{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:58Z","timestamp":1791296698743,"version":"4.1.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0083446","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T22:13:07Z","timestamp":1387491187000},"page":"e83446","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Polymorphism in the Alpha Cardiac Muscle Actin 1 Gene Is Associated to Susceptibility to Chronic Inflammatory Cardiomyopathy"],"prefix":"10.1371","volume":"8","author":[{"given":"Amanda Farage","family":"Frade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Camilo","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Maria","family":"Ianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Wide","family":"Pissetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Saba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Hui Tzu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia","family":"Kuramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Gabriel","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Giniaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Llored","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sthefanny","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Donadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Marin-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ab\u00edlio","family":"Fragata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edimar Alcides","family":"Bocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Noedir","family":"Stolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Inacio","family":"Fiorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Honorato Barros","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virmondes","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Costa","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edecio","family":"Cunha-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chevillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/S0074-02762007005000105","article-title":"Andean subregional Chagas disease area and the Andean initiative of Chagas disease","volume":"102","author":"R Salvatella","year":"2007","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2741\/1255","article-title":"Parasitic diseases of the heart","volume":"9","author":"LV Kirchhoff","year":"2004","journal-title":"Front Biosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pt.2006.09.011","article-title":"The future of Chagas disease control","volume":"22","author":"CJ Schofield","year":"2006","journal-title":"Trends Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.CIR.14.6.1035","article-title":"Chagas&apos; disease; a clinical, epidemiologic, and pathologic study","volume":"14","author":"E Dias","year":"1956","journal-title":"Circulation"},{"key":"ref5","first-page":"159","article-title":"Circulating immune complexes in different developmental stages of Chagas&apos; disease","volume":"47","author":"UO Martin","year":"1987","journal-title":"Medicina (B Aires)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S0074-02762007000900018","article-title":"Chagas disease: what is known and what is needed--a background article","volume":"102","author":"JR Coura","year":"2007","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1161\/01.CIR.90.6.3098","article-title":"Survival and predictors of survival in patients with congestive heart failure due to Chagas&apos; cardiomyopathy","volume":"90","author":"C Mady","year":"1994","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-5273(97)00083-1","article-title":"Clinical course of Chagas&apos; heart disease: a comparison with dilated cardiomyopathy","volume":"60","author":"RB Bestetti","year":"1997","journal-title":"Int J Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0002-8703(86)90144-4","article-title":"Right ventricular endomyocardial biopsy in chronic Chagas&apos; disease","volume":"111","author":"AC Pereira Barretto","year":"1986","journal-title":"Am Heart J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/clc.4960101113","article-title":"The role of active myocarditis in the development of heart failure in chronic Chagas&apos; disease: a study based on endomyocardial biopsies","volume":"10","author":"ML Higuchi","year":"1987","journal-title":"Clin Cardiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1365-3024.2000.00260.x","article-title":"Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase","volume":"22","author":"M Ribeirao","year":"2000","journal-title":"Parasite Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/jaut.2001.0523","article-title":"Chronic Chagas&apos; disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection","volume":"17","author":"LC Abel","year":"2001","journal-title":"J Autoimmun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1471-4922(02)02283-3","article-title":"Chemokines, inflammation and Trypanosoma cruzi infection","volume":"18","author":"MM Teixeira","year":"2002","journal-title":"Trends Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S0074-02762003000300021","article-title":"Increased plasma levels of tumor necrosis factor-alpha in asymptomatic\/&quot;indeterminate&quot; and Chagas disease cardiomyopathy patients","volume":"98","author":"RC Ferreira","year":"2003","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1086\/381892","article-title":"Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy","volume":"38","author":"A Talvani","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref16","first-page":"e1867","article-title":"Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10. PLoS Negl Trop","volume":"6","author":"LG Nogueira","year":"2012","journal-title":"Drosophila Inf Service"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0002-9440(10)62976-8","article-title":"Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas&apos; disease cardiomyopathy","volume":"167","author":"E Cunha-Neto","year":"2005","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.4049\/jimmunol.174.7.4070","article-title":"The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed","volume":"174","author":"L Riol-Blanco","year":"2005","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1073\/pnas.0511200103","article-title":"Secondary lymphoid tissue chemokine (SLC\/CCL21)\/CCR7 signaling regulates fibrocytes in renal fibrosis","volume":"103","author":"N Sakai","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/jcp.21348","article-title":"Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation","volume":"215","author":"VS Reddy","year":"2008","journal-title":"J Cell Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/01.CIR.101.21.2518","article-title":"Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy","volume":"101","author":"T Kubota","year":"2000","journal-title":"Circulation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2353\/ajpath.2007.060906","article-title":"Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice","volume":"171","author":"K Reifenberg","year":"2007","journal-title":"Am J Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.micinf.2003.07.001","article-title":"The Syrian hamster as a model for the dilated cardiomyopathy of Chagas&apos; disease: a quantitative echocardiographical and histopathological analysis","volume":"5","author":"AM Bilate","year":"2003","journal-title":"Microbes Infect"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.4269\/ajtmh.1990.43.498","article-title":"Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas&apos; cardiopathy","volume":"43","author":"F Zicker","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1086\/505395","article-title":"The monocyte chemoattractant protein-1 gene polymorphism is associated with cardiomyopathy in human chagas disease","volume":"43","author":"R Ramasawmy","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1590\/S0074-02762009000900032","article-title":"Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy","volume":"104","author":"E Cunha-Neto","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5495\/wjcid.v2.i3.39","article-title":"Pathogenesis of Chagas disease cardiomyopathy","volume":"2","author":"PC Teixeira","year":"2012","journal-title":"World Journal-- Clinical Infectious Diseases"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.genom.6.080604.162132","article-title":"The genetic basis for cardiac remodeling","volume":"6","author":"F Ahmad","year":"2005","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/HCO.0b013e328337ba52","article-title":"The genetics of dilated cardiomyopathy","volume":"25","author":"L Dellefave","year":"2010","journal-title":"Curr Opin Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1083\/jcb.117.5.1007","article-title":"The vinculin\/sarcomeric-alpha-actinin\/alpha-actin nexus in cultured cardiac myocytes","volume":"117","author":"MH Lu","year":"1992","journal-title":"J Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1247\/csf.22.191","article-title":"Models of thin filament assembly in cardiac and skeletal muscle","volume":"22","author":"CC Gregorio","year":"1997","journal-title":"Cell Struct Funct"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.280.5364.750","article-title":"Actin mutations in dilated cardiomyopathy, a heritable form of heart failure","volume":"280","author":"TM Olson","year":"1998","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1253\/circj.CJ-10-0234","article-title":"Reduced ACTC1 expression might play a role in the onset of congenital heart disease by inducing cardiomyocyte apoptosis","volume":"74","author":"HK Jiang","year":"2010","journal-title":"Circ J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijcard.2004.01.026","article-title":"Myocardiocyte apoptosis in heart failure in chronic Chagas&apos; disease","volume":"99","author":"S Jr Tostes","year":"2005","journal-title":"Int J Cardiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI24569","article-title":"Death begets failure in the heart","volume":"115","author":"RS Foo","year":"2005","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1086\/590347","article-title":"Distinct outcomes of Trypanosoma cruzi infection in hamsters are related to myocardial parasitism, cytokine\/chemokine gene expression, and protein expression profile","volume":"198","author":"AM Bilate","year":"2008","journal-title":"J Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1179\/000349803235001561","article-title":"Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients","volume":"97","author":"MT Jorge","year":"2003","journal-title":"Ann Trop Med Parasitol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.jacc.2012.12.044","article-title":"B-type natriuretic peptide and prognosis in heart failure patients with preserved and reduced ejection fraction","volume":"61","author":"DJ van Veldhuisen","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jacc.2013.01.039","article-title":"Natriuretic peptides, ejection fraction, and prognosis: parsing the phenotypes of heart failure","volume":"61","author":"JL Jr Januzzi","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref40","first-page":"e1205","article-title":"Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy. PLoS Negl Trop","volume":"5","author":"PC Teixeira","year":"2011","journal-title":"Drosophila Inf Service"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T)","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Methods - Nat Protoc"},{"key":"ref42","first-page":"225","article-title":"Male sex. Prognostic factor in Chagas&apos; disease","volume":"60","author":"AC Barretto","year":"1993","journal-title":"Arq Bras Cardiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1286-4579(00)00501-3","article-title":"HLA and beta-myosin heavy chain do not influence susceptibility to Chagas disease cardiomyopathy","volume":"2","author":"KC Fa\u00e9","year":"2000","journal-title":"Microbes Infect"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1136\/heart.89.10.1186","article-title":"Risk progression to chronic Chagas cardiomyopathy: influence of male sex and of parasitaemia detected by polymerase chain reaction","volume":"89","author":"AL Basquiera","year":"2003","journal-title":"Heart"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/383251","article-title":"A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other","volume":"74","author":"DR Nyholt","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000087919","article-title":"Evaluation of Nyholt&apos;s procedure for multiple testing correction - author&apos;s reply","volume":"60","author":"DR Nyholt","year":"2005","journal-title":"Hum Hered"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/gene.2010.43","article-title":"Association of rs7719175, located in the IL13 gene promoter, with Schistosoma haematobium infection levels and identification of a susceptibility haplotype","volume":"12","author":"A Isnard","year":"2011","journal-title":"Genes Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1101\/gad.3.2.131","article-title":"Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles","volume":"3","author":"CJ Beall","year":"1989","journal-title":"Genes Dev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.yjmcc.2009.01.004","article-title":"Titin-based mechanical signalling in normal and failing myocardium","volume":"46","author":"M Kr\u00fcger","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"ref50","first-page":"569628","article-title":"The sarcomeric Z-disc and Z-discopathies","author":"R Knoll","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/07853899708999358","article-title":"Cytokines and cardiomyocyte death","volume":"29","author":"KJ Pulkki","year":"1997","journal-title":"Ann Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ejheart.2004.10.014","article-title":"The influence of aetiology on inflammatory and neurohumoral activation in patients with severe heart failure: a prospective study comparing Chagas&apos; heart disease and idiopathic dilated cardiomyopathy","volume":"7","author":"AO Mocelin","year":"2005","journal-title":"Eur J Heart Fail"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0083446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:55:27Z","timestamp":1540270527000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0083446"}},"subtitle":[],"editor":[{"given":"Marie-Pierre","family":"Dub\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0083446","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}