{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:57:16Z","timestamp":1790506636390,"version":"4.1.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:00:00Z","timestamp":1391126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0085976","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T22:34:11Z","timestamp":1391207651000},"page":"e85976","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Block Copolymer\/DNA Vaccination Induces a Strong Allergen-Specific Local Response in a Mouse Model of House Dust Mite Asthma"],"prefix":"10.1371","volume":"9","author":[{"given":"Camille","family":"Rolland-Debord","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphaine","family":"Roussey-Bihou\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian","family":"Hassoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Evrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Aude","family":"Cheminant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Chesn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Braza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Mahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Portero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pitard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Magnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"ref1","unstructured":"Global Initiative for Asthma (GINA) website. Global Strategy for Asthma Management and Prevention report Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_March13.pdf\" xlink:type=\"simple\">http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_March13.pdf<\/ext-link>. Accessed 2013 Nov 15."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.rmed.2009.01.008","article-title":"Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy","volume":"103(6)","author":"A Pipet","year":"2009","journal-title":"Respir Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jaci.2010.11.030","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"127(1)","author":"CA Akdis","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2567.2004.01927.x","article-title":"Reversal of established CD4+ type 2 T helper-mediated allergic airway inflammation and eosinophilia by therapeutic treatment with DNA vaccines limits progression towards chronic inflammation and remodelling","volume":"112(4)","author":"ER Jarman","year":"2004","journal-title":"Immunology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/02770900600701424","article-title":"Co-administration of vaccination with DNA encoding T cell epitope on the Der p and BCG inhibited airway remodeling in a murine model of chronic asthma","volume":"43(5)","author":"CH Kim","year":"2006","journal-title":"J Asthma"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/mt.2009.84","article-title":"DNA\/amphiphilic block copolymer nanospheres promote low-dose DNA vaccination","volume":"17(8)","author":"D McIlroy","year":"2009","journal-title":"Mol Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.hrthm.2009.08.009","article-title":"Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction","volume":"6(12)","author":"P Biliczki","year":"2009","journal-title":"Heart Rhythm"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1093\/nar\/gnh153","article-title":"Negatively charged self-assembling DNA\/poloxamine nanospheres for in vivo gene transfer","volume":"32(20)","author":"B Pitard","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jgm.631","article-title":"Inducible production of erythropoietin using intramuscular injection of block copolymer\/DNA formulation","volume":"7(1)","author":"P Richard","year":"2005","journal-title":"J Gene Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1089\/hum.2005.16.1318","article-title":"Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles","volume":"16(11)","author":"P Richard","year":"2005","journal-title":"Hum Gene Ther"},{"key":"ref11","first-page":"597","article-title":"DNA\/amphiphilic block copolymer nanospheres reduce asthmatic response in a mouse model of allergic asthma. Hum Gene Ther","volume":"23(6)","author":"F Beilvert","year":"2012"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1084\/jem.178.6.2123","article-title":"Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals","volume":"178(6)","author":"H Secrist","year":"1993","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1398-9995.2011.02589.x","article-title":"Immunological mechanisms of allergen-specific immunotherapy","volume":"66(6)","author":"M Jutel","year":"2011","journal-title":"Allergy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1365-2222.2006.02487.x","article-title":"Ultra-rush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy","volume":"36(6)","author":"E Mamessier","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1172\/JCI2250","article-title":"Role of interleukin 10 in specific immunotherapy","volume":"102(1)","author":"CA Akdis","year":"1998","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2222.2011.03845.x","article-title":"Recombinant DNA immunotherapy ameliorate established airway allergy in a IL-10 dependent pathway","volume":"42(1)","author":"DM Fonseca","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00262-004-0653-2","article-title":"Tumor antigen-specific T helper cells in cancer immunity and immunotherapy","volume":"54(8)","author":"KL Knutson","year":"2005","journal-title":"Cancer Immunol Immunother"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0264-410X(02)00029-4","article-title":"Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Der f 11","volume":"20(13\u201314)","author":"HJ Peng","year":"2002","journal-title":"Vaccine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/CVI.00275-09","article-title":"Block copolymers have differing adjuvant effects on the primary immune response elicited by genetic immunization and on further induced allergy","volume":"17(1)","author":"K Adel-Patient","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1002\/eji.200737899","article-title":"Protein\/DNA vaccine-induced antigen-specific Treg confer protection against asthma","volume":"38(9)","author":"H Jin","year":"2008","journal-title":"Eur J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0085976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:58:44Z","timestamp":1589018324000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0085976"}},"subtitle":[],"editor":[{"given":"Irving Coy","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,31]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0085976","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,31]]}}}