{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:55:39Z","timestamp":1768535739672,"version":"3.49.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082597","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T21:11:46Z","timestamp":1388178706000},"page":"e82597","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models"],"prefix":"10.1371","volume":"8","author":[{"given":"Paula S.","family":"Montenegro-Miranda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Pa\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysbeth","family":"ten Bloemendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Duijst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk R.","family":"de Waart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Gonzalez","family":"Aseguinolaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piter J.","family":"Bosma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1161\/ATVBAHA.108.175620","article-title":"Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients","volume":"28","author":"ES Stroes","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm1358","article-title":"Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response","volume":"12","author":"CS Manno","year":"2006","journal-title":"Nat Med"},{"key":"ref3","first-page":"2357","article-title":"Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med","volume":"365","author":"AC Nathwani","year":"2011"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/mt.2009.277","article-title":"Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration","volume":"18","author":"F Simonelli","year":"2010","journal-title":"Mol Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1182\/blood-2008-07-167510","article-title":"AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells","volume":"114","author":"F Mingozzi","year":"2009","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1086\/595830","article-title":"Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses","volume":"199","author":"R Calcedo","year":"2009","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1089\/hum.2009.182","article-title":"Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors","volume":"21","author":"S Boutin","year":"2010","journal-title":"Hum Gene Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/1566523054065057","article-title":"New recombinant serotypes of AAV vectors","volume":"5","author":"G Gao","year":"2005","journal-title":"Curr Gene Ther"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/1801426a0","article-title":"A biochemical lesion in congenital, nonobstructive, non-haemolytic jaundice","volume":"180","author":"J Axelrod","year":"1957","journal-title":"Nature"},{"key":"ref10","first-page":"941","article-title":"Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I. Hepatology","volume":"15","author":"PJ Bosma","year":"1992"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.ymthe.2006.01.014","article-title":"Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats","volume":"13","author":"J Seppen","year":"2006","journal-title":"Mol Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1182\/blood-2006-03-010181","article-title":"Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates","volume":"109","author":"AC Nathwani","year":"2007","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/sj.gt.3302766","article-title":"Long-term expression and repeated administration of AAV type 1, 2 and 5 vectors in skeletal muscle of immunocompetent adult mice","volume":"13","author":"C Riviere","year":"2006","journal-title":"Gene Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/mt.2008.284","article-title":"Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented","volume":"17","author":"CS Peden","year":"2009","journal-title":"Mol Ther"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1182\/blood-2005-10-4035","article-title":"Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver","volume":"107","author":"AC Nathwani","year":"2006","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mt.2010.210","article-title":"Sustained enzymatic correction by rAAV-mediated liver gene therapy protects against induced motor neuropathy in acute porphyria mice","volume":"19","author":"C Unzu","year":"2011","journal-title":"Mol Ther"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1089\/10430349950017563","article-title":"Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system","volume":"10","author":"WT Hermens","year":"1999","journal-title":"Hum Gene Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/mt.2011.37","article-title":"Development of a liver-specific Tet-on inducible system for AAV vectors and its application in the treatment of liver cancer","volume":"19","author":"L Vanrell","year":"2011","journal-title":"Mol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/JCM.29.9.1804-1811.1991","article-title":"Rapid purification of hepatitis B virus DNA from serum","volume":"29","author":"R Boom","year":"1991","journal-title":"J Clin Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/gkp045","article-title":"Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data","volume":"37","author":"JM Ruijter","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/bj3140477","article-title":"Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase","volume":"2)","author":"J Seppen","year":"1996","journal-title":"Biochem J 314 (Pt"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm929","article-title":"Identification of PDGFR as a receptor for AAV-5 transduction","volume":"9","author":"PG Di","year":"2003","journal-title":"Nat Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1128\/JVI.75.15.6884-6893.2001","article-title":"Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity","volume":"75","author":"N Kaludov","year":"2001","journal-title":"J Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1099\/vir.0.005595-0","article-title":"Adeno-associated virus type 5 exploits two different entry pathways in human embryo fibroblasts","volume":"90","author":"U Bantel-Schaal","year":"2009","journal-title":"J Gen Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1128\/jvi.76.5.2340-2349.2002","article-title":"Endocytosis of adeno-associated virus type 5 leads to accumulation of virus particles in the Golgi compartment","volume":"76","author":"U Bantel-Schaal","year":"2002","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.virol.2006.05.023","article-title":"Adeno-associated virus (AAV) capsid genes isolated from rat and mouse liver genomic DNA define two new AAV species distantly related to AAV-5","volume":"353","author":"MA Lochrie","year":"2006","journal-title":"Virology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1089\/hum.2010.155","article-title":"Safety of liver gene transfer following peripheral intravascular delivery of adeno-associated virus (AAV)-5 and AAV-6 in a large animal model","volume":"22","author":"P Favaro","year":"2011","journal-title":"Hum Gene Ther"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0101857","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000}},{"DOI":"10.1371\/journal.pone.0119777","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T23:28:40Z","timestamp":1597274920000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082597"}},"subtitle":[],"editor":[{"given":"R. Jude","family":"Samulski","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,27]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082597","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0101857","asserted-by":"object"},{"id-type":"doi","id":"10.1371\/journal.pone.0119777","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,27]]}}}