{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:08:19Z","timestamp":1777622899197,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0083112","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T21:39:51Z","timestamp":1387575591000},"page":"e83112","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Suppressive Effect of CORM-2 on LPS-Induced Platelet Activation by Glycoprotein Mediated HS1 Phosphorylation Interference"],"prefix":"10.1371","volume":"8","author":[{"given":"Dadong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiting","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"GS Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00134-009-1738-3","article-title":"The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis","volume":"36","author":"MM Levy","year":"2010","journal-title":"Intensive Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1549-8719.2010.00080.x","article-title":"Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis","volume":"18","author":"K Tyml","year":"2011","journal-title":"Microcirculation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2353\/ajpath.2007.060872","article-title":"Pathophysiology of sepsis","volume":"170","author":"DG Remick","year":"2007","journal-title":"Am J Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1056\/NEJMp020096","article-title":"Treating sepsis","volume":"347","author":"RP Wenzel","year":"2002","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0765.2010.01307.x","article-title":"Carbon monoxide releasing molecule-3 inhibits concurrent tumor necrosis factor-alpha- and interleukin-1beta-induced expression of adhesion molecules on human gingival fibroblasts","volume":"46","author":"H Song","year":"2011","journal-title":"J Periodontal Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"341","author":"M Levi","year":"1999","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00018-008-8487-2","article-title":"Carbon monoxide releasing molecules: new insights for anticoagulation strategy in sepsis","volume":"66","author":"BW Sun","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.thromres.2010.10.010","article-title":"Platelets as immune mediators: their role in host defense responses and sepsis","volume":"127","author":"Z Li","year":"2011","journal-title":"Thromb Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1113\/jphysiol.2011.225417","article-title":"Platelets: a critical link between inflammation and microvascular dysfunction","volume":"590","author":"KY Stokes","year":"2012","journal-title":"J Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2010.04131.x","article-title":"The platelet contribution to cancer progression","volume":"9","author":"NM Bambace","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/0250-474X.107047","article-title":"Mechanism(s) Involved in Carbon Monoxide-releasing Molecule-2-mediated Cardioprotection During Ischaemia-reperfusion Injury in Isolated Rat Heart","volume":"74","author":"HM Soni","year":"2012","journal-title":"Indian J Pharm Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/MOH.0b013e32832e9dc6","article-title":"The platelet proteome","volume":"16","author":"L Senzel","year":"2009","journal-title":"Curr Opin Hematol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1160\/TH11-10-0745","article-title":"Focusing on plasma glycoprotein VI","volume":"107","author":"M Al-Tamimi","year":"2012","journal-title":"Thromb Haemost"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1538-7836.2011.04274.x","article-title":"Advances in our understanding of the molecular basis of disorders of platelet function","volume":"9","author":"A Nurden","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1182\/blood-2006-11-056069","article-title":"Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation","volume":"110","author":"BN Kahner","year":"2007","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2011.03.013","article-title":"Beneficial effects of carbon monoxide-releasing molecule-2 (CORM-2) on acute doxorubicin cardiotoxicity in mice: role of oxidative stress and apoptosis","volume":"253","author":"H Soni","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"E780","DOI":"10.1152\/ajpendo.00466.2012","article-title":"Carbon monoxide-releasing molecules reverse leptin resistance induced by endoplasmic reticulum stress","volume":"304","author":"M Zheng","year":"2013","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1471-4906(03)00181-9","article-title":"Heme oxygenase-1: unleashing the protective properties of heme","volume":"24","author":"LE Otterbein","year":"2003","journal-title":"Trends Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice","volume":"8","author":"TS Lee","year":"2002","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2174\/1381612033453785","article-title":"Bioactivity and pharmacological actions of carbon monoxide-releasing molecules","volume":"9","author":"R Motterlini","year":"2003","journal-title":"Curr Pharm Des"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"E188","DOI":"10.1016\/j.thromres.2012.07.002","article-title":"Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells","volume":"130","author":"K Maruyama","year":"2012","journal-title":"Thrombosis Research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s10753-009-9144-0","article-title":"Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages","volume":"32","author":"K Tsoyi","year":"2009","journal-title":"Inflammation"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.trsl.2011.10.009","article-title":"Enhanced induction of heme oxygenase-1 suppresses thrombus formation and affects the protein C system in sepsis","volume":"159","author":"D Fei","year":"2012","journal-title":"Transl Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/SHK.0b013e3181e46f15","article-title":"Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-beta\/JAK2\/STAT-1\/INOS\/NO signaling but not COX-2 in TLR-activated macrophages","volume":"34","author":"K Tsoyi","year":"2010","journal-title":"Shock"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/mol.109.055137","article-title":"Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo","volume":"76","author":"K Tsoyi","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"H920","DOI":"10.1152\/ajpheart.00305.2009","article-title":"CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase","volume":"297","author":"S Mizuguchi","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"G184","DOI":"10.1152\/ajpgi.00348.2007","article-title":"Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice","volume":"294","author":"G Cepinskas","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.3748\/wjg.v18.i40.5719","article-title":"Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice","volume":"18","author":"X Wang","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7150\/ijbs.4.270","article-title":"Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC","volume":"4","author":"B Sun","year":"2008","journal-title":"Int J Biol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/BCR.0b013E31802CA491","article-title":"Attenuation of leukocytes sequestration by carbon monoxide-releasing molecules: liberated carbon monoxide in the liver of thermally injured mice","volume":"28","author":"BW Sun","year":"2007","journal-title":"J Burn Care Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jss.2006.08.032","article-title":"Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice","volume":"139","author":"B Sun","year":"2007","journal-title":"J Surg Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.7150\/ijbs.4.176","article-title":"CO-releasing molecules (CORM-2)-liberated CO attenuates leukocytes infiltration in the renal tissue of thermally injured mice","volume":"4","author":"B Sun","year":"2008","journal-title":"Int J Biol Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0092-8674(91)90458-B","article-title":"Ligands \u201cactivate\u201d integrin alpha IIb beta 3 (platelet GPIIb-IIIa)","volume":"65","author":"XP Du","year":"1991","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7997","DOI":"10.4049\/jimmunol.0802884","article-title":"Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4\/MyD88 and the cGMP-dependent protein kinase pathway","volume":"182","author":"G Zhang","year":"2009","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1083\/jcb.147.5.1085","article-title":"Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression model","volume":"147","author":"M Gu","year":"1999","journal-title":"J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/BJ20100538","article-title":"Human platelets express and are activated by galectin-8","volume":"432","author":"MA Romaniuk","year":"2010","journal-title":"Biochem J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1182\/blood-2007-04-085514","article-title":"The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation","volume":"111","author":"H Yin","year":"2008","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0092-8674(02)01254-0","article-title":"A stimulatory role for cGMP-dependent protein kinase in platelet activation","volume":"112","author":"Z Li","year":"2003","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/aja.2009.78","article-title":"The protective effects of alpha-ketoacids against oxidative stress on rat spermatozoa in vitro","volume":"12","author":"SF Li","year":"2010","journal-title":"Asian J Androl"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.thromres.2012.02.041","article-title":"Multicolor flow cytometry for evaluation of platelet surface antigens and activation markers","volume":"130","author":"JF van Velzen","year":"2012","journal-title":"Thromb Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1007\/s00018-011-0678-6","article-title":"Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2","volume":"68","author":"Y Zhang","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1182\/blood-2010-07-296194","article-title":"High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbalpha-filamin interaction","volume":"117","author":"SL Cranmer","year":"2011","journal-title":"Blood"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/09537100802351057","article-title":"Hematopoietic lineage cell-specific protein-1 (HS1) regulates PAR-mediated ERK activation and thromboxane generation in platelets","volume":"19","author":"BN Kahner","year":"2008","journal-title":"Platelets"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1182\/blood-2003-08-2804","article-title":"Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions","volume":"103","author":"JA Coppinger","year":"2004","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1182\/blood-2006-10-053462","article-title":"How complex is the platelet GP Ib complex?","volume":"109","author":"KJ Clemetson","year":"2007","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/ATVBAHA.107.150474","article-title":"Cell adhesion mechanisms in platelets","volume":"28","author":"D Varga-Szabo","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1160\/TH04-09-0584","article-title":"Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets","volume":"93","author":"JF Arthur","year":"2005","journal-title":"Thrombosis and Haemostasis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2174\/138945011797635867","article-title":"Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy","volume":"12","author":"B Bigalke","year":"2011","journal-title":"Current Drug Targets"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrd3615","article-title":"Targeting proteinase-activated receptors: therapeutic potential and challenges","volume":"11","author":"R Ramachandran","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref51","first-page":"9367","article-title":"Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage","volume":"17","author":"D Kitamura","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e39902","DOI":"10.1371\/journal.pone.0039902","article-title":"HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen","volume":"7","author":"F Frezzato","year":"2012","journal-title":"PLoS One"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/ard.2010.147025","article-title":"Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus","volume":"71","author":"D Frezza","year":"2012","journal-title":"Ann Rheum Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0083112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T06:24:21Z","timestamp":1564986261000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0083112"}},"subtitle":[],"editor":[{"given":"Tianqing","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,20]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0083112","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,20]]}}}