{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:36:00Z","timestamp":1791354960189,"version":"4.3.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085589","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T16:41:09Z","timestamp":1388421669000},"page":"e85589","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neuropilin-1 Expression Characterizes T Follicular Helper (Tfh) Cells Activated during B Cell Differentiation in Human Secondary Lymphoid Organs"],"prefix":"10.1371","volume":"8","author":[{"given":"Am\u00e9d\u00e9e","family":"Renand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Milpied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rossignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bruneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lemonnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dussiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Coulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.it.2010.07.001","article-title":"The elusive identity of T follicular helper cells","volume":"31","author":"D Yu","year":"2010","journal-title":"Trends Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/eji.200636136","article-title":"Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression","volume":"36","author":"AU Rasheed","year":"2006","journal-title":"Eur J Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1084\/jem.193.12.1373","article-title":"Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells","volume":"193","author":"CH Kim","year":"2001","journal-title":"J Exp Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.192.11.1553","article-title":"CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function","volume":"192","author":"P Schaerli","year":"2000","journal-title":"J Exp Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","article-title":"Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production","volume":"192","author":"D Breitfeld","year":"2000","journal-title":"J Exp Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1084\/jem.20091738","article-title":"IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses","volume":"207","author":"MA Linterman","year":"2010","journal-title":"J Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2009.03.003","article-title":"Follicular helper T cells: lineage and location","volume":"30","author":"N Fazilleau","year":"2009","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nature07345","article-title":"SAP-controlled T-B cell interactions underlie germinal centre formation","volume":"455","author":"H Qi","year":"2008","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ni.1877","article-title":"PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells","volume":"11","author":"KL Good-Jacobson","year":"2010","journal-title":"Nat Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1126\/science.1217718","article-title":"The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut","volume":"336","author":"S Kawamoto","year":"2012","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.immuni.2011.03.025","article-title":"Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity","volume":"34","author":"M Kitano","year":"2011","journal-title":"Immunity"},{"key":"ref12","article-title":"Interleukin- 2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation","author":"A Ballesteros-Tato","year":"2012","journal-title":"Immunity"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1084\/jem.20111174","article-title":"STAT5 is a potent negative regulator of TFH cell differentiation","volume":"209","author":"RJ Johnston","year":"2012","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20071639","article-title":"Neuropilins: structure, function and role in disease","volume":"411","author":"C Pellet-Many","year":"2008","journal-title":"Biochem J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0092-8674(00)80535-8","article-title":"Neuropilin is a semaphorin III receptor","volume":"90","author":"AL Kolodkin","year":"1997","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.4049\/jimmunol.165.11.6037","article-title":"BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood","volume":"165","author":"A Dzionek","year":"2000","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ni789","article-title":"A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response","volume":"3","author":"R Tordjman","year":"2002","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1182\/blood-2011-01-329268","article-title":"IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression","volume":"118","author":"P Milpied","year":"2011","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/eji.200324799","article-title":"Neuropilin-1: a surface marker of regulatory T cells","volume":"34","author":"D Bruder","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.immuni.2008.01.012","article-title":"Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition","volume":"28","author":"M Sarris","year":"2008","journal-title":"Immunity"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1084\/jem.20111497","article-title":"Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth","volume":"209","author":"W Hansen","year":"2012","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1189\/jlb.0208090","article-title":"Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity","volume":"84","author":"Y Glinka","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20120822","article-title":"Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo","volume":"209","author":"M Yadav","year":"2012","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2567.2007.02737.x","article-title":"Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer","volume":"123","author":"A Battaglia","year":"2008","journal-title":"Immunology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/eji.200839040","article-title":"Neuropilin-1 is not a marker of human Foxp3+ Treg","volume":"39","author":"P Milpied","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.immuni.2011.03.023","article-title":"ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6","volume":"34","author":"YS Choi","year":"2011","journal-title":"Immunity"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2172-6-3","article-title":"Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination","volume":"6","author":"JR Kim","year":"2005","journal-title":"BMC Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.2425","article-title":"Foxp3+ follicular regulatory T cells control the germinal center response","volume":"17","author":"MA Linterman","year":"2011","journal-title":"Nat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Y Chung","year":"2011","journal-title":"Nat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1172\/JCI24179","article-title":"Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus","volume":"115","author":"A Cappione 3rd","year":"2005","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1182\/blood-2008-03-145979","article-title":"Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression","volume":"113","author":"SM Jackson","year":"2009","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0198-8859(02)00752-8","article-title":"Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions","volume":"63","author":"A Dzionek","year":"2002","journal-title":"Hum Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2010.12.012","article-title":"Human Blood CXCR5(+)CD4(+) T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion","volume":"34","author":"R Morita","year":"2011","journal-title":"Immunity"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1182\/blood-2006-10-055145","article-title":"The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells","volume":"109","author":"L de Leval","year":"2007","journal-title":"Blood"},{"key":"ref35","article-title":"Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters","author":"F Lemonnier","year":"2012","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"MM Oken","year":"1982","journal-title":"Am J Clin Oncol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature06253","article-title":"Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA","volume":"450","author":"D Yu","year":"2007","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","article-title":"Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter","volume":"143","author":"GD Victora","year":"2010","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ni.1837","article-title":"Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation","volume":"11","author":"S Crotty","year":"2010","journal-title":"Nat Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.0903505","article-title":"Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)","volume":"185","author":"I Yusuf","year":"2010","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"E488","DOI":"10.1073\/pnas.1100898108","article-title":"Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers","volume":"108","author":"SE Bentebibel","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1073\/pnas.0700705104","article-title":"Control of human thymocyte migration by Neuropilin-1\/Semaphorin-3A-mediated interactions","volume":"104","author":"Y Lepelletier","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1749-6632.2008.03980.x","article-title":"Neuropilins, semaphorins, and their role in thymocyte development","volume":"1153","author":"DA Mendes-da-Cruz","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.icb.7100123","article-title":"Axon growth and guidance genes identify T-dependent germinal centre B cells","volume":"86","author":"D Yu","year":"2008","journal-title":"Immunol Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2011-07-365130","article-title":"Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice","volume":"120","author":"JI Ellyard","year":"2012","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/1535-7163.MCT-05-0538","article-title":"The role of neuropilins in cancer","volume":"5","author":"LM Ellis","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ccr.2006.10.018","article-title":"Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth","volume":"11","author":"Q Pan","year":"2007","journal-title":"Cancer Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1182\/blood-2010-05-282921","article-title":"Targeting neuropilin-1 in human leukemia and lymphoma","volume":"117","author":"K Karjalainen","year":"2011","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/onc.2010.9","article-title":"Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo","volume":"29","author":"C Nasarre","year":"2010","journal-title":"Oncogene"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.1183057","article-title":"Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs","volume":"328","author":"KN Sugahara","year":"2010","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"16157","DOI":"10.1073\/pnas.0908201106","article-title":"C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration","volume":"106","author":"T Teesalu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T13:04:31Z","timestamp":1565010271000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085589"}},"subtitle":[],"editor":[{"given":"Yolande","family":"Richard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,30]]},"references-count":51,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085589","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,30]]}}}