{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:36:01Z","timestamp":1772548561855,"version":"3.50.1"},"reference-count":104,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082206","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T22:08:03Z","timestamp":1387490883000},"page":"e82206","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Over-Expression of hNGF in Adult Human Olfactory Bulb Neural Stem Cells Promotes Cell Growth and Oligodendrocytic Differentiation"],"prefix":"10.1371","volume":"8","author":[{"given":"Hany E. S.","family":"Marei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Althani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla","family":"Afifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abd-Elmaksoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Michetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Barba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pescatori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Maira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Paldino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Manni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Casalbore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cenciarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/329065a0","article-title":"Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor","volume":"329","author":"W Fischer","year":"1987","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1523\/JNEUROSCI.06-08-02155.1986","article-title":"Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection","volume":"6","author":"F Hefti","year":"1986","journal-title":"J Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.3798108","article-title":"Nerve growth factor treatment after brain injury prevents neuronal death","volume":"235","author":"LF Kromer","year":"1987","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ana.410300613","article-title":"Human nerve growth factor prevent Mouse nerve growth factorprevents degeneration of basal forebrain cholinergic neurons in primates","volume":"30","author":"VE Koliatsos","year":"1991","journal-title":"Ann Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1073\/pnas.91.23.10898","article-title":"The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor","volume":"91","author":"JH Kordower","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","first-page":"305","article-title":"Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration","volume":"3","author":"MH Tuszynski","year":"1996","journal-title":"Gene Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1523\/JNEUROSCI.10-11-03604.1990","article-title":"Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degenemouseion","volume":"10","author":"MH Tuszynski","year":"1990","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"MH Tuszynski","year":"2005","journal-title":"Nat Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1474-4422(05)70086-7","article-title":"Hope for AD with NGF gene therapy trial","volume":"4","author":"J Bradbury","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pharmthera.2004.08.001","article-title":"Delivery of therapeutic agents to the central nervous system: the problems and the possibilities","volume":"104","author":"Begley","year":"2004","journal-title":"Pharmacol Therapeutics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1126\/science.3201248","article-title":"Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression","volume":"242","author":"MB Rosenberg","year":"1988","journal-title":"Science"},{"key":"ref12","first-page":"128","article-title":"Reversible induction of Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites in vivo after continuous intracerebroventricular administration of nerve growth factor","volume":"40","author":"J Winkler","year":"1996","journal-title":"Ann Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.expneurol.2008.03.004","article-title":"Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons","volume":"211","author":"KM Bishop","year":"2008","journal-title":"Exp Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S1474-4422(10)70254-4","article-title":"Gene delivery of AAV2-neurturin for Parkinson\u2019s disease: a double-blind, randomized, controlled trial","volume":"9","author":"WJ Jr Marks","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/j.1460-9568.2008.06452.x","article-title":"Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve","volume":"28","author":"MR Tannermaat","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0306-4522(91)90271-O","article-title":"Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids","volume":"45","author":"JM Schumacher","year":"1991","journal-title":"Neuroscience"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0896-6273(95)90051-9","article-title":"Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain","volume":"15","author":"A Martinez-Serrano","year":"1995","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.expneurol.2008.10.004","article-title":"Long term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery","volume":"215","author":"AH Nagahara","year":"2009","journal-title":"Exp Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JAD-2008-15210","article-title":"Towards noninvasive nerve growth factor therapies for Alzheimer\u2019s disease","volume":"15","author":"A Cattaneo","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"ref20","author":"MH Tuszynski","year":"1996"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.expneurol.2003.10.022","article-title":"Adult human olfactory neural progenitors cultured in defined medium","volume":"186","author":"X Zhang","year":"2004","journal-title":"Exp Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1523\/JNEUROSCI.21-21-08505.2001","article-title":"Phenotipic differentiation during migration of dopaminergic progenitor cells to the olfactory bulb","volume":"21","author":"H Baker","year":"2001","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1073\/pnas.1132092100","article-title":"Neural stem cells and cholinergic neurons: regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor","volume":"100","author":"L Calza","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1136281","article-title":"Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension","volume":"315","author":"MA Curtis","year":"2007","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2005.10.029","article-title":"Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis","volume":"198","author":"L Crigler","year":"2006","journal-title":"Exp Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1460-9568.2004.03849.x","article-title":"Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro","volume":"21","author":"E Gascon","year":"2005","journal-title":"Eur J Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1749-6632.1998.tb09553.x","article-title":"The neurotrophins and neuropoietic cytokines: two families of growth factors acting on neural and hematopoietic cells","volume":"840","author":"NY Ip","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-1-4615-0123-7_11","article-title":"Neurotrophins","volume":"513","author":"G Dechant","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"EJ Huang","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","article-title":"Trk receptors: roles in neuronal signal transduction","volume":"72","author":"EJ Huang","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3727\/096368910X557155","article-title":"Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair","volume":"20","author":"DH Hwang","year":"2011","journal-title":"Cell Transplant"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway","volume":"101","author":"J Imitola","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1440-1789.2006.00688.x","article-title":"Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease","volume":"26","author":"SU Kim","year":"2006","journal-title":"Neuropathology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1634\/stemcells.2006-0409","article-title":"Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model","volume":"25","author":"HJ Lee","year":"2007","journal-title":"Stem Cells"},{"key":"ref35","first-page":"e156","article-title":"Human neural stem cells overexpressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model","volume":"1","author":"HJ Lee","year":"2007","journal-title":"PLOS ONE"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1002\/jnr.22474","article-title":"Human neural stem cells genetically modified to overexpress BDNF promote functional recovery and neuroprotection in mouse stroke model","volume":"88","author":"HJ Lee","year":"2010","journal-title":"J Neurosci Res"},{"key":"ref37","article-title":"Human neural stem cells overexpressing glial cell line derived neurotrophic factor (GDNF) promote functional recovery and neuroprotection in experimental cerebral hemorrhage. Gene The 16:1066-1076","author":"HJ Lee","year":"2009"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Antiinflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke","volume":"131","author":"ST Lee","year":"2008","journal-title":"Brain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.expneurol.2011.12.040","article-title":"Human neural stem cells overexpressing choline acetyltransferase restore cognition in mouse model of cognitive dysfunction","volume":"234","author":"D Park","year":"2012","journal-title":"Exp Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nbd.2004.01.016","article-title":"Proactive transplantation of human neural stem cells blocks neuronal cell death in mouse model of Huntington disease","volume":"16","author":"JK Ryu","year":"2004","journal-title":"Neurobiol Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e28420","DOI":"10.1371\/journal.pone.0028420","article-title":"Gene Expression Profiling of Embryonic Human Neural Stem Cells and Dopaminergic Neurons from Adult Human Substantia Nigra","volume":"6","author":"HES Marei","year":"2011","journal-title":"PLoS ONE"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e33542","DOI":"10.1371\/journal.pone.0033542","article-title":"Gene Expression Profile of Adult Human Olfactory Bulb and Embryonic Neural Stem Cell Suggests Distinct Signaling Pathways and Epigenetic Control","volume":"7","author":"HES Marei","year":"2012","journal-title":"PLOS ONE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1179\/016164106X115161","article-title":"In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system","volume":"28","author":"C Cenciarelli","year":"2006","journal-title":"Neurol Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1179\/016164107X230667","article-title":"Identification and early characterization of genetically modified NGF-producing neural stem cells grafted into the injured adult rat brain","volume":"3","author":"L Pagani","year":"2008","journal-title":"Neurol Res"},{"key":"ref45","article-title":"Transplantation of bone mesenchymal stem cells containing the nerve growth factor gene in adult rat brain with fimbria fornix lesion","author":"SL Leng","year":"2009"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Y Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1093\/bioinformatics\/btg345","article-title":"A random variance model for detection of differential gene expression in small microarray experiments","volume":"19","author":"GW Wright","year":"2003","journal-title":"Bioinformatics"},{"key":"ref48","article-title":"BRB-ArrayTools User Guide","author":"R Simon"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1023\/B:NERE.0000023608.29741.45","article-title":"Using the Gene Ontology for microarray data mining: A comparison of methods and application to age effects in human prefrontal cortex","volume":"29","author":"P Pavlidis","year":"2004","journal-title":"Neurochem Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2105-6-232","article-title":"EXPANDER\u2013an integrative program suite for microarray data analysis","volume":"6","author":"R Shamir","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8-a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"LJ Jensen","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"S Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"RA Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources","volume":"4","author":"DW Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"ref56","first-page":"730","article-title":"EphB signaling controls lineage plasticity of adult neural stem cell niche cells","volume":"7","author":"T Nomura","year":"2010","journal-title":"Cell\u00a0Stem\u00a0Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2009.03.033","article-title":"Fibroblast growth factor-2 increases the expression of neurogenic genes and promotes the migration and differentiation of neurons derived from transplanted neural stem\/progenitor cells","volume":"162","author":"E Verga\u00f1o-Vera","year":"2009","journal-title":"Neuroscience"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e46009","DOI":"10.1371\/journal.pone.0046009","article-title":"Transcriptional and Non-Transcriptional Functions of PPAR\u03b2\/\u03b4 in Non-Small Cell Lung Cancer","volume":"7","author":"D Genini","year":"2012","journal-title":"PLOS ONE"},{"key":"ref59","first-page":"6","article-title":"The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels","volume":"18","author":"MN Manuel","year":"2011","journal-title":"Neural\u00a0Dev"},{"key":"ref60","first-page":"F41:469-80","article-title":"BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse","author":"V Louhivuori","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2009.05.070","article-title":"Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of ratneural stem cells","volume":"1284","author":"I Martin","year":"2009","journal-title":"Brain Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1523\/JNEUROSCI.16-09-02972.1996","article-title":"The divergent homeobox gene PBX1 is expressed in the postnatal subventricular zone and interneurons of the olfactory bulb","volume":"9","author":"L Redmond","year":"1996","journal-title":"J Neurosci"},{"key":"ref63","first-page":"359","article-title":"Ephrin-B3 decreases the survival of adult rat spinal cord-derived neural stem\/progenitor cells in vitro and after transplantation into the injured rat spinal cord","volume":"22","author":"XY Fan","year":"2013","journal-title":"Stem\u00a0Cells\u00a0Dev"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0896-6273(03)00730-X","article-title":"Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET","volume":"40","author":"A Barlow","year":"2003","journal-title":"Neuron"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.neuron.2011.09.032","article-title":"Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia","volume":"72","author":"E Kang","year":"2011","journal-title":"Neuron"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1242\/dev.041129","article-title":"FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain","volume":"136","author":"BV Jacquet","year":"2009","journal-title":"Development"},{"key":"ref67","first-page":"913","article-title":"p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1","volume":"22","author":"H Liu","year":"2013","journal-title":"Stem\u00a0Cells\u00a0Dev"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e59685","DOI":"10.1371\/journal.pone.0059685","article-title":"Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models","volume":"8","author":"L Zeng","year":"2013","journal-title":"PLOS ONE"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/dvdy.23779","article-title":"Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth","volume":"241","author":"R S\u00e1nchez-S\u00e1nchez","year":"2012","journal-title":"Dev Dyn"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cne.20825","article-title":"Neural activity- and development-dependent expression and distribution of CASK interacting nucleosome assembly protein in mouse brain","volume":"494","author":"CW Lin","year":"2006","journal-title":"J Comp Neurol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"14000","DOI":"10.1523\/JNEUROSCI.2274-12.2012","article-title":"TrkB down regulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis","volume":"32","author":"LC Schecterson","year":"2012","journal-title":"J Neurosci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e53594","DOI":"10.1371\/journal.pone.0053594","article-title":"A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation","volume":"8","author":"V Nieto-Est\u00e9vez","year":"2013","journal-title":"PLOS ONE"},{"key":"ref73","first-page":"2387","article-title":"Neurotrophic effects of leukemia inhibitory factor on neural cells derived from human embryonic stem cells","volume":"30","author":"A Majumder","year":"2012","journal-title":"Stem\u00a0Cells"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"16121","DOI":"10.1074\/jbc.M110.199166","article-title":"Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation","volume":"286","author":"H Kawahara","year":"2011","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1242\/jcs.076059","article-title":"EphA4 preserves postnatal and adult neural stem cells in an undifferentiated state in vivo","volume":"124","author":"K Khodosevich","year":"2011","journal-title":"J Cell Sci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1017\/S0317167100014372","article-title":"The Expression of FOXJ1 in Neurogenesis after Transient Focal Cerebral Ischemia","volume":"40","author":"Y Huang","year":"2013","journal-title":"Can J Neurol Sci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1471-4159.2009.06225.x","article-title":"A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus","volume":"110","author":"T Takarada","year":"2009","journal-title":"J Neurochem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"e59685","DOI":"10.1371\/journal.pone.0059685","article-title":"Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models","volume":"8","author":"L Zeng","year":"2013","journal-title":"PLOS ONE"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF02982106","article-title":"The notch pathway: modulation of cell fate decisions in hematopoiesis","volume":"75","author":"K Ohishi","year":"2002","journal-title":"Int J Hematol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1084-9521(02)00183-0","article-title":"Notch signalling in hematopoiesis","volume":"14","author":"K Ohishi","year":"2003","journal-title":"Semin Cell Dev Biol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0092-8674(02)00709-2","article-title":"WNT signaling and lymphocyte development","volume":"109","author":"M van de Wetering","year":"2002","journal-title":"Cell"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01611","article-title":"Wnt proteins are lipid-modified and can act as stem cell growth factors","volume":"423","author":"K Willert","year":"2003","journal-title":"Nature"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1101\/gad.14.14.1741","article-title":"Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein","volume":"14","author":"K Tago","year":"2000","journal-title":"Genes Dev"},{"key":"ref84","first-page":"3354","article-title":"Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta catenin","volume":"60","author":"T Kawasoe","year":"2000","journal-title":"Cancer Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/303390a0","article-title":"A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium","volume":"303","author":"MC Raff","year":"1983","journal-title":"Nature"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/(SICI)1098-1136(199903)26:1<84::AID-GLIA9>3.0.CO;2-L","article-title":"Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter","volume":"26","author":"AM Butt","year":"1999","journal-title":"Glia"},{"key":"ref87","first-page":"56(3):e27","article-title":"Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging","volume":"29","author":"S Lomoio","year":"2012","journal-title":"Eur J Histochem"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/303390a0","article-title":"A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium&quot;","volume":"303","author":"MC Raff","year":"1983","journal-title":"Nature"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrn2495","article-title":"Polydendrocytes (NG2 cells): Multifunctional cells with lineage plasticity","volume":"10","author":"A Nishiyama","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nn1854","article-title":"Vesicular release of glutamate from unmyelinated axons in white matter","volume":"10","author":"JL Ziskin","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref91","first-page":"710","article-title":"Neural stem cells modified to express BDNF antagonize trimethyltin-induced neurotoxicity through PI3K\/AKT and MAP kinase pathways","volume":"224","author":"P Casalbore","year":"2010","journal-title":"J Chem Phys"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at Serine 133","volume":"59","author":"GA Gonzalez","year":"1989","journal-title":"Cell"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0896-6273(90)90115-V","article-title":"Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB","volume":"4","author":"M Sheng","year":"1990","journal-title":"Neuron"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0092-8674(94)90055-8","article-title":"Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB","volume":"77","author":"DD Ginty","year":"1994","journal-title":"Cell"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0896-6273(00)80026-4","article-title":"Signaling from synapse to nucleus: post-synaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity","volume":"16","author":"K Deisseroth","year":"1996","journal-title":"Neuron"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature07061","article-title":"Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors","volume":"454","author":"JB Kim","year":"2008","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0896-6273(03)00497-5","article-title":"SOX2 functions to maintain neural progenitor identity","volume":"39","author":"V Graham","year":"2003","journal-title":"Neuron"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(03)01080-8","article-title":"Recycling the cell cycle: cyclins revisited","volume":"23","author":"AW Murray","year":"2004","journal-title":"Cell"},{"key":"ref99","first-page":"34cdc2","article-title":"A predictive scale for evaluating cyclin-dependent kinase substrates","author":"JK Holmes","year":"1996","journal-title":"A Comparison P"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1365-2443.2006.01002.x","article-title":"Sustained activation ofM-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells","volume":"11","author":"P Sun","year":"2006","journal-title":"Genes\u00a0Cells"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1097-4547(19960201)43:3<299::AID-JNR5>3.0.CO;2-E","article-title":"Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitorcells in the developing rat brain","volume":"43","author":"A Nishiyama","year":"1996","journal-title":"J Neurosci Res"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/(SICI)1097-4547(19960201)43:3<315::AID-JNR6>3.0.CO;2-M","article-title":"Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF","volume":"43","author":"A Nishiyama","year":"1996","journal-title":"J Neurosci Res"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1523\/JNEUROSCI.17-01-00125.1997","article-title":"Developmental expression of platelet-derived growth factor alpha-receptor in neurons and glial cells of the mouse CNS","volume":"17","author":"BN Oumesmar","year":"1997","journal-title":"J Neurosci"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1097\/00001756-199510010-00010","article-title":"PDGF-alpha receptor is expressed by mature neurones of the central nervous system","volume":"6","author":"L Vignais","year":"1995","journal-title":"Neuroreport"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0125885","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T09:32:03Z","timestamp":1647768723000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082206"}},"subtitle":[],"editor":[{"given":"Alice Y. W.","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":104,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082206","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}