{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:26:12Z","timestamp":1778311572467,"version":"3.51.4"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082123","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:26:55Z","timestamp":1384993615000},"page":"e82123","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-Invasive Monitoring of Streptococcus pyogenes Vaccine Efficacy Using Biophotonic Imaging"],"prefix":"10.1371","volume":"8","author":[{"given":"Faraz M.","family":"Alam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siouxsie","family":"Wiles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiranee","family":"Sriskandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of group A streptococcal diseases","volume":"5","author":"JR Carapetis","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/QCO.0b013e328332bbfe","article-title":"Group A streptococcal vaccines: facts versus fantasy","volume":"22","author":"AC Steer","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1016\/j.vaccine.2011.09.005","article-title":"New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci","volume":"29","author":"JB Dale","year":"2011","journal-title":"Vaccine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/CVI.00256-09","article-title":"Correlation between bioluminescence and bacterial burden in passively protected mice challenged with a recombinant bioluminescent M49 group A streptococcus Strain","volume":"17","author":"M Sheel","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1473-3099(09)70178-1","article-title":"Global emm type distribution of group A streptococci: systematic review and implications for vaccine development","volume":"9","author":"AC Steer","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7878","DOI":"10.1128\/IAI.73.12.7878-7886.2005","article-title":"Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils","volume":"73","author":"HS Park","year":"2005","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/S0264-410X(02)00803-4","article-title":"Stimulation of long-lasting protection against <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein","volume":"21","author":"K Schulze","year":"2003","journal-title":"Vaccine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1128\/IAI.69.2.924-930.2001","article-title":"Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> challenge in mice","volume":"69","author":"S Kawabata","year":"2001","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nbt1179","article-title":"Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome","volume":"24","author":"M Rodr\u00edguez-Ortega","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"015693","DOI":"10.1074\/mcp.M111.015693","article-title":"Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case","volume":"11","author":"G Bensi","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1365-2958.2010.07065.x","article-title":"Chemokine-cleaving <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract","volume":"76","author":"P Kurupati","year":"2010","journal-title":"Mol Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/j.vaccine.2009.06.042","article-title":"Impact of immunization against SpyCEP during invasive disease with two streptococcal species: <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> and <italic>Streptococcus<\/italic> <italic>equi<\/italic>","volume":"27","author":"CE Turner","year":"2009","journal-title":"Vaccine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1128\/IAI.00295-10","article-title":"Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine","volume":"78","author":"A Fritzer","year":"2010","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1574-6976.2010.00252.x","article-title":"Noninvasive biophotonic imaging for studies of infectious disease","volume":"35","author":"N Andreu","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"ref15","article-title":"The Principles of Humane Experimental Technique. Methuen","author":"WMS Russell","year":"1959"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.4049\/jimmunol.171.5.2532","article-title":"Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus","volume":"171","author":"HS Park","year":"2003","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e61655","DOI":"10.1371\/journal.pone.0061655","article-title":"Inactivation of the CovR\/S virulence regulator impairs infection in an improved murine model of <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> naso-pharyngeal infection","volume":"8","author":"FM Alam","year":"2013","journal-title":"PLOS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1365-2958.2007.05704.x","article-title":"<italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> pili promote pharyngeal cell adhesion and biofilm formation","volume":"64","author":"AGO Manetti","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/AAC.46.2.538-542.2002","article-title":"Expression of <italic>lux<\/italic> genes in a clinical isolate of <italic>Streptococcus<\/italic> <italic>pneumoniae<\/italic>: using bioluminescence to monitor gemifloxacin activity","volume":"46","author":"SJ Beard","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-1119(85)90120-9","article-title":"Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors","volume":"33","author":"C Yanisch-Perron","year":"1985","journal-title":"Gene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1128\/AEM.02940-06","article-title":"An improved luciferase tagging system for <italic>Listeria<\/italic> <italic>monocytogenes<\/italic> allows real-time monitoring <italic>in<\/italic> <italic>vivo<\/italic> and <italic>in<\/italic> <italic>vitro<\/italic>","volume":"73","author":"CU Riedel","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1365-2958.1999.01525.x","article-title":"Molecular analysis of the role of streptococcal pyrogenic exotoxin A ( SPEA ) in invasive soft-tissue infection resulting from <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic>","volume":"33","author":"S Sriskandan","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1099\/mic.0.2008\/019265-0","article-title":"Shuttle expression plasmids for genetic studies in <italic>Streptococcus<\/italic> <italic>mutans<\/italic>","volume":"154","author":"I Biswas","year":"2008","journal-title":"Microbiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1086\/603541","article-title":"Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic> infection","volume":"200","author":"CE Turner","year":"2009","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1128\/AEM.02018-12","article-title":"Construction and application of a <italic>luxABCDE<\/italic> reporter system for real-time monitoring of <italic>Enterococcus<\/italic> <italic>faecalis<\/italic> gene expression and growth","volume":"78","author":"SL La Rosa","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1462-2920.2004.00655.x","article-title":"Illuminating the detection chain of bacterial bioreporters","volume":"6","author":"JR Van der Meer","year":"2004","journal-title":"Environ Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00203-008-0387-1","article-title":"Effects of <italic>luxCDABEG<\/italic> induction in <italic>Vibrio<\/italic> <italic>fischeri<\/italic>: enhancement of symbiotic colonization and conditional attenuation of growth in culture","volume":"190","author":"JL Bose","year":"2008","journal-title":"Arch Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1162\/153535004773861688","article-title":"Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models","volume":"3","author":"T Troy","year":"2004","journal-title":"Mol Imaging"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"0041","DOI":"10.1371\/journal.ppat.0020005","article-title":"Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease Specificity","volume":"2","author":"P Sumby","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijmm.2005.02.010","article-title":"Analysis of the growth phase-associated transcriptome of <italic>Streptococcus<\/italic> <italic>pyogenes<\/italic>","volume":"295","author":"G Beyer-Sehlmeyer","year":"2005","journal-title":"Int J Med Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:36:06Z","timestamp":1589009766000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082123"}},"subtitle":[],"editor":[{"given":"Daniela\u00a0Flavia","family":"Hozbor","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082123","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]}}}