{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:10:58Z","timestamp":1791310258162,"version":"4.3.1"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0084726","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T17:16:40Z","timestamp":1387473400000},"page":"e84726","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6\/1 Mouse Model of Huntington\u2019s Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Ivan","family":"Rattray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Crum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian P.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Modo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"ref1","article-title":"s disease chromosomes","year":"1993"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington&apos;s disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"SJ Tabrizi","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/jnnp-2011-301940","article-title":"Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington&apos;s disease","volume":"83","author":"JC Stout","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/hbm.22055","article-title":"The structural correlates of functional deficits in early huntington&apos;s disease","volume":"34","author":"C Delmaire","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"L Mangiarini","year":"1996","journal-title":"Cell"},{"key":"ref6","first-page":"397","article-title":"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin","volume":"8","author":"G Schilling","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"EJ Slow","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"M Gray","year":"2008","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington&apos;s disease","volume":"10","author":"CH Lin","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/hmg\/9.4.503","article-title":"Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice","volume":"9","author":"VC Wheeler","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1523\/JNEUROSCI.22-18-08266.2002","article-title":"Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington&apos;s disease knock-in mice","volume":"22","author":"LB Menalled","year":"2002","journal-title":"J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2006.11.004","article-title":"The Hdh(Q150\/Q150) knock-in mouse model of HD and the R6\/2 exon 1 model develop comparable and widespread molecular phenotypes. Brain","volume":"72","author":"B Woodman","year":"2007","journal-title":"Res Bull"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","article-title":"Mutant huntingtin&apos;s effects on striatal gene expression in mice recapitulate changes observed in human Huntington&apos;s disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage","volume":"16","author":"A Kuhn","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e8025","DOI":"10.1371\/journal.pone.0008025","article-title":"Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington&apos;s disease","volume":"4","author":"H Moffitt","year":"2009","journal-title":"PLOS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/hmg\/ddp467","article-title":"Identical oligomeric and fibrillar structures captured from the brains of R6\/2 and knock-in mouse models of Huntington&apos;s disease","volume":"19","author":"K Sathasivam","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1172\/JCI57413","article-title":"Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease","volume":"121","author":"J Labbadia","year":"2011","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1074\/jbc.M109.075028","article-title":"Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease","volume":"285","author":"C Landles","year":"2010","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1073\/pnas.1221891110","article-title":"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease","volume":"110","author":"K Sathasivam","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e60012","DOI":"10.1371\/journal.pone.0060012","article-title":"Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6\/2 Mouse Model of HD","volume":"8","author":"I Rattray","year":"2013","journal-title":"PLOS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainresbull.2011.01.010","article-title":"Longitudinal analysis of the behavioural phenotype in R6\/1 (C57BL\/6J) Huntington&apos;s disease transgenic mice. Brain","volume":"88","author":"SP Brooks","year":"2012","journal-title":"Res Bull"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainresbull.2011.07.009","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in the R6\/1 Huntington&apos;s disease transgenic mice. Brain","volume":"88","author":"Z Bayram-Weston","year":"2012","journal-title":"Res Bull"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbr.2012.10.039","article-title":"Motor, emotional and cognitive deficits in adult BACHD mice: a model for Huntington&apos;s disease","volume":"238","author":"YS Abada","year":"2013","journal-title":"Behav Brain Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainresbull.2010.05.005","article-title":"Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL\/6J) Huntington&apos;s disease transgenic mice. Brain","volume":"88","author":"S Brooks","year":"2012","journal-title":"Res Bull"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainresbull.2011.05.010","article-title":"Selective cognitive impairment in the YAC128 Huntington&apos;s disease mouse. Brain","volume":"88","author":"SP Brooks","year":"2012","journal-title":"Res Bull"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainresbull.2011.06.008","article-title":"Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington&apos;s disease mouse line. Brain","volume":"88","author":"SP Brooks","year":"2012","journal-title":"Res Bull"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainresbull.2011.05.005","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington&apos;s disease transgenic mice. Brain","volume":"88","author":"Z Bayram-Weston","year":"2012","journal-title":"Res Bull"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainresbull.2010.05.003","article-title":"Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington&apos;s disease knock-in mice. Brain","volume":"88","author":"S Brooks","year":"2012","journal-title":"Res Bull"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.brainresbull.2011.10.019","article-title":"Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington&apos;s disease. Brain","volume":"88","author":"RC Trueman","year":"2012","journal-title":"Res Bull"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainresbull.2011.03.013","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington&apos;s disease knock-in mice. Brain","volume":"88","author":"Z Bayram-Weston","year":"2012","journal-title":"Res Bull"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainresbull.2010.05.004","article-title":"Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington&apos;s disease knock-in mice. Brain","volume":"88","author":"S Brooks","year":"2012","journal-title":"Res Bull"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainresbull.2011.03.012","article-title":"Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington&apos;s disease. Brain","volume":"88","author":"RC Trueman","year":"2012","journal-title":"Res Bull"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainresbull.2011.03.014","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington&apos;s disease knock-in mouse. Brain","volume":"88","author":"Z Bayram-Weston","year":"2012","journal-title":"Res Bull"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainresbull.2011.10.001","article-title":"Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington&apos;s disease. Brain","volume":"88","author":"P Giles","year":"2012","journal-title":"Res Bull"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e50717","DOI":"10.1371\/journal.pone.0050717","article-title":"Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington&apos;s disease","volume":"7","author":"T Heikkinen","year":"2012","journal-title":"PLOS ONE"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington&apos;s disease: zQ175","volume":"7","author":"LB Menalled","year":"2012","journal-title":"PLOS ONE"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1523\/JNEUROSCI.0474-06.2006","article-title":"Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice","volume":"26","author":"A Izquierdo","year":"2006","journal-title":"J Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/nprot.2009.141","article-title":"Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition","volume":"4","author":"AH Macbeth","year":"2009","journal-title":"Nat Protoc"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-2202-13-97","article-title":"Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6\/2 transgenic mouse model of Huntington&apos;s disease","volume":"13","author":"G El-Akabawy","year":"2012","journal-title":"BMC Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jneumeth.2013.05.009","article-title":"A comparison of automated anatomical-behavioural mapping methods in a rodent model of stroke","volume":"218","author":"WR Crum","year":"2013","journal-title":"J Neurosci Methods"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jneumeth.2013.03.015","article-title":"Registration of challenging pre-clinical brain images","volume":"216","author":"WR Crum","year":"2013","journal-title":"J Neurosci Methods"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1088\/0031-9155\/50\/21\/014","article-title":"Anisotropic multi-scale fluid registration: evaluation in magnetic resonance breast imaging","volume":"50","author":"WR Crum","year":"2005","journal-title":"Phys Med Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/00004728-199809000-00031","article-title":"Modeling brain deformations in Alzheimer disease by fluid registration of serial 3D MR images","volume":"22","author":"PA Freeborough","year":"1998","journal-title":"J Comput Assist Tomogr"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(01)05408-3","article-title":"Imaging of onset and progression of Alzheimer&apos;s disease with voxel-compression mapping of serial magnetic resonance images","volume":"358","author":"NC Fox","year":"2001","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/hmg\/10.21.2425","article-title":"Centrosome disorganization in fibroblast cultures derived from R6\/2 Huntington&apos;s disease (HD) transgenic mice and HD patients","volume":"10","author":"K Sathasivam","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref45","article-title":"Unbiased stereology: A consise guide","author":"PR Mouton","year":"2011"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/(SICI)1096-9861(19971215)389:2<193::AID-CNE1>3.0.CO;2-X","article-title":"Neurogenesis in the mammalian neostriatum and nucleus accumbens: parvalbumin-immunoreactive GABAergic interneurons","volume":"389","author":"AF Sadikot","year":"1997","journal-title":"J Comp Neurol"},{"key":"ref47","article-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2001"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using the false discovery rate","volume":"15","author":"CR Genovese","year":"2002","journal-title":"NeuroImage"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2005.01.024","article-title":"Early behavioral deficits in R6\/2 mice suitable for use in preclinical drug testing","volume":"20","author":"MA Hickey","year":"2005","journal-title":"Neurobiol Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cne.20680","article-title":"Chronology of behavioral symptoms and neuropathological sequela in R6\/2 Huntington&apos;s disease transgenic mice","volume":"490","author":"EC Stack","year":"2005","journal-title":"J Comp Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbadis.2006.03.004","article-title":"Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington&apos;s disease mice","volume":"1762","author":"KM Smith","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1523\/JNEUROSCI.4320-04.2005","article-title":"Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington&apos;s disease mice","volume":"25","author":"NK Mazarakis","year":"2005","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2003.08.053","article-title":"Molecular and behavioral analysis of the R6\/1 Huntington&apos;s disease transgenic mouse","volume":"122","author":"B Naver","year":"2003","journal-title":"Neuroscience"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2004.01.021","article-title":"Early exploratory behavior abnormalities in R6\/1 Huntington&apos;s disease transgenic mice","volume":"1005","author":"VJ Bolivar","year":"2004","journal-title":"Brain Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1601-183X.2007.00350.x","article-title":"Brain gene expression correlates with changes in behavior in the R6\/1 mouse model of Huntington&apos;s disease","volume":"7","author":"A Hodges","year":"2008","journal-title":"Genes Brain Behav"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1523\/JNEUROSCI.2820-08.2008","article-title":"Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice","volume":"28","author":"GB Bissonette","year":"2008","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.neuropharm.2011.03.011","article-title":"Reversal learning and attentional set-shifting in mice","volume":"62","author":"GB Bissonette","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnsys.2011.00026","article-title":"Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington&apos;s Disease","volume":"5","author":"BR Miller","year":"2011","journal-title":"Frontiers in Systems Neuroscience"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neuroscience.2005.08.062","article-title":"Hyperactive striatal neurons in symptomatic Huntington R6\/2 mice: variations with behavioral state and repeated ascorbate treatment","volume":"137","author":"GV Rebec","year":"2006","journal-title":"Neuroscience"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1523\/JNEUROSCI.2804-08.2008","article-title":"Altered information processing in the prefrontal cortex of Huntington&apos;s disease mouse models","volume":"28","author":"AG Walker","year":"2008","journal-title":"J Neurosci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/jnnp.2007.116244","article-title":"Longitudinal analysis of regional grey matter loss in Huntington disease: effects of the length of the expanded CAG repeat","volume":"79","author":"HH Ruocco","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington&apos;s disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"SJ Tabrizi","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e74131","DOI":"10.1371\/journal.pone.0074131","article-title":"Multi-Modal Neuroimaging in Premanifest and Early Huntington&apos;s Disease: 18 Month Longitudinal Data from the IMAGE-HD Study","volume":"8","author":"DJ Dominguez","year":"2013","journal-title":"PLOS ONE"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biopsych.2011.07.030","article-title":"Striatal volume contributes to the prediction of onset of Huntington disease in incident cases","volume":"71","author":"EH Aylward","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref65","article-title":"A comparison of automated anatomical-behavioural mapping methods in a rodent model of stroke","author":"WR Crum","year":"2013","journal-title":"J Neuroscience Methods"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e17269","DOI":"10.1371\/journal.pone.0017269","article-title":"Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson&apos;s disease","volume":"6","author":"AC Vernon","year":"2011","journal-title":"PLOS ONE"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/glia.10261","article-title":"Microglia density decreases with age in a mouse model of Huntington&apos;s disease","volume":"43","author":"L Ma","year":"2003","journal-title":"Glia"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/1096-9861(20010219)430:4<485::AID-CNE1045>3.0.CO;2-6","article-title":"Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene","volume":"430","author":"M Kusakabe","year":"2001","journal-title":"J Comp Neurol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e47026","DOI":"10.1371\/journal.pone.0047026","article-title":"Dysfunctional behavioral modulation of corticostriatal communication in the R6\/2 mouse model of Huntington&apos;s disease","volume":"7","author":"SL Hong","year":"2012","journal-title":"PLOS ONE"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e30879","DOI":"10.1371\/journal.pone.0030879","article-title":"Altered neural and behavioral dynamics in Huntington&apos;s disease: an entropy conservation approach","volume":"7","author":"SL Hong","year":"2012","journal-title":"PLOS ONE"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnsys.2011.00026","article-title":"Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington&apos;s Disease","volume":"5","author":"BR Miller","year":"2011","journal-title":"Front Syst Neurosci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0278-5846(84)80032-9","article-title":"Learned helplessness and animal models of depression","volume":"8","author":"SF Maier","year":"1984","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0168-1591(02)00285-X","article-title":"Understanding behaviour: the relevance of ethological approaches in laboratory animal science","volume":"81","author":"IAS Olsson","year":"2003","journal-title":"Applied Animal Behaviour Science"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0166-2236(99)01438-1","article-title":"Stress and cognition: are corticosteroids good or bad guys?","volume":"22","author":"ER de Kloet","year":"1999","journal-title":"Trends Neurosci"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.neubiorev.2008.03.005","article-title":"What do we know about the long-term consequences of stress on ageing and the progression of age-related neurodegenerative disorders?","volume":"32","author":"MC Pardon","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/hmg\/ddl094","article-title":"Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6\/2 transgenic mouse model of Huntington&apos;s disease","volume":"15","author":"M Bj\u00f6rkqvist","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1038\/tp.2012.58","article-title":"Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington&apos;s disease","volume":"2","author":"X Du","year":"2012","journal-title":"Transl Psychiatry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0084726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T01:08:08Z","timestamp":1564967288000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0084726"}},"subtitle":[],"editor":[{"given":"David\u00a0R","family":"Borchelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":77,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0084726","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}