{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:49:16Z","timestamp":1694324956163},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082698","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T21:39:59Z","timestamp":1387229999000},"page":"e82698","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unique T Cells with Unconventional Cytokine Profiles Induced in the Livers of Mice during Schistosoma mansoni Infection"],"prefix":"10.1371","volume":"8","author":[{"given":"Keishi","family":"Adachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinjiro","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1034\/j.1600-0528.2002.017418.x","article-title":"Pathophysiological roles of interleukin-18 in inflammatory liver diseases","volume":"174","author":"H Tsutsui","year":"2000","journal-title":"Immunol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"IN Crispe","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nri2858","article-title":"Antigen-presenting cell function in the tolerogenic liver environment","volume":"10","author":"AW Thomson","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1034\/j.1600-0528.2002.017415.x","article-title":"Physiological responses of extrathymic T cells in the liver","volume":"174","author":"T Abo","year":"2000","journal-title":"Immunol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"IN Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nri1573","article-title":"Immunology of hepatitis B virus and hepatitis C virus infection","volume":"5","author":"B Rehermann","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.iy.13.040195.000333","article-title":"Hepatitis B virus immunopathogenesis","volume":"13","author":"FV Chisari","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0035-9203(02)90316-0","article-title":"Schistosomiasis and soil-transmitted helminth infections: forging control efforts","volume":"96","author":"L Savioli","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1084\/jem.20091903","article-title":"Regulation of pathogenesis and immunity in helminth infections","volume":"206","author":"RM Maizels","year":"2009","journal-title":"J Exp Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijpara.2008.06.015","article-title":"<italic>Schistosoma mansoni<\/italic> arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity","volume":"39","author":"JM Fitzpatrick","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1321","DOI":"10.1371\/journal.pntd.0001321","article-title":"Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review","volume":"5","author":"CH King","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"EJ Pearce","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.0105-2896.2004.00176.x","article-title":"Immunopathogenesis of schistosomiasis","volume":"201","author":"TA Wynn","year":"2004","journal-title":"Immunol Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","article-title":"Schistosomiasis and liver fibrosis","volume":"31","author":"ZA Andrade","year":"2009","journal-title":"Parasite Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-5699(99)01551-0","article-title":"Immunopathology of schistosomiasis: a cautionary tale of mice and men","volume":"21","author":"PG Fallon","year":"2000","journal-title":"Immunol Today"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0167-5699(00)01626-1","article-title":"Immunopathology of schistosomiasis mansoni in mice and men","volume":"21","author":"AW Cheever","year":"2000","journal-title":"Immunol Today"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0105-2896.2004.00187.x","article-title":"Th2 response polarization during infection with the helminth parasite <italic>Schistosoma mansoni<\/italic>","volume":"201","author":"EJ Pearce","year":"2004","journal-title":"Immunol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/eji.1830250436","article-title":"Reciprocal regulation of the nitric oxide synthase\/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines","volume":"25","author":"M Modolell","year":"1995","journal-title":"Eur J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0002-9440(10)64607-X","article-title":"NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease","volume":"157","author":"M Hesse","year":"2000","journal-title":"Am J Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.4049\/jimmunol.167.11.6533","article-title":"Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1\/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism","volume":"167","author":"M Hesse","year":"2001","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.15.1.297","article-title":"Induction of Th1 and Th2 CD4<sup>+<\/sup> T cell responses: the alternative approaches","volume":"15","author":"SL Constant","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"TR Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijpara.2008.08.007","article-title":"<italic>Schistosoma mansoni<\/italic> infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators","volume":"39","author":"Y Osada","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.parint.2004.08.004","article-title":"Mutagenicity evaluation of <italic>Schistosoma<\/italic> spp. extracts by the umu-test and V79\/HGPRT gene mutation assay","volume":"54","author":"Y Osada","year":"2005","journal-title":"Parasitol Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.4049\/jimmunol.163.12.6702","article-title":"Kupffer cells from <italic>Schistosoma mansoni<\/italic>-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens","volume":"163","author":"N Hayashi","year":"1999","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1073\/pnas.1017340108","article-title":"T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells","volume":"108","author":"K Adachi","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/intimm\/dxh080","article-title":"Contribution of CD1d-unrestricted hepatic DX5<sup>+<\/sup> NKT cells to liver injury in <italic>Plasmodium berghei<\/italic>-parasitized erythrocyte-injected mice","volume":"16","author":"K Adachi","year":"2004","journal-title":"Int Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.4049\/jimmunol.167.10.5928","article-title":"<italic>Plasmodium berghei<\/italic> infection in mice induces liver injury by an IL-12- and toll-like receptor\/myeloid differentiation factor 88-dependent mechanism","volume":"167","author":"K Adachi","year":"2001","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1074-7613(01)00132-7","article-title":"SOCS-1\/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo","volume":"14","author":"T Naka","year":"2001","journal-title":"Immunity"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"MS Wilson","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4049\/jimmunol.163.1.337","article-title":"Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile","volume":"163","author":"D Jankovic","year":"1999","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response","volume":"104","author":"MG Chiaramonte","year":"1999","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.164.5.2585","article-title":"Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent","volume":"164","author":"PG Fallon","year":"2000","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.smim.2010.03.006","article-title":"gammadelta T cell subsets: a link between TCR and function?","volume":"22","author":"RL O'Brien","year":"2010","journal-title":"Semin Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/eji.1830270228","article-title":"A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire","volume":"27","author":"V Azuara","year":"1997","journal-title":"Eur J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.4049\/jimmunol.163.6.3076","article-title":"IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen","volume":"163","author":"DJ Gerber","year":"1999","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/373255a0","article-title":"Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo","volume":"373","author":"DA Ferrick","year":"1995","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.it.2004.09.006","article-title":"The composition of intrahepatic lymphocytes: shaped by selective recruitment?","volume":"25","author":"K Klugewitz","year":"2004","journal-title":"Trends Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.15.1.535","article-title":"Mouse CD1-specific NK1 T cells: development, specificity, and function","volume":"15","author":"A Bendelac","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.4049\/jimmunol.161.7.3271","article-title":"Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14<sup>+<\/sup> NK T lymphocytes","volume":"161","author":"N Burdin","year":"1998","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"T Kawano","year":"1997","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1128\/IAI.01818-06","article-title":"Primary infection of C57BL\/6 mice with <italic>Plasmodium yoelii<\/italic> induces a heterogeneous response of NKT cells","volume":"75","author":"V Soulard","year":"2007","journal-title":"Infect Immun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.coi.2009.03.010","article-title":"How are T(H)1 and T(H)2 effector cells made?","volume":"21","author":"D Amsen","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0952-7915(02)00340-0","article-title":"T helper cell differentiation: on again, off again","volume":"14","author":"JL Grogan","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/intimm\/dxr087","article-title":"Requirement of GATA-binding protein 3 for <italic>Il13<\/italic> gene expression in IL-18-stimulated Th1 cells","volume":"23","author":"M Nakahira","year":"2011","journal-title":"Int Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20031368","article-title":"Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse","volume":"199","author":"T Sugimoto","year":"2004","journal-title":"J Exp Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.0105-2896.2004.00205.x","article-title":"Induction of allergic inflammation by interleukin-18 in experimental animal models","volume":"202","author":"H Tsutsui","year":"2004","journal-title":"Immunol Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"12453","DOI":"10.1073\/pnas.0903895106","article-title":"TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity","volume":"106","author":"T Kreslavsky","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.immuni.2008.07.011","article-title":"The transcription factor PLZF directs the effector program of the NKT cell lineage","volume":"29","author":"AK Savage","year":"2008","journal-title":"Immunity"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.1641","article-title":"The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions","volume":"9","author":"D Kovalovsky","year":"2008","journal-title":"Nat Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/1521-4141(200105)31:5<1523::AID-IMMU1523>3.0.CO;2-S","article-title":"Expression of the DX5 antigen on CD8<sup>+<\/sup> T cells is associated with activation and subsequent cell death or memory during influenza virus infection","volume":"31","author":"T Kambayashi","year":"2001","journal-title":"Eur J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.4049\/jimmunol.177.6.3806","article-title":"Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b<sup>+<\/sup> regulatory T cells","volume":"177","author":"LM Charbonnier","year":"2006","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.4049\/jimmunol.1000776","article-title":"PLZF induces the spontaneous acquisition of memory\/effector functions in T cells independently of NKT cell-related signals","volume":"184","author":"D Kovalovsky","year":"2010","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.coi.2010.12.016","article-title":"Development of PLZF-expressing innate T cells","volume":"23","author":"ES Alonzo","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","article-title":"Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages","volume":"29","author":"RI Nurieva","year":"2008","journal-title":"Immunity"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/imr.12031","article-title":"T-cell subsets in the germinal center","volume":"252","author":"RR Ramiscal","year":"2013","journal-title":"Immunol Rev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.0903505","article-title":"Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)","volume":"185","author":"I Yusuf","year":"2010","journal-title":"J Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrrheum.2012.58","article-title":"Follicular helper T cells in immunity and systemic autoimmunity","volume":"8","author":"JE Craft","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1073\/pnas.0602900103","article-title":"Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by <italic>Staphylococcus aureus<\/italic> product in mice","volume":"103","author":"M Terada","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.20082462","article-title":"The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)","volume":"206","author":"S Steinfelder","year":"2009","journal-title":"J Exp Med"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1084\/jem.20111381","article-title":"Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor","volume":"209","author":"B Everts","year":"2012","journal-title":"J Exp Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by <italic>Schistosoma mansoni<\/italic> eggs, drives Th2 responses","volume":"206","author":"B Everts","year":"2009","journal-title":"J Exp Med"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jhep.2010.10.005","article-title":"Liver antigen-presenting cells","volume":"54","author":"IN Crispe","year":"2011","journal-title":"J Hepatol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T02:08:02Z","timestamp":1688868482000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082698"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":63,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082698","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}