{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:37:43Z","timestamp":1773020263505,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085481","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T21:55:59Z","timestamp":1389995759000},"page":"e85481","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Exercise Training Attenuates Hypertension and Cardiac Hypertrophy by Modulating Neurotransmitters and Cytokines in Hypothalamic Paraventricular Nucleus"],"prefix":"10.1371","volume":"9","author":[{"given":"Lin-Lin","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ming","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Bao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ping","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Nian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00395-011-0215-7","article-title":"NF-\u03baB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure","volume":"106","author":"YM Kang","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1152\/ajpheart.00376.2007","article-title":"TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol","volume":"293","author":"N Mariappan","year":"2007","journal-title":"Am J Physio Heart Circ Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/HJH.0b013e32834e1df4","article-title":"Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats","volume":"30","author":"M Nishihara","year":"2012","journal-title":"J Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00395-011-0231-7","article-title":"Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR","volume":"106","author":"D Agarwal","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1249\/01.MSS.0000115224.88514.3A","article-title":"American College of Sports Medicine Position Stand: Exercise and hypertension","volume":"36","author":"LS Pescatello","year":"2004","journal-title":"Medicine & Science in Sports & Exercise"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00004872-200502000-00003","article-title":"Effect of resistance training on resting blood pressure: a meta-analysis of randomized controlled trials","volume":"23","author":"V Cornelissen","year":"2005","journal-title":"Journal of Hypertension"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1476-5381.2012.02224.x","article-title":"Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension","volume":"168","author":"FR Roque","year":"2013","journal-title":"Br J Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/jhh.2011.95","article-title":"The effect of 4 weeks of aerobic exercise on vascular and baroreflex function of young men with a family history of hypertension","volume":"26","author":"MJ Goldberg","year":"2012","journal-title":"J Hum Hypertens"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e46568","DOI":"10.1371\/journal.pone.0046568","article-title":"Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats","volume":"7","author":"N Mariappan","year":"2012","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/cvr\/cvp073","article-title":"Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension","volume":"82","author":"YM Kang","year":"2009","journal-title":"Cardiovasc Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/cvr\/cvp160","article-title":"Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure","volume":"83","author":"RL KangYM, He","year":"2009","journal-title":"Cardiovasc Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/cvr\/cvn119","article-title":"Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB","volume":"79","author":"YM Kang","year":"2008","journal-title":"Cardiovasc Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-8993(02)04091-X","article-title":"Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin","volume":"964","author":"M Barber","year":"2003","journal-title":"Brain Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e63847","DOI":"10.1371\/journal.pone.0063847","article-title":"Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension","volume":"8","author":"S Sriramula","year":"2013","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Yu XJ, Suo YP, Qi J, Yang Q, Li HH, <etal>et al<\/etal>.. (2013) Interaction between AT1 receptor and NF-\u03baB in hypothalamic paraventricular nucleus contributes to oxidative stress and sympathoexcitation by modulating neurotransmitters in heart failure. Cardiovascular Toxicology doi:10.1007\/s12012-013-9219-x.","DOI":"10.1007\/s12012-013-9219-x"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00395-011-0155-2","article-title":"Paraventricular nucleus corticotrophin releasing hormone contributes to sympathoexcitation via interaction with neurotransmitters in heart failure","volume":"106","author":"YM Kang","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"PG Guyenet","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/hyp.38.4.896","article-title":"Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release","volume":"38","author":"T Kishi","year":"2001","journal-title":"Hypertension"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1469-445X.2000.tb00019.x","article-title":"Local circuitry regulates the excitability of rat neurohypophysial neurones","volume":"85","author":"AV Ferguson","year":"2000","journal-title":"Exp Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.RES.0000244092.95152.86","article-title":"Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure","volume":"99","author":"YM Kang","year":"2006","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-4615-4871-3_11","article-title":"Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei","volume":"449","author":"JG Tasker","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/01.HYP.0000085197.20043.44","article-title":"Sympathoexcitation by PVN injected bicuculline requires activation of excitatory amino acid receptors","volume":"42","author":"QH Chen","year":"2003","journal-title":"Hypertension"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/01.RES.0000112964.40701.93","article-title":"Superoxide is involved in the central nervous system activation and sympathoexcitation of myocardial infarction-induced heart failure","volume":"94","author":"TE Lindley","year":"2004","journal-title":"Circ Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/10641963.2012.681084","article-title":"Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats","volume":"34","author":"T Kishi","year":"2012","journal-title":"Clin Exp Hypertens"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1152\/physrev.00031.2007","article-title":"Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production","volume":"88","author":"SK Powers","year":"2008","journal-title":"Physiol Rev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/HYPERTENSIONAHA.111.182154","article-title":"Angiotensin II-induced hypertension is modulated by nuclear factor-\u03baB in the paraventricular nucleus","volume":"59","author":"JP Cardinale","year":"2012","journal-title":"Hypertension"},{"key":"ref27","first-page":"20","article-title":"Role of reactive oxygen species in brainstem in neural mechanisms of hypertension. Auton","volume":"142","author":"Y Hirooka","year":"2008","journal-title":"Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1440-1681.2009.05234.x","article-title":"Brain cytokines as neuromodulators in cardiovascular control","volume":"37","author":"P Shi","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00007256-200636020-00002","article-title":"The anti-hypertensive effects of exercise","volume":"36","author":"M Hamer","year":"2006","journal-title":"Sports Medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1097\/00004872-200410000-00009","article-title":"Exercise intensity alters postexercise hypotension","volume":"22","author":"L Pescatello","year":"2004","journal-title":"Journal of Hypertension"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/ajh.2008.270","article-title":"Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats","volume":"21","author":"M Bertagnolli","year":"2008","journal-title":"Am J Hypertens"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Casillas JM, Gremeaux V, Damak S, Feki A, P\u00e9rennou D (2007) Exercise training for patients with cardiovascular disease. Ann Readapt Med Phys 50: 403\u201318, 386\u2013402.","DOI":"10.1016\/j.annrmp.2007.03.008"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1096\/fj.05-5547fje","article-title":"Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii","volume":"20","author":"S Wang","year":"2006","journal-title":"FASEB J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1152\/ajpheart.00473.2004","article-title":"Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure","volume":"288","author":"H Zheng","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref35","first-page":"59","article-title":"Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology","volume":"112","author":"YF Li","year":"2005","journal-title":"Methods Mol Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1523\/JNEUROSCI.5339-03.2004","article-title":"Numerous GABAergic afferents to locus ceruleus in the pericerulear dendritic zone: possible interneuronal pool","volume":"24","author":"JG Aston","year":"2004","journal-title":"J Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1152\/jn.00540.2002","article-title":"Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release","volume":"88","author":"DP Li","year":"2002","journal-title":"J. Neurophysiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainres.2005.07.070","article-title":"Chronic administration of olmesartan attenuates the exaggerated pressor response to glutamate in the rostral ventrolateral medulla of SHR","volume":"1058","author":"Y Lin","year":"2005","journal-title":"Brain Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1440-1681.2005.04205.x","article-title":"Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions","volume":"32","author":"RA Dampney","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1113\/expphysiol.2009.047449","article-title":"Exercise-induced neuronal plasticity in central autonomic networks: role in cardiovascular control","volume":"94","author":"LC Michelini","year":"2009","journal-title":"Exp Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1113\/expphysiol.2005.032227","article-title":"Inhibitory neurotransmission in the nucleus tractus solitarii: implications for baroreflex resetting during exercise","volume":"91","author":"JT Potts","year":"2006","journal-title":"Exp Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T19:35:29Z","timestamp":1565120129000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085481"}},"subtitle":[],"editor":[{"given":"Alejandro","family":"Lucia","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,17]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085481","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,17]]}}}