{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:35:00Z","timestamp":1777649700607,"version":"3.51.4"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0084565","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T17:15:41Z","timestamp":1387473341000},"page":"e84565","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":74,"title":["Increased Functional Connectivity between Prefrontal Cortex and Reward System in Pathological Gambling"],"prefix":"10.1371","volume":"8","author":[{"given":"Saskia","family":"Koehler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smadar","family":"Ovadia-Caro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Villringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Romanczuk-Seiferth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Margulies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/00952990.2010.491884","article-title":"Introduction to Behavioral Addictions","volume":"36","author":"JE Grant","year":"2010","journal-title":"Am J Drug Alcohol Abuse"},{"key":"ref2","article-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1523\/JNEUROSCI.4690-09.2010","article-title":"When desire collides with reason: functional interactions between anteroventral prefrontal cortex and nucleus accumbens underlie the human ability to resist impulsive desires","volume":"30","author":"EK Diekhof","year":"2010","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1002\/hbm.21398","article-title":"Impulsive personality and the ability to resist immediate reward: An fMRI study examining interindividual differences in the neural mechanisms underlying self-control","volume":"33","author":"EK Diekhof","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An integrative theory of prefrontal cortex function","volume":"24","author":"EK Miller","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/1073858404263526","article-title":"The neural substrates of reward processing in humans: the modern role of FMRI","volume":"10","author":"SM McClure","year":"2004","journal-title":"Neuroscientist"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1162\/jocn.2011.21624","article-title":"Functional connectivity and coactivation of the nucleus accumbens: a combined functional connectivity and structure-based meta-analysis","volume":"23","author":"F Cauda","year":"2011","journal-title":"J Cogn Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/cercor\/bhn041","article-title":"Functional connectivity of human striatum: a resting state FMRI study","volume":"18","author":"A Di Martino","year":"2008","journal-title":"Cereb Cortex"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/neuro.09.019.2008","article-title":"Functional connectivity of reward processing in the brain","volume":"2","author":"E Camara","year":"2008","journal-title":"Front Hum Neuroscience"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications","volume":"12","author":"RZ Goldstein","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.biopsych.2005.04.028","article-title":"Ventral striatum\/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study","volume":"58","author":"SP David","year":"2005","journal-title":"Biol Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1176\/ajp.161.10.1783","article-title":"Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving","volume":"161","author":"A Heinz","year":"2004","journal-title":"Am J Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuroimage.2006.11.043","article-title":"Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics","volume":"35","author":"J Wrase","year":"2007","journal-title":"NeuroImage"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.biopsych.2009.04.035","article-title":"Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics","volume":"66","author":"A Beck","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1176\/appi.ajp.2010.10071024","article-title":"Lower ventral striatal activation during reward anticipation in adolescent smokers","volume":"168","author":"J Peters","year":"2011","journal-title":"Am J Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.euroneuro.2009.11.010","article-title":"Chronic effects of cannabis use on the human reward system: an fMRI study","volume":"20","author":"HH van Hell","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopsych.2011.05.008","article-title":"An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence","volume":"70","author":"Z Jia","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nn1584","article-title":"Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective","volume":"8","author":"A Bechara","year":"2005","journal-title":"Nat Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tics.2010.12.005","article-title":"Cognitive neuroscience of self-regulation failure","volume":"15","author":"TF Heatherton","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1176\/appi.ajp.160.11.1990","article-title":"An FMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers","volume":"160","author":"MN Potenza","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0006-3223(01)01227-6","article-title":"Frontal lobe dysfunction in pathological gambling patients","volume":"51","author":"P Cavedini","year":"2002","journal-title":"Biol Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cogbrainres.2005.01.017","article-title":"Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. Brain","volume":"23","author":"AE Goudriaan","year":"2005","journal-title":"Resour - Cogn Brain Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1360-0443.2006.01380.x","article-title":"Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls","volume":"101","author":"AE Goudriaan","year":"2006","journal-title":"Addiction"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1745-0179-4-7","article-title":"Clinical Practice and Epidemiology Executive function abnormalities in pathological gamblers. Clin Pract","volume":"4","author":"D Marazziti","year":"2008","journal-title":"Epidemiol - Ment Health"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.biopsych.2012.01.006","article-title":"Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling","volume":"71","author":"IM Balodis","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/npp.2008.175","article-title":"Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers","volume":"34","author":"MB de Ruiter","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nn1378","article-title":"Pathological gambling is linked to reduced activation of the mesolimbic reward system","volume":"8","author":"J Reuter","year":"2005","journal-title":"Nat Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.biopsych.2005.04.037","article-title":"Cue-induced brain activity in pathological gamblers","volume":"58","author":"DN Crockford","year":"2005","journal-title":"Biol Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e30909","DOI":"10.1371\/journal.pone.0030909","article-title":"Response Inhibition during Cue Reactivity in Problem Gamblers: An fMRI Study","volume":"7","author":"RJ van Holst","year":"2012","journal-title":"PLOS ONE"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.biopsych.2009.11.009","article-title":"Hypersensitivity to reward in problem gamblers","volume":"67","author":"J Hewig","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1016\/j.neuropsychologia.2011.09.037","article-title":"Problem gamblers exhibit reward hypersensitivity in medial frontal cortex during gambling","volume":"49","author":"SA Oberg","year":"2011","journal-title":"Neuropsychologia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e45938","DOI":"10.1371\/journal.pone.0045938","article-title":"Altered brain activity during reward anticipation in pathological gambling and obsessive-compulsive disorder","volume":"7","author":"JS Choi","year":"2012","journal-title":"PLOS ONE"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.biopsych.2011.12.030","article-title":"Distorted expectancy coding in problem gambling: is the addictive in the anticipation?","volume":"71","author":"RJ van Holst","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"MD Fox","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain\u2019s functional architecture during activation and rest","volume":"106","author":"SM Smith","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1152\/jn.00783.2009","article-title":"Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization","volume":"103","author":"KR Van Dijk","year":"2010","journal-title":"J Neurophysiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/bhq297","article-title":"Disruption of Functional Connectivity of the Default-Mode Network in Alcoholism","volume":"21","author":"S Chanraud","year":"2011","journal-title":"Cereb Cortex"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.neuroimage.2010.06.066","article-title":"Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity","volume":"53","author":"H Gu","year":"2010","journal-title":"NeuroImage"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.biopsych.2010.11.022","article-title":"Reduced interhemispheric resting state functional connectivity in cocaine addiction","volume":"69","author":"C Kelly","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e23098","DOI":"10.1371\/journal.pone.0023098","article-title":"Interaction between Dysfunctional Connectivity at Rest and Heroin Cues-Induced Brain Responses in Male Abstinent Heroin-Dependent Individuals","volume":"6","author":"J Liu","year":"2011","journal-title":"PLOS ONE"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.neuroimage.2009.08.037","article-title":"Addiction related alteration in resting-state brain connectivity","volume":"49","author":"N Ma","year":"2010","journal-title":"NeuroImage"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1530-0277.2011.01614.x","article-title":"Reduced Fronto-Cerebellar Functional Connectivity in Chronic Alcoholic Patients","volume":"36","author":"BP Rogers","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e10815","DOI":"10.1371\/journal.pone.0010815","article-title":"Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers","volume":"5","author":"D Tomasi","year":"2010","journal-title":"PLOS ONE"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1093\/brain\/awq138","article-title":"Alterations in brain structure and functional connectivity in prescription opioid-dependent patients","volume":"133","author":"J Upadhyay","year":"2010","journal-title":"Brain"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.drugalcdep.2011.01.009","article-title":"Enhanced cue reactivity and fronto-striatal functional connectivity in cocaine use disorders","volume":"115","author":"CE Wilcox","year":"2011","journal-title":"Drug Alcohol Depend"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neulet.2010.07.005","article-title":"Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals","volume":"482","author":"K Yuan","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2012.01.117","article-title":"Resting state functional connectivity in addiction: Lessons learned and a road ahead","volume":"62","author":"MT Sutherland","year":"2012","journal-title":"NeuroImage"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3389\/fnhum.2013.00625","article-title":"Abnormalities of functional brain networks in pathological gambling: a graph-theoretical approach","volume":"7","author":"M Tschernegg","year":"2013","journal-title":"Front Hum Neuroscience"},{"key":"ref49","article-title":"Higher volume of ventral striatum and right prefrontal cortex in pathological gambling. Brain Struct Funct","author":"S Koehler","year":"2013"},{"key":"ref50","first-page":"300","article-title":"KFG: Kurzfragebogen zum Gl\u00fccksspielverhalten. Psychotherapie der Gluecksspielsucht","author":"J Petry","year":"1996"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.psychres.2007.11.008","article-title":"The Gambling Symptom Assessment Scale (G-SAS): a reliability and validity study","volume":"166","author":"SW Kim","year":"2009","journal-title":"Psychiatry Res"},{"key":"ref52","article-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen (SCID-I\/PW\/PSYSCREEN)","author":"M First","year":"2001"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"RC Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"ref54","article-title":"Wechsler Intelligenztest f\u00fcr Erwachsene (WIE). Deutschsprachige Bearbeitung und Adaption des WAIS-III von David Wechsler","author":"M Aster","year":"2006"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1","article-title":"Factor structure of the Barratt impulsiveness scale","volume":"51","author":"JH Patton","year":"1995","journal-title":"J Clin Psychol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/brain.2012.0080","article-title":"Trouble at Rest: How Correlation Patterns and Group Differences Become Distorted After Global Signal Regression","volume":"2","author":"ZS Saad","year":"2012","journal-title":"Brain Connect"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/neuro.01.034.2009","article-title":"Reward networks in the brain as captured by connectivity measures","volume":"3","author":"E Camara","year":"2009","journal-title":"Front Neuroscience"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e58098","DOI":"10.1371\/journal.pone.0058098","article-title":"Altered fronto-striatal and fronto-cerebellar circuits in heroin-dependent individuals: a resting-state FMRI study","volume":"8","author":"Y Wang","year":"2013","journal-title":"PLOS ONE"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/hbm.20344","article-title":"Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making","volume":"28","author":"J Tanabe","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/brain\/awp269","article-title":"Executive function and fluid intelligence after frontal lobe lesions","volume":"133","author":"M Roca","year":"2010","journal-title":"Brain"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tics.2004.02.010","article-title":"Inhibition and the right inferior frontal cortex","volume":"8","author":"AR Aron","year":"2004","journal-title":"Trends Cogn Sci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/hbm.20128","article-title":"Meta-analysis of neuroimaging studies of the Wisconsin card-sorting task and component processes","volume":"25","author":"BR Buchsbaum","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuropsychologia.2007.07.015","article-title":"Meta-analysis of Go\/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent","volume":"46","author":"DJ Simmonds","year":"2008","journal-title":"Neuropsychologia"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1196\/annals.1390.004","article-title":"Resisting the power of temptations: the right prefrontal cortex and self-control","volume":"1104","author":"D Knoch","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1523\/JNEUROSCI.0804-06.2006","article-title":"Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior","volume":"26","author":"D Knoch","year":"2006","journal-title":"J Neurosci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.1100907","article-title":"Separate neural systems value immediate and delayed monetary rewards","volume":"306","author":"SM McClure","year":"2004","journal-title":"Science"},{"key":"ref67","first-page":"141","article-title":"The Common Neural Basis of Exerting Self-Control in Multiple Domains","year":"2010"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.neuroimage.2010.08.063","article-title":"Network modelling methods for FMRI","volume":"54","author":"SM Smith","year":"2011","journal-title":"NeuroImage"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/archpsyc.61.1.34","article-title":"Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy","volume":"61","author":"K Goldapple","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"ref70","first-page":"41","article-title":"The therapeutic concept of euthymic treatment. The little school of pleasure","volume":"147","author":"R Lutz","year":"2005","journal-title":"MMW Fortschr Med"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0134179","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0084565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T03:27:27Z","timestamp":1540006047000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0084565"}},"subtitle":[],"editor":[{"given":"Yu-Feng","family":"Zang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0084565","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0134179","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}