{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:43:29Z","timestamp":1788878609322,"version":"build-2803163510"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0083560","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T21:44:45Z","timestamp":1387230285000},"page":"e83560","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["YopP-Expressing Variant of Y. pestis Activates a Potent Innate Immune Response Affording Cross-Protection against Yersiniosis and Tularemia"],"prefix":"10.1371","volume":"8","author":[{"given":"Ayelet","family":"Zauberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Flashner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinon","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Vagima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Tidhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Bar-Haim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Aftalion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avigdor","family":"Shafferman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuelle","family":"Mamroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"<italic>Yersinia pestis<\/italic>-etiologic agent of plague","volume":"10","author":"R Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1086\/428617","article-title":"Risk of person-to-person transmission of pneumonic plague","volume":"40","author":"JL Kool","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Butler T (1983) Plague and other Yersian infections. New York: Plenum press.","DOI":"10.1007\/978-1-4684-8422-9"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1128\/AAC.00306-06","article-title":"Resistance of <italic>Yersinia pestis<\/italic> to antimicrobial agents","volume":"50","author":"M Galimand","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e19716","DOI":"10.1371\/journal.pone.0019716","article-title":"Identification of small-molecule inhibitors of <italic>Yersinia pestis<\/italic> Type III secretion system YscN ATPase","volume":"6","author":"W Swietnicki","year":"2011","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/978-0-387-72124-8_34","article-title":"High throughput screening for small-molecule inhibitors of type III secretion in <italic>Yersinia pestis<\/italic>","volume":"603","author":"N Pan","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1128\/IAI.01305-09","article-title":"Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model","volume":"78","author":"LK Garrity-Ryan","year":"2010","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/978-1-4614-3561-7_43","article-title":"Small molecule screening for inhibitors of the YopH phosphatase of <italic>Yersinia pseudotuberculosis<\/italic>","volume":"954","author":"J Eriksson","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4049\/jimmunol.1100174","article-title":"<italic>Yersinia pestis<\/italic> YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague","volume":"187","author":"JS Lin","year":"2011","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.12044","article-title":"Protecting against plague: towards a next-generation vaccine","volume":"172","author":"ED Williamson","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e7023","DOI":"10.1371\/journal.pone.0007023","article-title":"The NlpD lipoprotein is a novel <italic>Yersinia pestis<\/italic> virulence factor essential for the development of plague","volume":"4","author":"A Tidhar","year":"2009","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1586\/14760584.7.2.209","article-title":"Current challenges in the development of vaccines for pneumonic plague","volume":"7","author":"ST Smiley","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1038\/emi.2012.34","article-title":"Plague vaccines: current developments and future perspectives","volume":"1","author":"VA Feodorova","year":"2012","journal-title":"Emerging Microbes & Infections"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00253-011-3380-6","article-title":"Progress on plague vaccine development","volume":"91","author":"JA Rosenzweig","year":"2011","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3103\/S089141681303004X","article-title":"Molecular Bases of Vaccine Prevention of Plague","volume":"28","author":"SV Dentovskaya","year":"2013","journal-title":"Molecular Genetics, Microbiology and Virology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1586\/erv.13.42","article-title":"Live-attenuated <italic>Yersinia pestis<\/italic> vaccines","volume":"12","author":"X Wang","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e5938","DOI":"10.1371\/journal.pone.0005938","article-title":"<italic>Yersinia pestis<\/italic> endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague","volume":"4","author":"A Zauberman","year":"2009","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1073\/pnas.94.19.10385","article-title":"Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death","volume":"94","author":"D Monack","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"15920","DOI":"10.1074\/jbc.272.25.15920","article-title":"<italic>Yersinia enterocolitica<\/italic> promotes deactivation of macrophage mitogen-activated protein kinases extracellular signal-regulated kinase-1\/2, p38, and c-Jun NH2-terminal kinase. Correlation with its inhibitory effect on tumor necrosis factor-alpha production","volume":"272","author":"K Ruckdeschel","year":"1997","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.4049\/jimmunol.174.12.7939","article-title":"Inhibition of MAPK and NF-kappaB pathways is necessary for rapid apoptosis in macrophages infected with Yersinia","volume":"174","author":"Y Zhang","year":"2005","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1128\/IAI.00097-06","article-title":"Interaction of <italic>Yersinia pestis<\/italic> with macrophages: limitations in YopJ-dependent apoptosis","volume":"74","author":"A Zauberman","year":"2006","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000067","DOI":"10.1371\/journal.ppat.1000067","article-title":"Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence","volume":"4","author":"IE Brodsky","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1002619","DOI":"10.1371\/journal.ppat.1002619","article-title":"The role of mast cells in the defence against pathogens","volume":"8","author":"M Urb","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coi.2006.11.006","article-title":"New and emerging roles for mast cells in host defence","volume":"19","author":"W Dawicki","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"SN Abraham","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1073\/pnas.0510414103","article-title":"Histamine signaling through the H(2) receptor in the Peyer&apos;s patch is important for controlling <italic>Yersinia enterocolitica<\/italic> infection","volume":"103","author":"SA Handley","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"K Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF00191545","article-title":"In vivo neutralization of tumor necrosis factor-alpha and interferon- gamma abrogates resistance to <italic>Yersinia enterocolitica<\/italic> infection in mice","volume":"181","author":"IB Autenrieth","year":"1992","journal-title":"Med Microbiol Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/IAI.61.1.23-31.1993","article-title":"Association between virulence of <italic>Yersinia pestis<\/italic> and suppression of gamma interferon and tumor necrosis factor alpha","volume":"61","author":"R Nakajima","year":"1993","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1128\/IAI.62.7.3027-3032.1994","article-title":"Early gamma interferon mRNA expression is associated with resistance of mice against <italic>Yersinia enterocolitica<\/italic>","volume":"62","author":"E Bohn","year":"1994","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.micpath.2004.06.009","article-title":"Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague","volume":"37","author":"SJ Elvin","year":"2004","journal-title":"Microb Pathog"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.clim.2004.07.013","article-title":"Turning Yersinia pathogenesis outside in: subversion of macrophage function by intracellular yersiniae","volume":"114","author":"C Pujol","year":"2005","journal-title":"Clin Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1128\/IAI.00185-06","article-title":"Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary <italic>Yersinia pestis<\/italic> infection","volume":"74","author":"MA Parent","year":"2006","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.vaccine.2010.08.099","article-title":"TNFalpha and IFNgamma contribute to F1\/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague","volume":"29","author":"JS Lin","year":"2010","journal-title":"Vaccine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1128\/IAI.00094-10","article-title":"YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of <italic>Yersinia pseudotuberculosis<\/italic> infection","volume":"78","author":"Y Zhang","year":"2010","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.4049\/jimmunol.137.8.2662","article-title":"Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of <italic>Legionella pneumophila<\/italic>","volume":"137","author":"N Bhardwaj","year":"1986","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.micinf.2004.11.020","article-title":"The contribution of reactive nitrogen and oxygen species to the killing of <italic>Francisella tularensis<\/italic> LVS by murine macrophages","volume":"7","author":"H Lindgren","year":"2005","journal-title":"Microbes Infect"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1099\/mic.0.031716-0","article-title":"Restricted cytosolic growth of <italic>Francisella tularensis<\/italic> subsp. tularensis by IFN-gamma activation of macrophages","volume":"156","author":"JA Edwards","year":"2010","journal-title":"Microbiology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e19105","DOI":"10.1371\/journal.pone.0019105","article-title":"Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis","volume":"6","author":"S Herbst","year":"2011","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"12909","DOI":"10.1073\/pnas.0502849102","article-title":"Replication of <italic>Yersinia pestis<\/italic> in interferon gamma-activated macrophages requires ripA, a gene encoded in the pigmentation locus","volume":"102","author":"C Pujol","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1016\/j.vaccine.2008.09.063","article-title":"Antibodies and cytokines independently protect against pneumonic plague","volume":"26","author":"LW Kummer","year":"2008","journal-title":"Vaccine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.120.1.105","article-title":"The Immunological Basis of Acquired Cellular Resistance","volume":"120","author":"GB Mackaness","year":"1964","journal-title":"J Exp Med"},{"key":"ref43","first-page":"241","article-title":"Mixed populations in vivo and in vitro","volume":"14","author":"DW Henderson","year":"1964","journal-title":"Symp Soc Gen Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1128\/IAI.47.3.605-612.1985","article-title":"Immunity to <italic>Salmonella typhimurium<\/italic> infection in C3H\/HeJ and C3H\/HeNCrlBR mice: studies with an aromatic-dependent live S. typhimurium strain as a vaccine","volume":"47","author":"LM Killar","year":"1985","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1128\/IAI.66.7.3467-3469.1998","article-title":"Nonspecific early protective immunity in Francisella and Listeria infections can be dependent on lymphocytes","volume":"66","author":"KL Elkins","year":"1998","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.4049\/jimmunol.162.4.2291","article-title":"Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria","volume":"162","author":"KL Elkins","year":"1999","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/CMR.4.3.309","article-title":"Factors promoting acute and chronic diseases caused by Yersiniae","volume":"4","author":"RR Brubaker","year":"1991","journal-title":"Clin Microbiol Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1128\/IAI.64.8.3288-3293.1996","article-title":"Minimal requirements for murine resistance to infection with <italic>Francisella tularensis<\/italic> LVS","volume":"64","author":"KL Elkins","year":"1996","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0147-619X(81)90019-6","article-title":"Essential virulence determinants of different Yersinia species are carried on a common plasmid","volume":"5","author":"R Ben-Gurion","year":"1981","journal-title":"Plasmid"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1128\/AEM.69.10.5787-5792.2003","article-title":"Development of an improved selective agar medium for isolation of <italic>Yersinia pestis<\/italic>","volume":"69","author":"R Ber","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/0-306-48416-1_85","article-title":"Evaluation of protective immunity induced by <italic>Yersinia enterocolitica<\/italic> type-III secretion system mutants","volume":"529","author":"E Mamroud","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e1000211","DOI":"10.1371\/journal.ppat.1000211","article-title":"Interrelationship between dendritic cell trafficking and <italic>Francisella tularensis<\/italic> dissemination following airway infection","volume":"4","author":"E Bar-Haim","year":"2008","journal-title":"PLoS Pathog"}],"updated-by":[{"DOI":"10.1371\/annotation\/0ec1f217-4e7a-4dee-9a71-1076a3ac73f1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000}},{"DOI":"10.1371\/annotation\/e6ae3cd6-3d55-4ec6-8437-19572280e260","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0083560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T02:08:23Z","timestamp":1688868503000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0083560"}},"subtitle":[],"editor":[{"given":"Yousef Abu","family":"Kwaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0083560","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/e6ae3cd6-3d55-4ec6-8437-19572280e260","asserted-by":"object"},{"id-type":"doi","id":"10.1371\/annotation\/0ec1f217-4e7a-4dee-9a71-1076a3ac73f1","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}