097\/00005768-199609000-00017","article-title":"Effect of inosine supplementation on aerobic and anaerobic cycling performance","volume":"28","author":"RD Starling","year":"1996","journal-title":"Med Sci Sports Exerc"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0005-2736(75)90259-X","article-title":"Independent blood-brain barrier transport systems for nucleic acid precursors","volume":"394","author":"EM Cornford","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1471-4159.1973.tb00084.x","article-title":"The uptake of purines by rat brain in vivo and in vitro","volume":"20","author":"S Nakagawa","year":"1973","journal-title":"J Neurochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:29:05Z","timestamp":1588973345000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081948"}},"subtitle":[],"editor":[{"given":"Simone","family":"Di Giovanni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,2]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081948","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,2]]}}}