{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:07:20Z","timestamp":1791274040501,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082032","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T21:26:22Z","timestamp":1386365182000},"page":"e82032","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Pseudomonas syringae pv. tomato Type III Effector HopM1 Suppresses Arabidopsis Defenses Independent of Suppressing Salicylic Acid Signaling and of Targeting AtMIN7"],"prefix":"10.1371","volume":"8","author":[{"given":"Anju","family":"Gangadharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mysore-Venkatarau","family":"Sreerekha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Whitehill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hyun","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2006.02.008","article-title":"Host-microbe interactions: shaping the evolution of the plant immune response","volume":"124","author":"ST Chisholm","year":"2006","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2958.2006.05311.x","article-title":"MAMPs and MIMPs: proposed classifications for inducers of innate immunity","volume":"61","author":"D Mackey","year":"2006","journal-title":"Molecular microbiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature05286","article-title":"The plant immune system","volume":"444","author":"JD Jones","year":"2006","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.1164627","article-title":"Glucosinolate metabolites required for an Arabidopsis innate immune response","volume":"323","author":"NK Clay","year":"2009","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.phyto.43.040204.135923","article-title":"Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens","volume":"43","author":"J Glazebrook","year":"2005","journal-title":"Annu Rev Phytopathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1365-313X.2007.03369.x","article-title":"Interplay between MAMP-triggered and SA-mediated defense responses","volume":"53","author":"K Tsuda","year":"2008","journal-title":"Plant J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0092-8674(03)00429-X","article-title":"Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes","volume":"113","author":"Z Mou","year":"2003","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature11162","article-title":"NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants","volume":"486","author":"ZQ Fu","year":"2012","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.1108791","article-title":"Induction of protein secretory pathway is required for systemic acquired resistance","volume":"308","author":"D Wang","year":"2005","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1105\/tpc.001628","article-title":"In vivo interaction between NPR1 and transcription factor TGA2 leads to Salicylic acid-mediated gene activation in Arabidopsis","volume":"14","author":"W Fan","year":"2002","journal-title":"Plant Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1360-1385(01)02223-3","article-title":"bZIP transcription factors in Arabidopsis","volume":"7","author":"M Jakoby","year":"2002","journal-title":"Trends Plant Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1104\/pp.110.165563","article-title":"The Arabidopsis PR-1 promoter contains multiple integration sites for the coactivator NPR1 and the repressor SNI1","volume":"154","author":"S Pape","year":"2010","journal-title":"Plant Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1365-313x.1998.00288.x","article-title":"Functional analysis of regulatory sequences controlling PR-1 gene expression in Arabidopsis","volume":"16","author":"E Lebel","year":"1998","journal-title":"Plant J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1104\/pp.106.095299","article-title":"Genetic interactions of TGA transcription factors in the regulation of pathogenesis-related genes and disease resistance in Arabidopsis","volume":"144","author":"M Kesarwani","year":"2007","journal-title":"Plant Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.devcel.2010.07.011","article-title":"The cytokinin-activated transcription factor ARR2 promotes plant immunity via TGA3\/NPR1-dependent salicylic acid signaling in Arabidopsis","volume":"19","author":"J Choi","year":"2010","journal-title":"Dev Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(00)81962-5","article-title":"Identification and cloning of a negative regulator of systemic acquired resistance, <italic>SNI1<\/italic>, through a screen for suppressors of <italic>npr1-1<\/italic>","volume":"98","author":"X Li","year":"1999","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1105\/tpc.105.039677","article-title":"A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity","volume":"18","author":"RA Mosher","year":"2006","journal-title":"Plant Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chom.2011.01.011","article-title":"DNA repair proteins are directly involved in regulation of gene expression during plant immune response","volume":"9","author":"J Song","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1105\/tpc.6.5.581","article-title":"Acquired resistance signal transduction in Arabidopsis is ethylene independent","volume":"6","author":"KA Lawton","year":"1994","journal-title":"Plant Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pbi.2010.04.003","article-title":"Bacterial virulence effectors and their activities","volume":"13","author":"DR Hann","year":"2010","journal-title":"Curr Opin Plant Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1073\/pnas.97.9.4856","article-title":"The Pseudomonas syringae Hrp pathogenicity island has a tripartite mosaic structure composed of a cluster of type III secretion genes bounded by exchangeable effector and conserved effector loci that contribute to parasitic fitness and pathogenicity in plants","volume":"97","author":"JR Alfano","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1094\/MPMI-19-0099","article-title":"A Pseudomonas syringae pv. tomato avrE1\/hopM1 mutant is severely reduced in growth and lesion formation in tomato","volume":"19","author":"JL Badel","year":"2006","journal-title":"Mol Plant Microbe Interact"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1073\/pnas.0401601101","article-title":"A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants","volume":"101","author":"S DebRoy","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1046\/j.1365-2958.2003.03647.x","article-title":"Pseudomonas syringae pv. tomato DC3000 HopPtoM (CEL ORF3) is important for lesion formation but not growth in tomato and is secreted and translocated by the Hrp type III secretion system in a chaperone-dependent manner","volume":"49","author":"JL Badel","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.pbi.2010.05.002","article-title":"Not a peripheral issue: secretion in plant-microbe interactions","volume":"13","author":"P Bednarek","year":"2010","journal-title":"Curr Opin Plant Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1091\/mbc.E04-02-0140","article-title":"The PEN1 syntaxin defines a novel cellular compartment upon fungal attack and is required for the timely assembly of papillae","volume":"15","author":"FF Assaad","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature02076","article-title":"SNARE-protein-mediated disease resistance at the plant cell wall","volume":"425","author":"NC Collins","year":"2003","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.1073\/pnas.0701083104","article-title":"The syntaxin SYP132 contributes to plant resistance against bacteria and secretion of pathogenesis-related protein 1","volume":"104","author":"M Kalde","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.1129523","article-title":"A bacterial virulence protein suppresses host innate immunity to cause plant disease","volume":"313","author":"K Nomura","year":"2006","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1073\/pnas.1103338108","article-title":"Effector-triggered immunity blocks pathogen degradation of an immunity-associated vesicle traffic regulator in Arabidopsis","volume":"108","author":"K Nomura","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cub.2009.01.057","article-title":"Fluorescence imaging-based screen identifies ARF GEF component of early endosomal trafficking","volume":"19","author":"H Tanaka","year":"2009","journal-title":"Curr Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cell.2005.10.031","article-title":"Identification of a bacterial type III effector family with G protein mimicry functions","volume":"124","author":"NM Alto","year":"2006","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1094\/MPMI-22-6-0703","article-title":"Multiple Activities of the Plant Pathogen Type III Effector Proteins WtsE and AvrE Require WxxxE Motifs","volume":"22","author":"JH Ham","year":"2009","journal-title":"Mol Plant Microbe Interact"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nsmb.1647","article-title":"Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics","volume":"16","author":"Z Huang","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1365-313X.2007.03165.x","article-title":"Layered basal defenses underlie non-host resistance of Arabidopsis to Pseudomonas syringae pv. phaseolicola","volume":"51","author":"JH Ham","year":"2007","journal-title":"Plant J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1105\/tpc.014894","article-title":"Knockout analysis of Arabidopsis transcription factors TGA2, TGA5, and TGA6 reveals their redundant and essential roles in systemic acquired resistance","volume":"15","author":"Y Zhang","year":"2003","journal-title":"Plant Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81858-9","article-title":"The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats","volume":"88","author":"H Cao","year":"1997","journal-title":"Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/35107108","article-title":"Isochorismate synthase is required to synthesize salicylic acid for plant defence","volume":"414","author":"MC Wildermuth","year":"2001","journal-title":"Nature"},{"key":"ref39","first-page":"443","article-title":"Measuring cell-wall-based defenses and their effect on bacterial growth in Arabidopsis","volume":"415","author":"MG Kim","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2005.03.025","article-title":"Two Pseudomonas syringae type III effectors inhibit RIN4-regulated basal defense in Arabidopsis","volume":"121","author":"MG Kim","year":"2005","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1094\/MPMI.1999.12.11.1022","article-title":"LSD1 regulates Salicylic Acid induction of copper-zinc superoxide dismutase in <italic>Arabidopsis thaliana<\/italic>","volume":"12","author":"DJ Kliebenstein","year":"1999","journal-title":"Mol Plant Microbe Interact"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1369-5266(03)00058-X","article-title":"The salicylic acid loop in plant defense","volume":"6","author":"J Shah","year":"2003","journal-title":"Curr Opin Plant Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1105\/tpc.112.105312","article-title":"The coronatine toxin of Pseudomonas syringae is a multifunctional suppressor of Arabidopsis defense","volume":"24","author":"X Geng","year":"2012","journal-title":"Plant Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1094\/MPMI-04-12-0078-IA","article-title":"From pioneers to team players: TGA transcription factors provide a molecular link between different stress pathways","volume":"26","author":"C Gatz","year":"2013","journal-title":"Mol Plant Microbe Interact"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1038\/sj.emboj.7600337","article-title":"The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis","volume":"23","author":"C Hass","year":"2004","journal-title":"EMBO J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1365-313X.2011.04843.x","article-title":"Cytokinin-facilitated proteolysis of ARABIDOPSIS RESPONSE REGULATOR 2 attenuates signaling output in two-component circuitry","volume":"69","author":"K Kim","year":"2012","journal-title":"Plant J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:57:30Z","timestamp":1589014650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082032"}},"subtitle":[],"editor":[{"given":"Dawn","family":"Arnold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,6]]},"references-count":46,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082032","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,6]]}}}