{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:23:44Z","timestamp":1778217824378,"version":"3.51.4"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085567","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T21:22:43Z","timestamp":1389648163000},"page":"e85567","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transcriptional Profiling of Whole Blood Identifies a Unique 5-Gene Signature for Myelofibrosis and Imminent Myelofibrosis Transformation"],"prefix":"10.1371","volume":"9","author":[{"given":"Hans Carl","family":"Hasselbalch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibe","family":"Skov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stauffer Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Thomassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Hasselbalch Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten K.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Weis","family":"Bjerrum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben A.","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1056\/NEJMra063728","article-title":"The myeloproliferative disorders","volume":"55","author":"PJ Campbell","year":"2006","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1056\/NEJM200004273421706","article-title":"Myelofibrosis with myeloid metaplasia","volume":"342 (17)","author":"A Tefferi","year":"2000","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood.V98.12.3249","article-title":"Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia","volume":"98(12)","author":"G Barosi","year":"2001","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/leu.2008.112","article-title":"Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia","volume":"22","author":"E Puigdecanet","year":"2008","journal-title":"Leukemia"},{"key":"ref5","first-page":"3940","article-title":"Gene expression profiling in polycythemia vera using cDNA microarray technology","volume":"63","author":"A Pellagatti","year":"2003","journal-title":"Cancer Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1634\/stemcells.2006-0351","article-title":"Molecular profiling of CD34+ cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms' tumor gene 1 (WT1)","volume":"25","author":"P Guglielmelli","year":"2007","journal-title":"Stem Cells"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1182\/blood-2005-05-1889","article-title":"Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2","volume":"106","author":"R Kralovics","year":"2005","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1634\/stemcells.2004-0131","article-title":"Detection of aberrant gene expression in CD34+ hematopoietic stem cells from patients with agnogenic myeloid metaplasia using oligonucleotide microarrays","volume":"23","author":"LC Jones","year":"2005","journal-title":"Stem Cells"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/leu.2008.357","article-title":"Molecular profile of CD34+ stem\/progenitor cells according to JAK2V617F mutation status in essential thrombocythemia","volume":"23","author":"L Catani","year":"2009","journal-title":"Leukemia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1182\/blood-2009-05-224477","article-title":"Class prediction models of thrombocytosis using genetic biomarkers","volume":"115","author":"DV Gnatenko","year":"2010","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1158\/1078-0432.CCR-10-1092","article-title":"Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F","volume":"16","author":"W Berkofsky-Fessler","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.leukres.2011.03.013","article-title":"High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis","volume":"35(10)","author":"HC Hasselbalch","year":"2011","journal-title":"Leuk Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/10428194.2011.597905","article-title":"Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms","volume":"53(1)","author":"V Skov","year":"2012","journal-title":"Leuk Lymphoma"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-0609.2011.01618.x","article-title":"Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis","volume":"87","author":"V Skov","year":"2011","journal-title":"Eur J Haematol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.exphem.2012.05.011","article-title":"Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis","volume":"40(9)","author":"V Skov","year":"2012","journal-title":"Exp Hematol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.leukres.2012.07.009","article-title":"Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance","volume":"36(11)","author":"V Skov","year":"2012","journal-title":"Leuk Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"R: a language for data analysis and graphics","volume":"5","author":"R Ihaka","year":"1996","journal-title":"J Comp Graph Stat"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"RA Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Statist Soc B"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1182\/blood.V89.10.3503","article-title":"Granules of the human neutrophilic polymorphonuclear leukocyte","volume":"89","author":"N Borregaard","year":"1997","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00062752-200101000-00005","article-title":"Regulation of human neutrophil granule protein expression","volume":"8","author":"N Borregaard","year":"2001","journal-title":"Curr Opin Hematol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1182\/blood-2004-08-3346","article-title":"The transcriptional program of terminal granulocytic differentiation","volume":"105","author":"K Theilgaard-Monch","year":"2005","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2796.2010.02237.x","article-title":"Neutrophil granules in health and disease","volume":"268","author":"M Hager","year":"2010","journal-title":"J Intern Med"},{"key":"ref25","first-page":"4805","article-title":"Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases","volume":"105(11)","author":"M Xu","year":"2005","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1182\/blood-2008-06-158386","article-title":"French INSERM and the European EUMNET Networks on Myelofibrosis. Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence","volume":"112(8)","author":"JJ Lataillade","year":"2008","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.leukres.2008.06.002","article-title":"Myelofibrosis with myeloid metaplasia: the advanced phase of an untreated disseminated hematological cancer. Time to change our therapeutic attitude with early upfront treatment","volume":"33(1)","author":"HC Hasselbalch","year":"2009","journal-title":"Leuk Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1182\/blood-2005-09-3826","article-title":"Relation between JAK2 (V617F) mutation status, granulocyte activation, and constitutive mobilization of CD34+ cells into peripheral blood in myeloproliferative disorders","volume":"107(9)","author":"F Passamonti","year":"2006","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s10555-010-9262-z","article-title":"Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis","volume":"4","author":"PK Grover","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4149\/neo_2011_01_9","article-title":"Olfactomedin 4, a novel marker for the differentiation and progression of gastrointestinal cancers","volume":"58(1)","author":"L Yu","year":"2011","journal-title":"Neoplasma"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1182\/blood-2009-10-246439","article-title":"Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2\u2032-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis","volume":"116(23)","author":"W Liu","year":"2010","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1189\/jlb.0811417","article-title":"Olfactomedin 4 defines a subset of human neutrophils","volume":"91(3)","author":"SN Clemmensen","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.exphem.2006.04.002","article-title":"Mutual, reciprocal SDF-1\/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD\/SCID chimeric mice","volume":"34","author":"A Dar","year":"2006","journal-title":"Exp Hematol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bcmd.2007.01.003","article-title":"The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia","volume":"38(3)","author":"V Rosti","year":"2007","journal-title":"Blood Cells Mol Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1182\/blood-2011-11-394775","article-title":"Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer","volume":"119(14)","author":"HC Hasselbalch","year":"2012","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.leukres.2012.10.020","article-title":"Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development","volume":"37(2)","author":"HC Hasselbalch","year":"2013","journal-title":"Leuk Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cytogfr.2013.01.004","article-title":"The role of cytokines in the initiation and progression of myelofibrosis","volume":"24(2)","author":"HC Hasselbalch","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Hasselbalch HC (2013) A role of NF-E2 of chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis? Leuk Res Aug 8.","DOI":"10.1016\/j.leukres.2013.07.002"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T02:18:24Z","timestamp":1716430704000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085567"}},"subtitle":[],"editor":[{"given":"Andre","family":"van Wijnen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,13]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085567","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,13]]}}}