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WHO\/HTM\/TB\/2011.16. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/tb\/publications\/global_report\/en\/index.html\" xlink:type=\"simple\">http:\/\/www.who.int\/tb\/publications\/global_report\/en\/index.html<\/ext-link>. Accessed: 30 Nov 2012."},{"key":"ref2","unstructured":"World Health Organization (2011) Top 10 causes of death: fact sheet no. 310: WHO 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/index.html\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/index.html<\/ext-link>. Accessed: 20 Jun 2011."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0140-6736(95)92348-9","article-title":"Variation in protection by BCG: implications of and for heterologous immunity","volume":"346","author":"PEM Fine","year":"1995","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","article-title":"The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analysis of the published literature","volume":"96","author":"GA Colditz","year":"1995","journal-title":"Pediatrics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/ije\/22.6.1154","article-title":"Protective effect of BCG against tuberculosis meningitis and military tuberculosis: a meta-analysis","volume":"22","author":"LC Rodrigues","year":"1993","journal-title":"Int J Epidemiol"},{"key":"ref6","unstructured":"Aeras (2012) Vaccine Development Process. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.aeras.org\/portfolio\" xlink:type=\"simple\">http:\/\/www.aeras.org\/portfolio<\/ext-link>. Accessed: 26 Oct 2012."},{"key":"ref7","unstructured":"Foundation AGTV (2011) Protective efficacy against tuberculosis (TB) disease, safety, and immunogenicity of MVA85A\/AERAS-485 in HIV-infected adults. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/nct01151189?intr=\" xlink:type=\"simple\">http:\/\/clinicaltrials.gov\/ct2\/show\/nct01151189?intr=<\/ext-link>\u201cmva85a%2faeras-485\u201d&amp;rank = 1. Accessed: 5 Jun 2011."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1164\/rccm.201108-1548OC","article-title":"A Phase IIA Trial of the new tuberculosis vaccine, MVA85A, in HIV- and\/or <italic>Mycobacterium tuberculosis<\/italic>- infected adults","volume":"185","author":"TJ Scriba","year":"2012","journal-title":"Am J Respir Crit Care"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/nm1128","article-title":"Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans","volume":"10","author":"H McShane","year":"2004","journal-title":"Nat Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1002\/eji.200737504","article-title":"Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional <italic>Mycobacterium tuberculosis<\/italic>-specific CD4+ memory T lymphocyte populations","volume":"37","author":"NER Beveridge","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(13)60177-4","article-title":"Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial","volume":"381","author":"MD Tameris","year":"2013","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1001\/jama.1996.03540150055031","article-title":"Recommendations of the Panel of cost -effectiveness in health and medicine","volume":"276","author":"MC Weinstein","year":"1996","journal-title":"JAMA"},{"key":"ref13","unstructured":"United Nations International Children&apos;s Emergency Fund (2010) UNICEF South Africa Statistics 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unicef.org\/infobycountry\/southafrica_statistics.html\" xlink:type=\"simple\">http:\/\/www.unicef.org\/infobycountry\/southafrica_statistics.html<\/ext-link>. Accessed: 7 Jun 2011."},{"key":"ref14","unstructured":"McShane H (2013) Global progress in TB vaccine development. In Gillespie, S. editor. Respiratory Infection. The Biomedical &amp; Life Sciences Collection, Henry Stewart Talks Ltd, London."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMoa0800971","article-title":"Early antiretroviral therapy and mortality among HIV Infected infants","volume":"359","author":"A Violari","year":"2008","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/INF.0b013e3182456ba2","article-title":"The effect of early initiation of antiretroviral treatment in infants on pediatric AIDS mortality in South Africa: a model-based analysis","volume":"5","author":"LF Johnson","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/INF.0b013e31817acf7b","article-title":"Two-year outcomes of children on a non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program","volume":"27","author":"HB Jaspan","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"ref18","unstructured":"Health Department: Republic of South Africa (2009) The National Tuberculosis Management Guidlelines 2009. Available: [<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/familymedicine.ukzn.ac.za\/Libraries\/Guidelines_Protocols\/TB_Guidelines_2009.sflb.ashx\" xlink:type=\"simple\">http:\/\/familymedicine.ukzn.ac.za\/Libraries\/Guidelines_Protocols\/TB_Guidelines_2009.sflb.ashx<\/ext-link>]. Accessed: 12 Jun 2011."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.5588\/ijtld.11.0722","article-title":"Survey of isoniazid preventive therapy in South Africa, 2011","volume":"16","author":"JC Chehab","year":"2012","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/adc.2006.097220","article-title":"Adherence to isoniazid preventive chemotherapy: a prospective community based study","volume":"91","author":"BJ Marais","year":"2006","journal-title":"Arch Dis Child"},{"key":"ref21","first-page":"556","article-title":"Cost and cost-effectiveness of community-based care for tuberculosis in Cape Town, South Africa","volume":"7","author":"E Sinanovic","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref22","first-page":"451","article-title":"Cost and cost-effectiveness of alternative tuberculosis management strategies in South Africa- implications for policy","volume":"87","author":"D Wilkinson","year":"1997","journal-title":"S Afr Med J"},{"key":"ref23","unstructured":"The South African National Tuberculosis Control Programme Practical Guidelines 2004. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.kznhealth.gov.za\/chrp\/documents\/Guidelines\/Guidelines%20National\/Tuberculosis\/SA%20TB%20Guidelines%202004.pdf\" xlink:type=\"simple\">http:\/\/www.kznhealth.gov.za\/chrp\/documents\/Guidelines\/Guidelines%20National\/Tuberculosis\/SA%20TB%20Guidelines%202004.pdf<\/ext-link>. Accessed: 2 Jul 2011."},{"key":"ref24","unstructured":"International Drug Price Indicator Guide 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/erc.msh.org\/dmpguide\" xlink:type=\"simple\">http:\/\/erc.msh.org\/dmpguide<\/ext-link>. Accessed: 7 Jun 2010."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1136\/bmj.315.7120.1407","article-title":"Comparison of cost effectiveness of directly observed treatment (DOT) and conventionally delivered treatment for tuberculosis: experience from rural South Africa","volume":"315","author":"K Floyd","year":"1997","journal-title":"BMJ"},{"key":"ref26","unstructured":"UN Department of Economic and Social Affairs, Population Division (2010) World Population Prospects: the 2010 Revision Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/esa.un.org\/wpp\/Documentation\/pdf\/WPP2010_Volume-I_Comprehensive-Tables.pdf\" xlink:type=\"simple\">http:\/\/esa.un.org\/wpp\/Documentation\/pdf\/WPP2010_Volume-I_Comprehensive-Tables.pdf<\/ext-link>. Accessed: 18 Oct 2011."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2458-11-55","article-title":"Cost-effectiveness of novel vaccines for tuberculosis control: a decision analysis study","volume":"11","author":"C-L Tseng","year":"2011","journal-title":"BMC Public Health"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"13980","DOI":"10.1073\/pnas.0901720106","article-title":"Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics","volume":"106","author":"LJ Abu-Raddad","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3201\/eid1009.030921","article-title":"Potential public health impact of new tuberculosis vaccines","volume":"10","author":"E Ziv","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"ref30","unstructured":"Stop TB Partnership and World Health Organization (2006) Global Plan to Stop TB 2006\u20132015 (WHO\/HTM\/STB\/2006.35). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.stoptb.org\/resources\/publications\/plans_strategies.asp\" xlink:type=\"simple\">http:\/\/www.stoptb.org\/resources\/publications\/plans_strategies.asp<\/ext-link>. Accessed: 12 Jul 2011."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa0907847","article-title":"Rapid molecular detection of tuberculosis and rifampin resistance","volume":"363","author":"CCMD Boehme","year":"2010","journal-title":"N Engl J Med"},{"key":"ref32","unstructured":"World Health Organization (2011) South Africa: Health Profile 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/gho\/countries\/zaf.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/gho\/countries\/zaf.pdf<\/ext-link>. Accessed: 10 Jun 2011."},{"key":"ref33","unstructured":"Central Intelligence Agency (2011) The World Factbook: South Africa. 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cia.gov\/library\/publications\/the-world-factbook\/geos\/sf.html\" xlink:type=\"simple\">https:\/\/www.cia.gov\/library\/publications\/the-world-factbook\/geos\/sf.html<\/ext-link>. Accessed: 10 Jun 2011."},{"key":"ref34","unstructured":"World Health Organization (2011) Immunization Profile-South Africa. 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/immunization_monitoring\/en\/globalsummary\/countryprofileresult.cfm?C=zaf\" xlink:type=\"simple\">http:\/\/apps.who.int\/immunization_monitoring\/en\/globalsummary\/countryprofileresult.cfm?C=zaf<\/ext-link>. Accessed: 20 Jun 2011."},{"key":"ref35","unstructured":"World Bank (2012) Gross national income per capita 2011, Atlas method and PPP. World Development Indicators database 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/databank.worldbank.org\/databank\/download\/GNIPC.pdf\" xlink:type=\"simple\">http:\/\/databank.worldbank.org\/databank\/download\/GNIPC.pdf<\/ext-link>. Accessed: 28 Nov 2012."},{"key":"ref36","unstructured":"CIA (2011) Life Expectancy at Birth, CIA World Factbook 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cia.gov\/library\/publications\/the-world-factbook\/rankorder\/2102rank.html\" xlink:type=\"simple\">https:\/\/www.cia.gov\/library\/publications\/the-world-factbook\/rankorder\/2102rank.html<\/ext-link>. Accessed: 7 Jul 2011."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e7749","DOI":"10.1371\/journal.pone.0007749","article-title":"Annual risk of tuberculosis infection using different methods in communities with a high prevalence of TB and HIV in Zambia and South Africa","volume":"4","author":"K Shanaube","year":"2009","journal-title":"PloS ONE"},{"key":"ref38","unstructured":"Johnson L (2010) A model of paediatric HIV in South Africa. Cape Town, South Africa: University of Cape Town."},{"key":"ref39","unstructured":"USAID (2008) South Africa Tuberculosis Profile 2008. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/transition.usaid.gov\/our_work\/global_health\/id\/tuberculosis\/countries\/africa\/southafrica.pdf\" xlink:type=\"simple\">http:\/\/transition.usaid.gov\/our_work\/global_health\/id\/tuberculosis\/countries\/africa\/southafrica.pdf<\/ext-link>. Accessed: 13 Jul 2011."},{"key":"ref40","unstructured":"World Health Organization (2010) South Africa Tuberculosis Profile 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.doh.gov.za\/docs\/stats\/2011\/SouthAfricanTuberculosisProfile2011WHO.pdf\" xlink:type=\"simple\">http:\/\/www.doh.gov.za\/docs\/stats\/2011\/SouthAfricanTuberculosisProfile2011WHO.pdf<\/ext-link>. Accessed: 6 Jun 2011."},{"key":"ref41","unstructured":"Surveillance TWIGPoA-TDR (2008) Anti-Tuberculosis Drug Resistance In The World: Report No. 4, 2008. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/tb\/publications\/2008\/drs_report4_26feb08.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/tb\/publications\/2008\/drs_report4_26feb08.pdf<\/ext-link>. Accessed: 18 Jun 2011."},{"key":"ref42","first-page":"186","article-title":"Reported childhood tuberculosis treatment outcomes, Gaborone and Francistown, Botswana, 1998\u20132002","volume":"12","author":"JE Oeltmann","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref43","unstructured":"World Vision (2009) Overview of child health in South Africa 2009. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.worldvision.co.za\/child-health-now\/overview-of-child-health-in-south-africa\" xlink:type=\"simple\">http:\/\/www.worldvision.co.za\/child-health-now\/overview-of-child-health-in-south-africa<\/ext-link>. Accessed: 2 Jul 2011."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/157016207780077002","article-title":"Disease progression in children with vertically-acquired HIV infection in sub-Saharan Africa: reviewing the need for HIV treatment","volume":"5","author":"K Little","year":"2007","journal-title":"Cur HIV Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0140-6736(04)17140-7","article-title":"Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis","volume":"364","author":"M-L Newell","year":"2004","journal-title":"Lancet"},{"key":"ref46","unstructured":"Department of Health, Republic of South Africa (2013) The South African antiretroviral treatment guidelines 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sahivsoc.org\/upload\/documents\/2013%20ART%20Guidelines-Short%20Combined%20FINAL%20draft%20guidelines%2014%20March%202013.pdf\" xlink:type=\"simple\">http:\/\/www.sahivsoc.org\/upload\/documents\/2013%20ART%20Guidelines-Short%20Combined%20FINAL%20draft%20guidelines%2014%20March%202013.pdf<\/ext-link>. Accessed: 26 Jul 2013."},{"key":"ref47","first-page":"308","article-title":"The evolution of clinical tuberculosis in adolescents","volume":"47","author":"I Sutherland","year":"1966","journal-title":"Tuberculosis"},{"key":"ref48","first-page":"90","article-title":"Contacts of cases of active pulmonary tuberculosis","volume":"50","author":"S Grzybowski","year":"1974","journal-title":"Bull Int Union Tuberc"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF03403887","article-title":"Issues in the management of contacts of patients with active pulmonary tuberculosis","volume":"88","author":"D Menzies","year":"1997","journal-title":"Can J Public Health"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"906","DOI":"10.7326\/0003-4819-122-12-199506150-00003","article-title":"Management of health care workers after inadvertent exposure to tuberculosis: a guide for the use of preventive therapy","volume":"122","author":"W Stead","year":"1995","journal-title":"Ann Intern Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1164\/ajrccm\/137.4.805","article-title":"Tuberculosis in a cohort of Southeast Asian refugees. A five-year surveillance study","volume":"137","author":"CM Nolan","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"ref52","first-page":"572","article-title":"Tuberculosis morbidity in the US Navy: its distribution and decline","volume":"110","author":"GW Comstock","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM199709183371201","article-title":"A trial of three regimens to prevent tuberculosis in Ugandan adults infected with the human immunodeficiency virus. Uganda-Case Western Reserve University Research Collaboration","volume":"337","author":"C Whalen","year":"1997","journal-title":"N Engl J Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/00002030-199310000-00007","article-title":"A prospective study of the risk of tuberculosis among HIV-infected patients","volume":"7","author":"A Guelar","year":"1993","journal-title":"AIDS"},{"key":"ref55","first-page":"75","article-title":"Risk factors for developing tuberculosis in HIV-1-infected adults from communities with low or very high incidence of tuberculosis","volume":"23","author":"R Wood","year":"2000","journal-title":"JAMA"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1056\/NEJM199206043262302","article-title":"An outbreak of multi-drug resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome","volume":"326","author":"BR Edlin","year":"1992","journal-title":"N Engl J Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1056\/NEJM199304223281601","article-title":"Hospital outbreak of multidrug-resistant <italic>Mycobaterium tuberculosis<\/italic> in patients with advanced HIV infection","volume":"328","author":"C Beck-Sague","year":"1993","journal-title":"N Engl J Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-117-3-177","article-title":"An outbreak of tuberculosis caused by multiple-drug-resistant tubercle bacilli among patients with HIV infection","volume":"117","author":"MA Fischl","year":"1992","journal-title":"Ann Intern Med"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1056\/NEJM199304223281601","article-title":"Exogenous reinfection with multidrug-resistant <italic>Mycobacterium tuberculosis<\/italic> in patients with advanced HIV infection","volume":"328","author":"PM Small","year":"1993","journal-title":"N Engl J Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1056\/NEJM199201233260404","article-title":"An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus: An analysis using restriction-fragment-length polymorphisms","volume":"326","author":"C Daley","year":"1992","journal-title":"N Engl J Med"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0002-9343(50)90212-9","article-title":"Course and prognosis of tuberculosis in children","volume":"9","author":"EM Lincoln","year":"1950","journal-title":"Am J Med"},{"key":"ref62","first-page":"70","article-title":"The fate of cases of pulmonary tuberculosis under various treatment programmes","volume":"53","author":"S Grzybowski","year":"1978","journal-title":"Bull Int Union against Tuberc"},{"key":"ref63","first-page":"183","article-title":"Public health aspects of relapsing tuberculosis","volume":"99","author":"O Horwitz","year":"1969","journal-title":"Am Rev Respir Dis"},{"key":"ref64","unstructured":"Rieder H (1999) Epidemiologic basis of tuberculosis control. First Edition ed. Paris, France: International Union Against Tuberculosis and Lung Disease."},{"key":"ref65","doi-asserted-by":"crossref","first-page":"407","DOI":"10.7326\/0003-4819-76-3-112-6-407","article-title":"A 62-dose 6-month therapy for pulmonary and extrapulmonary tuberculosis. A twice-weekly, directly observed, and cost-effective regimen","volume":"112","author":"D Cohn","year":"1990","journal-title":"Ann Intern Med"},{"key":"ref66","first-page":"3","article-title":"Results at 5 years of a controlled comparison of a 6-month and a standard 18-month regimen of chemotherapy for pulmonary tuberculosis","volume":"116","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"ref67","first-page":"1182","article-title":"Short-course chemotherapy in pulmonary tuberculosis. A controlled trial by the British Thoracic Association (third report)","volume":"1","author":"A Somner","year":"1980","journal-title":"Lancet"},{"key":"ref68","first-page":"921","article-title":"Controlled clinical trial comparing a 6-month and a 12-month regimen in the treatment of pulmonary tuberculosis in the Algerian Sahara","volume":"129","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0140-6736(02)09742-8","article-title":"Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial","volume":"360","author":"D Benator","year":"2002","journal-title":"Lancet"},{"key":"ref70","first-page":"496","article-title":"Patient and disease characteristics, and outcome of treatment defaulters from the Singapore TB control unit - a one-year retrospective survey","volume":"4","author":"C Chee","year":"2000","journal-title":"Int J Tuber Lung Dis"},{"key":"ref71","first-page":"27","article-title":"A controlled clinical trial of 3- and 5- month regimens in the treatment of sputum-positive pulmonary tuberculosis in South India","volume":"134","author":"R Parthasarathy","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"ref72","first-page":"165","article-title":"Controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis: Second report of the 4th study","volume":"123","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"ref73","first-page":"779","article-title":"Long-term follow-up of a clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis","volume":"133","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1001\/jama.283.19.2537","article-title":"Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries","volume":"283","author":"MA Espinal","year":"2000","journal-title":"JAMA"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3201\/eid1209.051618","article-title":"Multidrug-resistant tuberculosis management in resource-limited settings","volume":"12","author":"E Nathanson","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/adc.2004.070466","article-title":"Outcome of HIV infected children with culture confirmed tuberculosis","volume":"90","author":"AC Hessseling","year":"2005","journal-title":"Arch Dis Child"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0140-6736(01)06712-5","article-title":"HIV-1 and recurrence, relapse, and reinfection of tuberculosis after cure: a cohort study in South African mineworkers","volume":"358","author":"P Sonnenberg","year":"2001","journal-title":"Lancet"},{"key":"ref78","first-page":"446","article-title":"Risk factors for relapse in human immunodeficiency virus type 1 infected adults with pulmonary tuberculosis","volume":"1","author":"JL Johnson","year":"1997","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archinte.1997.00440230105014","article-title":"Relapse of tuberculosis after treatment in human immunodeficiency virus-infected patients","volume":"157","author":"F Pulido","year":"1997","journal-title":"Arch Intern Med"},{"key":"ref80","unstructured":"Statistics South Africa (2010) Monthly Earnings of South Africa 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.statssa.gov.za\/publications\/P02112\/P021122010.pdf\" xlink:type=\"simple\">http:\/\/www.statssa.gov.za\/publications\/P02112\/P021122010.pdf<\/ext-link>. Accessed: 4 Jul 2011."},{"key":"ref81","unstructured":"UNICEF Supplies and Logistics (2011) Vaccine Price Data 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unicef.org\/supply\/index_57476.html\" xlink:type=\"simple\">http:\/\/www.unicef.org\/supply\/index_57476.html<\/ext-link>. Accessed: 4 Dec 2011."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0083526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T18:58:51Z","timestamp":1648061931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0083526"}},"subtitle":[],"editor":[{"given":"Pere-Joan","family":"Cardona","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0083526","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2014,1,15]]}}}