{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:24:56Z","timestamp":1792553096074,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T00:00:00Z","timestamp":1388016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0083631","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T21:37:29Z","timestamp":1388093849000},"page":"e83631","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Persistent Autoantibody-Production by Intermediates between Short-and Long-Lived Plasma Cells in Inflamed Lymph Nodes of Experimental Epidermolysis Bullosa Acquisita"],"prefix":"10.1371","volume":"8","author":[{"given":"Benjamin","family":"Tiburzy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Szyska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navina","family":"Chrobok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upasana","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Kalies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf Armin","family":"Manz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.23.021704.115723","article-title":"Maintenance of Serum Antibody Levels","volume":"23","author":"RA Manz","year":"2005","journal-title":"Annual Review of Immunology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/eji.1830161018","article-title":"Distinct short-lived and long-lived antibody-producing cell populations","volume":"16","author":"F Ho","year":"1986","journal-title":"Eur J Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0952-7915(02)00356-4","article-title":"Humoral immunity and long-lived plasma cells","volume":"14","author":"RA Manz","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrrheum.2011.1","article-title":"Long-lived autoreactive plasma cells drive persistent autoimmune inflammation","volume":"7","author":"F Hiepe","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jaut.2012.05.010","article-title":"Bone marrow of NZB\/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity","volume":"39","author":"IM Mumtaz","year":"2012","journal-title":"J Autoimmun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.20040168","article-title":"Short-lived Plasmablasts and Long-lived Plasma Cells Contribute to Chronic Humoral Autoimmunity in NZB\/W Mice","volume":"199","author":"BF Hoyer","year":"2004","journal-title":"Journal of Experimental Medicine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archderm.136.2.174","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"136","author":"E Schmidt","year":"2000","journal-title":"Arch Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/jid.2008.192","article-title":"B-cell-directed therapy for inflammatory skin diseases","volume":"129","author":"A Nagel","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/eji.200737557","article-title":"Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab","volume":"38","author":"AJ Ferraro","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Ludwig RJ, Zillikens D (2011) Pathogenesis of epidermolysis bullosa acquisita. Dermatol Clin 29: 493\u2013501, xi. doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/j.det.2011.03.003\" xlink:type=\"simple\">10.1016\/j.det.2011.03.003<\/ext-link>.","DOI":"10.1016\/j.det.2011.03.003"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clindermatol.2011.03.011","article-title":"Epidermolysis bullosa acquisita","volume":"30","author":"R Gupta","year":"2012","journal-title":"Clin Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0002-9440(10)64182-X","article-title":"Autoantibodies to type VII collagen mediate Fcgamma-dependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skin","volume":"161","author":"C Sitaru","year":"2002","journal-title":"Am J Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI200521386","article-title":"Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen","volume":"115","author":"C Sitaru","year":"2005","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.177.5.3461","article-title":"Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice","volume":"177","author":"C Sitaru","year":"2006","journal-title":"The Journal of Immunology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/sj.jid.5700254","article-title":"Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients","volume":"126","author":"DT Woodley","year":"2006","journal-title":"J Invest Dermatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.2353\/ajpath.2007.061212","article-title":"The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita","volume":"170","author":"M Chen","year":"2007","journal-title":"Am J Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/08916934.2011.606451","article-title":"Model systems duplicating epidermolysis bullosa acquisita: a methodological review","volume":"45","author":"RJ Ludwig","year":"2012","journal-title":"Autoimmunity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.4049\/jimmunol.0901412","article-title":"T cells are required for the production of blister-inducing autoantibodies in experimental epidermolysis bullosa acquisita","volume":"184","author":"AG Sitaru","year":"2010","journal-title":"The Journal of Immunology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/eji.1830140215","article-title":"Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response. I. Isotype distribution","volume":"14","author":"H Tesch","year":"1984","journal-title":"Eur J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1084\/jem.20011112","article-title":"Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers","volume":"195","author":"K-M Toellner","year":"2002","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/jid.2010.248","article-title":"Generation of antibodies of distinct subclasses and specificity is linked to H2s in an active mouse model of epidermolysis bullosa acquisita","volume":"131","author":"RJ Ludwig","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20042060","article-title":"Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization","volume":"201","author":"EJ Blink","year":"2005","journal-title":"J Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1182\/blood-2009-12-259457","article-title":"Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow","volume":"116","author":"O Winter","year":"2010","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1002\/1521-4141(200109)31:9<2726::AID-IMMU2726>3.0.CO;2-H","article-title":"Inflamed kidneys of NZB\/W mice are a major site for the homeostasis of plasma cells","volume":"31","author":"G Cassese","year":"2001","journal-title":"European journal of immunology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"25876","DOI":"10.1016\/S0021-9258(19)62160-5","article-title":"Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization","volume":"275","author":"Parent Orsini","year":"2000","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1084\/jem.194.1.45","article-title":"A coordinated change in chemokine responsiveness guides plasma cell movements","volume":"194","author":"DC Hargreaves","year":"2001","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.4049\/jimmunol.171.4.1684","article-title":"Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals","volume":"171","author":"G Cassese","year":"2003","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/art.33424","article-title":"CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB\/NZW mice","volume":"64","author":"K Moser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/40540","article-title":"Lifetime of plasma cells in the bone marrow","volume":"388","author":"RA Manz","year":"1997","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral immunity due to long-lived plasma cells","volume":"8","author":"MK Slifka","year":"1998","journal-title":"Immunity"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nm1292","article-title":"Direct access to CD4+ T cells specific for defined antigens according to CD154 expression","volume":"11","author":"M Frentsch","year":"2005","journal-title":"Nature Medicine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1002\/eji.200737322","article-title":"Identification and isolation of murine antigen-reactive T cells according to CD154 expression","volume":"37","author":"D Kirchhoff","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jaut.2010.12.006","article-title":"Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-\u03b3 receptor knockout mice exposes an arthritis-promoting role of IFN-\u03b3","volume":"36","author":"O Frey","year":"2011","journal-title":"J Autoimmun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.4049\/jimmunol.169.3.1277","article-title":"Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response","volume":"169","author":"AE Hauser","year":"2002","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1182\/blood-2004-08-2992","article-title":"Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells","volume":"105","author":"G Muehlinghaus","year":"2005","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.coi.2006.03.004","article-title":"Stromal niches, plasma cell differentiation and survival","volume":"18","author":"K Moser","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jaut.2007.07.014","article-title":"Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicry","volume":"29","author":"KR Ryan","year":"2007","journal-title":"J Autoimmun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/eji.201041315","article-title":"High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB\/W F1 lupus mice","volume":"41","author":"C Starke","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/archderm.142.2.147","article-title":"Successful adjuvant treatment of recalcitrant epidermolysis bullosa acquisita with anti-CD20 antibody rituximab","volume":"142","author":"E Schmidt","year":"2006","journal-title":"Arch Dermatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jaad.2010.07.032","article-title":"Rituximab for treatment-refractory pemphigus and pemphigoid: a case series of 17 patients","volume":"65","author":"M Kasperkiewicz","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archdermatol.2011.54","article-title":"Rituximab for patients with refractory mucous membrane pemphigoid","volume":"147","author":"C Le Roux-Villet","year":"2011","journal-title":"Arch Dermatol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0083631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T17:16:05Z","timestamp":1647796565000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0083631"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Frey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,26]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0083631","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,26]]}}}