{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:17:35Z","timestamp":1770722255168,"version":"3.49.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0083271","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T22:30:17Z","timestamp":1387405817000},"page":"e83271","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antidepressant-Like Activity of YL-0919: A Novel Combined Selective Serotonin Reuptake Inhibitor and 5-HT1A Receptor Agonist"],"prefix":"10.1371","volume":"8","author":[{"given":"Hong-xia","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng-liang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-kun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-wang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-zhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ri-fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,18]]},"reference":[{"key":"ref1","first-page":"386","article-title":"Global burden of depressive disorders in the year 2000","volume":"Psychiatry184","author":"TB Ustun","year":"2004","journal-title":"Br J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projection of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"CD Mathers","year":"2006","journal-title":"Plos Med"},{"key":"ref3","first-page":"517","article-title":"Psychopharmacology of affective disorders in the 21st century","volume":"44","author":"CB Nemeroff","year":"1998","journal-title":"Biol Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/026988119801200201","article-title":"The serotonin transporter: a primary target for antidepressant drugs","volume":"12","author":"P Schloss","year":"1998","journal-title":"J Psychopharmacol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/sj.mp.4000728","article-title":"Neurotransmitter transporters: fruitful targets for CNS drug discovery","volume":"5","author":"L Iversen","year":"2000","journal-title":"Mol Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/10401239309148983","article-title":"Fluoxetine comparedwith imipramine in the treatment of inpatient depression. A multicenter trial","volume":"5","author":"CM Beasley Jr","year":"1993","journal-title":"Ann Clin Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Cookson J (1993) Side-effects of antidepressants. Br J Psychiatry Supp: 20\u201324.","DOI":"10.1192\/S0007125000292325"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.2610130304","article-title":"Third-generation antidepressants","volume":"13","author":"RM Pinder","year":"1993","journal-title":"Med Res Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1177\/0269881198012003041","article-title":"Selective serotonin reuptake inhibitors in the treatment of affective disorders\u2014III. Tolerability, safety and pharmacoeconomics","volume":"12","author":"BJ Goldstein","year":"1998","journal-title":"J Psychopharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0893-133X(97)00169-3","article-title":"Agonist and antagonist actions of (-)pindolol at recombinant, human serotonin1A (5-HT1A) receptors","volume":"18","author":"A Newman-Tancredi","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/sj.npp.1300472","article-title":"Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression","volume":"29","author":"EA Rabiner","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S1461145703003924","article-title":"An autoradiographic study of the influence of pindolol upon [35S] GTPgammasS binding in rat, guinea pig and human brain","volume":"7","author":"J Serrats","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00004714-199506000-00011","article-title":"Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression","volume":"15","author":"P Blier","year":"1995","journal-title":"J Clin Psychopharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.euroneuro.2009.04.004","article-title":"Pindolol augmentation enhances response outcomes in first depressive episodes","volume":"19","author":"MJ Portella","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-2999(99)00875-4","article-title":"Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone","volume":"389","author":"LJ Sim-Selley","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10401239509149042","article-title":"Augmentation with buspirone: a review","volume":"7","author":"KV Harvey","year":"1995","journal-title":"Ann Clin Psychiatry"},{"key":"ref17","first-page":"26","article-title":"New approaches to the treatment of refractory depression","volume":"61","author":"M Fava","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1056\/NEJMoa052964","article-title":"Medication augmentation after the failure of SSRIs for depression","volume":"354","author":"MH Trivedi","year":"2006","journal-title":"N Eng J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1517\/13543780903286396","article-title":"Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression","volume":"18","author":"A Khan","year":"2009","journal-title":"Expert Opin Invertig Drug"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1742-1241.2011.02885.x","article-title":"Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant \u2013what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?","volume":"66","author":"L Citrome","year":"2012","journal-title":"Int J Clin Pract"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1185\/03007995.2011.628303","article-title":"The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder","volume":"28","author":"CR Reed","year":"2012","journal-title":"Curr Med Res Opin"},{"key":"ref22","first-page":"676","article-title":"Antidepressant-like effects of YL-0919, a novel dual-acting antidepressant with 5-HT<sub>1A<\/sub> receptor agonist and serotonin transporter inhibitor","volume":"35","author":"HX Chen","year":"2011","journal-title":"Mil Med Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2008.02.031","article-title":"Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: Does hemisphere location matter?","volume":"190","author":"B Czeh","year":"2008","journal-title":"Behav Brain Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1046\/j.1471-4159.1996.66020599.x","article-title":"Antagonism of serotonin 5-HT1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus","volume":"66","author":"EA Englemen","year":"1996","journal-title":"J Neurochem"},{"key":"ref25","first-page":"487","article-title":"Visualization of serotonin 1A receptor trafficking in neuron-like PC12 cells","volume":"30","author":"YY Jin","year":"2010","journal-title":"Basic & ClinicalMedicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00395-009-0048-9","article-title":"Effects of muscarinic receptor simulation on Ca<sup>2+<\/sup> transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells","volume":"105","author":"MM van Borren","year":"2010","journal-title":"Basic Res Cardilo"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1124\/jpet.111.187468","article-title":"S32212, a novel serotonin type 2C receptor inverse agonist\/\u03b12-adrenoceptor antagonist and potential antidepressant: I. a mechanistic characterization","volume":"340","author":"MJ Millan","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-2999(93)90996-U","article-title":"The effect of 5-HT receptor ligands on the uptake of [3H]-5-HT into rat cortical synaptosomes","volume":"239","author":"B Cheng CHK Costall","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1471-4159.1986.tb00649.x","article-title":"Characterization of sodium-dependent [<sup>3<\/sup>H]GBR<sup>-1<\/sup>2935 bindingin brain: a radioligand for selective labellingof the dopamine transport complex","volume":"46","author":"A Janowsky","year":"1986","journal-title":"J.Neurochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"L Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"ref31","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"RD Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.brainres.2004.07.041","article-title":"Evidence for serotonin receptor subtypes involvement in agmatine antidepreddant-like effect in the mouse forced swimming test","volume":"1023","author":"A Dias Elpo Zomkowski","year":"2004","journal-title":"Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressive treat- ments","volume":"47","author":"RD Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"P Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.pbb.2008.02.014","article-title":"Role for serotonin in the antidepressant-like effects of a flavonoid extract of Xiaobuxin-Tang","volume":"89","author":"L An","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbr.2005.01.005","article-title":"Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains","volume":"161","author":"S Bekris","year":"2005","journal-title":"Behav Brain Res"},{"key":"ref37","first-page":"298","article-title":"The effects of chronic antidepressant treatment in an animal model of anxiety","volume":"95","author":"SR Bodnoff","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1039\/b903035m","article-title":"Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters","volume":"7","author":"J Andersen","year":"2009","journal-title":"Chem Commun(Camb)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2008.05.008","article-title":"D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action","volume":"89","author":"AK Dutta","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.euroneuro.2012.06.001","article-title":"Antidepressant-like effects of 071031B, a novel serotonin and norepinephrine reuptake inhibitor","volume":"23","author":"R Xue","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"L Santarelli","year":"2003","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0028-3908(97)00043-9","article-title":"Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors:Considerations on receptor effector coupling across systems","volume":"36","author":"P Schoeffier","year":"1997","journal-title":"Neuropharmacology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"JF Cryan","year":"2002","journal-title":"Trends Pharmacol Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0149-7634(94)00050-B","article-title":"Role of the serotonergic system in the forced swimming test. Neurosci","volume":"19","author":"F Borsini","year":"1995","journal-title":"Biobehav Rev"},{"key":"ref45","first-page":"265","article-title":"Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test. Prog. Neuropsychopharmacol","volume":"34","author":"S Kwon","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0149-7634(94)90039-6","article-title":"Antidepressant-like behavioral effects of serotonin receptor agonists","volume":"18","author":"I Lucki","year":"1994","journal-title":"Neurosci Biobehav Rev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0022-3565(24)29479-9","article-title":"Antidepressant-like behavioral effects in 5-HT1A and 5-HT1B receptor mutant mice","volume":"298","author":"AJ Mayorga","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1097\/00004714-199006001-00004","article-title":"Differential effects of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies","volume":"10","author":"P Blier","year":"1990","journal-title":"J Clin Psychopharmacol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1476-5381.1995.tb13321.x","article-title":"Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors","volume":"114","author":"C Davidson","year":"1995","journal-title":"Br J Pharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-2999(95)00697-4","article-title":"Pharmacological validation of the chronic mild stress model of depression","volume":"296","author":"M Papp","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.npp.1301410","article-title":"Chronic unpredictable stress induces a cognitive deficit and anxiety- like behavior in rats that is prevented by chronic antidepressant drug treatment","volume":"33","author":"CO Bondi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s11064-010-0245-9","article-title":"Na<sup>+<\/sup>, K<sup>+<\/sup> ATPase activity is reduced in amygdale of rats with chronic stress-induced anxiety-like behavior","volume":"35","author":"L Crema","year":"2010","journal-title":"Neurochem Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1124\/jpet.102.034280","article-title":"Behavioral and Neurochemical Effects of 5-{4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843): A Combined Selective Inhibitor of Serotonin Reuptake and 5-Hydroxytryptamine1A Receptor Partial Agonist","volume":"302","author":"ME Page","year":"2002","journal-title":"J Pharmacol Exp"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"857","DOI":"10.4140\/TCP.n.2012.857","article-title":"Vilazodone hydrochloride, a combined SSRI and 5-HT1A receptor agonist for major depressive disorder","volume":"27","author":"DR Guay","year":"2012","journal-title":"Consult Pharm"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(02)01504-2","article-title":"Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors","volume":"44","author":"RM Tordera","year":"2002","journal-title":"European J Pharmacology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/sj.npp.1300062","article-title":"Modulation of Serotonergic Function in Rat Brain by VN2222, a Serotonin Reuptake Inhibitor and 5-HT1A Receptor Agonist","volume":"28","author":"L Romero","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref57","first-page":"28","article-title":"Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake inhibitor For the Treatment of Major Depressive Disorder","volume":"37","author":"MP Cruz","year":"2012","journal-title":"PT"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0304643","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"record-id":"53722"},{"DOI":"10.1371\/journal.pone.0304643","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0083271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T07:32:10Z","timestamp":1746084730000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0083271"}},"subtitle":[],"editor":[{"given":"Lin","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,18]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0083271","relation":{"retraction":[{"id-type":"doi","id":"10.1371\/journal.pone.0304643","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,18]]}}}