{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:39:30Z","timestamp":1778629170814,"version":"3.51.4"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085914","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T21:32:59Z","timestamp":1390253579000},"page":"e85914","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Neural Network of Body Representation Differs between Transsexuals and Cissexuals"],"prefix":"10.1371","volume":"9","author":[{"given":"Chia-Shu","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Lun","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Tai","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Chi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Ta","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chou-Ming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung-Ping","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Chiao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Chuen","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,20]]},"reference":[{"key":"ref1","unstructured":"American Psychiatric Association, editor (2000) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revised. Washington, DC.: American Psychiatric Association."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e70808","DOI":"10.1371\/journal.pone.0070808","article-title":"Brain signature characterizing the body-brain-mind axis of transsexuals","volume":"8","author":"H-L Ku","year":"2013","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jpsychores.2004.08.010","article-title":"Psychiatric comorbidity in gender identity disorder","volume":"58","author":"U Hepp","year":"2005","journal-title":"J Psychosom Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/BF01544272","article-title":"A body image scale for evaluating transsexuals","volume":"4","author":"TW Lindgren","year":"1975","journal-title":"Arch Sex Behav"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0924-9338(02)00703-4","article-title":"The transsexual: what about the future","volume":"17","author":"A Michel","year":"2002","journal-title":"Eur Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1743-6109.2008.01082.x","article-title":"Long-term assessment of the physical, mental, and sexual health among transsexual women","volume":"6","author":"S Weyers","year":"2009","journal-title":"J Sex Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.neuropsychologia.2009.08.022","article-title":"More than skin deep: body representation beyond primary somatosensory cortex","volume":"48","author":"MR Longo","year":"2010","journal-title":"Neuropsychologia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.neuro.24.1.107","article-title":"Touch and go: decision-making mechanisms in somatosensation","volume":"24","author":"R Romo","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","article-title":"Circuitry and functional aspects of the insular lobe in primates including humans","volume":"22","author":"JR Augustine","year":"1996","journal-title":"Brain Res Brain Res Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/cercor\/bhq186","article-title":"Three systems of insular functional connectivity identified with cluster analysis","volume":"21","author":"B Deen","year":"2011","journal-title":"Cereb Cortex"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2013now? The anterior insula and human awareness","volume":"10","author":"AD Craig","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Simmons WK, Avery JA, Barcalow JC, Bodurka J, Drevets WC, et al. (2012) Keeping the body in mind: Insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness. Hum Brain Mapp.","DOI":"10.1002\/hbm.22113"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"WW Seeley","year":"2007","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.071043098","article-title":"Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function","volume":"98","author":"DA Gusnard","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuroimage.2004.01.019","article-title":"Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level: a physiological account of a \u201cdefault mode\u201d of brain function","volume":"22","author":"Y Nagai","year":"2004","journal-title":"Neuroimage"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"17558","DOI":"10.1073\/pnas.0902455106","article-title":"Learning sculpts the spontaneous activity of the resting human brain","volume":"106","author":"CM Lewis","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e66761","DOI":"10.1371\/journal.pone.0066761","article-title":"Sculpting the Intrinsic Modular Organization of Spontaneous Brain Activity by Art","volume":"8","author":"CS Lin","year":"2013","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1503\/jpn.100050","article-title":"Default mode alterations in posttraumatic stress disorder related to early-life trauma: a developmental perspective","volume":"36","author":"JK Daniels","year":"2011","journal-title":"J Psychiatry Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.conb.2012.11.015","article-title":"Network attributes for segregation and integration in the human brain","volume":"23","author":"O Sporns","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/cercor\/bhr269","article-title":"Network centrality in the human functional connectome","volume":"22","author":"XN Zuo","year":"2012","journal-title":"Cereb Cortex"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.biopsych.2012.03.026","article-title":"Disrupted functional brain connectome in individuals at risk for Alzheimer\u2019s disease","volume":"73","author":"J Wang","year":"2013","journal-title":"Biol Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1523\/JNEUROSCI.0964-10.2011","article-title":"Globally altered structural brain network topology in grapheme-color synesthesia","volume":"31","author":"J Hanggi","year":"2011","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1152\/jn.00606.2012","article-title":"Dynamic modulation of intrinsic functional connectivity by transcranial direct current stimulation","volume":"108","author":"B Sehm","year":"2012","journal-title":"J Neurophysiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.neuroimage.2011.05.078","article-title":"Long-term effects of motor training on resting-state networks and underlying brain structure","volume":"57","author":"M Taubert","year":"2011","journal-title":"Neuroimage"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"<italic>An inventory for measuring depression<\/italic>","volume":"4","author":"AT Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Bond M (1986) An empirical study of defense styles: The Defense Style Questionnaire, in Vaillant GE (ed); Empirical Studies of Ego Mechanisms of Defense. Washington, D.C.: American Psychiatric Press Inc. 127\u2013158 p.","DOI":"10.1176\/appi.books.9798894550190.lg09"},{"key":"ref27","unstructured":"Lee YC, Chen YS, Yang CH, Yang YM, Huang SC, et al. (2000) Development of \u201cDefense Style Questionnaire-Chinese version\u201d and normative data establishment. Taipei Veterans General Hospital, Taiwan, R.O.C."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1300\/J082v11n01_04","article-title":"Sexual orientation: a multi-variable dynamic process","volume":"11","author":"F Klein","year":"1985","journal-title":"J Homosex"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroimage.2011.07.044","article-title":"The influence of head motion on intrinsic functional connectivity MRI","volume":"59","author":"KR Van Dijk","year":"2012","journal-title":"Neuroimage"},{"key":"ref30","first-page":"13","article-title":"DPARSF: A MATLAB Toolbox for \u201cPipeline\u201d Data Analysis of Resting-State fMRI","volume":"4","author":"Y Chao-Gan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuroimage.2008.09.036","article-title":"The impact of global signal regression on resting state correlations: are anti-correlated networks introduced","volume":"44","author":"K Murphy","year":"2009","journal-title":"Neuroimage"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/brain.2012.0080","article-title":"Trouble at rest: how correlation patterns and group differences become distorted after global signal regression","volume":"2","author":"ZS Saad","year":"2012","journal-title":"Brain Connect"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/nimg.1999.0440","article-title":"Areas 3a, 3b, and 1 of human primary somatosensory cortex","volume":"10","author":"S Geyer","year":"1999","journal-title":"Neuroimage"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fnsys.2010.00147","article-title":"Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia","volume":"4","author":"AF Alexander-Bloch","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Yan CG, Craddock RC, Zuo XN, Zang YF, Milham MP (2013) Standardizing the intrinsic brain: Towards robust measurement of inter-individual variation in 1000 functional connectomes. Neuroimage.","DOI":"10.1016\/j.neuroimage.2013.04.081"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1093\/cercor\/bhr032","article-title":"Sex dimorphism of the brain in male-to-female transsexuals","volume":"21","author":"I Savic","year":"2011","journal-title":"Cereb Cortex"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.mehy.2007.02.024","article-title":"Occurrence of phantom genitalia after gender reassignment surgery","volume":"69","author":"VS Ramachandran","year":"2007","journal-title":"Med Hypotheses"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biopsych.2012.04.025","article-title":"Disruption of visuospatial and somatosensory functional connectivity in anorexia nervosa","volume":"72","author":"A Favaro","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/npp.2013.18","article-title":"Abnormal brain network organization in body dysmorphic disorder","volume":"38","author":"D Arienzo","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nrn2478","article-title":"Functional role of the supplementary and pre-supplementary motor areas","volume":"9","author":"P Nachev","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/cercor\/bhr088","article-title":"Resting-state functional connectivity of the medial superior frontal cortex","volume":"22","author":"S Zhang","year":"2012","journal-title":"Cereb Cortex"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1162\/jocn_a_00230","article-title":"A sensorimotor network for the bodily self","volume":"24","author":"F Ferri","year":"2012","journal-title":"J Cogn Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/2245","article-title":"Maintaining internal representations: the role of the human superior parietal lobe","volume":"1","author":"DM Wolpert","year":"1998","journal-title":"Nat Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.pain.2013.05.009","article-title":"The anticipation of pain at a specific location of the body prioritizes tactile stimuli at that location","volume":"154","author":"C Vanden Bulcke","year":"2013","journal-title":"Pain"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"R164","DOI":"10.1016\/j.cub.2013.01.047","article-title":"Spatial sensory organization and body representation in pain perception","volume":"23","author":"P Haggard","year":"2013","journal-title":"Curr Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnhum.2013.00216","article-title":"Insular Dysfunction Reflects Altered Between-Network Connectivity and Severity of Negative Symptoms in Schizophrenia during Psychotic Remission","volume":"7","author":"A Manoliu","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1002\/hbm.20705","article-title":"Two systems of resting state connectivity between the insula and cingulate cortex","volume":"30","author":"KS Taylor","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/j.neuroimage.2010.10.010","article-title":"Attention to aversive emotion and specific activation of the right insula and right somatosensory cortex","volume":"54","author":"T Straube","year":"2011","journal-title":"Neuroimage"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/hbm.21049","article-title":"Embodied visual perception of distorted finger postures","volume":"32","author":"M Schurmann","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fnhum.2012.00246","article-title":"Error awareness and salience processing in the oddball task: shared neural mechanisms","volume":"6","author":"HA Harsay","year":"2012","journal-title":"Front Hum Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1523\/JNEUROSCI.4692-12.2013","article-title":"Cognitive control and the salience network: an investigation of error processing and effective connectivity","volume":"33","author":"T Ham","year":"2013","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1017\/S0033291712001390","article-title":"Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress","volume":"43","author":"JM Cisler","year":"2013","journal-title":"Psychol Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jad.2012.11.023","article-title":"Functional connectivity in apathy of late-life depression: a preliminary study","volume":"149","author":"GS Alexopoulos","year":"2013","journal-title":"J Affect Disord"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tics.2005.03.010","article-title":"The cognitive control of emotion","volume":"9","author":"KN Ochsner","year":"2005","journal-title":"Trends Cogn Sci"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Romanski LM (2012) Convergence of Auditory, Visual, and Somatosensory Information in Ventral Prefrontal Cortex. In: Murray MM, T WM, editors. The Neural Bases of Multisensory Processes. Boca Raton (FL): CRC Press.","DOI":"10.1201\/b11092-42"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"RC165","DOI":"10.1523\/JNEUROSCI.21-18-j0001.2001","article-title":"Neural correlates of conscious self-regulation of emotion","volume":"21","author":"M Beauregard","year":"2001","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.brainresbull.2007.06.013","article-title":"Self-awareness and the left inferior frontal gyrus: inner speech use during self-related processing","volume":"74","author":"A Morin","year":"2007","journal-title":"Brain Res Bull"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T16:18:09Z","timestamp":1746116289000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085914"}},"subtitle":[],"editor":[{"given":"Cosimo","family":"Urgesi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,20]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085914","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,20]]}}}