{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:18:18Z","timestamp":1790759898740,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T00:00:00Z","timestamp":1386288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082713","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T21:33:38Z","timestamp":1386365618000},"page":"e82713","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":79,"title":["Folic Acid Protects against Lipopolysaccharide-Induced Preterm Delivery and Intrauterine Growth Restriction through Its Anti-Inflammatory Effect in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Mei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Ting","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Xian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Zhen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bbalip.2009.01.011","article-title":"The lipopolysaccharide transport system of Gram-negative bacteria","volume":"1791","author":"P Sperandeo","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0016-5085(77)80025-5","article-title":"Endotoxin and bacteria in portal blood","volume":"72","author":"AI Jacob","year":"1977","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/0016-5085(95)90708-4","article-title":"Intestinal permeability: an overview","volume":"108","author":"I Bjarnason","year":"1995","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0002-9378(93)90274-M","article-title":"Endotoxin and interleukin-1 alpha in the cervical mucus and vaginal fluid of pregnant women with bacterial vaginosis","volume":"169","author":"JJ Platz-Christensen","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bpobgyn.2006.12.005","article-title":"Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome","volume":"21","author":"H Leitich","year":"2007","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"RL Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1067\/mob.2003.112","article-title":"Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation","volume":"188","author":"IA Buhimschi","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2005.09.009","article-title":"Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice","volume":"163","author":"DX Xu","year":"2006","journal-title":"Toxicol Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tox.2007.02.010","article-title":"Effects of low-dose lipopolysaccharide (LPS) pretreatment on LPS-induced intra-uterine fetal death and preterm labor","volume":"234","author":"DX Xu","year":"2007","journal-title":"Toxicology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.ajog.2006.03.047","article-title":"Reactive oxygen species are involved in lipopolysaccharide-induced intrauterine growth restriction and skeletal development retardation in mice","volume":"195","author":"DX Xu","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref11","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"KA Workowski","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000262.pub4","article-title":"Antibiotics for treating bacterial vaginosis in pregnancy","volume":"1","author":"P Brocklehurst","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref13","first-page":"157159","article-title":"Antimicrobials for preterm birth prevention: an overview","author":"A Subramaniam","year":"2012","journal-title":"Infect Dis Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1097\/01.AOG.0000216197.26783.b5","article-title":"Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks","volume":"107","author":"GG Nahum","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2012.09.049","article-title":"Use of antibiotics during pregnancy increases the risk of asthma in early childhood","volume":"162","author":"LG Stensballe","year":"2013","journal-title":"J Pediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1073\/pnas.0702279104","article-title":"Nitric oxide mediates prostaglandins&apos; deleterious effect on lipopolysaccharide-triggered murine fetal resorption","volume":"104","author":"J Aisemberg","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1172\/JCI117719","article-title":"Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide","volume":"95","author":"RM Silver","year":"1995","journal-title":"J Clin Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"R1415","DOI":"10.1152\/ajpregu.2000.278.6.R1415","article-title":"Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse","volume":"278","author":"G Gross","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/molehr\/7.6.595","article-title":"Evaluation of the tocolytic effect of a selective cyclooxygenase-2 inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery","volume":"7","author":"M Sakai","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1600-079X.2007.00445.x","article-title":"Maternally administered melatonin differentially regulates lipopolysaccharide-induced proinflammatory and anti-inflammatory cytokines in maternal serum, amniotic fluid, fetal liver, and fetal brain","volume":"43","author":"DX Xu","year":"2007","journal-title":"J Pineal Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.ajpath.2011.02.042","article-title":"Placental TNF-alpha signaling in illness-induced complications of pregnancy","volume":"178","author":"PA Carpentier","year":"2011","journal-title":"Am J Pathol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)00401-9","article-title":"Folate-mediated one-carbon metabolism","volume":"79","author":"JT Fox","year":"2008","journal-title":"Vitam Horm"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group","volume":"338","year":"1991","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"AE Czeizel","year":"1992","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/adc.51.12.944","article-title":"Vitamin dificiencies and neural tube defects","volume":"51","author":"RW Smithells","year":"1976","journal-title":"Arch Dis Child"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.7326\/0003-4819-150-9-200905050-00009","article-title":"Folic acid for the prevention of neural tube defects: U.S. Preventive Services Task Force recommendation statement","volume":"150","year":"2009","journal-title":"Ann Intern Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejogrb.2009.10.016","article-title":"Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study","volume":"148","author":"AE Czeizel","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00394-012-0339-z","article-title":"The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study)","volume":"52","author":"E Papadopoulou","year":"2013","journal-title":"Eur J Nutr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2011.03.039","article-title":"Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu","volume":"205","author":"HN Simhan","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-011-0337-2","article-title":"Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-kappaB activation","volume":"60","author":"D Feng","year":"2011","journal-title":"Inflamm Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2337\/diabetes.54.2.546","article-title":"Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro","volume":"54","author":"P Wentzel","year":"2005","journal-title":"Diabetes"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/jn\/129.11.2070","article-title":"Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring","volume":"129","author":"JH Shin","year":"1999","journal-title":"J Nutr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1600-079X.2012.01002.x","article-title":"Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells","volume":"53","author":"MZ Xia","year":"2012","journal-title":"J Pineal Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2005.05.010","article-title":"Determinants of trophoblast lineage and cell subtype specification in the mouse placenta","volume":"284","author":"DG Simmons","year":"2005","journal-title":"Dev Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0076-6879(96)68026-4","article-title":"Quantitation of nitrate and nitrite in extracellular fluids","volume":"268","author":"MB Grisham","year":"1996","journal-title":"Methods Enzymol"},{"key":"ref36","article-title":"U.S","year":"2009"},{"key":"ref37","first-page":"52","article-title":"Folic Acid supplementation and pregnancy: more than just neural tube defect prevention","volume":"4","author":"JA Greenberg","year":"2011","journal-title":"Rev Obstet Gynecol"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006896.pub2","article-title":"Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes","volume":"3","author":"ZS Lassi","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.0001-6349.2005.00708.x","article-title":"Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery","volume":"84","author":"RM Holst","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1530\/eje.1.02251","article-title":"Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls","volume":"155","author":"ME Street","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1515\/JPM.2009.115","article-title":"Serum proinflammatory cytokine - interleukin-8 as possible infection site marker in preterm deliveries","volume":"37","author":"MA Bogavac","year":"2009","journal-title":"J Perinat Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/sj.ijo.0803265","article-title":"Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects","volume":"30","author":"A Solini","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10620-008-0398-4","article-title":"Increased folate intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases","volume":"54","author":"PG Chiarello","year":"2009","journal-title":"Dig Dis Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappa B in the immune system","volume":"12","author":"PA Baeuerle","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights","volume":"14","author":"AS Jr Baldwin","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.placenta.2005.06.003","article-title":"Lipopolysaccharide and TNF-alpha activate the nuclear factor kappa B pathway in the human placental JEG-3 cells","volume":"27","author":"M Lappas","year":"2006","journal-title":"Placenta"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/rep.0.1250095","article-title":"The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice","volume":"125","author":"DG Ogando","year":"2003","journal-title":"Reproduction"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2010.00911.x","article-title":"Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour","volume":"161","author":"M Cella","year":"2010","journal-title":"Br J Pharmacol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T17:40:42Z","timestamp":1597167642000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082713"}},"subtitle":[],"editor":[{"given":"Ana\u00a0Claudia","family":"Zenclussen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,6]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082713","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,6]]}}}