{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:39:36Z","timestamp":1764783576456},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085632","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T22:35:19Z","timestamp":1387838119000},"page":"e85632","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Homocysteine Homeostasis and Betaine-Homocysteine S-Methyltransferase Expression in the Brain of Hibernating Bats"],"prefix":"10.1371","volume":"8","author":[{"given":"Yijian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengteng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hsuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1111\/j.1538-7836.2005.01364.x","article-title":"Mechanisms of homocysteine-induced atherothrombosis","volume":"3","author":"SR Lentz","year":"2005","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00018-003-3204-7","article-title":"Molecular basis of homocysteine toxicity in humans","volume":"61","author":"H Jakubowski","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1089\/ars.2005.7.547","article-title":"Homocysteine and redox signaling","volume":"7","author":"C-G Zou","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jns.2004.09.006","article-title":"Homocysteine, cerebrovascular disease and brain atrophy","volume":"226","author":"P Sachdev","year":"2004","journal-title":"J Neurol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF00588024","article-title":"Hyperhomocysteinaemia; with reference to its neuroradiological aspects","volume":"37","author":"M Van den Berg","year":"1995","journal-title":"Neuroradiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1074\/jbc.273.16.9987","article-title":"Tissue plasminogen activator binding to the annexin II tail domain direct modulation by homocysteine","volume":"273","author":"KA Hajjar","year":"1998","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1172\/JCI115514","article-title":"Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine","volume":"88","author":"SR Lentz","year":"1991","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood.V94.3.959.415k20_959_967","article-title":"Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells","volume":"94","author":"PA Outinen","year":"1999","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00726-006-0432-9","article-title":"Mechanisms of homocysteine toxicity in humans","volume":"32","author":"J Per\u0142a-Kaj\u00e1n","year":"2007","journal-title":"Amino Acids"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: a perspective for the 1990s","author":"R Ross","year":"1993"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"S Seshadri","year":"2002","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","volume":"5","author":"AD Smith","year":"2010","journal-title":"PLOS ONE"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed in Alzheimer disease","volume":"55","author":"R Clarke","year":"1998","journal-title":"Archives of Neurology"},{"key":"ref14","first-page":"126","article-title":"Homocysteine and Alzheimer's disease","volume":"57","author":"JW Miller","year":"1999","journal-title":"Nutr Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","article-title":"Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity","volume":"20","author":"II Kruman","year":"2000","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","article-title":"Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease","volume":"80","author":"W Duan","year":"2002","journal-title":"J Neurochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.18388\/abp.2004_3580","article-title":"Methylation demand: a key determinant of homocysteine metabolism","volume":"51","author":"JT Brosnan","year":"2004","journal-title":"ACTA BIOCHIMICA POLONICA-ENGLISH EDITION"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"J Selhub","year":"1999","journal-title":"Annu Rev Nutr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1007\/s00018-006-6249-6","article-title":"Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?","volume":"63","author":"MA Pajares","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","article-title":"Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia","volume":"580","author":"R Obeid","year":"2006","journal-title":"FEBS Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/ajcn\/57.1.47","article-title":"Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia","volume":"57","author":"JB Ubbink","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/physrev.00008.2003","article-title":"Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature","volume":"83","author":"HV Carey","year":"2003","journal-title":"Physiol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1016\/j.cub.2013.01.062","article-title":"Hibernation","volume":"23","author":"F Geiser","year":"2013","journal-title":"Curr Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1387\/ijdb.082643pm","article-title":"Mammalian hibernation: differential gene expression and novel application of epigenetic controls","volume":"53","author":"P Jr Morin","year":"2009","journal-title":"Int J Dev Biol"},{"key":"ref25","article-title":"Biology of bats","author":"G Neuweiler","year":"2000"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e58427","DOI":"10.1371\/journal.pone.0058427","article-title":"Seasonal and Regional Differences in Gene Expression in the Brain of a Hibernating Mammal","volume":"8","author":"C Schwartz","year":"2013","journal-title":"PLOS ONE"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00360-009-0422-9","article-title":"Seasonal protein changes support rapid energy production in hibernator brainstem","volume":"180","author":"LE Epperson","year":"2010","journal-title":"J Comp Physiol B"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2006.03.017","article-title":"Circannual control of hibernation by HP complex in the brain","volume":"125","author":"N Kondo","year":"2006","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"R1297","DOI":"10.1152\/ajpregu.00260.2005","article-title":"Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels","volume":"289","author":"YL Ma","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1460-9568.2006.05250.x","article-title":"Hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons\u2013implications for Alzheimer's disease","volume":"25","author":"W H\u00e4rtig","year":"2007","journal-title":"Eur J Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0002-9440(10)64686-X","article-title":"Hibernation, a model of neuroprotection","volume":"158","author":"F Zhou","year":"2001","journal-title":"Am J Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpb.2012.01.008","article-title":"Neuroprotection: Lessons from hibernators","volume":"162","author":"KR Dave","year":"2012","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e62039","DOI":"10.1371\/journal.pone.0062039","article-title":"Adaptation of Phenylalanine and Tyrosine Catabolic Pathway to Hibernation in Bats","volume":"8","author":"Y-H Pan","year":"2013","journal-title":"PLOS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0021-9258(18)96205-8","article-title":"Trans-sulfuration in Mammals The Methionine-Sparing Effect Of Cystine","volume":"242","author":"JD Finkelstein","year":"1967","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"22831","DOI":"10.1074\/jbc.271.37.22831","article-title":"Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase","volume":"271","author":"TA Garrow","year":"1996","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0009-8981(91)90235-5","article-title":"Betaine: homocysteine methyltransferase\u2014a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes","volume":"204","author":"J Wang","year":"1991","journal-title":"Clinica Chimica Acta"},{"key":"ref37","article-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2004"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"25","author":"JD Thompson","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2164-7-8","article-title":"Evidence of host-virus co-evolution in tetranucleotide usage patterns of bacteriophages and eukaryotic viruses","volume":"7","author":"DT Pride","year":"2006","journal-title":"BMC Genomics"},{"key":"ref40","first-page":"418","article-title":"Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions","volume":"3","author":"M Nei","year":"1986","journal-title":"Mol Biol Evol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"W13","DOI":"10.1093\/nar\/gkr245","article-title":"T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension","volume":"39","author":"P Di Tommaso","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"D387","DOI":"10.1093\/nar\/gkn750","article-title":"The SWISS-MODEL Repository and associated resources","volume":"37","author":"F Kiefer","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1007\/PL00014300","article-title":"The metabolism of homocysteine: pathways and regulation","volume":"157","author":"JD Finkelstein","year":"1998","journal-title":"Eur J Pediatr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jmb.2004.03.005","article-title":"Crystal Structure of Rat Liver Betaine Homocysteine S-Methyltransferase Reveals New Oligomerization Features and Conformational Changes Upon Substrate Binding","volume":"338","author":"B Gonz\u00e1lez","year":"2004","journal-title":"J Mol Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/j.1471-4159.2008.05294.x","article-title":"Physiological regulation of tau phosphorylation during hibernation","volume":"105","author":"B Su","year":"2008","journal-title":"J Neurochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/hep.21854","article-title":"Mechanisms of protection by the betaine homocysteine methyltransferase\/betaine system in HepG2 cells and primary mouse hepatocytes","volume":"46","author":"C Ji","year":"2007","journal-title":"Hepatology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"36258","DOI":"10.1074\/jbc.M111.265348","article-title":"Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas","volume":"286","author":"Y-W Teng","year":"2011","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"E933","DOI":"10.1152\/ajpendo.00498.2005","article-title":"Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver","volume":"290","author":"S Ratnam","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jn\/137.2.311","article-title":"New insights into the regulation of methyl group and homocysteine metabolism","volume":"137","author":"KT Williams","year":"2007","journal-title":"J Nutr"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ajcn\/80.3.539","article-title":"Betaine in human nutrition","volume":"80","author":"SAS Craig","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00585834","article-title":"Effect of hibernation and noradrenaline on acetylcholine release and action at neuromuscular junction of the golden hamster (Mesocricetus auratus)","volume":"345","author":"I Melichar","year":"1973","journal-title":"Pfl\u00fcgers Archiv"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"E Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"ref53","first-page":"325","article-title":"Homocysteine and B vitamins","author":"S Cook","year":"2005"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1017\/S0007114575000463","article-title":"Vitamin B12 metabolism in the fruit bat (Rousettus aegyptiacus). The induction of vitamin B12 deficiency and its effect on folate levels","volume":"34","author":"SV van Tonder","year":"1975","journal-title":"Br J Nutr"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000228829","article-title":"Out cold: biochemical regulation of mammalian hibernation\u2013a mini-review","volume":"56","author":"KB Storey","year":"2010","journal-title":"Gerontology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1046\/j.1432-1327.2001.02278.x","article-title":"Roles of homocysteine in cell metabolism","volume":"268","author":"MA Medina","year":"2001","journal-title":"European Journal of Biochemistry"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0021-9150(90)90058-Q","article-title":"Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease effects of pyridoxine and folic acid treatment","volume":"81","author":"L Brattstr\u00f6m","year":"1990","journal-title":"Atherosclerosis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/oxfordjournals.aje.a008828","article-title":"Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate","volume":"143","author":"P Verhoef","year":"1996","journal-title":"Am J Epidemiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI104589","article-title":"Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies","volume":"41","author":"V Herbert","year":"1962","journal-title":"J Clin Invest"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.nu.05.070185.000555","article-title":"Vitamin B12-folate interrelationships","volume":"5","author":"B Shane","year":"1985","journal-title":"Annu Rev Nutr"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0021-9258(17)43702-1","article-title":"Biosynthesis and proteolytic activation of cystathionine beta-synthase in rat liver","volume":"259","author":"F Skovby","year":"1984","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e4032","DOI":"10.1371\/journal.pone.0004032","article-title":"Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine \u03b2-synthase sumoylation","volume":"3","author":"N Agrawal","year":"2008","journal-title":"PLOS ONE"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1471-4159.2010.06580.x","article-title":"Hydrogen sulfide as a gasotransmitter","volume":"113","author":"MM Gadalla","year":"2010","journal-title":"J Neurochem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/abbi.1998.0723","article-title":"Trypsin cleavage of human cystathionine \u03b2-synthase into an evolutionarily conserved active core: structural and functional consequences","volume":"355","author":"V Kery","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/jnnp.53.2.161","article-title":"A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease","volume":"53","author":"MM Esiri","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0969-2126(02)00796-7","article-title":"Betaine-homocysteine methyltransferase: zinc in a distorted barrel","volume":"10","author":"JC Evans","year":"2002","journal-title":"Structure"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T14:53:51Z","timestamp":1647788031000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085632"}},"subtitle":[],"editor":[{"given":"Michelle\u00a0L.","family":"Baker","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,23]]},"references-count":66,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085632","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,23]]}}}