{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:43:19Z","timestamp":1771472599078,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085599","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T21:57:00Z","timestamp":1389995820000},"page":"e85599","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Genome-Wide Analysis of Long Noncoding RNA (lncRNA) Expression in Hepatoblastoma Tissues"],"prefix":"10.1371","volume":"9","author":[{"given":"Rui","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghuo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuiran","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1634\/theoncologist.5-6-445","article-title":"Childhood cancers: hepatoblastoma","volume":"5","author":"CE Herzog","year":"2000","journal-title":"Oncologist"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.sempedsurg.2011.10.011","article-title":"Hepatoblastoma: recent developments in research and treatment","volume":"21","author":"D von Schweinitz","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejca.2007.11.022","article-title":"Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience","volume":"44","author":"M De Ioris","year":"2008","journal-title":"Eur J Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1634\/theoncologist.2008-0011","article-title":"Liver tumors in children","volume":"13","author":"JB Litten","year":"2008","journal-title":"Oncologist"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/1097-0142(20011215)92:12<3130::AID-CNCR10115>3.0.CO;2-#","article-title":"Small cell undifferentiated histology in hepatoblastoma may be unfavorable","volume":"92","author":"JE Haas","year":"2001","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/1097-0142(19890901)64:5<1169::AID-CNCR2820640534>3.0.CO;2-I","article-title":"A case-control study of risk factors for hepatoblastoma. A report from the Childrens Cancer Study Group","volume":"64","author":"JD Buckley","year":"1989","journal-title":"Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/sj.bjc.6604335","article-title":"Perinatal risk factors for hepatoblastoma","volume":"98","author":"LG Spector","year":"2008","journal-title":"Br J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/pbc.24213","article-title":"Genetics and epigenetics of hepatoblastoma","volume":"59","author":"GE Tomlinson","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"CP Ponting","year":"2009","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1007\/s13277-013-0821-0","article-title":"Decreased expression of long noncoding RNA AC096655.1\u2013002 in gastric cancer and its clinical significance","volume":"34","author":"W Sun","year":"2013","journal-title":"Tumour Biol.Tumour Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12032-013-0588-6","article-title":"Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer","volume":"30","author":"X Ge","year":"2013","journal-title":"Med Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.7314\/APJCP.2013.14.2.1077","article-title":"Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma","volume":"14","author":"HP Qiao","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11596-013-1078-y","article-title":"Expression profile of altered long non-coding RNAs in patients with HBV-associated hepatocellular carcinoma","volume":"33","author":"YF Pan","year":"2013","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"D122","DOI":"10.1093\/nar\/gkn617","article-title":"NRED: a database of long noncoding RNA expression","volume":"37","author":"ME Dinger","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"GJ Dennis","year":"2003","journal-title":"Genome Biol"},{"key":"ref16","first-page":"2004","article-title":"LncRNA pro fi le of glioblastoma reveals the potential role of lncRNAs in contributing to glioblastoma pathogenesis","volume":"40","author":"L Han","year":"2012","journal-title":"Int J Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbrc.2013.02.083","article-title":"Microarray expression profile of long noncoding RNAs in human osteosarcoma","volume":"433","author":"JP Li","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbagen.2011.10.005","article-title":"Effects of resveratrol on HepG2 cells as revealed by (1)H-NMR based metabolic profiling","volume":"1820","author":"M Massimi","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1593\/tlo.09124","article-title":"Altered microRNA Expression Patterns in Hepatoblastoma Patients","volume":"2","author":"A Magrelli","year":"2009","journal-title":"Transl Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.24125","article-title":"MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma","volume":"53","author":"J von Frowein","year":"2011","journal-title":"Hepatology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/2159-8290.CD-11-0209","article-title":"The emergence of lncRNAs in cancer biology","volume":"1","author":"JR Prensner","year":"2011","journal-title":"Cancer Discov"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/bfgp\/elp038","article-title":"Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications","volume":"8","author":"ME Dinger","year":"2009","journal-title":"Brief Funct Genomic Proteomic"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"TR Mercer","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e10316","DOI":"10.1371\/journal.pone.0010316","article-title":"Mining mammalian transcript data for functional long non-coding RNAs","volume":"5","author":"AN Khachane","year":"2010","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4161\/rna.7.5.13216","article-title":"Long noncoding RNA in genome regulation: prospects and mechanisms","volume":"7","author":"T Hung","year":"2010","journal-title":"RNA Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2010.03.110","article-title":"Long non-coding RNAs in nervous system function and disease","volume":"1338","author":"IA Qureshi","year":"2010","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1093\/nar\/gkq285","article-title":"CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer","volume":"38","author":"J Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"24731","DOI":"10.1074\/jbc.M702029200","article-title":"Activation of p53 by MEG3 non-coding RNA","volume":"282","author":"Y Zhou","year":"2007","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/jcb.24055","article-title":"Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation","volume":"113","author":"P Wang","year":"2012","journal-title":"J Cell Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.humpath.2012.08.003","article-title":"High mobility group AT-hook 2 is overexpressed in hepatoblastoma","volume":"44","author":"CT Lee","year":"2013","journal-title":"Hum Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2443.2007.01065.x","article-title":"Oxidative stress induces p53-dependent apoptosis in hepatoblastoma cell through its nuclear translocation","volume":"12","author":"H Yamamoto","year":"2007","journal-title":"Genes Cells"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1245\/s10434-010-1037-9","article-title":"Overexpression of endothelial cell specific molecule-1 (ESM-1) in gastric cancer","volume":"17","author":"N Liu","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2559.2009.03458.x","article-title":"Vascular endocan (ESM-1) is markedly overexpressed in clear cell renal cell carcinoma","volume":"56","author":"X Leroy","year":"2010","journal-title":"Histopathology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1111\/j.1349-7006.2010.01665.x","article-title":"Identification of endothelial cell-specific molecule-1 as a potential serum marker for colorectal cancer","volume":"101","author":"NY Ji","year":"2010","journal-title":"Cancer Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.cellsig.2012.06.004","article-title":"ESM-1 regulates cell growth and metastatic process through activation of NF-kappaB in colorectal cancer","volume":"24","author":"YH Kang","year":"2012","journal-title":"Cell Signal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/en.2009-0657","article-title":"Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions","volume":"151","author":"X Zhang","year":"2010","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-012-1038-6","article-title":"MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas","volume":"112","author":"V Balik","year":"2013","journal-title":"J Neurooncol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4149\/neo_2013_063","article-title":"Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis","volume":"60","author":"R Qin","year":"2013","journal-title":"Neoplasma"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/2159-8290.CD-11-0209","article-title":"The emergence of lncRNAs in cancer biology","volume":"1","author":"JR Prensner","year":"2011","journal-title":"Cancer Discov"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:42:31Z","timestamp":1589010151000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085599"}},"subtitle":[],"editor":[{"given":"Qiong","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,17]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085599","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,17]]}}}