{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:02:55Z","timestamp":1778349775359,"version":"3.51.4"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0084214","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T21:51:49Z","timestamp":1389217909000},"page":"e84214","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["TRAF5 and TRAF3IP2 Gene Polymorphisms Are Associated with Beh\u00e7et's Disease and Vogt-Koyanagi-Harada Syndrome: A Case-Control Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Qin","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunjia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","article-title":"Clinical features of Chinese patients with Beh\u00e7et&apos;s disease","volume":"115","author":"P Yang","year":"2008","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ophtha.2006.07.040","article-title":"Clinical characteristics of Vogt\u2013Koyanagi\u2013Harada syndrome in Chinese patients","volume":"114","author":"P Yang","year":"2007","journal-title":"Ophthalmology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1479-8077.2006.00208.x","article-title":"Clinical manifestations of Behcet&apos;s disease in Chinese patients","volume":"9","author":"Z Zhang","year":"2006","journal-title":"APLAR Journal of Rheumatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MD.0b013e318211bf28","article-title":"Behcet disease: evolution of clinical manifestations","volume":"90","author":"H Ideguchi","year":"2011","journal-title":"Medicine (Baltimore)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1136\/bjo.2007.124875","article-title":"Behcet&apos;s disease: global epidemiology of an Old Silk Road disease","volume":"91","author":"H Keino","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/ard.2009.108571","article-title":"Genetics of Beh\u00e7et disease inside and outside the MHC","volume":"69","author":"A Meguro","year":"2010","journal-title":"Annals of the rheumatic diseases"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/rheumatology\/ker345","article-title":"CD40 gene polymorphisms confer risk of Behcet&apos;s disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population","volume":"51","author":"F Chen","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"ref8","article-title":"Genome-wide association study identifies susceptible locus in STAT4 for Behcet&apos;s disease in Han Chinese","author":"S Hou","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1167\/iovs.11-8440","article-title":"JAK2 and STAT3 polymorphisms in a Han Chinese population with Behcet&apos;s disease","volume":"53","author":"K Hu","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref10","first-page":"647","article-title":"Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature","volume":"131","author":"RW Read","year":"2001","journal-title":"American journal of ophthalmology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0161-6420(90)32446-6","article-title":"HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia","volume":"97","author":"J Davis","year":"1990","journal-title":"Ophthalmology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archopht.1991.01080030070041","article-title":"Association of HLA antigens with Vogt-Koyanagi-Harada syndrome in a Han Chinese population","volume":"109","author":"M Zhao","year":"1991","journal-title":"Archives of ophthalmology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.humimm.2010.01.026","article-title":"Polymorphisms of IL23R and Vogt\u2013Koyanagi\u2013Harada syndrome in a Chinese Han population","volume":"71","author":"Z Jiang","year":"2010","journal-title":"Human Immunology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.humimm.2010.06.020","article-title":"Interleukin-17 gene polymorphism is associated with Vogt\u2013Koyanagi\u2013Harada syndrome but not with Beh\u00e7et&apos;s disease in a Chinese Han population","volume":"71","author":"Q Shu","year":"2010","journal-title":"Human Immunology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1167\/iovs.11-7539","article-title":"Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease","volume":"52","author":"M Chu","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/978-0-387-70630-6_3","article-title":"Physiological roles and mechanisms of signaling by TRAF2 and TRAF5","volume":"597","author":"PY Au","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni.2080","article-title":"The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation","volume":"12","author":"K Bulek","year":"2011","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1136\/ard.2006.065706","article-title":"Investigation of association between the TRAF family genes and RA susceptibility","volume":"66","author":"C Potter","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ni.2448","article-title":"The ubiquitous nature of IL-17","volume":"13","author":"AI Ma","year":"2012","journal-title":"Nat Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/ar4071","article-title":"New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis","volume":"14","author":"MS Doyle","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/ni.2081","article-title":"Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)","volume":"12","author":"D Sun","year":"2011","journal-title":"Nature immunology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1196\/annals.1447.064","article-title":"Gene expression profiles stratified according to type 1 diabetes mellitus susceptibility regions","volume":"1150","author":"DM Rassi","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ng.689","article-title":"Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2","volume":"42","author":"E Ellinghaus","year":"2010","journal-title":"Nat Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ng.688","article-title":"Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis","volume":"42","author":"U Huffmeier","year":"2010","journal-title":"Nat Genet"},{"key":"ref25","article-title":"TRAF3IP2 gene is associated with cutaneous extraintestinal manifestations in Inflammatory Bowel Disease","author":"C Ciccacci","year":"2012","journal-title":"Journal of Crohn's and Colitis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2337\/db11-1263","article-title":"Identification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression","volume":"61","author":"R Bergholdt","year":"2012","journal-title":"Diabetes"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nrrheum.2011.169","article-title":"Genetics of susceptibility and treatment response in psoriatic arthritis","volume":"7","author":"DD O'Rielly","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1167\/iovs.07-1390","article-title":"Upregulated IL-23 and IL-17 in Beh\u00e7et patients with active uveitis","volume":"49","author":"W Chi","year":"2008","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2007.01.010","article-title":"IL-23 promotes CD4<sup>+<\/sup> T cells to produce IL-17 in Vogt-Koyanagi-Harada disease","volume":"119","author":"W Chi","year":"2007","journal-title":"Journal of allergy and clinical immunology"},{"key":"ref30","first-page":"1078","article-title":"Criteria for diagnosis of Behcet&apos;s disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"17140","DOI":"10.1073\/pnas.0903786106","article-title":"TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40","volume":"106","author":"ZJ Kraus","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1158\/1055-9965.EPI-08-0536","article-title":"Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin&apos;s lymphoma","volume":"17","author":"JR Cerhan","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1600-065X.2011.01063.x","article-title":"T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy","volume":"244","author":"LM Snell","year":"2011","journal-title":"Immunol Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000333006","article-title":"Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development","volume":"34","author":"D Zhang","year":"2011","journal-title":"Am J Nephrol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/ATVBAHA.107.140566","article-title":"TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells","volume":"27","author":"A Zirlik","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1167\/iovs.05-1547","article-title":"Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens","volume":"47","author":"S Sugita","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref37","first-page":"335","article-title":"Immunological aspects of Beh\u00e7et&apos;s and Vogt-Koyanagi-Harada&apos;s diseases","volume":"101","author":"S Ohno","year":"1981","journal-title":"Trans Ophthalmol Soc UK"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/02713680802233968","article-title":"Vogt-koyanagi-harada syndrome","volume":"33","author":"W Fang","year":"2008","journal-title":"Curr Eye Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/02713680500263606","article-title":"Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China","volume":"30","author":"P Yang","year":"2005","journal-title":"Curr Eye Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.humimm.2010.04.007","article-title":"STAT4 polymorphism in a Chinese Han population with Vogt\u2013Koyanagi\u2013Harada syndrome and Beh\u00e7et&apos;s disease","volume":"71","author":"K Hu","year":"2010","journal-title":"Human Immunology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/9780470743553.ch4","article-title":"The role of Act1 in the control of autoimmunity","author":"TN J\u00f8rgensen","year":"2009","journal-title":"The Epigenetics of Autoimmune Diseases"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"198956","DOI":"10.1155\/2012\/198956","article-title":"Gene expression profiling in dermatitis herpetiformis skin lesions","volume":"2012","author":"M Dolcino","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1189\/jlb.0805453","article-title":"Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-\u03baB (NF-\u03baB), pyrrolidine dithiocarbamate","volume":"79","author":"H Kitamei","year":"2006","journal-title":"Journal of leukocyte biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/rheumatology\/kem101","article-title":"Long-term efficacy of infliximab in refractory posterior uveitis of Behcet&apos;s disease: a 24-month follow-up study","volume":"46","author":"L Niccoli","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/archophthalmol.2011.2698","article-title":"Multicenter study of infliximab for refractory uveoretinitis in Beh\u00e7et disease","volume":"130","author":"AA Okada","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni1439","article-title":"The adaptor Act1 is required for interleukin 17\u2013dependent signaling associated with autoimmune and inflammatory disease","volume":"8","author":"Y Qian","year":"2007","journal-title":"Nature immunology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ni0307-232","article-title":"Act1-ivating IL-17 inflammation","volume":"8","author":"CA Hunter","year":"2007","journal-title":"Nat Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00439-012-1250-7","article-title":"TNFAIP3 gene polymorphisms confer risk for Behcet&apos;s disease in a Chinese Han population","volume":"132","author":"H Li","year":"2013","journal-title":"Hum Genet"},{"key":"ref49","article-title":"MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet&apos;s disease and Vogt-Koyanagi-Harada syndrome","author":"Q Zhou","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/ard.2009.119420","article-title":"IL-23R gene confers susceptibility to Behcet&apos;s disease in a Chinese Han population","volume":"69","author":"Z Jiang","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/ard.2008.104315","article-title":"Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese","volume":"69","author":"K Nishimoto","year":"2010","journal-title":"Annals of the rheumatic diseases"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa073491","article-title":"TRAF1\u2013C5 as a risk locus for rheumatoid arthritis\u2014a genomewide study","volume":"357","author":"RM Plenge","year":"2007","journal-title":"New England Journal of Medicine"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/art.24759","article-title":"TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians","volume":"60","author":"TU Han","year":"2009","journal-title":"Arthritis & Rheumatism"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/art.34361","article-title":"Evaluation of TRAF6 in a large multiancestral lupus cohort","volume":"64","author":"B Namjou","year":"2012","journal-title":"Arthritis & Rheumatism"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00251-013-0717-6","article-title":"TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development","volume":"65","author":"C Perricone","year":"2013","journal-title":"Immunogenetics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.crohns.2012.02.020","article-title":"TRAF3IP2 gene is associated with cutaneous extraintestinal manifestations in Inflammatory Bowel Disease","volume":"7","author":"C Ciccacci","year":"2013","journal-title":"Journal of Crohn's and Colitis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0084214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:02:21Z","timestamp":1540339341000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0084214"}},"subtitle":[],"editor":[{"given":"Yong-Gang","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,8]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0084214","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,8]]}}}