{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T20:15:59Z","timestamp":1771964159087,"version":"3.50.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082287","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T21:35:08Z","timestamp":1386624908000},"page":"e82287","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Prevention of Diabetic Cardiomyopathy by Non-Mitogenic Acidic Fibroblast Growth Factor Is Probably Mediated by the Suppression of Oxidative Stress and Damage"],"prefix":"10.1371","volume":"8","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Skibba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Litai","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subrata","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"H567","DOI":"10.1152\/ajpheart.00650.2012","article-title":"Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-kappaB","volume":"304","author":"Y Wang","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.fct.2012.03.006","article-title":"Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats","volume":"50","author":"SJ Guan","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.jacc.2011.12.034","article-title":"Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C\/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner","volume":"59","author":"Y Tan","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/me.2010-0142","article-title":"Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse","volume":"24","author":"K Fon Tacer","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuron.2012.08.037","article-title":"The fibroblast growth factor family: neuromodulation of affective behavior","volume":"76","author":"CA Turner","year":"2012","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/humu.21067","article-title":"Molecular pathology of the fibroblast growth factor family","volume":"30","author":"P Krejci","year":"2009","journal-title":"Hum Mutat"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/jn\/137.11.2339","article-title":"Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone","volume":"137","author":"H Shen","year":"2007","journal-title":"J Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1248\/bpb.33.444","article-title":"Cardiac protection by basic fibroblast growth factor from ischemia\/reperfusion-induced injury in diabetic rats","volume":"33","author":"J Xiao","year":"2010","journal-title":"Biol Pharm Bull"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcb.240450208","article-title":"Extracellular matrix-resident basic fibroblast growth factor: implication for the control of angiogenesis","volume":"45","author":"I Vlodavsky","year":"1991","journal-title":"J Cell Biochem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0092-8674(89)90928-8","article-title":"How does extracellular matrix control capillary morphogenesis?","volume":"58","author":"DE Ingber","year":"1989","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.RES.72.1.7","article-title":"Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis","volume":"72","author":"GL Engelmann","year":"1993","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/01.RES.71.2.251","article-title":"Acidic and basic fibroblast growth factors in adult rat heart myocytes. Localization, regulation in culture, and effects on DNA synthesis","volume":"71","author":"E Speir","year":"1992","journal-title":"Circ Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0008-6363(02)00708-3","article-title":"Biological activities of fibroblast growth factor-2 in the adult myocardium","volume":"57","author":"KA Detillieux","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1161\/01.CIR.96.11.4083","article-title":"Modulation of growth factor action: implications for the treatment of cardiovascular diseases","volume":"96","author":"J Waltenberger","year":"1997","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/1061186X.2012.702771","article-title":"Improving the cardio protective effect of aFGF in ischemic myocardium with ultrasound-mediated cavitation of heparin modified microbubbles: preliminary experiment","volume":"20","author":"YZ Zhao","year":"2012","journal-title":"J Drug Target"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1155\/2007\/962892","article-title":"Low plasma levels of FGF-2 and PDGF-BB are associated with cardiovascular events in type II diabetes mellitus (diabetes heart study)","volume":"23","author":"J Yeboah","year":"2007","journal-title":"Dis Markers"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/1523-1747.ep12607026","article-title":"Acidic fibroblast growth factor accelerates dermal wound healing in diabetic mice","volume":"104","author":"TN Mellin","year":"1995","journal-title":"J Invest Dermatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1018993610801","article-title":"Acidic fibroblast growth factor: evaluation of topical formulations in a diabetic mouse wound healing model","volume":"11","author":"B Matuszewska","year":"1994","journal-title":"Pharm Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.diabres.2011.05.016","article-title":"Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats","volume":"93","author":"L Xie","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jcp.10036","article-title":"Basic fibroblast growth factor protects cardiac myocytes from iNOS-mediated apoptosis","volume":"190","author":"E Iwai-Kanai","year":"2002","journal-title":"J Cell Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/152308603770380043","article-title":"Growth factor signaling for cardioprotection against oxidative stress-induced apoptosis","volume":"5","author":"YJ Suzuki","year":"2003","journal-title":"Antioxid Redox Signal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1161\/01.CIR.0000105723.91637.1C","article-title":"Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia","volume":"108","author":"SL House","year":"2003","journal-title":"Circulation"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/jop.2009.0015","article-title":"Non-mitogenic human acidic fibroblast growth factor reduces retinal degeneration induced by sodium iodate","volume":"25","author":"W Chen","year":"2009","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pep.2004.07.021","article-title":"High-level expression and purification of a nonmitogenic form of human acidic fibroblast growth factor in Escherichia coli","volume":"42","author":"X Wu","year":"2005","journal-title":"Protein Expr Purif"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"C263","DOI":"10.1152\/ajpcell.00192.2002","article-title":"High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1","volume":"284","author":"S Chen","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1139\/y03-030","article-title":"Increased endothelin-1 and endothelin receptor expression in myocytes of ischemic and reperfused rat hearts and ventricular myocytes exposed to ischemic conditions and its inhibition by nitric oxide generation","volume":"81","author":"XT Gan","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.2337\/diabetes.54.6.1829","article-title":"Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy","volume":"54","author":"L Cai","year":"2005","journal-title":"Diabetes"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"H2096","DOI":"10.1152\/ajpheart.00452.2009","article-title":"Type 1 diabetic cardiomyopathy in the Akita (Ins2WT\/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function","volume":"297","author":"R Basu","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jacc.2008.05.019","article-title":"Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart","volume":"52","author":"G Zhou","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"E1149","DOI":"10.1152\/ajpendo.00410.2002","article-title":"A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum","volume":"284","author":"JW Chen","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1167\/iovs.03-0540","article-title":"Oncofetal fibronectin in diabetic retinopathy","volume":"45","author":"ZA Khan","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/15376516.2012.666650","article-title":"Oxidative stress and cardiac hypertrophy: a review","volume":"22","author":"SK Maulik","year":"2012","journal-title":"Toxicol Mech Methods"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1475-2840-11-45","article-title":"Mammalian target of rapamycin signaling in diabetic cardiovascular disease","volume":"11","author":"ZZ Chong","year":"2012","journal-title":"Cardiovasc Diabetol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/dmrr.1054","article-title":"miR133a regulates cardiomyocyte hypertrophy in diabetes","volume":"26","author":"B Feng","year":"2010","journal-title":"Diabetes Metab Res Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.RES.0000072977.86706.23","article-title":"Roles of cardiac transcription factors in cardiac hypertrophy","volume":"92","author":"H Akazawa","year":"2003","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1096\/fj.10-168625","article-title":"Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization","volume":"25","author":"CY Chung","year":"2011","journal-title":"FASEB J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.HYP.35.1.19","article-title":"Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured cardiac myocytes","volume":"35","author":"T Horio","year":"2000","journal-title":"Hypertension"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.CIR.91.1.161","article-title":"Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat","volume":"91","author":"CH Conrad","year":"1995","journal-title":"Circulation"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"CY Ho","year":"2010","journal-title":"N Engl J Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0008-6363(00)00118-8","article-title":"Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm","volume":"47","author":"A Mezzetti","year":"2000","journal-title":"Cardiovasc Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/157340310793566145","article-title":"Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy","volume":"6","author":"K Watanabe","year":"2010","journal-title":"Curr Cardiol Rev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2013.05.035","article-title":"Enhancement of FGF-1 release along with cytosolic proteins from rat astrocytes by hydrogen peroxide","volume":"1522","author":"JI Ito","year":"2013","journal-title":"Brain Res"},{"key":"ref43","first-page":"179","article-title":"Molecular mechanisms of angiogenesis: experimental models define cellular trafficking of FGF-1","volume":"15","author":"KK Hicks","year":"1996","journal-title":"P R Health Sci J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1471-4159.2004.02984.x","article-title":"Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis","volume":"93","author":"P Cassina","year":"2005","journal-title":"J Neurochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.3748\/wjg.v10.i24.3590","article-title":"Enhanced anti-apoptosis and gut epithelium protection function of acidic fibroblast growth factor after cancelling of its mitogenic activity","volume":"10","author":"XB Fu","year":"2004","journal-title":"World J Gastroenterol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1440-1746.2006.04457.x","article-title":"Non-mitogenic acidic fibroblast growth factor reduces intestinal dysfunction induced by ischemia and reperfusion injury in rats","volume":"22","author":"HH Li","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1464-410X.2005.05328.x","article-title":"Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach","volume":"95","author":"A Agarwal","year":"2005","journal-title":"BJU Int"},{"key":"ref48","first-page":"323","article-title":"Effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor","volume":"23","author":"JY Miao","year":"2002","journal-title":"Acta Pharmacol Sin"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"D Levy","year":"1990","journal-title":"N Engl J Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1098\/rstb.2005.1772","article-title":"NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology","volume":"360","author":"A Cave","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI21968","article-title":"Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load","volume":"115","author":"E Takimoto","year":"2005","journal-title":"J Clin Invest"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1161\/01.CIR.0000055318.09997.1F","article-title":"Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes","volume":"107","author":"N Suematsu","year":"2003","journal-title":"Circulation"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:51:44Z","timestamp":1588992704000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082287"}},"subtitle":[],"editor":[{"given":"Tianqing","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,9]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082287","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,9]]}}}