{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:11:49Z","timestamp":1761844309021},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085527","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T21:51:28Z","timestamp":1390341088000},"page":"e85527","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer"],"prefix":"10.1371","volume":"9","author":[{"given":"Manel","family":"Puig-Domingo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal M.","family":"Luque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi L.","family":"Reverter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel D.","family":"Gahete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Culler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"D\u00edaz-Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Lome\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Squarcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Mate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireia","family":"Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laureano","family":"Fern\u00e1ndez-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Alastru\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Balibrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00eddac","family":"Mauricio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justo P.","family":"Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"DS Cooper","year":"2009","journal-title":"Thyroid"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/eje.1.02158","article-title":"European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium and the European Thyroid Cancer Taskforce","volume":"154","author":"F Pacini","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2174\/138920211798120808","article-title":"New targeted therapies for thyroid cancer","volume":"12","author":"A Antonelli","year":"2011","journal-title":"Curr Genomics"},{"key":"ref4","first-page":"40","article-title":"Target therapies for radioiodine refractory advanced thyroid tumors","volume":"35","author":"M Schlumberger","year":"2012","journal-title":"J Endocrinol Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JME-11-0121","article-title":"Molecular mechanisms of somatostatin receptor trafficking","volume":"48","author":"Z Csaba","year":"2012","journal-title":"J Mol Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000339539","article-title":"Current status and perspectives of targeted therapy in well-differentiated neuroendocrine tumors","volume":"83","author":"BG Naraev","year":"2012","journal-title":"Oncology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1634\/theoncologist.2011-0458","article-title":"Antitumor effects of somatostatin analogs in neuroendocrine tumors","volume":"17","author":"L Sid\u00e9ris","year":"2012","journal-title":"Oncologist"},{"key":"ref8","first-page":"1857","article-title":"Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines","volume":"82","author":"KB Ain","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/iep.12024","article-title":"Somatostatin receptor expression in thyroid disease","volume":"94","author":"H Atkinson","year":"2013","journal-title":"Int J Exp Pat"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1055\/s-0032-1314859","article-title":"Differential expression of somatostatin receptor subtype 1\u20135 proteins in numerous human normal tissues","volume":"120","author":"N Unger","year":"2012","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-6614-2-1","article-title":"Expression of somatostatin receptor subtypes in human thyroid tumors: the immunohistochemical and molecular biology (RT-PCR) investigation","volume":"2","author":"H Pisarek","year":"2009","journal-title":"Thyroid Research"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-0029-1243636","article-title":"Somatostatin receptor subtype expression in human thyroid tumours","volume":"42","author":"A Klagge","year":"2010","journal-title":"Horm Metab Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1089\/thy.2006.16.1113","article-title":"Is there a role for sandostatin treatment in patients with progressive thyroid cancer and iodine-negative but somatostatin-receptor-positive metastases?","volume":"16","author":"S Kohlfuerst","year":"2006","journal-title":"Thyroid"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1210\/jc.2011-2088","article-title":"Clinical review: Current scientific rationale for the use of somatostatin analogs and mTOR inhibitors in neuroendocrine tumor therapy","volume":"97","author":"C Bousquet","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/annonc\/mdl105","article-title":"Rationale for the use of somatostatin analogs as antitumor agents","volume":"17","author":"C Susini","year":"2006","journal-title":"Ann Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1210\/jc.2006-0825","article-title":"99mTc-depreotide scintigraphy versus 18F-FDG-PET in the diagnosis of radioiodine-negative thyroid cancer","volume":"91","author":"M Rodrigues","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000314352","article-title":"Medical treatment of Cushing&apos;s disease: somatostatin analogues and pasireotide","volume":"92","author":"AM Pedroncelli","year":"2010","journal-title":"Neuroendocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/jc.2008-2564","article-title":"Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors","volume":"94","author":"M Dur\u00e1n-Prado","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1749-6632.2011.05985.x","article-title":"Truncated somatostatin receptors as new players in somatostatin-cortistatin pathophysiology","volume":"1220","author":"J C\u00f3rdoba-Chac\u00f3n","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1210\/jc.2009-2247","article-title":"A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs","volume":"95","author":"M Dur\u00e1n-Prado","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/onc.2011.389","article-title":"The new truncated somatostatin receptor variant sst5TMD4 is associated with poor prognosis in breast cancer and increases malignancy in MCF-7 cells","volume":"31","author":"M Dur\u00e1n-Prado","year":"2013","journal-title":"Oncogene"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/eje.1.02313","article-title":"Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas","volume":"156","author":"GF Taboada","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1158\/1541-7786.MCR-07-2073","article-title":"The effect of transforming growth factor beta on human neuroendocrine tumor BON cell proliferation and differentiation is mediated through somatostatin signal","volume":"6","author":"FP Leu","year":"2008","journal-title":"Mol Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1530\/EJE-11-0631","article-title":"Approach to the patient with advanced differentiated thyroid cancer","volume":"166","author":"M Schlumberger","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref25","first-page":"364","article-title":"Comparative study of historical series of differentiated thyroid carcinoma in two tertiary hospitals in Spain versus North American series","volume":"57","author":"JL Reverter","year":"2010","journal-title":"Endocrinol Nutr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11102-011-0335-y","article-title":"Comparison of octreotide LAR and lanreotide autogel as post-operative medical treatment in acromegaly","volume":"15","author":"Y Tutuncu","year":"2012","journal-title":"Pituitary"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11102-010-0282-z","article-title":"Clinical efficacy and safety results for dose escalation of somatostatin receptor ligands in patients with acromegaly: a literature review","volume":"14","author":"M Fleseriu","year":"2011","journal-title":"Pituitary"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"42S","DOI":"10.2967\/jnumed.110.085753","article-title":"Radiopeptide imaging and therapy in Europe","volume":"2","author":"V Ambrosini","year":"2011","journal-title":"J Nucl Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.14310\/horm.2002.1357","article-title":"Somatostatin receptor expression in non-medullary thyroid carcinomas","volume":"11","author":"K Pazaitou-Panayiotou","year":"2012","journal-title":"Hormones (Athens)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1210\/jc.2006-0334","article-title":"Selective activation of somatostatin receptor subtypes differentially modulates secretion and viability in human medullary thyroid carcinoma primary cultures: potential clinical perspectives","volume":"91","author":"MC Zatelli","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","first-page":"2161","article-title":"Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt","volume":"86","author":"MC Zatelli","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/thy.2009.0453","article-title":"Somatostatin receptor scintigraphy as a potential diagnostic and treatment modality for thyroid follicular-cell-derived cancers","volume":"20","author":"DJ Margulies","year":"2010","journal-title":"Thyroid"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1210\/jc.2006-0825","article-title":"99mTc-depreotide scintigraphy versus 18F-FDG-PET in the diagnosis of radioiodine-negative thyroid cancer","volume":"91","author":"M Rodrigues","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1046\/j.1432-1033.2003.03755.x","article-title":"The phosphorylation pattern of human alphas1-casein is markedly different from the ruminant species","volume":"270","author":"ES S\u00f8rensen","year":"2003","journal-title":"Eur J Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9180","DOI":"10.1073\/pnas.130196697","article-title":"Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238","volume":"97","author":"N Benali","year":"2000","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:53:20Z","timestamp":1589025200000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085527"}},"subtitle":[],"editor":[{"given":"Miguel","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,21]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085527","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,21]]}}}