{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:52:08Z","timestamp":1792029128911,"version":"4.4.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082728","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T16:40:09Z","timestamp":1387212009000},"page":"e82728","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Upregulation of Cleavage and Polyadenylation Specific Factor 4 in Lung Adenocarcinoma and Its Critical Role for Cancer Cell Survival and Proliferation"],"prefix":"10.1371","volume":"8","author":[{"given":"Wangbing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingbo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuguo","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"R Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1056\/NEJMoa0909530","article-title":"Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR","volume":"362","author":"M Maemondo","year":"2010","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1200\/JCO.2009.22.6993","article-title":"Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK","volume":"27","author":"AT Shaw","year":"2009","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/jnci\/djn389","article-title":"Annual report to the nation on the status of cancer, 1975\u20132005, featuring trends in lung cancer, tobacco use, and tobacco control","volume":"100","author":"A Jemal","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1101\/gad.1093603","article-title":"Strange bedfellows: polyadenylation factors at the promoter","volume":"17","author":"O Calvo","year":"2003","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/sj.emboj.7600070","article-title":"Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase","volume":"23","author":"I Kaufmann","year":"2004","journal-title":"EMBO J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.1093\/emboj\/19.21.5895","article-title":"Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors","volume":"19","author":"H de Vries","year":"2000","journal-title":"EMBO J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1101\/gad.11.13.1703","article-title":"The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins","volume":"11","author":"SM Barabino","year":"1997","journal-title":"Genes Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/385357a0","article-title":"The C-terminal domain of RNA polymerase II couples mRNA processing to transcription","volume":"385","author":"S McCracken","year":"1997","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1073\/pnas.0812023106","article-title":"The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3&apos; mRNA processing factors","volume":"106","author":"O Rozenblatt-Rosen","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0092-8674(01)00270-7","article-title":"The BARD1-CstF-50 interaction links mRNA 3&apos; end formation to DNA damage and tumor suppression","volume":"104","author":"FE Kleiman","year":"2001","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00062752-200401000-00008","article-title":"The FIP1L1-PDGFRalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia","volume":"11","author":"J Cools","year":"2004","journal-title":"Curr Opin Hematol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/blood-2003-06-1824","article-title":"The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management","volume":"103","author":"J Gotlib","year":"2004","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1128\/MCB.21.16.5614-5623.2001","article-title":"Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors","volume":"21","author":"SL Topalian","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1158\/1078-0432.CCR-11-0240","article-title":"Characterization of a cleavage stimulation factor, 3&apos; pre-RNA, subunit 2, 64 kDa (CSTF2) as a therapeutic target for lung cancer","volume":"17","author":"M Aragaki","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S1097-2765(00)80099-4","article-title":"Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3&apos;end formation of cellular pre-mRNAs","volume":"1","author":"ME Nemeroff","year":"1998","journal-title":"Mol Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10694","DOI":"10.1074\/jbc.M807136200","article-title":"Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3&apos; processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation","volume":"284","author":"H Kiefer","year":"2009","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.2174\/138161212800672723","article-title":"Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors in cancer therapy: advances and perspectives","volume":"18","author":"M Xue","year":"2012","journal-title":"Curr Pharm Des"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1517\/14728222.2011.639361","article-title":"The RAS\/RAF\/MEK\/ERK and the PI3K\/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches","volume":"16","author":"A De Luca","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e31825493eb","article-title":"Development of PI3K\/AKT\/mTOR pathway inhibitors and their application in personalized therapy for non-small-cell lung cancer","volume":"7","author":"V Papadimitrakopoulou","year":"2012","journal-title":"J Thorac Oncol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.cllc.2011.09.004","article-title":"Oncogenic pathways, molecularly targeted therapies, and highlighted clinical trials in non-small-cell lung cancer (NSCLC)","volume":"13","author":"T Reungwetwattana","year":"2012","journal-title":"Clin Lung Cancer"},{"key":"ref22","first-page":"955","article-title":"Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review)","volume":"12","author":"G Wang","year":"2004","journal-title":"Oncol Rep"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-2004-836141","article-title":"Pathology of pulmonary vasculitis","volume":"25","author":"WD Travis","year":"2004","journal-title":"Semin Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0378-5173(01)00721-9","article-title":"Filter extrusion of liposomes using different devices: comparison of liposome size, encapsulation efficiency, and process characteristics","volume":"223","author":"N Berger","year":"2001","journal-title":"Int J Pharm"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jconrel.2005.02.001","article-title":"Preparation of plasmid DNA-containing liposomes using a high-pressure homogenization\u2014extrusion technique","volume":"104","author":"E Pupo","year":"2005","journal-title":"J Control Release"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"26460","DOI":"10.1074\/jbc.M610579200","article-title":"Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells","volume":"282","author":"WG Deng","year":"2007","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1158\/0008-5472.CAN-06-1483","article-title":"The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells","volume":"66","author":"K Ueda","year":"2006","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1158\/0008-5472.CAN-06-3463","article-title":"Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells","volume":"67","author":"WG Deng","year":"2007","journal-title":"Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-4598-10-60","article-title":"Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells","volume":"10","author":"M Tabuse","year":"2011","journal-title":"Mol Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:19:51Z","timestamp":1540217991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082728"}},"subtitle":[],"editor":[{"given":"Chunhong","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":29,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082728","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}