{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:28:13Z","timestamp":1790065693997,"version":"4.0.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0084835","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T16:45:29Z","timestamp":1388681129000},"page":"e84835","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Women Commencing Anastrozole, Letrozole or Tamoxifen for Early Breast Cancer: The Impact of Comorbidity and Demographics on Initial Choice"],"prefix":"10.1371","volume":"9","author":[{"given":"Anna","family":"Kemp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Preen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christobel","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bulsara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D\u2019Arcy J.","family":"Holman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Malacova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Roughead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.breast.2007.03.004","article-title":"Endocrine therapy for breast cancer: An overview","volume":"16","author":"KL Cheung","year":"2007","journal-title":"The Breast"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1056\/NEJMoa052258","article-title":"A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer","volume":"353","year":"2005","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0140-6736(97)11423-4","article-title":"Tamoxifen for early breast cancer: an overview of the randomised trials","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0140-6736(04)17666-6","article-title":"Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years&apos; adjuvant treatment for breast cancer","volume":"365","year":"2005","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1200\/JCO.2006.08.8617","article-title":"Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1\u201398","volume":"25","author":"A Coates","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.critrevonc.2012.06.005","article-title":"De Vos FYFL, van Laarhoven HWM, Laven JSE, Themmen APN, Beex LVAM, et al. Menopausal status and adjuvant hormonal therapy for breast cancer patients: A practical guideline","volume":"84","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1200\/JCO.2005.04.120","article-title":"Switching to anastrazole versus continued tamoxifen treatment of early breast cancer: Preliminary results of the Italian Tamoxifen Anastrazole trial","volume":"23","author":"F Boccardo","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1470-2045(07)70385-6","article-title":"Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial","volume":"9","author":"JF Forbes","year":"2008","journal-title":"Lancet Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.breast.2006.01.005","article-title":"Improving bone health in patients with early breast cancer by adding bisphosphonates to letrozole: the Z-ZO-E-ZO-FAST program","volume":"15","author":"M Aapro","year":"2006","journal-title":"Breast"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/jnci\/djr242","article-title":"Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: A systematic review and meta-analysis","volume":"103","author":"W Amir","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"ref11","unstructured":"Australian Government Department of Health (2013) Schedule of Pharmaceutical Benefits, 1 October 2013. Canberra: Department of Health. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pbs.gov.au\/pbs\/home\" xlink:type=\"simple\">http:\/\/www.pbs.gov.au\/pbs\/home<\/ext-link>. Accessed 2013, October 31."},{"key":"ref12","unstructured":"National Breast Cancer Centre (NBCC), National Health and Medical Research Council (NHMRC) (2001) Clinical practice guidelines for the management of early breast cancer: second edition. Canberra: NBCC, NHMRC. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nhmrc.gov.au\/guidelines\/publications\/cp74\" xlink:type=\"simple\">http:\/\/www.nhmrc.gov.au\/guidelines\/publications\/cp74<\/ext-link>. Accessed 2013, October 31."},{"key":"ref13","unstructured":"National Breast Cancer Centre (NBCC) (2006) Recommendations for aromatase inhibitors as adjuvant endocrine therapy for post-menopausal women with hormone receptor-positive early breast cancer. Sydney: NBCC. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/guidelines.nbocc.org.au\/guidelines\/print\/ch02.php\" xlink:type=\"simple\">http:\/\/guidelines.nbocc.org.au\/guidelines\/print\/ch02.php<\/ext-link>. Accessed 2013, October 31."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/ije\/dym184","article-title":"Cohort profile: The 45 and Up Study","volume":"37","author":"Collaborators 45 and Up Study","year":"2008","journal-title":"Int J Epidemiol"},{"key":"ref15","unstructured":"Sax Insitute (2013) Researcher toolkit. Sydney: Sax Institute. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.saxinstitute.org.au\/our-work\/45-up-study\/for-researchers\/\" xlink:type=\"simple\">https:\/\/www.saxinstitute.org.au\/our-work\/45-up-study\/for-researchers\/<\/ext-link>. Accessed 2013, October 31."},{"key":"ref16","unstructured":"Centre for Health Record Linkage (CHeReL) (2009) Information for researchers. Sydney: CHeReL. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cherel.org.au\/\" xlink:type=\"simple\">http:\/\/www.cherel.org.au\/<\/ext-link>. Accessed 2013, October 31."},{"key":"ref17","unstructured":"Cancer Institute of New South Wales (2013) NSW Central Cancer Registry Data Access. Sydney: Cancer Institute NSW. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cancerinstitute.org.au\/data-and-statistics\/cancer-registries\/nsw-central-cancer-registry-data-access\" xlink:type=\"simple\">http:\/\/www.cancerinstitute.org.au\/data-and-statistics\/cancer-registries\/nsw-central-cancer-registry-data-access<\/ext-link>. Accessed 2013, October 31."},{"key":"ref18","unstructured":"Cancer Institute of New South Wales (2013) Latest publications. Sydney: Cancer Institute NSW. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cancerinstitute.org.au\/publications#categoryName=cancer-reports\" xlink:type=\"simple\">http:\/\/www.cancerinstitute.org.au\/publications#categoryName=cancer-reports<\/ext-link>. Accessed 2013, October 31."},{"key":"ref19","unstructured":"World Health Organization (2001) International Classification of Diseases for Oncology (ICD-O) Albany, NY: WHO Publication Centers."},{"key":"ref20","unstructured":"Kemp A, Preen DB, Saunders C, Holman CDJ, Rogers K, et al. (2013) Ascertaining invasive breast cancer cases; the validity of administrative and self-reported data sources in Australia. BMC Medical Research Methodology 13: doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1186\/1471-2288-1113-1117\" xlink:type=\"simple\">10.1186\/1471-2288-1113-1117<\/ext-link>."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(02)08789-5","article-title":"Start tamoxifen after completing chemotherapy, US researchers say","volume":"359","author":"K Albain","year":"2002","journal-title":"Lancet"},{"key":"ref22","unstructured":"Australian Government Department of Health (2013) About the PBS. Canberra: Department of Health. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pbs.gov.au\/info\/about-the-pbs\" xlink:type=\"simple\">http:\/\/www.pbs.gov.au\/info\/about-the-pbs<\/ext-link>. Accessed 2013, October 31."},{"key":"ref23","unstructured":"Australian Government Department of Health (2013) Exemestane. Canberra: Department of Health. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pbs.gov.au\/medicine\/item\/8506Q\" xlink:type=\"simple\">http:\/\/www.pbs.gov.au\/medicine\/item\/8506Q<\/ext-link>. Accessed 2013, October 31."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1158\/1055-9965.EPI-08-0570","article-title":"Tamoxifen Treatment in Danish Breast Cancer Patients and 5-Year Risk of Arterial Atherosclerotic Events: A Null Association","volume":"17","author":"RK Hernandez","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref25","unstructured":"Australian Population and Migration Research Centre (2013) Accessibility and Remoteness Index of Australia (ARIA). Adelaide: The University of Adelaide. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.adelaide.edu.au\/apmrc\/research\/projects\/category\/aria.html\" xlink:type=\"simple\">http:\/\/www.adelaide.edu.au\/apmrc\/research\/projects\/category\/aria.html<\/ext-link>. Accessed 2013, October 31."},{"key":"ref26","unstructured":"Australian Bureau of Statistics (2003) Information paper: Census of Population and Housing - Socio-Economic Indexes for Areas, Australia, 2001 Canberra: ABS. Cat. 2039.0."},{"key":"ref27","unstructured":"Australian Government Department of Health (2005) Public Summary Documents. Anastrozole, tablets, 1 mg, Arimidex, July 2005. Canberra: Department of Health. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.health.gov.au\/internet\/main\/publishing.nsf\/Content\/pbac-psd-anastrozole\" xlink:type=\"simple\">http:\/\/www.health.gov.au\/internet\/main\/publishing.nsf\/Content\/pbac-psd-anastrozole<\/ext-link>. Accessed 2013, October 31."},{"key":"ref28","unstructured":"Australian Government Department of Health (2006) Government funds new breast cancer treatments. Canberra: Department of Health. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pbs.gov.au\/info\/news\/2006\/10\/govt-funds-new-brst-cncr-trtmnt\" xlink:type=\"simple\">http:\/\/www.pbs.gov.au\/info\/news\/2006\/10\/govt-funds-new-brst-cncr-trtmnt<\/ext-link>. Accessed 2013, 31 October."},{"key":"ref29","unstructured":"Australian Government Department of Health (2013) Fees, patient contributions and safety net thresholds, history of PBS copayments and safety net thresholds. Canberra: Department of Health. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pbs.gov.au\/info\/healthpro\/explanatory-notes\/front\/fee\" xlink:type=\"simple\">http:\/\/www.pbs.gov.au\/info\/healthpro\/explanatory-notes\/front\/fee<\/ext-link>. Accessed 2013, October 31."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A modified poisson regression approach to prospective studies with binary data","volume":"159","author":"G Zou","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10549-009-0692-7","article-title":"Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study","volume":"120","author":"K Briot","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/annonc\/mdt037","article-title":"Aromatase inhibitor-induced arthralgia: a review","volume":"24","author":"P Niravath","year":"2013","journal-title":"Ann Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.breast.2007.12.003","article-title":"Translating trial data into patients benefits: Making the right choice","volume":"17","author":"RT Chlebowski","year":"2008","journal-title":"The Breast"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0084835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:50:01Z","timestamp":1540259401000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0084835"}},"subtitle":[],"editor":[{"given":"William B.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,2]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0084835","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,2]]}}}