{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:02:10Z","timestamp":1783004530792,"version":"3.54.5"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085062","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T21:14:07Z","timestamp":1389734047000},"page":"e85062","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["The Multicenter Study of a New Assay for Simultaneous Detection of Multiple Anti-Aminoacyl-tRNA Synthetases in Myositis and Interstitial Pneumonia"],"prefix":"10.1371","volume":"9","author":[{"given":"Ran","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Imura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hosono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minae","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kizuku","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Handa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michito","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Fujio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kohsaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Takasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingo","family":"Chida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Hisata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Nukiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyo","family":"Mimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08916930600622884","article-title":"Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies","volume":"39","author":"H Yoshifuji","year":"2006","journal-title":"Autoimmunity"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/BOR.0b013e3282f01a8c","article-title":"Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance","volume":"19","author":"T Mimori","year":"2007","journal-title":"Curr Opin Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/art.1780230802","article-title":"Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Characterization of the Jo-1 antibody system","volume":"23","author":"M Nishikai","year":"1980","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/304177a0","article-title":"Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity","volume":"304","author":"MB Mathews","year":"1983","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/ard.60.2.116","article-title":"Autoantibody profiles in the sera of European patients with myositis","volume":"60","author":"R Brouwer","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1084\/jem.160.2.420","article-title":"Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody","volume":"160","author":"MB Mathews","year":"1984","journal-title":"J? Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.163.5.1281","article-title":"Autoantibodies against alanyl-tRNA synthetase and tRNAAla coexist and are associated with myositis","volume":"163","author":"CC Bunn","year":"1986","journal-title":"J? Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0002-9343(90)90149-8","article-title":"Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase)","volume":"88","author":"IN Targoff","year":"1990","journal-title":"Am? J? Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/art.1780350718","article-title":"Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease","volume":"35","author":"IN Targoff","year":"1992","journal-title":"Arthritis Rheum"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1172\/JCI116493","article-title":"Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase","volume":"91","author":"IN Targoff","year":"1993","journal-title":"J? Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.4049\/jimmunol.162.4.2315","article-title":"Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease","volume":"162","author":"M Hirakata","year":"1999","journal-title":"J? Immunol"},{"key":"ref12","first-page":"S312","article-title":"Igentification of autoantibodies to tyrosyl-tRNA synthetase in dermatomyositis with features consistent with antisynthetase syndrome [abstract]","volume":"52","author":"TE Hashish L","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/rheumatology\/kem045","article-title":"Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia","volume":"46","author":"Z Betteridge","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Aggarwal R, Cassidy E, Fertig N, Koontz DC, Lucas M, <etal>et al<\/etal>.. (2013) Patients with non-Jo-1 anti-tRNA-synthetase autoantibodies have worse survival than Jo-1 positive patients. Ann Rheum Dis.","DOI":"10.1136\/annrheumdis-2012-201800"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.autrev.2012.06.006","article-title":"Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity","volume":"12","author":"B Hervier","year":"2012","journal-title":"Autoimmun Rev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis (first of two parts)","volume":"292","author":"A Bohan","year":"1975","journal-title":"N? Engl? J? Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780230510","article-title":"Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee","volume":"23","journal-title":"Arthritis Rheum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"EM Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.rmed.2011.03.022","article-title":"Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias","volume":"105","author":"K Watanabe","year":"2011","journal-title":"Respir Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1002\/art.27700","article-title":"Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease","volume":"62","author":"T Sato","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"H Towbin","year":"1979","journal-title":"Proc Natl Acad Sci? U? S? A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/08916930600622645","article-title":"Clinical implications of autoantibody screening in patients with autoimmune myositis","volume":"39","author":"A Ghirardello","year":"2006","journal-title":"Autoimmunity"},{"key":"ref24","first-page":"1012","article-title":"Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis","volume":"34","author":"T Matsushita","year":"2007","journal-title":"J? Rheumatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0049-0172(96)80026-6","article-title":"Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis","volume":"26","author":"AW Friedman","year":"1996","journal-title":"Semin Arthritis Rheum"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00005792-199111000-00002","article-title":"A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups","volume":"70","author":"LA Love","year":"1991","journal-title":"Medicine (Baltimore)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1096\/fasebj.2.8.2452112","article-title":"Myositis autoantibody reactivity and catalytic function of threonyl-tRNA synthetase","volume":"2","author":"CV Dang","year":"1988","journal-title":"FASEB? J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.4049\/jimmunol.144.5.1737","article-title":"Autoantibodies to aminoacyl-transfer RNA synthetases for isoleucine and glycine. Two additional synthetases are antigenic in myositis","volume":"144","author":"IN Targoff","year":"1990","journal-title":"J? Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/jmbi.1998.2316","article-title":"Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein","volume":"285","author":"S Quevillon","year":"1999","journal-title":"J? Mol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/art.22506","article-title":"Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase","volume":"56","author":"M Hirakata","year":"2007","journal-title":"Arthritis Rheum"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T20:15:26Z","timestamp":1688933726000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085062"}},"subtitle":[],"editor":[{"given":"Masataka","family":"Kuwana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,14]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085062","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,14]]}}}